{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T03:42:07Z","timestamp":1770694927135,"version":"3.49.0"},"reference-count":35,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2006,4,1]],"date-time":"2006-04-01T00:00:00Z","timestamp":1143849600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2006,4]]},"DOI":"10.1016\/j.bbrc.2006.02.108","type":"journal-article","created":{"date-parts":[[2006,3,1]],"date-time":"2006-03-01T18:46:10Z","timestamp":1141238770000},"page":"1382-1388","source":"Crossref","is-referenced-by-count":22,"title":["Critical role of cholic acid for development of hypercholesterolemia and gallstones in diabetic mice"],"prefix":"10.1016","volume":"342","author":[{"given":"Jin","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mats","family":"G\u00e5fvels","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mats","family":"Rudling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlotte","family":"Murphy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingemar","family":"Bj\u00f6rkhem","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Curt","family":"Einarsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00f6sta","family":"Eggertsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2006.02.108_bib1","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1055\/s-2000-8401","article-title":"Short and long-term effects of streptozotocin on dietary cholesterol absorption, plasma lipoproteins and liver lipoprotein receptors in RICO rats","volume":"108","author":"Milliat","year":"2000","journal-title":"Exp. Clin. Endocrinol. Diabetes"},{"key":"10.1016\/j.bbrc.2006.02.108_bib2","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/0300-483X(91)90070-H","article-title":"Studies on the mechanism of bile salt-independent bile flow impairment in streptozotocin-induced hepatotoxicity","volume":"68","author":"Carnovale","year":"1991","journal-title":"Toxicology"},{"key":"10.1016\/j.bbrc.2006.02.108_bib3","first-page":"277","article-title":"Anomalies of lipid metabolism in diabetes mellitus","volume":"12","author":"Verges","year":"1991","journal-title":"Rev. Med. Interne."},{"key":"10.1016\/j.bbrc.2006.02.108_bib4","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1002\/hep.510250401","article-title":"Gallstones and diabetes: a case-control study in a free-living population sample","volume":"25","author":"De Santis","year":"1997","journal-title":"Hepatology"},{"key":"10.1016\/j.bbrc.2006.02.108_bib5","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1007\/BF01947564","article-title":"Reversible impairment of hepatobiliary function induced by streptozotocin in the rat","volume":"40","author":"Carnovale","year":"1984","journal-title":"Experientia"},{"key":"10.1016\/j.bbrc.2006.02.108_bib6","doi-asserted-by":"crossref","first-page":"52","DOI":"10.5551\/jat1994.3.52","article-title":"Altered bile acid metabolism related to atherosclerosis in alloxan diabetic rats","volume":"3","author":"Uchida","year":"1996","journal-title":"J. Atheroscler. Thromb."},{"key":"10.1016\/j.bbrc.2006.02.108_bib7","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1007\/BF02469813","article-title":"Increased biliary cholesterol secretion in alloxan diabetic mice","volume":"14","author":"Ishikawa","year":"1984","journal-title":"Jpn. J. Surg."},{"key":"10.1016\/j.bbrc.2006.02.108_bib8","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1152\/ajplegacy.1964.206.3.628","article-title":"Induction of gallstones in mice by feeding a cholesterol-cholic acid containing diet","volume":"206","author":"Tepperman","year":"1964","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.bbrc.2006.02.108_bib9","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1172\/JCI0216309","article-title":"Cholic acid mediates negative feedback regulation of bile acid synthesis in mice","volume":"110","author":"Li-Hawkins","year":"2002","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbrc.2006.02.108_bib10","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1093\/oxfordjournals.jbchem.a022422","article-title":"Structure, evolution, and liver-specific expression of sterol 12alpha-hydroxylase P450 (CYP8B)","volume":"126","author":"Ishida","year":"1999","journal-title":"J. Biochem. (Tokyo)"},{"key":"10.1016\/j.bbrc.2006.02.108_bib11","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1111\/j.1365-2362.2006.01597.x","article-title":"Lipoprotein profiles in plasma and interstitial fluid analyzed with an automated gel-filtration system","volume":"36","author":"Parini","year":"2006","journal-title":"Eur. J. Clin. Invest."},{"key":"10.1016\/j.bbrc.2006.02.108_bib12","doi-asserted-by":"crossref","first-page":"28947","DOI":"10.1074\/jbc.M002782200","article-title":"The peroxisome proliferator-activated receptor alpha (PPARalpha) regulates bile acid biosynthesis","volume":"275","author":"Hunt","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2006.02.108_bib13","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/0009-8981(75)90364-2","article-title":"Enzymatic determination of cholesterol in bile","volume":"64","author":"Roda","year":"1975","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.bbrc.2006.02.108_bib14","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1080\/00365521.1974.12096821","article-title":"Quantitative determination of bile acids and their conjugates using thin-layer chromatography and a purified 3alpha-hydroxysteroid dehydrogenase","volume":"9","author":"Fausa","year":"1974","journal-title":"Scand. J. Gastroenterol."},{"key":"10.1016\/j.bbrc.2006.02.108_bib15","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1007\/BF02531316","article-title":"Two dimensional then layer chromatographic separation of polar lipids and determination of phospholipids by phosphorus analysis of spots","volume":"5","author":"Rouser","year":"1970","journal-title":"Lipids"},{"key":"10.1016\/j.bbrc.2006.02.108_bib16","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1016\/S0022-2275(20)40677-7","article-title":"Critical tables for calculating the cholesterol saturation of native bile","volume":"19","author":"Carey","year":"1978","journal-title":"J. Lipid. Res."},{"key":"10.1016\/j.bbrc.2006.02.108_bib17","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1194\/jlr.M500441-JLR200","article-title":"Studies on LXR- and FXR-mediated effects on cholesterol homeostasis in normal and cholic acid-depleted mice","volume":"47","author":"Wang","year":"2006","journal-title":"J. Lipid. Res."},{"key":"10.1016\/j.bbrc.2006.02.108_bib18","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/S0022-2275(20)38774-5","article-title":"Cholesterol gallstones in alloxan-diabetic mice","volume":"27","author":"Akiyoshi","year":"1986","journal-title":"J. Lipid. Res."},{"key":"10.1016\/j.bbrc.2006.02.108_bib19","unstructured":"N.H. Afdhal, Gallbladder and Biliary Tract Diseases, ed., Marcel Dekker Inc., New York, 2000."},{"key":"10.1016\/j.bbrc.2006.02.108_bib20","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1016\/S0016-5085(98)70322-1","article-title":"Cholesterol saturation, not proteins or cholecystitis, is critical for crystal formation in human gallbladder bile","volume":"114","author":"Miquel","year":"1998","journal-title":"Gastroenterology"},{"key":"10.1016\/j.bbrc.2006.02.108_bib21","first-page":"G751","article-title":"Cholic acid aids absorption, biliary secretion, and phase transitions of cholesterol in murine cholelithogenesis","volume":"276","author":"Wang","year":"1999","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.bbrc.2006.02.108_bib22","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1093\/oxfordjournals.jbchem.a022584","article-title":"Insulin is a dominant suppressor of sterol 12 alpha-hydroxylase P450 (CYP8B) expression in rat liver: possible role of insulin in circadian rhythm of CYP8B","volume":"127","author":"Ishida","year":"2000","journal-title":"J. Biochem. (Tokyo)"},{"key":"10.1016\/j.bbrc.2006.02.108_bib23","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1515\/bchm3.1988.369.2.1117","article-title":"Effect of streptozotocin-induced diabetes on the activity of 7 alpha-hydroxy-4-cholesten-3-one-specific 12 alpha-hydroxylase in rats","volume":"369","author":"Kimura","year":"1988","journal-title":"Biol. Chem. Hoppe Seyler"},{"key":"10.1016\/j.bbrc.2006.02.108_bib24","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1172\/JCI0216001","article-title":"Overexpression of ABCG5 and ABCG8 promotes biliary cholesterol secretion and reduces fractional absorption of dietary cholesterol","volume":"110","author":"Yu","year":"2002","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbrc.2006.02.108_bib25","doi-asserted-by":"crossref","first-page":"18793","DOI":"10.1074\/jbc.M109927200","article-title":"Regulation of ATP-binding cassette sterol transporters ABCG5 and ABCG8 by the liver X receptors alpha and beta","volume":"277","author":"Repa","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2006.02.108_bib26","doi-asserted-by":"crossref","first-page":"2922","DOI":"10.2337\/diabetes.51.10.2922","article-title":"Polyunsaturated fatty acids and acetoacetate downregulate the expression of the ATP-binding cassette transporter A1","volume":"51","author":"Uehara","year":"2002","journal-title":"Diabetes"},{"key":"10.1016\/j.bbrc.2006.02.108_bib27","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1007\/s00125-003-1261-y","article-title":"Down-regulation of hepatic and intestinal Abcg5 and Abcg8 expression associated with altered sterol fluxes in rats with streptozotocin-induced diabetes","volume":"47","author":"Bloks","year":"2004","journal-title":"Diabetologia"},{"key":"10.1016\/j.bbrc.2006.02.108_bib28","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1073\/pnas.98.4.2011","article-title":"Targeted inactivation of sister of P-glycoprotein gene (spgp) in mice results in nonprogressive but persistent intrahepatic cholestasis","volume":"98","author":"Wang","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbrc.2006.02.108_bib29","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/0092-8674(93)90380-9","article-title":"Homozygous disruption of the murine mdr2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease","volume":"75","author":"Smit","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2006.02.108_bib30","doi-asserted-by":"crossref","first-page":"1842","DOI":"10.1053\/gast.2002.33582","article-title":"Differential effects of streptozotocin-induced diabetes on expression of hepatic ABC-transporters in rats","volume":"122","author":"van Waarde","year":"2002","journal-title":"Gastroenterology"},{"key":"10.1016\/j.bbrc.2006.02.108_bib31","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/S0022-2275(20)37603-3","volume":"37","author":"Wang","year":"1996","journal-title":"J. Lipid. Res."},{"key":"10.1016\/j.bbrc.2006.02.108_bib32","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.arcmed.2005.01.005","article-title":"Regulation of plasma triglycerides in insulin resistance and diabetes","volume":"36","author":"Ginsberg","year":"2005","journal-title":"Arch. Med. Res."},{"key":"10.1016\/j.bbrc.2006.02.108_bib33","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.atherosclerosissup.2005.06.003","article-title":"What is the consequence of an abnormal lipid profile in patients with type 2 diabetes or the metabolic syndrome?","volume":"6","author":"Windler","year":"2005","journal-title":"Atheroscler Suppl."},{"key":"10.1016\/j.bbrc.2006.02.108_bib34","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1007\/s001250051252","article-title":"The role of microsomal triglyceride transfer protein and dietary cholesterol in chylomicron production in diabetes","volume":"42","author":"Gleeson","year":"1999","journal-title":"Diabetologia"},{"key":"10.1016\/j.bbrc.2006.02.108_bib35","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1097\/00041433-200406000-00007","article-title":"Hepatic cholesterol transport from plasma into bile: implications for gallstone disease","volume":"15","author":"Zanlungo","year":"2004","journal-title":"Curr. Opin. Lipidol."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X06003858?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X06003858?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,7,24]],"date-time":"2021-07-24T11:16:05Z","timestamp":1627125365000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X06003858"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,4]]},"references-count":35,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2006,4]]}},"alternative-id":["S0006291X06003858"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2006.02.108","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2006,4]]}}}