{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T18:54:40Z","timestamp":1758048880635,"version":"3.44.0"},"reference-count":41,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2006,8,1]],"date-time":"2006-08-01T00:00:00Z","timestamp":1154390400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,8,1]],"date-time":"2006-08-01T00:00:00Z","timestamp":1154390400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2006,8,1]],"date-time":"2006-08-01T00:00:00Z","timestamp":1154390400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2006,8,1]],"date-time":"2006-08-01T00:00:00Z","timestamp":1154390400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2006,8,1]],"date-time":"2006-08-01T00:00:00Z","timestamp":1154390400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2006,8,1]],"date-time":"2006-08-01T00:00:00Z","timestamp":1154390400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2006,8,1]],"date-time":"2006-08-01T00:00:00Z","timestamp":1154390400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["GM024441","T32 CA09363","T32 GM068411-01"],"award-info":[{"award-number":["GM024441","T32 CA09363","T32 GM068411-01"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2006,8]]},"DOI":"10.1016\/j.bbrc.2006.06.064","type":"journal-article","created":{"date-parts":[[2006,6,22]],"date-time":"2006-06-22T07:34:42Z","timestamp":1150961682000},"page":"232-237","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["The Rad9 protein enhances survival and promotes DNA repair following exposure to ionizing radiation"],"prefix":"10.1016","volume":"347","author":[{"given":"Patrick D.","family":"Brandt","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher E.","family":"Helt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter C.","family":"Keng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert A.","family":"Bambara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2006.06.064_bib1","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1091\/mbc.10.6.1985","article-title":"The human G2 checkpoint control protein hRAD9 is a nuclear phosphoprotein that forms complexes with hRAD1 and hHUS1","volume":"10","author":"St Onge","year":"1999","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.bbrc.2006.06.064_bib2","doi-asserted-by":"crossref","first-page":"25903","DOI":"10.1074\/jbc.M102946200","article-title":"Reconstitution and molecular analysis of the hRad9-hHus1-hRad1 (9-1-1) DNA damage responsive checkpoint complex","volume":"276","author":"Burtelow","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2006.06.064_bib3","doi-asserted-by":"crossref","first-page":"11236","DOI":"10.1073\/pnas.201373498","article-title":"Purification and characterization of human DNA damage checkpoint Rad complexes","volume":"98","author":"Lindsey-Boltz","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbrc.2006.06.064_bib4","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1074\/jbc.274.2.567","article-title":"Human homologs of Schizosaccharomyces pombe rad1, hus1, and rad9 form a DNA damage-responsive protein complex","volume":"274","author":"Volkmer","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2006.06.064_bib5","doi-asserted-by":"crossref","first-page":"13827","DOI":"10.1073\/pnas.2336100100","article-title":"Replication protein A-mediated recruitment and activation of Rad17 complexes","volume":"100","author":"Zou","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbrc.2006.06.064_bib6","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1073\/pnas.0437927100","article-title":"Loading of the human 9-1-1 checkpoint complex onto DNA by the checkpoint clamp loader hRad17-replication factor C complex in vitro","volume":"100","author":"Bermudez","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbrc.2006.06.064_bib7","doi-asserted-by":"crossref","first-page":"15233","DOI":"10.1074\/jbc.C200129200","article-title":"Structures of the human Rad17-replication factor C and checkpoint Rad 9-1-1 complexes visualized by glycerol spray\/low voltage microscopy","volume":"277","author":"Griffith","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2006.06.064_bib8","doi-asserted-by":"crossref","first-page":"29767","DOI":"10.1074\/jbc.M005782200","article-title":"The human checkpoint protein hRad17 interacts with the PCNA-like proteins hRad1, hHus1, and hRad9","volume":"275","author":"Rauen","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2006.06.064_bib9","doi-asserted-by":"crossref","first-page":"26343","DOI":"10.1074\/jbc.M001244200","article-title":"Retention of the human Rad9 checkpoint complex in extraction-resistant nuclear complexes after DNA damage","volume":"275","author":"Burtelow","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2006.06.064_bib10","doi-asserted-by":"crossref","first-page":"43809","DOI":"10.1074\/jbc.M207272200","article-title":"Genotoxin-induced Rad9-Hus1-Rad1 (9-1-1) chromatin association is an early checkpoint signaling event","volume":"277","author":"Roos-Mattjus","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2006.06.064_bib11","first-page":"4829","article-title":"hRad9 rapidly binds DNA containing double-strand breaks and is required for damage-dependent topoisomerase II beta binding protein 1 focus formation","volume":"63","author":"Greer","year":"2003","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbrc.2006.06.064_bib12","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1126\/science.1083430","article-title":"Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes","volume":"300","author":"Zou","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.bbrc.2006.06.064_bib13","doi-asserted-by":"crossref","first-page":"5586","DOI":"10.1038\/sj.onc.1207753","article-title":"Disruption of the Rad9\/Rad1\/Hus1 (9-1-1) complex leads to checkpoint signaling and replication defects","volume":"23","author":"Bao","year":"2004","journal-title":"Oncogene"},{"key":"10.1016\/j.bbrc.2006.06.064_bib14","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1046\/j.1365-2443.2002.00566.x","article-title":"Clamp and clamp loader structures of the human checkpoint protein complexes, Rad9-1-1 and Rad17-RFC","volume":"7","author":"Shiomi","year":"2002","journal-title":"Genes Cells"},{"key":"10.1016\/j.bbrc.2006.06.064_bib15","doi-asserted-by":"crossref","first-page":"2481","DOI":"10.1093\/nar\/28.13.2481","article-title":"Structure-based predictions of Rad1, Rad9, Hus1 and Rad17 participation in sliding clamp and clamp-loading complexes","volume":"28","author":"Venclovas","year":"2000","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bbrc.2006.06.064_bib16","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0960-9822(99)00263-8","article-title":"A novel Rad24 checkpoint protein complex closely related to replication factor C","volume":"10","author":"Green","year":"2000","journal-title":"Curr. Biol."},{"key":"10.1016\/j.bbrc.2006.06.064_bib17","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1128\/MCB.19.2.1136","article-title":"Role of a complex containing Rad17, Mec3, and Ddc1 in the yeast DNA damage checkpoint pathway","volume":"19","author":"Kondo","year":"1999","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.bbrc.2006.06.064_bib18","doi-asserted-by":"crossref","first-page":"529","DOI":"10.4161\/cc.4.4.1598","article-title":"Evidence that DNA damage detection machinery participates in DNA repair","volume":"4","author":"Helt","year":"2005","journal-title":"Cell Cycle"},{"key":"10.1016\/j.bbrc.2006.06.064_bib19","doi-asserted-by":"crossref","first-page":"3610","DOI":"10.1021\/bi00769a018","article-title":"Rate of depurination of native deoxyribonucleic acid","volume":"11","author":"Lindahl","year":"1972","journal-title":"Biochemistry"},{"key":"10.1016\/j.bbrc.2006.06.064_bib20","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1016\/j.biochi.2003.11.003","article-title":"The base excision repair: mechanisms and its relevance for cancer susceptibility","volume":"85","author":"Fortini","year":"2003","journal-title":"Biochimie"},{"key":"10.1016\/j.bbrc.2006.06.064_bib21","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1074\/jbc.M406800200","article-title":"Interaction of checkpoint proteins Hus1\/Rad1\/Rad9 with DNA base excision repair enzyme MutY homolog in fission yeast, Schizosaccharomyces pombe","volume":"280","author":"Chang","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2006.06.064_bib22","doi-asserted-by":"crossref","first-page":"16762","DOI":"10.1073\/pnas.0407686101","article-title":"The human Rad9-Rad1-Hus1 checkpoint complex stimulates flap endonuclease 1","volume":"101","author":"Wang","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbrc.2006.06.064_bib23","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1016\/j.jmb.2005.09.018","article-title":"The two DNA clamps Rad9\/Rad1\/Hus1 complex and proliferating cell nuclear antigen differentially regulate flap endonuclease 1 activity","volume":"353","author":"Friedrich-Heineken","year":"2005","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.bbrc.2006.06.064_bib24","doi-asserted-by":"crossref","first-page":"3316","DOI":"10.1093\/nar\/gkh652","article-title":"The human Rad9\/Rad1\/Hus1 damage sensor clamp interacts with DNA polymerase beta and increases its DNA substrate utilisation efficiency: implications for DNA repair","volume":"32","author":"Toueille","year":"2004","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bbrc.2006.06.064_bib25","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1042\/BJ20050211","article-title":"The human checkpoint sensor and alternative DNA clamp Rad9-Rad1-Hus1 modulates the activity of DNA ligase I, a component of the long-patch base excision repair machinery","volume":"389","author":"Smirnova","year":"2005","journal-title":"Biochem. J."},{"key":"10.1016\/j.bbrc.2006.06.064_bib26","doi-asserted-by":"crossref","first-page":"L506","DOI":"10.1152\/ajplung.00243.2003","article-title":"The Cdk and PCNA domains on p21Cip1 both function to inhibit G1\/S progression during hyperoxia","volume":"286","author":"Helt","year":"2004","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.bbrc.2006.06.064_bib27","doi-asserted-by":"crossref","first-page":"L691","DOI":"10.1152\/ajplung.00034.2003","article-title":"Identification and isolation of mouse type II cells on the basis of intrinsic expression of enhanced green fluorescent protein","volume":"285","author":"Roper","year":"2003","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.bbrc.2006.06.064_bib28","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S1383-5718(99)00232-6","article-title":"A public domain image-analysis program for the single-cell gel-electrophoresis (comet) assay","volume":"466","author":"Helma","year":"2000","journal-title":"Mutat. Res."},{"key":"10.1016\/j.bbrc.2006.06.064_bib29","doi-asserted-by":"crossref","first-page":"4340","DOI":"10.1093\/nar\/28.21.4340","article-title":"Mutant alleles of Schizosaccharomyces pombe rad9(+) alter hydroxyurea resistance, radioresistance and checkpoint control","volume":"28","author":"Hang","year":"2000","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bbrc.2006.06.064_bib30","doi-asserted-by":"crossref","first-page":"7235","DOI":"10.1128\/MCB.24.16.7235-7248.2004","article-title":"Deletion of mouse rad9 causes abnormal cellular responses to DNA damage, genomic instability, and embryonic lethality","volume":"24","author":"Hopkins","year":"2004","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.bbrc.2006.06.064_bib31","doi-asserted-by":"crossref","first-page":"18641","DOI":"10.1074\/jbc.M313536200","article-title":"Rad9 protects cells from topoisomerase poison-induced cell death","volume":"279","author":"Loegering","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2006.06.064_bib32","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1016\/j.dnarep.2004.03.032","article-title":"Dial 9-1-1 for DNA damage: the Rad9-Hus1-Rad1 (9-1-1) clamp complex","volume":"3","author":"Parrilla-Castellar","year":"2004","journal-title":"DNA Repair (Amst)"},{"key":"10.1016\/j.bbrc.2006.06.064_bib33","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1146\/annurev.biochem.73.011303.073723","article-title":"Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints","volume":"73","author":"Sancar","year":"2004","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.bbrc.2006.06.064_bib34","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1002\/j.1460-2075.1992.tb05179.x","article-title":"DNA repair mutants defining G2 checkpoint pathways in Schizosaccharomyces pombe","volume":"11","author":"al-Khodairy","year":"1992","journal-title":"EMBO J."},{"key":"10.1016\/j.bbrc.2006.06.064_bib35","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1091\/mbc.5.2.147","article-title":"Identification and characterization of new elements involved in checkpoint and feedback controls in fission yeast","volume":"5","author":"al-Khodairy","year":"1994","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.bbrc.2006.06.064_bib36","doi-asserted-by":"crossref","first-page":"2035","DOI":"10.1101\/gad.6.11.2035","article-title":"Fission yeast genes involved in coupling mitosis to completion of DNA replication","volume":"6","author":"Enoch","year":"1992","journal-title":"Genes Dev."},{"key":"10.1016\/j.bbrc.2006.06.064_bib37","doi-asserted-by":"crossref","first-page":"1850","DOI":"10.1128\/MCB.26.5.1850-1864.2006","article-title":"Mammalian Rad9 plays a role in telomere stability, S- and G2-phase-specific cell survival, and homologous recombinational repair","volume":"26","author":"Pandita","year":"2006","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.bbrc.2006.06.064_bib38","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1080\/09553009314551901","article-title":"Saturated and unsaturated repair of DNA strand breaks in CHO cells after X-irradiation with doses ranging from 3 to 90Gy","volume":"64","author":"Dikomey","year":"1993","journal-title":"Int. J. Radiat. Biol."},{"key":"10.1016\/j.bbrc.2006.06.064_bib39","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1080\/09553008414551431","article-title":"Repair of DNA double-strand breaks in colcemid-arrested mitotic Chinese hamster cells","volume":"46","author":"Rydberg","year":"1984","journal-title":"Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med."},{"key":"10.1016\/j.bbrc.2006.06.064_bib40","doi-asserted-by":"crossref","first-page":"224","DOI":"10.2307\/3578161","article-title":"Reduction of radiation-induced G2 arrest by caffeine","volume":"129","author":"Rowley","year":"1992","journal-title":"Radiat. Res."},{"key":"10.1016\/j.bbrc.2006.06.064_bib41","first-page":"4375","article-title":"Inhibition of ATM and ATR kinase activities by the radiosensitizing agent, caffeine","volume":"59","author":"Sarkaria","year":"1999","journal-title":"Cancer Res."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X06013738?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X06013738?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T10:28:24Z","timestamp":1757759304000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X06013738"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,8]]},"references-count":41,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,8]]}},"alternative-id":["S0006291X06013738"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2006.06.064","relation":{},"ISSN":["0006-291X"],"issn-type":[{"type":"print","value":"0006-291X"}],"subject":[],"published":{"date-parts":[[2006,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Rad9 protein enhances survival and promotes DNA repair following exposure to ionizing radiation","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2006.06.064","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}