{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:53:32Z","timestamp":1788872012847,"version":"build-2803163510"},"reference-count":45,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2007,7,1]],"date-time":"2007-07-01T00:00:00Z","timestamp":1183248000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,7,1]],"date-time":"2007-07-01T00:00:00Z","timestamp":1183248000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2007,7,1]],"date-time":"2007-07-01T00:00:00Z","timestamp":1183248000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2007,7,1]],"date-time":"2007-07-01T00:00:00Z","timestamp":1183248000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2007,7,1]],"date-time":"2007-07-01T00:00:00Z","timestamp":1183248000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2007,7,1]],"date-time":"2007-07-01T00:00:00Z","timestamp":1183248000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2007,7,1]],"date-time":"2007-07-01T00:00:00Z","timestamp":1183248000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["30470087"],"award-info":[{"award-number":["30470087"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["30570070"],"award-info":[{"award-number":["30570070"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012336","name":"Major State Basic Research Development Program of China","doi-asserted-by":"publisher","award":["2005CB522901"],"award-info":[{"award-number":["2005CB522901"]}],"id":[{"id":"10.13039\/501100012336","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2007,7]]},"DOI":"10.1016\/j.bbrc.2007.05.052","type":"journal-article","created":{"date-parts":[[2007,5,23]],"date-time":"2007-05-23T07:54:13Z","timestamp":1179906853000},"page":"70-75","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"title":["NS5A protein of HCV enhances HBV replication and resistance to interferon response"],"prefix":"10.1016","volume":"359","author":[{"given":"Ying","family":"Pan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongqiang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiali","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianguo","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2007.05.052_bib1","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1016\/S0140-6736(81)90585-7","article-title":"Hepatocellular carcinoma and hepatitis B virus, A prospective study of 22,707 men in Taiwan","volume":"2","author":"Beasley","year":"1981","journal-title":"Lancet"},{"key":"10.1016\/j.bbrc.2007.05.052_bib2","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1016\/S0140-6736(89)91946-6","article-title":"Prevalence of antibodies to hepatitis C virus in hepatocellular carcinoma","volume":"2","author":"Simonetti","year":"1989","journal-title":"Lancet"},{"key":"10.1016\/j.bbrc.2007.05.052_bib3","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1016\/S0140-6736(89)91016-7","article-title":"Prevalence of antibodies to hepatitis C virus in Italian patients with hepatocellular carcinoma","volume":"2","author":"Colombo","year":"1989","journal-title":"Lancet"},{"key":"10.1016\/j.bbrc.2007.05.052_bib4","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1016\/S0140-6736(89)91015-5","article-title":"Prevalence of antibodies to hepatitis C virus in Spanish patients with hepatocellular carcinoma and hepatic cirrhosis","volume":"2","author":"Bruix","year":"1989","journal-title":"Lancet"},{"key":"10.1016\/j.bbrc.2007.05.052_bib5","first-page":"5","article-title":"The global health burden of infection associated cancers","volume":"33","author":"Parkin","year":"1999","journal-title":"Cancer Surv."},{"key":"10.1016\/j.bbrc.2007.05.052_bib6","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1038\/sj.bjc.6602333","article-title":"A meta-analysis of case-control studies on the combined effect of hepatitis B and C virus infections in causing hepatocellular carcinoma in China","volume":"92","author":"Shi","year":"2005","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.bbrc.2007.05.052_bib7","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1111\/j.1440-1746.2005.03722.x","article-title":"Dual hepatitis B virus and hepatitis C virus infection: to treat or not to treat, and how?","volume":"20","author":"Peter","year":"2005","journal-title":"J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.bbrc.2007.05.052_bib8","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/S0140-6736(06)69347-1","article-title":"Prevention of mortality from hepatitis B and hepatitis C","volume":"368","author":"Eugene","year":"2006","journal-title":"Lancet"},{"key":"10.1016\/j.bbrc.2007.05.052_bib9","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1016\/S0140-6736(06)69374-4","article-title":"Causes of death after diagnosis of hepatitis B or hepatitis C infection: a large community-based linkage study","volume":"368","author":"Janaki","year":"2006","journal-title":"Lancet"},{"key":"10.1016\/j.bbrc.2007.05.052_bib10","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1128\/CMR.14.4.778-809.2001","article-title":"Antiviral actions of interferons","volume":"14","author":"Charles","year":"2001","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.bbrc.2007.05.052_bib11","doi-asserted-by":"crossref","first-page":"5017","DOI":"10.1016\/S0021-9258(18)42719-6","article-title":"The interferon system, A bird\u2019s eye view of its biochemistry","volume":"267","author":"Sen","year":"1992","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2007.05.052_bib12","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1146\/annurev.bi.56.070187.003455","article-title":"Interferons and their actions","volume":"56","author":"Pestka","year":"1987","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.bbrc.2007.05.052_bib13","doi-asserted-by":"crossref","first-page":"8841","DOI":"10.1073\/pnas.92.19.8841","article-title":"Involvement of the double-stranded-RNA-dependent kinase PKR in interferon expression and interferon-mediated antiviral activity","volume":"92","author":"Der","year":"1995","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbrc.2007.05.052_bib14","first-page":"796","article-title":"Interferon\u2014a therapy in chronic hepatitis B: early monitoring of hepatitis B e antigen may help to decide whether to stop or to prolong therapy","volume":"13","author":"Heijtink","year":"2006","journal-title":"J. Viral. Hepat."},{"key":"10.1016\/j.bbrc.2007.05.052_bib15","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1046\/j.1440-1746.1999.01952.x","article-title":"Alpha-interferon therapy in chronic hepatitis due to active dual infection with hepatitis B and C viruses","volume":"14","author":"Guptan","year":"1999","journal-title":"J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.bbrc.2007.05.052_bib16","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1089\/jir.1997.17.449","article-title":"Response of patients with dual hepatitis B virus and C virus infection to interferon therapy","volume":"17","author":"Liaw","year":"1997","journal-title":"J. Interferon Cytokine Res."},{"key":"10.1016\/j.bbrc.2007.05.052_bib17","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1128\/MMBR.00027-06","article-title":"Impact of protein kinase PKR in cell biology: from antiviral to antiproliferative action","volume":"70","author":"Garc\u00eda","year":"2006","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"10.1016\/j.bbrc.2007.05.052_bib18","first-page":"RE2","article-title":"Signal integration via PKR","volume":"89","author":"Williams","year":"2001","journal-title":"Sci. STKE"},{"key":"10.1016\/j.bbrc.2007.05.052_bib19","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1146\/annurev.bi.60.070191.003441","article-title":"Translational control in mammalian cells","volume":"60","author":"Hershey","year":"1991","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.bbrc.2007.05.052_bib20","doi-asserted-by":"crossref","first-page":"5208","DOI":"10.1128\/MCB.18.9.5208","article-title":"Control of PKR protein kinase by hepatitis C virus nonstructural 5A protein: molecular mechanisms of kinase regulation","volume":"18","author":"Gale","year":"1998","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.bbrc.2007.05.052_bib21","doi-asserted-by":"crossref","first-page":"5338","DOI":"10.1073\/pnas.96.10.5533","article-title":"NS5A, a nonstructural protein of hepatitis C virus, binds growth factor receptor-bound protein 2 adaptor protein in a Src homology 3 domain\/ligand-dependent manner and perturbs mitogenic signaling","volume":"96","author":"Tan","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbrc.2007.05.052_bib22","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1016\/S0016-5085(03)00290-7","article-title":"Expression of hepatitis C virus proteins inhibits interferon alpha signaling in the liver of transgenic mice","volume":"124","author":"Duong","year":"2003","journal-title":"Gastroenterology"},{"key":"10.1016\/j.bbrc.2007.05.052_bib23","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1006\/viro.2001.0815","article-title":"Analyzing the mechanisms of interferon-induced apoptosis using CrmA and hepatitis C virus NS5A","volume":"281","author":"Ezelle","year":"2001","journal-title":"Virology"},{"key":"10.1016\/j.bbrc.2007.05.052_bib24","doi-asserted-by":"crossref","first-page":"9599","DOI":"10.1073\/pnas.171311298","article-title":"Human hepatitis C virus NS5A protein alters intracellular calcium levels, induces oxidative stress, and activates STAT-3 and NF-\u03baB","volume":"98","author":"Gong","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbrc.2007.05.052_bib25","doi-asserted-by":"crossref","first-page":"8469","DOI":"10.1128\/JVI.73.10.8469-8475.1999","article-title":"Expression of hepatitis C virus proteins inhibits signal transduction through the Jak-STAT pathway","volume":"73","author":"Heim","year":"1999","journal-title":"J. Virol."},{"key":"10.1016\/j.bbrc.2007.05.052_bib26","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1056\/NEJM199601113340203","article-title":"Mutations in the nonstructural protein 5A gene and response to interferon in patients with chronic hepatitis C virus 1b infection","volume":"334","author":"Enomoto","year":"1996","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbrc.2007.05.052_bib27","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1111\/j.1348-0421.2001.tb01322.x","article-title":"Effects of mutation in Hepatitis C virus nonstructural protein 5A on interferon resistance mediated by inhibition of PKR kinase activity in mammalian cells","volume":"45","author":"Noguchi","year":"2001","journal-title":"Microbiol. Immunol."},{"key":"10.1016\/j.bbrc.2007.05.052_bib28","doi-asserted-by":"crossref","first-page":"9028","DOI":"10.1128\/JVI.74.19.9028-9038.2000","article-title":"Prospective characterization of full-length hepatitis C virus NS5A quasispecies during induction and combination antiviral therapy","volume":"74","author":"Nousbaum","year":"2000","journal-title":"J. Virol."},{"key":"10.1016\/j.bbrc.2007.05.052_bib29","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1002\/hep.510290438","article-title":"Characterization of the effects of hepatitis C virus nonstructural 5A protein expression in human cell lines and on interferon-sensitive virus replication","volume":"29","author":"Polyak","year":"1999","journal-title":"Hepatology"},{"key":"10.1016\/j.bbrc.2007.05.052_bib30","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1089\/107999000750053780","article-title":"Suppression of interferon-induced antiviral activity in cells expressing hepatitis C virus proteins","volume":"20","author":"Aizaki","year":"2000","journal-title":"J. Interferon Cytokine Res."},{"key":"10.1016\/j.bbrc.2007.05.052_bib31","doi-asserted-by":"crossref","first-page":"6203","DOI":"10.1128\/JVI.74.13.6203-6206.2000","article-title":"Influenza virus NS1 protein counteracts PKR-mediated inhibition of replication","volume":"74","author":"Bergmann","year":"2000","journal-title":"J. Virol."},{"key":"10.1016\/j.bbrc.2007.05.052_bib32","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1128\/JVI.76.3.1206-1212.2002","article-title":"Effects of influenza A virus NS1 protein on protein expression: the NS1 protein enhances translation and is not required for shutoff of host protein synthesis","volume":"76","author":"Mirella","year":"2002","journal-title":"J. Virol."},{"key":"10.1016\/j.bbrc.2007.05.052_bib33","doi-asserted-by":"crossref","first-page":"11566","DOI":"10.1128\/JVI.74.24.11566-11573.2000","article-title":"Influenza A virus NS1 protein prevents activation of NF-\u03baB and induction of alpha\/beta interferon","volume":"74","author":"Wang","year":"2000","journal-title":"J. Virol."},{"key":"10.1016\/j.bbrc.2007.05.052_bib34","doi-asserted-by":"crossref","first-page":"13257","DOI":"10.1128\/JVI.77.24.13257-13266.2003","article-title":"A recombinant influenza A virus expressing an RNA-binding-defective NS1 protein induces high levels of beta interferon and is attenuated in mice","volume":"77","author":"Donelan","year":"2003","journal-title":"J. Virol."},{"key":"10.1016\/j.bbrc.2007.05.052_bib35","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1128\/JVI.01265-06","article-title":"Inhibition of retinoic acid-inducible gene I-mediated induction of beta interferon by the NS1 protein of influenza A virus","volume":"81","author":"Mibayashi","year":"2007","journal-title":"J. Virol."},{"key":"10.1016\/j.bbrc.2007.05.052_bib36","doi-asserted-by":"crossref","first-page":"11574","DOI":"10.1128\/JVI.78.21.11574-11582.2004","article-title":"The N- and C-terminal domains of the NS1 protein of influenza B virus can independently inhibit IRF-3 and beta interferon promoter activation","volume":"78","author":"Donelan","year":"2004","journal-title":"J. Virol."},{"key":"10.1016\/j.bbrc.2007.05.052_bib37","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1128\/JVI.76.3.1206-1212.2002","article-title":"Effects of influenza A virus NS1 protein on protein expression: the NS1 protein enhances translation and is not required for shut off of host protein synthesis","volume":"76","author":"Mirella","year":"2002","journal-title":"J. Virol."},{"key":"10.1016\/j.bbrc.2007.05.052_bib38","doi-asserted-by":"crossref","DOI":"10.1128\/JCM.02157-06","article-title":"Clinical and virological characteristics of hepatitis B virus subgenotypes Ba, C1 and C2 in China","author":"Wang","year":"2007","journal-title":"Clin. Microbiol."},{"key":"10.1016\/j.bbrc.2007.05.052_bib39","doi-asserted-by":"crossref","first-page":"312","DOI":"10.7326\/0003-4819-119-4-199308150-00011","article-title":"Effect of alpha-interferon treatment in patients with hepatitis B e antigen-positive chronic hepatitis B: a meta-analysis","volume":"119","author":"Wong","year":"1993","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.bbrc.2007.05.052_bib40","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1002\/hep.20119","article-title":"Diagnosis, management, and treatment of hepatitis C","volume":"39","author":"Strader","year":"2004","journal-title":"Hepatology"},{"key":"10.1016\/j.bbrc.2007.05.052_bib41","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1002\/(SICI)1096-9071(199704)51:4<313::AID-JMV9>3.0.CO;2-8","article-title":"Relevance of inapparent coinfection by hepatitis B virus in alpha interferon-treated patients with hepatitis C virus chronic hepatitis","volume":"51","author":"Zignego","year":"1997","journal-title":"J. Med. Virol."},{"key":"10.1016\/j.bbrc.2007.05.052_bib42","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1002\/(SICI)1096-9071(199907)58:3<201::AID-JMV3>3.0.CO;2-2","article-title":"Serologically silent hepatitis B virus coinfection in patients with hepatitis C virus-associated chronic liver disease: clinical and virological significance","volume":"58","author":"Fukuda","year":"1999","journal-title":"J. Med. Virol."},{"key":"10.1016\/j.bbrc.2007.05.052_bib43","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1172\/JCI118025","article-title":"Comparison of full-length sequences of interferon-sensitive and resistant hepatitis C virus 1b. Sensitivity to interferon is conferred by amino acid substitutions in the NS5A region","volume":"96","author":"Enomoto","year":"1995","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbrc.2007.05.052_bib44","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1056\/NEJM199601113340203","article-title":"Mutations in the nonstructural protein 5A gene and response to interferon in patients with chronic hepatitis C virus 1b infection","volume":"334","author":"Enomoto","year":"1996","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbrc.2007.05.052_bib45","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1038\/nri1961","article-title":"Interferons, immunity and cancer immunoediting","volume":"6","author":"Dunn","year":"2006","journal-title":"Nat. Rev. Immunol."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X07010066?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X07010066?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T10:33:44Z","timestamp":1757759624000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X07010066"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,7]]},"references-count":45,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,7]]}},"alternative-id":["S0006291X07010066"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2007.05.052","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2007,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"NS5A protein of HCV enhances HBV replication and resistance to interferon response","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2007.05.052","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2007 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}