{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T15:51:34Z","timestamp":1789919494300,"version":"4.0.1"},"reference-count":39,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2007,6,1]],"date-time":"2007-06-01T00:00:00Z","timestamp":1180656000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,6,1]],"date-time":"2007-06-01T00:00:00Z","timestamp":1180656000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2007,6,1]],"date-time":"2007-06-01T00:00:00Z","timestamp":1180656000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2007,6,1]],"date-time":"2007-06-01T00:00:00Z","timestamp":1180656000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2007,6,1]],"date-time":"2007-06-01T00:00:00Z","timestamp":1180656000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2007,6,1]],"date-time":"2007-06-01T00:00:00Z","timestamp":1180656000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2007,6,1]],"date-time":"2007-06-01T00:00:00Z","timestamp":1180656000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2007,6]]},"DOI":"10.1016\/j.bbrc.2007.04.055","type":"journal-article","created":{"date-parts":[[2007,4,19]],"date-time":"2007-04-19T07:28:22Z","timestamp":1176967702000},"page":"1096-1099","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"title":["Complement activation by islet amyloid polypeptide (IAPP) and \u03b1-synuclein 112"],"prefix":"10.1016","volume":"357","author":[{"given":"Andis","family":"Klegeris","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick L.","family":"McGeer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2007.04.055_bib1","doi-asserted-by":"crossref","first-page":"85","DOI":"10.21307\/immunohematology-2019-398","article-title":"Review: the burgeoning history of the complement system 1888\u20132005","volume":"21","author":"Chaplin","year":"2005","journal-title":"Immunohematology"},{"key":"10.1016\/j.bbrc.2007.04.055_bib2","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/S0002-9394(02)01624-0","article-title":"A role for local inflammation in the formation of drusen in the aging eye","volume":"134","author":"Anderson","year":"2002","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.bbrc.2007.04.055_bib3","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1084\/jem.190.12.1733","article-title":"C-reactive protein and complement are important mediators of tissue damage in acute myocardial infarction","volume":"190","author":"Griselli","year":"1999","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.bbrc.2007.04.055_bib4","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0162-3109(97)00057-X","article-title":"Controlling the complement system in inflammation","volume":"38","author":"Kirschfink","year":"1997","journal-title":"Immunopharmacology"},{"key":"10.1016\/j.bbrc.2007.04.055_bib5","doi-asserted-by":"crossref","first-page":"S94","DOI":"10.1016\/j.neurobiolaging.2005.08.008","article-title":"Inflammation, the complement system and the diseases of aging","volume":"26S","author":"McGeer","year":"2005","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.bbrc.2007.04.055_bib6","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0162-3109(97)00059-3","article-title":"The role of complement in disorders of the nervous system","volume":"38","author":"Morgan","year":"1997","journal-title":"Immunopharmacology"},{"key":"10.1016\/j.bbrc.2007.04.055_bib7","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1097\/00005072-199605000-00010","article-title":"Role of complement in aetiology of Pick\u2019s disease?","volume":"55","author":"Singhrao","year":"1996","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.bbrc.2007.04.055_bib8","doi-asserted-by":"crossref","first-page":"247","DOI":"10.3109\/13506129809007297","article-title":"Macrophages and pancreatic islet amyloidosis","volume":"5","author":"de Koning","year":"1998","journal-title":"Amyloid"},{"key":"10.1016\/j.bbrc.2007.04.055_bib9","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1007\/s00125-006-0206-7","article-title":"Intracellular amyloid-like deposits contain unprocessed pro-islet amyloid polypeptide (proIAPP) in beta cells of transgenic mice overexpressing the gene for human IAPP and transplanted human islets","volume":"49","author":"Paulsson","year":"2006","journal-title":"Diabetologia"},{"key":"10.1016\/j.bbrc.2007.04.055_bib10","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/s00125-003-1304-4","article-title":"Islet amyloid: a complication of islet dysfunction or an aetiological factor in Type 2 diabetes?","volume":"47","author":"Clark","year":"2004","journal-title":"Diabetologia"},{"key":"10.1016\/j.bbrc.2007.04.055_bib11","doi-asserted-by":"crossref","first-page":"3629","DOI":"10.1210\/jc.2004-0405","article-title":"Islet amyloid: a critical entity in the pathogenesis of type 2 diabetes","volume":"89","author":"Hull","year":"2004","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bbrc.2007.04.055_bib12","doi-asserted-by":"crossref","first-page":"241","DOI":"10.2337\/diabetes.48.2.241","article-title":"Islet amyloid: a long-recognized but underappreciated pathological feature of type 2 diabetes","volume":"48","author":"Kahn","year":"1999","journal-title":"Diabetes"},{"key":"10.1016\/j.bbrc.2007.04.055_bib13","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1007\/s11892-005-0007-2","article-title":"Is aggregated IAPP a cause of beta-cell failure in transplanted human pancreatic islets?","volume":"5","author":"Westermark","year":"2005","journal-title":"Curr. Diab. Rep."},{"key":"10.1016\/j.bbrc.2007.04.055_bib14","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1212\/WNL.38.8.1285","article-title":"Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson\u2019s and Alzheimer\u2019s disease brains","volume":"38","author":"McGeer","year":"1988","journal-title":"Neurology"},{"key":"10.1016\/j.bbrc.2007.04.055_bib15","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/0304-3940(94)90508-8","article-title":"Interleukin-1 beta, interleukin-6, epidermal growth factor and transforming growth factor-alpha are elevated in the brain from parkinsonian patients","volume":"180","author":"Mogi","year":"1994","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.bbrc.2007.04.055_bib16","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/1742-2094-3-29","article-title":"Complement activation in the Parkinson\u2019s disease substantia nigra: an immunocytochemical study","volume":"3","author":"Loeffler","year":"2006","journal-title":"J. Neuroinflam."},{"issue":"Suppl.1","key":"10.1016\/j.bbrc.2007.04.055_bib17","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1016\/j.parkreldis.2004.01.005","article-title":"Inflammation and neurodegeneration in Parkinson\u2019s disease","volume":"10","author":"McGeer","year":"2004","journal-title":"Parkinsonism. Relat. Disord."},{"key":"10.1016\/j.bbrc.2007.04.055_bib18","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1007\/BF00427222","article-title":"Lewy bodies in Parkinson\u2019s disease are recognized by antibodies to complement proteins","volume":"84","author":"Yamada","year":"1992","journal-title":"Acta. Neuropathol."},{"key":"10.1016\/j.bbrc.2007.04.055_bib19","doi-asserted-by":"crossref","first-page":"6469","DOI":"10.1073\/pnas.95.11.6469","article-title":"Alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson\u2019s disease and dementia with Lewy bodies","volume":"95","author":"Spillantini","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbrc.2007.04.055_bib20","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1126\/science.276.5321.2045","article-title":"Mutation in the alpha-synuclein gene identified in families with Parkinson\u2019s disease","volume":"276","author":"Polymeropoulos","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.bbrc.2007.04.055_bib21","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1016\/S0140-6736(04)17103-1","article-title":"Alpha-synuclein locus duplication as a cause of familial Parkinson\u2019s disease","volume":"364","author":"Chartier-Harlin","year":"2004","journal-title":"Lancet"},{"key":"10.1016\/j.bbrc.2007.04.055_bib22","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1126\/science.1090278","article-title":"\u03b1-Synuclein locus triplication causes Parkinson\u2019s disease","volume":"302","author":"Singleton","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.bbrc.2007.04.055_bib23","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/s00401-006-0104-6","article-title":"Alpha-synuclein structure, posttranslational modification and alternative splicing as aggregation enhancers","volume":"112","author":"Beyer","year":"2006","journal-title":"Acta. Neuropathol."},{"key":"10.1016\/j.bbrc.2007.04.055_bib24","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1046\/j.1365-2567.2002.01425.x","article-title":"Effects of C-reactive protein and pentosan polysulphate on human complement activation","volume":"106","author":"Klegeris","year":"2002","journal-title":"Immunology"},{"key":"10.1016\/j.bbrc.2007.04.055_bib25","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0006-8993(96)01324-8","article-title":"Apolipoprotein E4 (ApoE4) but not ApoE3 or ApoE2 potentiates beta-amyloid protein activation of complement in vitro","volume":"749","author":"McGeer","year":"1997","journal-title":"Brain Res."},{"key":"10.1016\/j.bbrc.2007.04.055_bib26","doi-asserted-by":"crossref","first-page":"163","DOI":"10.4049\/jimmunol.85.2.163","article-title":"Biologic activity of aggregated \u03b3-globulin. II. A study of various methods for aggregation and species differences","volume":"85","author":"Ishizaka","year":"1960","journal-title":"J. Immunol."},{"key":"10.1016\/j.bbrc.2007.04.055_bib27","doi-asserted-by":"crossref","unstructured":"Neuroinflammation Working Group, Inflammation and Alzheimer\u2019s disease, Neurobiol. Aging 21 (2000) 383-421.","DOI":"10.1016\/S0197-4580(00)00124-X"},{"key":"10.1016\/j.bbrc.2007.04.055_bib28","doi-asserted-by":"crossref","first-page":"10016","DOI":"10.1073\/pnas.89.21.10016","article-title":"Complement activation by beta-amyloid in Alzheimer disease","volume":"89","author":"Rogers","year":"1992","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbrc.2007.04.055_bib29","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1007\/s001250050822","article-title":"NIDDM as a disease of the innate immune system: association of acute-phase reactants and interleukin-6 with metabolic syndrome X","volume":"40","author":"Pickup","year":"1997","journal-title":"Diabetologia"},{"key":"10.1016\/j.bbrc.2007.04.055_bib30","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1093\/ajcn\/82.3.675","article-title":"Dietary pattern, inflammation, and incidence of type 2 diabetes in women","volume":"82","author":"Schulze","year":"2005","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.bbrc.2007.04.055_bib31","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1001\/archneur.63.11.1551","article-title":"Diabetes mellitus and risk of developing Alzheimer disease: results from the Framingham Study","volume":"63","author":"Akomolafe","year":"2006","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.bbrc.2007.04.055_bib32","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1093\/oxfordjournals.aje.a009106","article-title":"Risk of dementia among persons with diabetes mellitus: a population-based cohort study","volume":"145","author":"Leibson","year":"1997","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.bbrc.2007.04.055_bib33","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1212\/WNL.53.9.1937","article-title":"Diabetes mellitus and the risk of dementia: the Rotterdam Study","volume":"53","author":"Ott","year":"1999","journal-title":"Neurology"},{"key":"10.1016\/j.bbrc.2007.04.055_bib34","doi-asserted-by":"crossref","first-page":"445","DOI":"10.2337\/diacare.16.2.445","article-title":"Plasma C3d levels and ischemic heart disease in type II diabetes","volume":"16","author":"Figueredo","year":"1993","journal-title":"Diabetes Care"},{"key":"10.1016\/j.bbrc.2007.04.055_bib35","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0168-8227(88)80093-7","article-title":"Complements in non-insulin-dependent diabetes mellitus with complications","volume":"5","author":"Morimoto","year":"1988","journal-title":"Diabetes Res. Clin. Pract."},{"key":"10.1016\/j.bbrc.2007.04.055_bib36","doi-asserted-by":"crossref","first-page":"9496","DOI":"10.1021\/bi060579z","article-title":"Conserved and cooperative assembly of membrane-bound alpha-helical states of islet amyloid polypeptide","volume":"45","author":"Knight","year":"2006","journal-title":"Biochemistry"},{"key":"10.1016\/j.bbrc.2007.04.055_bib37","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1007\/s00125-005-1764-9","article-title":"An immune origin of type 2 diabetes?","volume":"48","author":"Kolb","year":"2005","journal-title":"Diabetologia"},{"key":"10.1016\/j.bbrc.2007.04.055_bib38","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1007\/s004010000225","article-title":"Activated microglial cells and complement factors are unrelated to cortical Lewy bodies","volume":"100","author":"Rozemuller","year":"2000","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.bbrc.2007.04.055_bib39","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1093\/jnen\/62.12.1241","article-title":"Morphogenesis of Lewy bodies: dissimilar incorporation of alpha-synuclein, ubiquitin, and p62","volume":"62","author":"Kuusisto","year":"2003","journal-title":"J. Neuropathol. Exp. Neurol."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X07007802?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X07007802?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T14:17:04Z","timestamp":1762093024000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X07007802"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,6]]},"references-count":39,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2007,6]]}},"alternative-id":["S0006291X07007802"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2007.04.055","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2007,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Complement activation by islet amyloid polypeptide (IAPP) and \u03b1-synuclein 112","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2007.04.055","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2007 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}