{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T14:57:10Z","timestamp":1780757830226,"version":"3.54.1"},"reference-count":33,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2005,12,1]],"date-time":"2005-12-01T00:00:00Z","timestamp":1133395200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2005,12]]},"DOI":"10.1016\/j.bbrc.2005.09.045","type":"journal-article","created":{"date-parts":[[2005,9,17]],"date-time":"2005-09-17T11:12:00Z","timestamp":1126955520000},"page":"277-284","source":"Crossref","is-referenced-by-count":11,"title":["Distinctive iron requirement of tryptophan 5-monooxygenase: TPH1 requires dissociable ferrous iron"],"prefix":"10.1016","volume":"338","author":[{"given":"Hiroyuki","family":"Hasegawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arata","family":"Ichiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2005.09.045_bib1","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/0014-2999(67)90061-1","article-title":"Characterization of a tryptophan hydroxylating enzyme from malignant mouse mast cell","volume":"1","author":"Sato","year":"1967","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.bbrc.2005.09.045_bib2","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1016\/S0021-9258(19)77149-X","article-title":"Enzymic studies on the biosynthesis of serotonin in mammalian brain","volume":"245","author":"Ichiyama","year":"1970","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2005.09.045_bib3","doi-asserted-by":"crossref","first-page":"4165","DOI":"10.1016\/S0021-9258(19)45055-2","article-title":"Partial purification and characterization of tryptophan hydroxylase from rabbit hindbrain","volume":"247","author":"Friedman","year":"1972","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2005.09.045_bib4","doi-asserted-by":"crossref","first-page":"12569","DOI":"10.1021\/bi026561f","article-title":"Three-dimensional structure of human tryptophan hydroxylase and its implications for the biosynthesis of the neurotransmitters serotonin and melatonin","volume":"41","author":"Wang","year":"2002","journal-title":"Biochemistry"},{"key":"10.1016\/j.bbrc.2005.09.045_bib5","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1124\/mi.3.2.72","article-title":"Knockout mouse points to second form of tryptophan hydroxylase","volume":"3","author":"Veenstra-VanderWeele","year":"2003","journal-title":"Mol. Interv."},{"key":"10.1016\/j.bbrc.2005.09.045_bib6","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1126\/science.1078197","article-title":"Synthesis of serotonin by a second tryptophan hydroxylase isoform","volume":"299","author":"Walther","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.bbrc.2005.09.045_bib7","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.biopsych.2003.09.002","article-title":"Robust and tissue-specific expression of TPH2 versus TPH1 in rat raphe and pineal gland","volume":"55","author":"Patel","year":"2004","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.bbrc.2005.09.045_bib8","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1042\/bj2480501","article-title":"Demonstration of non-neural tryptophan 5-mono-oxygenase in mouse intestinal mucosa","volume":"248","author":"Hasegawa","year":"1987","journal-title":"Biochem. J."},{"key":"10.1016\/j.bbrc.2005.09.045_bib9","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1111\/j.1432-1033.1982.tb06636.x","article-title":"Tryptophan 5-monooxygenase from mouse mastocytoma P815. A simple purification and general properties","volume":"124","author":"Nakata","year":"1982","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.bbrc.2005.09.045_bib10","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1111\/j.1432-1033.1982.tb05845.x","article-title":"Purification and properties of tryptophan 5-monooxygenase from rat brainstem","volume":"122","author":"Nakata","year":"1982","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.bbrc.2005.09.045_bib11","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/0014-5793(74)80900-2","article-title":"The activation of bovine pineal tryptophan 5-monooxygenase","volume":"40","author":"Ichiyama","year":"1974","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bbrc.2005.09.045_bib12","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/978-1-4684-3270-1_9","article-title":"Some properties of bovine pineal tryptophan hydroxylase","volume":"74","author":"Ichiyama","year":"1976","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.bbrc.2005.09.045_bib13","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1007\/BF00963761","article-title":"Characteristics of the activation by dithiothreitol and Fe(2+) of tryptophan hydroxylase from the rat brain","volume":"3","author":"Hamon","year":"1978","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.bbrc.2005.09.045_bib14","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/0922-4106(89)90048-5","article-title":"Acute inactivation of tryptophan hydroxylase by amphetamine analogs involves the oxidation of sulfhydryl sites","volume":"172","author":"Stone","year":"1989","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.bbrc.2005.09.045_bib15","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1111\/j.1471-4159.1989.tb07372.x","article-title":"In vitro reactivation of rat cortical tryptophan hydroxylase following in vivo inactivation by methylenedioxymethamphetamine","volume":"53","author":"Stone","year":"1989","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbrc.2005.09.045_bib16","doi-asserted-by":"crossref","first-page":"4137","DOI":"10.1016\/S0021-9258(19)85644-2","article-title":"Tryptophan hydroxylase. The role of oxygen, iron, and sulfhydryl groups as determinants of stability and catalytic activity","volume":"255","author":"Kuhn","year":"1980","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2005.09.045_bib17","series-title":"Methods in Biogenic Amine Research","first-page":"387","article-title":"Activation by dithiothreitol and assay methods of bovine pineal tryptophan hydroxylase","author":"Ichiyama","year":"1983"},{"key":"10.1016\/j.bbrc.2005.09.045_bib18","first-page":"1751","article-title":"Assay of tryptophan hydroxylase and aromatic l-amino acid decarboxylase based on the rapid separation of reaction product by high performance liquid chromatography","volume":"95","author":"Hasegawa","year":"1984","journal-title":"J. Biochem."},{"key":"10.1016\/j.bbrc.2005.09.045_bib19","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/S0076-6879(87)42013-2","article-title":"Tryptophan 5-monooxygenase from mouse mastocytoma: high-performance liquid chromatography assay","volume":"142","author":"Hasegawa","year":"1987","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.bbrc.2005.09.045_bib20","series-title":"Unconjugated pterins and related biogenic amines","first-page":"353","article-title":"Mechanism of activation of tryptophan 5-monooxygenase by mercaptides","author":"Hasegawa","year":"1987"},{"key":"10.1016\/j.bbrc.2005.09.045_bib21","unstructured":"H. Hasegawa, A. Ichiyama, Mechanism of the activation by dithiothreitol of mastocytoma tryptophan 5-monooxyganase and of inactivation of the activated enzyme under aerobic conditions., in International symposium on oxyganase and oxygen activation, in Yamamoto, S., Nozaki, M., Ichimura, Y., (Eds.), Yamada Science Foundation, 1991, pp. 83\u201386."},{"key":"10.1016\/j.bbrc.2005.09.045_bib22","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1093\/oxfordjournals.jbchem.a131432","article-title":"Dihydropteridine reductase from bovine liver. Purification, crystallization, and isolation of a binary complex with NADH","volume":"81","author":"Hasegawa","year":"1977","journal-title":"J. Biochem."},{"key":"10.1016\/j.bbrc.2005.09.045_bib23","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1093\/oxfordjournals.jbchem.a133952","article-title":"Tryptophan hydroxylase from mouse mastocytoma P-815. Reversible activation by ethylenediaminetetraacetate","volume":"92","author":"Yanagisawa","year":"1982","journal-title":"J. Biochem."},{"key":"10.1016\/j.bbrc.2005.09.045_bib24","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/0003-2697(77)90381-5","article-title":"Fluorescent thiol reagents: XII. Fluorescent tracer method for protein SH groups using N-(7-dimethylamino-4-methyl coumarinyl) maleimide. An application to the proteins separated by SDS\u2013polyacrylamide gel electrophoresis","volume":"79","author":"Yamamoto","year":"1977","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.bbrc.2005.09.045_bib25","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/S0021-9258(19)68274-8","article-title":"Phenylalanine hydroxylase. Correlation of the iron content with activity and the preparation and reconstitution of the apoenzyme","volume":"257","author":"Gottschall","year":"1982","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2005.09.045_bib26","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/0003-2697(82)90358-X","article-title":"Determination of phosphate content of purified proteins","volume":"120","author":"Hasegawa","year":"1982","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.bbrc.2005.09.045_bib27","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/S0003-2670(01)85035-2","article-title":"An algorism for the computation of aqueous multicomponent, multiphase equilibria","volume":"112","author":"Eriksson","year":"1979","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.bbrc.2005.09.045_bib28","unstructured":"L. Backman, in: 1988 Biosoft, Cambridge."},{"key":"10.1016\/j.bbrc.2005.09.045_bib29","doi-asserted-by":"crossref","first-page":"4345","DOI":"10.1016\/S0021-9258(19)43778-2","article-title":"The Stimulation of rat liver phenylalanine hydroxylase be lysolecitin and alpha-chymotrypsin","volume":"248","author":"Fisher","year":"1973","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2005.09.045_bib30","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1002\/jnr.490280402","article-title":"Isolation and structural characterization of the murine tryptophan hydroxylase gene","volume":"28","author":"Stoll","year":"1991","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.bbrc.2005.09.045_bib31","series-title":"Pterins and Biogenic Amines in Neurology, Pediatrics, and Immunology","first-page":"245","article-title":"Iron acquisition by tryptophan hydroxylase is a bottle neck of serotonin biosynthesis","author":"Hasegawa","year":"1991"},{"key":"10.1016\/j.bbrc.2005.09.045_bib32","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1007\/978-1-4613-0381-7_79","article-title":"Tryptophan hydroxylase activity in serotonin producing mast cells. Dependence on intracellular iron concentration manipulated by permeable chelators","author":"Hasegawa","year":"1996","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.bbrc.2005.09.045_bib33","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1046\/j.1432-1327.1999.00316.x","article-title":"Iron dependence of tryptophan hydroxylase activity in RBL2H3 cells and its manipulation by chelators","volume":"261","author":"Hasegawa","year":"1999","journal-title":"Eur. J. Biochem."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X05020541?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X05020541?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,7,17]],"date-time":"2021-07-17T19:45:50Z","timestamp":1626551150000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X05020541"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,12]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2005,12]]}},"alternative-id":["S0006291X05020541"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2005.09.045","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2005,12]]}}}