{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T03:19:10Z","timestamp":1761707950526},"reference-count":22,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2006,10,1]],"date-time":"2006-10-01T00:00:00Z","timestamp":1159660800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2006,10]]},"DOI":"10.1016\/j.bbrc.2006.08.112","type":"journal-article","created":{"date-parts":[[2006,8,29]],"date-time":"2006-08-29T11:41:20Z","timestamp":1156851680000},"page":"799-803","source":"Crossref","is-referenced-by-count":15,"title":["Inhibition of the anti-adipogenic Hedgehog signaling pathway by cyclopamine does not trigger adipocyte differentiation"],"prefix":"10.1016","volume":"349","author":[{"given":"W.","family":"Cousin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Dani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Peraldi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2006.08.112_bib1","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/S0092-8674(01)00240-9","article-title":"Obesity and the regulation of energy balance","volume":"104","author":"Spiegelman","year":"2001","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2006.08.112_bib2","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1172\/JCI10842","article-title":"Obesity and insulin resistance","volume":"106","author":"Kahn","year":"2000","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbrc.2006.08.112_bib3","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1007\/s00125-002-0873-y","article-title":"Adipose tissue as a buffer for daily lipid flux","volume":"45","author":"Frayn","year":"2002","journal-title":"Diabetologia"},{"key":"10.1016\/j.bbrc.2006.08.112_bib4","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1126\/science.289.5481.950","article-title":"Inhibition of adipogenesis by Wnt signaling","volume":"289","author":"Ross","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.bbrc.2006.08.112_bib5","doi-asserted-by":"crossref","first-page":"35503","DOI":"10.1074\/jbc.M402937200","article-title":"Wnt10b inhibits development of white and brown adipose tissues","volume":"279","author":"Longo","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2006.08.112_bib6","doi-asserted-by":"crossref","first-page":"45020","DOI":"10.1074\/jbc.M407050200","volume":"279","author":"Liu","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2006.08.112_bib7","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1242\/jcs.114.11.2085","article-title":"Sonic hedgehog increases the commitment of pluripotent mesenchymal cells into the osteoblastic lineage and abolishes adipocytic differentiation","volume":"114","author":"Spinella-Jaegle","year":"2001","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.bbrc.2006.08.112_bib8","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/j.bone.2003.07.004","article-title":"Hedgehog stimulates only osteoblastic differentiation of undifferentiated KS483 cells","volume":"33","author":"van der Horst","year":"2003","journal-title":"Bone"},{"key":"10.1016\/j.bbrc.2006.08.112_bib9","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.cmet.2005.11.012","article-title":"Hedgehog signaling plays a conserved role in inhibiting fat formation","volume":"3","author":"Suh","year":"2006","journal-title":"Cell Metab."},{"key":"10.1016\/j.bbrc.2006.08.112_bib10","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.ejca.2005.08.039","article-title":"GLI transcription factors: mediators of oncogenic Hedgehog signalling","volume":"42","author":"Kasper","year":"2006","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.bbrc.2006.08.112_bib11","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1038\/nrc796","article-title":"Gli and hedgehog in cancer: tumours, embryos and stem cells","volume":"2","author":"Ruiz i Altaba","year":"2002","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.bbrc.2006.08.112_bib12","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.devcel.2005.01.008","article-title":"Hedgehog signaling: from the Drosophila cuticle to anti-cancer drugs","volume":"8","author":"Briscoe","year":"2005","journal-title":"Dev. Cell"},{"key":"10.1016\/j.bbrc.2006.08.112_bib13","doi-asserted-by":"crossref","first-page":"2537","DOI":"10.1242\/dev.124.13.2537","article-title":"Gli1 is a target of Sonic hedgehog that induces ventral neural tube development","volume":"124","author":"Lee","year":"1997","journal-title":"Development"},{"key":"10.1016\/j.bbrc.2006.08.112_bib14","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0896-6273(00)80344-X","article-title":"Control of cell pattern in the neural tube by the zinc finger transcription factor and oncogene Gli-1","volume":"19","author":"Hynes","year":"1997","journal-title":"Neuron"},{"key":"10.1016\/j.bbrc.2006.08.112_bib15","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1038\/35023008","article-title":"Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine","volume":"406","author":"Taipale","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2006.08.112_bib16","doi-asserted-by":"crossref","first-page":"2743","DOI":"10.1101\/gad.1025302","article-title":"Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened","volume":"16","author":"Chen","year":"2002","journal-title":"Genes Dev."},{"key":"10.1016\/j.bbrc.2006.08.112_bib17","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.canlet.2004.11.030","article-title":"Hedgehog signaling pathway as a therapeutic target in breast cancer","volume":"227","author":"Katano","year":"2005","journal-title":"Cancer Lett."},{"key":"10.1016\/j.bbrc.2006.08.112_bib18","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.yexcr.2003.10.020","article-title":"Transdifferentiation of preadipose cells into smooth muscle-like cells: role of aortic carboxypeptidase-like protein","volume":"293","author":"Abderrahim-Ferkoune","year":"2004","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.bbrc.2006.08.112_bib19","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1097\/00041433-200406000-00010","article-title":"New insights into inhibitors of adipogenesis","volume":"15","author":"Harp","year":"2004","journal-title":"Curr. Opin. Lipidol."},{"key":"10.1016\/j.bbrc.2006.08.112_bib20","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s002580050265","article-title":"Adipocyte differentiation is modulated by secreted delta-like (dlk) variants and requires the expression of membrane-associated dlk","volume":"64","author":"Garces","year":"1999","journal-title":"Differentiation"},{"key":"10.1016\/j.bbrc.2006.08.112_bib21","doi-asserted-by":"crossref","first-page":"3059","DOI":"10.1101\/gad.938601","article-title":"Hedgehog signaling in animal development: paradigms and principles","volume":"15","author":"Ingham","year":"2001","journal-title":"Genes Dev."},{"key":"10.1016\/j.bbrc.2006.08.112_bib22","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1242\/dev.01006","article-title":"Ihh signaling is directly required for the osteoblast lineage in the endochondral skeleton","volume":"131","author":"Long","year":"2004","journal-title":"Development"}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X06019255?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X06019255?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,7,31]],"date-time":"2021-07-31T22:54:28Z","timestamp":1627772068000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X06019255"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,10]]},"references-count":22,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2006,10]]}},"alternative-id":["S0006291X06019255"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2006.08.112","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2006,10]]}}}