{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T21:20:33Z","timestamp":1778707233624,"version":"3.51.4"},"reference-count":35,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2006,10,1]],"date-time":"2006-10-01T00:00:00Z","timestamp":1159660800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2006,10]]},"DOI":"10.1016\/j.bbrc.2006.08.106","type":"journal-article","created":{"date-parts":[[2006,8,25]],"date-time":"2006-08-25T15:43:13Z","timestamp":1156520593000},"page":"709-715","source":"Crossref","is-referenced-by-count":30,"title":["Obstructive hypertrophic cardiomyopathy is associated with reduced expression of vinculin in the intercalated disc"],"prefix":"10.1016","volume":"349","author":[{"given":"Vlad C.","family":"Vasile","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William D.","family":"Edwards","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steve R.","family":"Ommen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael J.","family":"Ackerman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2006.08.106_bib1","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.ymgme.2005.08.006","article-title":"Identification of a metavinculin missense mutation, R975W, associated with both hypertrophic and dilated cardiomyopathy","volume":"87","author":"Vasile","year":"2006","journal-title":"Mol. Genet. Metab."},{"key":"10.1016\/j.bbrc.2006.08.106_bib2","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1161\/hc0402.102930","article-title":"Metavinculin mutations alter actin interaction in dilated cardiomyopathy","volume":"105","author":"Olson","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.bbrc.2006.08.106_bib3","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1016\/j.bbrc.2006.04.151","article-title":"A missense mutation in a ubiquitously expressed protein, vinculin, confers susceptibility to hypertrophic cardiomyopathy","volume":"345","author":"Vasile","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2006.08.106_bib4","doi-asserted-by":"crossref","first-page":"4318","DOI":"10.1016\/S0021-9258(18)53612-7","article-title":"Organization of the human gene encoding the cytoskeletal protein vinculin and the sequence of the vinculin promoter","volume":"268","author":"Moiseyeva","year":"1993","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2006.08.106_bib5","doi-asserted-by":"crossref","first-page":"6631","DOI":"10.1016\/S0021-9258(18)68688-0","article-title":"Diversity of vinculin\/meta-vinculin in human tissues and cultivated cells. Expression of muscle specific variants of vinculin in human aorta smooth muscle cells","volume":"263","author":"Belkin","year":"1988","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2006.08.106_bib6","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1083\/jcb.107.2.545","article-title":"Immunolocalization of meta-vinculin in human smooth and cardiac muscles","volume":"107","author":"Belkin","year":"1988","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.bbrc.2006.08.106_bib7","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/S0002-9440(10)63364-0","article-title":"Heterozygous inactivation of the vinculin gene predisposes to stress-induced cardiomyopathy","volume":"165","author":"Zemljic-Harpf","year":"2004","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.bbrc.2006.08.106_bib8","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1016\/j.str.2004.05.009","article-title":"Crystal structure of human vinculin","volume":"12","author":"Borgon","year":"2004","journal-title":"Structure"},{"key":"10.1016\/j.bbrc.2006.08.106_bib9","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0014-5793(98)00723-6","article-title":"Differential actin organization by vinculin isoforms: implications for cell type-specific microfilament anchorage","volume":"431","author":"Rudiger","year":"1998","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bbrc.2006.08.106_bib10","doi-asserted-by":"crossref","first-page":"7228","DOI":"10.1074\/jbc.M510397200","article-title":"The vinculin binding sites of talin and {alpha}-actinin are sufficient to activate vinculin","volume":"281","author":"Bois","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2006.08.106_bib11","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1242\/dev.125.2.327","article-title":"Vinculin knockout results in heart and brain defects during embryonic development","volume":"125","author":"Xu","year":"1998","journal-title":"Development"},{"key":"10.1016\/j.bbrc.2006.08.106_bib12","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1146\/annurev.physiol.65.092101.142243","article-title":"Cardiac hypertrophy: the good, the bad, and the ugly","volume":"65","author":"Frey","year":"2003","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.bbrc.2006.08.106_bib13","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1083\/jcb.139.6.1583","article-title":"Muscle beta1D integrin reinforces the cytoskeleton-matrix link: modulation of integrin adhesive function by alternative splicing","volume":"139","author":"Belkin","year":"1997","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.bbrc.2006.08.106_bib14","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1161\/hh0402.105790","article-title":"Cardiac myocyte-specific excision of the beta1 integrin gene results in myocardial fibrosis and cardiac failure","volume":"90","author":"Shai","year":"2002","journal-title":"Circ. Res."},{"key":"10.1016\/j.bbrc.2006.08.106_bib15","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1161\/01.RES.87.7.558","article-title":"Early activation of the multicomponent signaling complex associated with focal adhesion kinase induced by pressure overload in the rat heart","volume":"87","author":"Franchini","year":"2000","journal-title":"Circ. Res."},{"key":"10.1016\/j.bbrc.2006.08.106_bib16","doi-asserted-by":"crossref","first-page":"35624","DOI":"10.1074\/jbc.M006124200","article-title":"Integrin activation and focal complex formation in cardiac hypertrophy","volume":"275","author":"Laser","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2006.08.106_bib17","first-page":"431","article-title":"Modulation of integrins and integrin signaling molecules in the pressure-loaded murine ventricle, Histochem","volume":"118","author":"Babbitt","year":"2002","journal-title":"Cell Biol."},{"key":"10.1016\/j.bbrc.2006.08.106_bib18","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1161\/hy0202.102699","article-title":"Integrins play a critical role in mechanical stress-induced p38 MAPK activation","volume":"39","author":"Aikawa","year":"2002","journal-title":"Hypertension"},{"key":"10.1016\/j.bbrc.2006.08.106_bib19","doi-asserted-by":"crossref","first-page":"6341","DOI":"10.1093\/emboj\/19.23.6341","article-title":"The MEK1-ERK1\/2 signaling pathway promotes compensated cardiac hypertrophy in transgenic mice","volume":"19","author":"Bueno","year":"2000","journal-title":"EMBO J."},{"key":"10.1016\/j.bbrc.2006.08.106_bib20","doi-asserted-by":"crossref","first-page":"2757","DOI":"10.1093\/emboj\/20.11.2757","article-title":"Activated MEK5 induces serial assembly of sarcomeres and eccentric cardiac hypertrophy","volume":"20","author":"Nicol","year":"2001","journal-title":"EMBO J."},{"key":"10.1016\/j.bbrc.2006.08.106_bib21","doi-asserted-by":"crossref","first-page":"12333","DOI":"10.1073\/pnas.172376399","article-title":"Akt induces enhanced myocardial contractility and cell size in vivo in transgenic mice","volume":"99","author":"Condorelli","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbrc.2006.08.106_bib22","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1172\/JCI25900","article-title":"Akt1 in the cardiovascular system: friend or foe?","volume":"115","author":"O\u2019Neill","year":"2005","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbrc.2006.08.106_bib23","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.cardiores.2005.12.015","article-title":"Integrin signalling: the tug-of-war in heart hypertrophy","volume":"70","author":"Brancaccio","year":"2006","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.bbrc.2006.08.106_bib24","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1056\/NEJM199910213411706","article-title":"Signaling pathways for cardiac hypertrophy and failure","volume":"341","author":"Hunter","year":"1999","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbrc.2006.08.106_bib25","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1146\/annurev.physiol.59.1.551","article-title":"The cellular and molecular response of cardiac myocytes to mechanical stress","volume":"59","author":"Sadoshima","year":"1997","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.bbrc.2006.08.106_bib26","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0008-6363(00)00076-6","article-title":"Mechanical stress-induced cardiac hypertrophy: mechanisms and signal transduction pathways","volume":"47","author":"Ruwhof","year":"2000","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.bbrc.2006.08.106_bib27","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0092-8674(03)00037-0","article-title":"Sensing stretch is fundamental","volume":"112","author":"Epstein","year":"2003","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2006.08.106_bib28","doi-asserted-by":"crossref","first-page":"10109","DOI":"10.1073\/pnas.91.21.10109","article-title":"Myocardial expression of a constitutively active alpha 1B-adrenergic receptor in transgenic mice induces cardiac hypertrophy","volume":"91","author":"Milano","year":"1994","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbrc.2006.08.106_bib29","doi-asserted-by":"crossref","first-page":"1952","DOI":"10.1161\/01.CIR.97.19.1952","article-title":"Pressure overload induces cardiac hypertrophy in angiotensin II type 1A receptor knockout mice","volume":"97","author":"Harada","year":"1998","journal-title":"Circulation"},{"key":"10.1016\/j.bbrc.2006.08.106_bib30","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1172\/JCI0214190","article-title":"TGF-beta1 mediates the hypertrophic cardiomyocyte growth induced by angiotensin II","volume":"109","author":"Schultz Jel","year":"2002","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbrc.2006.08.106_bib31","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1161\/01.CIR.0000020689.12472.E0","article-title":"Transforming growth factor-beta function blocking prevents myocardial fibrosis and diastolic dysfunction in pressure-overloaded rats","volume":"106","author":"Kuwahara","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.bbrc.2006.08.106_bib32","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S1071-9164(97)90045-2","article-title":"Cardiac-specific overexpression of tumor necrosis factor-alpha causes lethal myocarditis in transgenic mice","volume":"3","author":"Kubota","year":"1997","journal-title":"J. Card. Fail."},{"key":"10.1016\/j.bbrc.2006.08.106_bib33","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1054\/jcaf.2001.28221","article-title":"Myocardial hypertrophy in transgenic mice overexpressing human interleukin 1alpha","volume":"7","author":"Isoda","year":"2001","journal-title":"J. Card. Fail."},{"key":"10.1016\/j.bbrc.2006.08.106_bib34","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/S1471-4914(03)00164-3","article-title":"Molecular interplay between mechanical and humoral signalling in cardiac hypertrophy","volume":"9","author":"Tarone","year":"2003","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.bbrc.2006.08.106_bib35","first-page":"H546","article-title":"Mechanical forces regulate focal adhesion and costamere assembly in cardiac myocytes","volume":"273","author":"Sharp","year":"1997","journal-title":"Am. J. Physiol."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X06018936?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X06018936?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,7,31]],"date-time":"2021-07-31T17:22:31Z","timestamp":1627752151000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X06018936"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,10]]},"references-count":35,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2006,10]]}},"alternative-id":["S0006291X06018936"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2006.08.106","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2006,10]]}}}