{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T04:07:56Z","timestamp":1790827676017,"version":"4.1.0"},"reference-count":26,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2007,4,1]],"date-time":"2007-04-01T00:00:00Z","timestamp":1175385600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2007,4]]},"DOI":"10.1016\/j.bbrc.2007.02.003","type":"journal-article","created":{"date-parts":[[2007,2,9]],"date-time":"2007-02-09T12:05:52Z","timestamp":1171022752000},"page":"538-542","source":"Crossref","is-referenced-by-count":51,"title":["Haploinsufficiency of Bcl11b for suppression of lymphomagenesis and thymocyte development"],"prefix":"10.1016","volume":"355","author":[{"given":"Kenya","family":"Kamimura","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Ohi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoyuki","family":"Kubota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyoshi","family":"Okazuka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiro","family":"Yoshikai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-ichi","family":"Wakabayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutaka","family":"Aoyagi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukio","family":"Mishima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryo","family":"Kominami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2007.02.003_bib1","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/0168-9525(93)90209-Z","article-title":"The multi-step nature of cancer","volume":"9","author":"Vogelstein","year":"1993","journal-title":"Trends Genet"},{"key":"10.1016\/j.bbrc.2007.02.003_bib2","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S0092-8674(03)01075-4","article-title":"Principles of tumor suppression","volume":"116","author":"Sherr","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2007.02.003_bib3","doi-asserted-by":"crossref","first-page":"3434","DOI":"10.1038\/sj.onc.1203653","article-title":"Accommodating haploinsufficient tumour suppressor genes in Knudson\u2019s model","volume":"19","author":"Cook","year":"2004","journal-title":"Oncogene"},{"key":"10.1016\/j.bbrc.2007.02.003_bib4","doi-asserted-by":"crossref","first-page":"2917","DOI":"10.1101\/gad.949001","article-title":"Haplo-insufficiency? Let me count the ways","volume":"15","author":"Quon","year":"2001","journal-title":"Genes Dev."},{"key":"10.1016\/j.bbrc.2007.02.003_bib5","doi-asserted-by":"crossref","first-page":"10315","DOI":"10.1074\/jbc.275.14.10315","article-title":"Isolation of a novel family of C2H2 zinc finger proteins implicated in transcriptional repression mediated by chicken ovalbumin upstream promoter transcription factor (COUP-TF) orphan nuclear receptors","volume":"275","author":"Avram","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2007.02.003_bib6","doi-asserted-by":"crossref","first-page":"3413","DOI":"10.1182\/blood.V98.12.3413","article-title":"The BCL11 gene family: involvement of BCL11A in lymphoid malignancies","volume":"98","author":"Satterwhite","year":"2001","journal-title":"Blood"},{"key":"10.1016\/j.bbrc.2007.02.003_bib7","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1016\/S0006-291X(02)03069-3","article-title":"Homozygous deletions and point mutations of the Rit1\/Bcl11b gene in \u03b3-ray induced mouse thymic lymphomas","volume":"301","author":"Wakabayashi","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2007.02.003_bib8","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1038\/ni927","article-title":"Bcl11b is required for differentiation and survival of \u03b1\u03b2 T lymphocytes","volume":"4","author":"Wakabayashi","year":"2003","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.bbrc.2007.02.003_bib9","doi-asserted-by":"crossref","first-page":"5871","DOI":"10.4049\/jimmunol.176.10.5871","article-title":"Expression of TCR\u03b1\u03b2 partly rescues developmental arrest and apoptosis of \u03b1\u03b2T cells in Bcl11b\u2212\/\u2212 mice","volume":"176","author":"Inoue","year":"2006","journal-title":"J. Immunol."},{"key":"10.1016\/j.bbrc.2007.02.003_bib10","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/S0165-4608(03)00302-9","article-title":"A novel t(6;14)(q25\u2013q27;q32) in acute myelocytic leukemia involves the BCL11B gene","volume":"149","author":"Bezrookove","year":"2004","journal-title":"Cancer Genet. Cytogenet."},{"key":"10.1016\/j.bbrc.2007.02.003_bib11","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/sj.leu.2403619","article-title":"Disruption of the BCL11B gene through inv(14)(q11.2q32.31) results in the expression of BCL11B-TRDC fusion transcripts and is associated with the absence of wild-type BCL11B transcripts in T-ALL","volume":"19","author":"Przybylski","year":"2005","journal-title":"Leukemia"},{"key":"10.1016\/j.bbrc.2007.02.003_bib12","doi-asserted-by":"crossref","first-page":"2747","DOI":"10.1038\/sj.onc.1201810","article-title":"Allelic loss analysis of gamma-ray-induced mouse thymic lymphomas: two candidate tumor suppressor gene loci on chromosomes 12 and 16","volume":"16","author":"Matsumoto","year":"1998","journal-title":"Oncogene"},{"key":"10.1016\/j.bbrc.2007.02.003_bib13","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1093\/carcin\/bgh094","article-title":"Involvement of V(D)J recombinase in the generation of intragenic deletions in the Rit1\/Bcl11b tumor suppressor gene in \u03b3-ray-induced thymic lymphomas and in normal thymus of the mouse","volume":"25","author":"Sakata","year":"2004","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.bbrc.2007.02.003_bib14","doi-asserted-by":"crossref","first-page":"4657","DOI":"10.1093\/emboj\/17.16.4657","article-title":"Retention of wild-type p53 in tumors from p53 heterozygous mice: reduction of p53 dosage can promote cancer formation","volume":"17","author":"Venkatachalam","year":"1998","journal-title":"EMBO J."},{"key":"10.1016\/j.bbrc.2007.02.003_bib15","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.neuron.2004.12.036","article-title":"Neuronal subtype-specific genes that control corticospinal motor neuron development in vivo","volume":"45","author":"Arlotta","year":"2005","journal-title":"Neuron"},{"key":"10.1016\/j.bbrc.2007.02.003_bib16","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S1535-6108(03)00021-7","article-title":"PTEN tumor suppressor regulates p53 protein levels and activity through phosphatase-dependent and -independent mechanisms","volume":"3","author":"Freeman","year":"2003","journal-title":"Cancer Cell"},{"key":"10.1016\/j.bbrc.2007.02.003_bib17","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/24179","article-title":"The murine gene p27Kip1 is haplo-insufficient for tumor suppression","volume":"396","author":"Fero","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2007.02.003_bib18","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.ccr.2004.06.015","article-title":"Chk1 is haploinsufficient for multiple functions critical to tumor suppression","volume":"6","author":"Lam","year":"2004","journal-title":"Cancer Cell"},{"key":"10.1016\/j.bbrc.2007.02.003_bib19","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1038\/nature03155","article-title":"Fbxw7\/Cdc4 is a p53-dependent, haploinsufficient tumour suppressor gene","volume":"432","author":"Mao","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2007.02.003_bib20","first-page":"3937","article-title":"Functional evaluation of p53 and PTEN gene mutations in gliomas","volume":"6","author":"Kato","year":"2000","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.bbrc.2007.02.003_bib21","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/ng1013","article-title":"Frequent somatic mutations in PTEN and TP53 are mutually exclusive in the stroma of breast carcinomas","volume":"32","author":"Kurose","year":"2002","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bbrc.2007.02.003_bib22","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1038\/sj.leu.2402249","article-title":"A new recurrent and specific cryptic translocation, t(5;14)(q35;q32), is associated with expression of the Hox11L2 gene in T acute lymphoblastic leukemia","volume":"15","author":"Bernard","year":"2001","journal-title":"Leukemia"},{"key":"10.1016\/j.bbrc.2007.02.003_bib23","doi-asserted-by":"crossref","first-page":"3612","DOI":"10.1182\/blood.V97.11.3612","article-title":"Cytogenetic analysis and clinical significance in adult T-cell leukemia\/lymphoma: a study of 50 cases from the human T-cell leukemia virus type-1 endemic area, Nagasaki","volume":"97","author":"Itoyama","year":"2001","journal-title":"Blood"},{"key":"10.1016\/j.bbrc.2007.02.003_bib24","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1002\/gcc.10194","article-title":"Activation of HOX11L2 by juxtaposition with 3\u2032-BCL11B in an acute lymphoblastic leukemia cell line (HPB-ALL) with t(5;14)(q35;q32.2)","volume":"37","author":"MacLeod","year":"2003","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1016\/j.bbrc.2007.02.003_bib25","first-page":"5329","article-title":"The cardiac homeobox gene NKX2-5 is deregulated by juxtaposition with BCL11B in pediatric T-ALL cell lines via a novel t(5;14)(q35.1;q32.2)","volume":"63","author":"Nagel","year":"2003","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbrc.2007.02.003_bib26","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1002\/gcc.20348","article-title":"Transforming potential of the T-cell acute lymphoblastic leukemia-associated homeobox genes HOXA13, TLX1, and TLX3","volume":"45","author":"Su","year":"2006","journal-title":"Genes Chromosomes Cancer"}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X07002707?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X07002707?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,1,9]],"date-time":"2019-01-09T10:58:17Z","timestamp":1547031497000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X07002707"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,4]]},"references-count":26,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2007,4]]}},"alternative-id":["S0006291X07002707"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2007.02.003","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2007,4]]}}}