{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T09:37:03Z","timestamp":1789205823489,"version":"build-2803163510"},"reference-count":36,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2007,6,1]],"date-time":"2007-06-01T00:00:00Z","timestamp":1180656000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,6,1]],"date-time":"2007-06-01T00:00:00Z","timestamp":1180656000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2007,6,1]],"date-time":"2007-06-01T00:00:00Z","timestamp":1180656000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2007,6,1]],"date-time":"2007-06-01T00:00:00Z","timestamp":1180656000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2007,6,1]],"date-time":"2007-06-01T00:00:00Z","timestamp":1180656000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2007,6,1]],"date-time":"2007-06-01T00:00:00Z","timestamp":1180656000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2007,6,1]],"date-time":"2007-06-01T00:00:00Z","timestamp":1180656000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["30628013"],"award-info":[{"award-number":["30628013"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2004CCA02200"],"award-info":[{"award-number":["2004CCA02200"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"publisher","award":["Z204492"],"award-info":[{"award-number":["Z204492"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000055","name":"National Institute on Deafness and Other Communication Disorders","doi-asserted-by":"publisher","award":["RO1NS44015"],"award-info":[{"award-number":["RO1NS44015"]}],"id":[{"id":"10.13039\/100000055","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["RO1DC05230"],"award-info":[{"award-number":["RO1DC05230"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2007,6]]},"DOI":"10.1016\/j.bbrc.2007.04.025","type":"journal-article","created":{"date-parts":[[2007,4,17]],"date-time":"2007-04-17T07:16:56Z","timestamp":1176794216000},"page":"910-916","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"title":["The coexistence of mitochondrial ND6 T14484C and 12S rRNA A1555G mutations in a Chinese family with Leber\u2019s hereditary optic neuropathy and hearing loss"],"prefix":"10.1016","volume":"357","author":[{"given":"Qi-Ping","family":"Wei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangtian","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-Hong","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Qu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min-Xin","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2007.04.025_bib1","first-page":"431","article-title":"Leber\u2019s hereditary optic neuropathy","volume":"4","author":"Newman","year":"1993","journal-title":"Ophthalmol. Clin. North Am."},{"key":"10.1016\/j.bbrc.2007.04.025_bib2","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1002\/humu.1380060405","article-title":"Phylogenetic analysis of Leber\u2019s hereditary optic neuropathy mitochondrial DNA\u2019s indicates multiple independent occurrences of the common mutations","volume":"6","author":"Brown","year":"1995","journal-title":"Hum. Mut."},{"key":"10.1016\/j.bbrc.2007.04.025_bib3","doi-asserted-by":"crossref","first-page":"3495","DOI":"10.1016\/S0042-6989(96)00167-8","article-title":"Leber hereditary optic neuropathy: mitochondrial mutations and degeneration of the optic nerve","volume":"37","author":"Howell","year":"1997","journal-title":"Vision Res."},{"key":"10.1016\/j.bbrc.2007.04.025_bib4","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1136\/jmg.39.3.162","article-title":"Leber hereditary optic neuropathy","volume":"39","author":"Man","year":"2002","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.bbrc.2007.04.025_bib5","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1126\/science.3201231","article-title":"Mitochondrial DNA mutation associated with Leber\u2019s hereditary optic neuropathy","volume":"242","author":"Wallace","year":"1988","journal-title":"Science"},{"key":"10.1016\/j.bbrc.2007.04.025_bib6","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1159\/000072041","article-title":"LHON and other optic nerve atrophies: the mitochondrial connection","volume":"37","author":"Howell","year":"2003","journal-title":"Dev. Ophthalmol."},{"key":"10.1016\/j.bbrc.2007.04.025_bib7","first-page":"341","article-title":"Molecular pathogenetic mechanism of Leber\u2019s hereditary optic neuropathy","volume":"8","author":"Qu","year":"2006","journal-title":"Chin. J. Optom. Ophthalmol."},{"key":"10.1016\/j.bbrc.2007.04.025_bib8","doi-asserted-by":"crossref","first-page":"D611","DOI":"10.1093\/nar\/gki079","article-title":"MITOMAP: a human mitochondrial genome database\u20142004 update","volume":"33","author":"Brandon","year":"2005","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bbrc.2007.04.025_bib9","first-page":"481","article-title":"Primary pathogenic mtDNA mutations in multigeneration pedigrees with Leber hereditary optic neuropathy","volume":"59","author":"Mackey","year":"1996","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.bbrc.2007.04.025_bib10","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1080\/02713689808951221","article-title":"Spectrum of pathogenic mitochondrial DNA mutations and clinical features in Japanese families with Leber\u2019s hereditary optic neuropathy","volume":"17","author":"Mashima","year":"1998","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.bbrc.2007.04.025_bib11","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1086\/346066","article-title":"The epidemiology of Leber hereditary optic neuropathy in the North East of England","volume":"72","author":"Man","year":"2003","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.bbrc.2007.04.025_bib12","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1016\/j.bbrc.2005.01.062","article-title":"Only male matrilineal relatives with Leber\u2019s hereditary optic neuropathy in a large Chinese family carrying the mitochondrial DNA G11778A mutation","volume":"328","author":"Qu","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2007.04.025_bib13","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/j.bbrc.2005.05.003","article-title":"Clinical evaluation and mitochondrial DNA sequence analysis in three Chinese families with Leber\u2019s hereditary optic neuropathy","volume":"332","author":"Qian","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2007.04.025_bib14","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1167\/iovs.05-0665","article-title":"The novel A4435G mutation in the mitochondrial tRNAMet may modulate the phenotypic expression of the LHON-associated ND4 G11778A mutation","volume":"47","author":"Qu","year":"2006","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.bbrc.2007.04.025_bib15","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.gene.2006.02.014","article-title":"The mitochondrial tRNA(Thr) A15951G mutation may influence the phenotypic expression of the LHON-associated ND4 G11778A mutation in a Chinese family","volume":"376","author":"Li","year":"2006","journal-title":"Gene"},{"key":"10.1016\/j.bbrc.2007.04.025_bib16","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.bbrc.2005.11.150","article-title":"Leber\u2019s hereditary optic neuropathy is associated with the mitochondrial ND4 G11696A mutation in five Chinese families","volume":"340","author":"Zhou","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2007.04.025_bib17","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.bbrc.2006.06.075","article-title":"Leber\u2019s hereditary optic neuropathy is associated with the mitochondrial ND6 T14484C mutation in three Chinese families","volume":"347","author":"Sun","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2007.04.025_bib18","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.mito.2006.11.015","article-title":"Cosegregation of the ND4 G11696A mutation with the LHON-associated ND4 G11778A mutation in a four generation Chinese family","volume":"7","author":"Qu","year":"2007","journal-title":"Mitochondrion"},{"key":"10.1016\/j.bbrc.2007.04.025_bib19","first-page":"211","article-title":"Prevalence of mitochondrial 12S rRNA mutations associated with aminoglycoside ototoxicity","volume":"105","author":"Guan","year":"2006","journal-title":"Voltra Rev."},{"key":"10.1016\/j.bbrc.2007.04.025_bib20","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1093\/nar\/26.4.967","article-title":"Automating the identification of DNA variations using quality-based fluorescence re-sequencing: analysis of the human mitochondrial genome","volume":"26","author":"Rieder","year":"1981","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bbrc.2007.04.025_bib21","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/290457a0","article-title":"Sequence and organization of the human mitochondrial genome","volume":"290","author":"Anderson","year":"1981","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2007.04.025_bib22","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1038\/ng0793-289","article-title":"Mitochondrial ribosomal RNA mutation associated with both antibiotic-induced and non-syndromic deafness","volume":"4","author":"Prezant","year":"1993","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bbrc.2007.04.025_bib23","doi-asserted-by":"crossref","first-page":"2188","DOI":"10.1002\/ajmg.a.31434","article-title":"Variants in mitochondrial tRNAGlu, tRNAArg, and tRNAThr may influence the phenotypic manifestation of deafness-associated 12S rRNA A1555G mutation in three Han Chinese families with hearing loss","volume":"140","author":"Young","year":"2006","journal-title":"Am. J. Med. Genet. A."},{"key":"10.1016\/j.bbrc.2007.04.025_bib24","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1517\/14622416.6.1.27","article-title":"Genetic factors in aminoglycoside toxicity","volume":"6","author":"Fischel-Ghodsian","year":"2005","journal-title":"Pharmacogenomics"},{"key":"10.1016\/j.bbrc.2007.04.025_bib25","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/0092-8674(81)90300-7","article-title":"Sequence and gene organization of mouse mitochondrial DNA","volume":"26","author":"Bibb","year":"1981","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2007.04.025_bib26","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1007\/BF02602930","article-title":"The complete nucleotide sequence of the Rattus norvegicus mitochondrial genome: cryptic signals revealed by comparative analysis between vertebrates","volume":"28","author":"Gadaleta","year":"1989","journal-title":"J. Mol. Evol."},{"key":"10.1016\/j.bbrc.2007.04.025_bib27","doi-asserted-by":"crossref","first-page":"9759","DOI":"10.1016\/S0021-9258(17)39303-1","article-title":"The complete nucleotide sequence of the Xenopus laevis mitochondrial genome","volume":"260","author":"Roe","year":"1985","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2007.04.025_bib28","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1212\/WNL.50.2.417","article-title":"Pedigree analysis of French Canadian families with T14484C Leber\u2019s hereditary optic neuropathy","volume":"50","author":"Macmillan","year":"1998","journal-title":"Neurology"},{"key":"10.1016\/j.bbrc.2007.04.025_bib29","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1001\/archopht.1993.01090040087038","article-title":"Leber\u2019s hereditary optic neuropathy. Clinical manifestations of the 14484 mutation","volume":"111","author":"Johns","year":"1993","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.bbrc.2007.04.025_bib30","first-page":"1107","article-title":"Haplotype and phylogenetic analyses suggest that one European-specific mtDNA background plays a role in the expression of Leber hereditary optic neuropathy by increasing the penetrance of the primary mutations 11778 and 14484","volume":"60","author":"Torroni","year":"1997","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.bbrc.2007.04.025_bib31","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1007\/s00439-001-0660-8","article-title":"The role of mtDNA background in disease expression: a new primary LHON mutation associated with Western Eurasian haplogroup","volume":"110","author":"Brown","year":"2002","journal-title":"J. Hum. Genet."},{"key":"10.1016\/j.bbrc.2007.04.025_bib32","doi-asserted-by":"crossref","first-page":"5868","DOI":"10.1128\/MCB.18.10.5868","article-title":"The deafness-associated mtDNA 7445 mutation, which affects tRNASer(UCN) precursor processing, has long-range effects on NADH dehydrogenase ND6 subunit gene expression","volume":"18","author":"Guan","year":"1998","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.bbrc.2007.04.025_bib33","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1002\/ajmg.a.30952","article-title":"Cosegregation of the G7444A mutation in the mitochondrial COI\/tRNASer(UCN) genes with the 12S rRNA A1555G mutation in a Chinese family with aminoglycoside-induced and non-syndromic hearing loss","volume":"138A","author":"Yuan","year":"2005","journal-title":"Am. J. Med. Genet."},{"key":"10.1016\/j.bbrc.2007.04.025_bib34","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.1101\/gr.2286304","article-title":"Mitochondrial genome variation in eastern Asia and the peopling of Japan","author":"Tanaka","year":"2004","journal-title":"Genome Res."},{"key":"10.1016\/j.bbrc.2007.04.025_bib35","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1093\/hmg\/5.7.963","article-title":"Biochemical evidence for nuclear gene involvement in phenotype of non-syndromic deafness associated with mitochondrial 12S rRNA mutation","volume":"5","author":"Guan","year":"1996","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bbrc.2007.04.025_bib36","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1093\/hmg\/10.6.573","article-title":"Nuclear background determines biochemical phenotype in the deafness-associated mitochondrial 12S rRNA mutation","volume":"10","author":"Guan","year":"2001","journal-title":"Hum. Mol. Genet."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X07007358?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X07007358?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T14:16:29Z","timestamp":1762092989000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X07007358"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,6]]},"references-count":36,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2007,6]]}},"alternative-id":["S0006291X07007358"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2007.04.025","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2007,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The coexistence of mitochondrial ND6 T14484C and 12S rRNA A1555G mutations in a Chinese family with Leber\u2019s hereditary optic neuropathy and hearing loss","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2007.04.025","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2007 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}