{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T02:52:16Z","timestamp":1790477536395,"version":"4.1.0"},"reference-count":30,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2006,3,1]],"date-time":"2006-03-01T00:00:00Z","timestamp":1141171200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,3,1]],"date-time":"2006-03-01T00:00:00Z","timestamp":1141171200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2006,3,1]],"date-time":"2006-03-01T00:00:00Z","timestamp":1141171200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2006,3,1]],"date-time":"2006-03-01T00:00:00Z","timestamp":1141171200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2006,3,1]],"date-time":"2006-03-01T00:00:00Z","timestamp":1141171200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2006,3,1]],"date-time":"2006-03-01T00:00:00Z","timestamp":1141171200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2006,3,1]],"date-time":"2006-03-01T00:00:00Z","timestamp":1141171200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100009673","name":"Gun och Bertil Stohnes Stiftelse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009673","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010815","name":"Stiftelsen f\u00f6r Gamla Tj\u00e4narinnor","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010815","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004047","name":"Karolinska Institutet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004047","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2006,3]]},"DOI":"10.1016\/j.bbrc.2006.01.096","type":"journal-article","created":{"date-parts":[[2006,2,1]],"date-time":"2006-02-01T07:16:55Z","timestamp":1138778215000},"page":"1294-1299","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["Antibody-bound amyloid precursor protein upregulates ornithine decarboxylase expression"],"prefix":"10.1016","volume":"341","author":[{"given":"Tatjana","family":"Nilsson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna","family":"Malkiewicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Gabrielsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronnie","family":"Folkesson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bengt","family":"Winblad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eirikur","family":"Benedikz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2006.01.096_bib1","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1146\/annurev.neuro.21.1.479","article-title":"Mutant genes in familial Alzheimer\u2019s disease and transgenic models","volume":"21","author":"Price","year":"1998","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.bbrc.2006.01.096_bib2","doi-asserted-by":"crossref","first-page":"3996","DOI":"10.1038\/sj.emboj.7600860","article-title":"The amyloid-beta precursor protein: integrating structure with biological function","volume":"24","author":"Reinhard","year":"2005","journal-title":"EMBO J."},{"key":"10.1016\/j.bbrc.2006.01.096_bib3","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1159\/000067424","article-title":"Molecular mechanisms for neuronal cell death by Alzheimer\u2019s amyloid precursor protein-relevant insults","volume":"11","author":"Kawasumi","year":"2002","journal-title":"Neurosignals"},{"key":"10.1016\/j.bbrc.2006.01.096_bib4","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/S0169-328X(02)00519-3","article-title":"Anti-apoptotic wild-type Alzheimer amyloid precursor protein signaling involves the p38 mitogen-activated protein kinase\/MEF2 pathway","volume":"108","author":"Burton","year":"2002","journal-title":"Mol. Brain Res."},{"key":"10.1016\/j.bbrc.2006.01.096_bib5","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1042\/bj20021197","article-title":"Late Simian virus 40 transcription factor is a target of the phosphoinositide 3-kinase\/Akt pathway in anti-apoptotic Alzheimer\u2019s amyloid precursor protein signalling","volume":"370","author":"Kashour","year":"2003","journal-title":"Biochem. J."},{"key":"10.1016\/j.bbrc.2006.01.096_bib6","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1136\/jmg.38.4.232","article-title":"Genetic association of an LBP-1c\/CP2\/LSF gene polymorphism with late onset Alzheimer\u2019s disease","volume":"38","author":"Taylor","year":"2001","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.bbrc.2006.01.096_bib7","doi-asserted-by":"crossref","first-page":"4665","DOI":"10.1093\/emboj\/19.17.4665","article-title":"Inhibition of the mammalian transcription factor LSF induces S-phase-dependent apoptosis by downregulating thymidylate synthase expression","volume":"19","author":"Powel","year":"2000","journal-title":"EMBO J."},{"key":"10.1016\/j.bbrc.2006.01.096_bib8","doi-asserted-by":"crossref","first-page":"13389","DOI":"10.1074\/jbc.M111571200","article-title":"Insulin-degrading enzyme rapidly removes the beta-amyloid precursor protein intracellular domain (AICD)","volume":"277","author":"Edbauer","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2006.01.096_bib9","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1046\/j.1471-4159.2001.00516.x","article-title":"The amyloid precursor protein (APP)-cytoplasmic fragment generated by gamma-secretase is rapidly degraded but distributes partially in a nuclear fraction of neurones in culture","volume":"78","author":"Cupers","year":"2001","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbrc.2006.01.096_bib10","doi-asserted-by":"crossref","first-page":"40288","DOI":"10.1074\/jbc.C100447200","article-title":"The intracellular domain of the beta-amyloid precursor protein is stabilized by Fe65 and translocates to the nucleus in a notch-like manner","volume":"276","author":"Kimberly","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2006.01.096_bib11","doi-asserted-by":"crossref","first-page":"6545","DOI":"10.1074\/jbc.M007340200","article-title":"The beta-amyloid precursor protein functions as a cytosolic anchoring site that prevents Fe65 nuclear translocation","volume":"276","author":"Minopoli","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2006.01.096_bib12","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1126\/science.1058783","article-title":"A transcriptionally active complex of APP with Fe65 and histone acetyltransferase Tip60","volume":"293","author":"Cao","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.bbrc.2006.01.096_bib13","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0092-8674(02)00809-7","article-title":"Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kappaB and beta-amyloid precursor protein","volume":"110","author":"Baek","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2006.01.096_bib14","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1002\/1097-4547(20010301)63:5<429::AID-JNR1038>3.0.CO;2-U","article-title":"Calcium ionophore A23187 specifically decreases the secretion of beta-secretase cleaved amyloid precursor protein during apoptosis in primary rat cortical cultures","volume":"63","author":"Sennvik","year":"2001","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.bbrc.2006.01.096_bib15","doi-asserted-by":"crossref","first-page":"2801","DOI":"10.1101\/gad.13.21.2801","article-title":"Mice lacking both presenilin genes exhibit early embryonic patterning defects","volume":"13","author":"Donoviel","year":"1999","journal-title":"Genes Dev."},{"key":"10.1016\/j.bbrc.2006.01.096_bib16","doi-asserted-by":"crossref","first-page":"6763","DOI":"10.1074\/jbc.C100649200","article-title":"A sensitive and quantitative assay for measuring cleavage of presenilin substrates","volume":"277","author":"Karlstr\u00f6m","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2006.01.096_bib17","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.nbd.2004.11.010","article-title":"Antibody-bound beta-amyloid precursor protein stimulates the production of tumor necrosis factor-alpha and monocyte chemoattractant protein-1 by cortical neurones","volume":"19","author":"Mbebi","year":"2005","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.bbrc.2006.01.096_bib18","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S1357-2725(98)00135-6","article-title":"Translational regulation of ornithine decarboxylase and other enzymes of the polyamine pathway","volume":"31","author":"Shantz","year":"1999","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.bbrc.2006.01.096_bib19","first-page":"1721","article-title":"c-Myc and Max transregulate the mouse ornithine decarboxylase promoter through interaction with two downstream CACGTG motifs","volume":"11","author":"Tobias","year":"1995","journal-title":"Oncogene"},{"key":"10.1016\/j.bbrc.2006.01.096_bib20","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/S0014-5793(01)02113-5","article-title":"Growth factor-dependent signaling and cell cycle progression","volume":"490","author":"Jones","year":"2001","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bbrc.2006.01.096_bib21","doi-asserted-by":"crossref","first-page":"6735","DOI":"10.1016\/S0021-9258(18)32281-6","article-title":"Ornithine decarboxylase in mouse kidney: purification, characterization, and radioimmunological determination of the enzyme protein","volume":"258","author":"Isomaa","year":"1983","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2006.01.096_bib22","first-page":"45","article-title":"The effect of testosterone on the half-life of ornithine decarboxylase-mRNA in mouse kidney","volume":"9","author":"Laitinen","year":"1984","journal-title":"Biochem. Int."},{"key":"10.1016\/j.bbrc.2006.01.096_bib23","doi-asserted-by":"crossref","first-page":"36895","DOI":"10.1074\/jbc.M502861200","article-title":"A gamma-secretase independent mechanism of signal transduction by the amyloid precursor protein","volume":"280","author":"Hass","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2006.01.096_bib24","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1146\/annurev.pa.35.040195.000415","article-title":"Polyamines as targets for therapeutic intervention","volume":"35","author":"Marton","year":"1995","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.bbrc.2006.01.096_bib25","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/0165-6147(96)81566-5","article-title":"Modulation of channel function by polyamines","volume":"17","author":"Johnson","year":"1996","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.bbrc.2006.01.096_bib26","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1023\/A:1007508008731","article-title":"Oxidation of polyamines and brain injury","volume":"25","author":"Seiler","year":"2000","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.bbrc.2006.01.096_bib27","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/S0301-0082(98)00065-3","article-title":"The cellular localization of the l-ornithine decarboxylase\/polyamine system in normal and diseased central nervous systems","volume":"57","author":"Bernstein","year":"1999","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.bbrc.2006.01.096_bib28","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/0305-0491(93)90269-B","article-title":"Antioxidant properties of di- and polyamines","volume":"104","author":"Matkovics","year":"1993","journal-title":"Comp. Biochem. Physiol. B"},{"key":"10.1016\/j.bbrc.2006.01.096_bib29","doi-asserted-by":"crossref","first-page":"11140","DOI":"10.1073\/pnas.95.19.11140","article-title":"The natural polyamine spermine functions directly as a free radical scavenger","volume":"95","author":"Ha","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbrc.2006.01.096_bib30","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S0006-8993(97)00011-5","article-title":"Polyamines prevent apoptotic cell death in cultured cerebellar granule neurons","volume":"753","author":"Harada","year":"1997","journal-title":"Brain Res."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X06001896?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X06001896?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T14:13:10Z","timestamp":1762092790000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X06001896"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,3]]},"references-count":30,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2006,3]]}},"alternative-id":["S0006291X06001896"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2006.01.096","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2006,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Antibody-bound amyloid precursor protein upregulates ornithine decarboxylase expression","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2006.01.096","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}