{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T06:32:17Z","timestamp":1783751537541,"version":"3.55.0"},"reference-count":30,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2007,12,1]],"date-time":"2007-12-01T00:00:00Z","timestamp":1196467200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2007,12]]},"DOI":"10.1016\/j.bbrc.2007.10.011","type":"journal-article","created":{"date-parts":[[2007,10,16]],"date-time":"2007-10-16T11:18:52Z","timestamp":1192533532000},"page":"719-724","source":"Crossref","is-referenced-by-count":16,"title":["Contribution of a putative salt bridge and backbone dynamics in the structural instability of human prion protein upon R208H mutation"],"prefix":"10.1016","volume":"364","author":[{"given":"Kourosh","family":"Bamdad","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hossein","family":"Naderi-Manesh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2007.10.011_bib1","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1126\/science.1675487","article-title":"Molecular biology of prion diseases","volume":"252","author":"Prusiner","year":"1991","journal-title":"Science"},{"key":"10.1016\/j.bbrc.2007.10.011_bib2","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1126\/science.6801762","article-title":"Novel proteinaceous infectious particles cause scrapie","volume":"216","author":"Prusiner","year":"1982","journal-title":"Science"},{"key":"10.1016\/j.bbrc.2007.10.011_bib3","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1006\/bbrc.1998.9169","article-title":"Transmissible spongiform encephalopathies","volume":"250","author":"Liemann","year":"1998","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2007.10.011_bib4","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0959-440X(97)80007-3","article-title":"The prion folding problem","volume":"7","author":"Harrison","year":"1997","journal-title":"Curr. Opin. Struct. Biol."},{"key":"10.1016\/j.bbrc.2007.10.011_bib5","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.bbrc.2006.09.082","article-title":"Identification of pH-sensitive regions in the mouse prion by the cysteine-scanning spin-labeling ESR technique","volume":"350","author":"Watanabe","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2007.10.011_bib6","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1126\/science.7761829","article-title":"Classical electrostatics in biology and chemistry","volume":"268","author":"Honig","year":"1995","journal-title":"Science"},{"key":"10.1016\/j.bbrc.2007.10.011_bib7","doi-asserted-by":"crossref","first-page":"3590","DOI":"10.1073\/pnas.96.7.3590","article-title":"Designing conditions for in vitro formation of amyloid protofilaments and fibrils","volume":"96","author":"Chiti","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbrc.2007.10.011_bib8","doi-asserted-by":"crossref","first-page":"22187","DOI":"10.1074\/jbc.M302130200","article-title":"Atypical effect of salts on the thermodynamic stability of human prion protein","volume":"278","author":"Apetri","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2007.10.011_bib9","doi-asserted-by":"crossref","first-page":"13862","DOI":"10.1021\/bi991469d","article-title":"Molecular dynamics simulations of human prion protein: importance of correct treatment of electrostatic interactions","volume":"38","author":"Zuegg","year":"1999","journal-title":"Biochemistry"},{"key":"10.1016\/j.bbrc.2007.10.011_bib10","doi-asserted-by":"crossref","first-page":"2293","DOI":"10.1073\/pnas.0307178101","article-title":"From conversion to aggregation: protofibril formation of the prion protein","volume":"101","author":"DeMarco","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbrc.2007.10.011_bib11","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1002\/jcc.20291","article-title":"GROMACS: fast, flexible and free","volume":"26","author":"van der Spoel","year":"2005","journal-title":"J. Comp. Chem."},{"key":"10.1016\/j.bbrc.2007.10.011_bib12","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1002\/jcc.1078","article-title":"An improved GROMOS96 force field for aliphatic hydrocarbons in the condensed phase","volume":"22","author":"Schuler","year":"2001","journal-title":"J. Comp. Chem."},{"key":"10.1016\/j.bbrc.2007.10.011_bib13","doi-asserted-by":"crossref","first-page":"2577","DOI":"10.1002\/bip.360221211","article-title":"Dictionary of protein secondary structure: pattern recognition of hydrogen-bonded and geometrical features","volume":"22","author":"Kabsch","year":"1983","journal-title":"Biopolymers"},{"key":"10.1016\/j.bbrc.2007.10.011_bib14","doi-asserted-by":"crossref","first-page":"35592","DOI":"10.1074\/jbc.M303005200","article-title":"Influence of pH on NMR structure and stability of the human prion protein globular domain","volume":"278","author":"Calzolai","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2007.10.011_bib15","doi-asserted-by":"crossref","first-page":"2714","DOI":"10.1002\/elps.1150181505","article-title":"SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling","volume":"18","author":"Guex","year":"1997","journal-title":"Electrophoresis"},{"key":"10.1016\/j.bbrc.2007.10.011_bib16","series-title":"Intermolecular Forces","first-page":"331","article-title":"Interaction models for water in relation to protein hydration","author":"Berendsen","year":"1981"},{"key":"10.1016\/j.bbrc.2007.10.011_bib17","doi-asserted-by":"crossref","first-page":"3684","DOI":"10.1063\/1.448118","article-title":"Molecular dynamics with coupling to an external bath","volume":"81","author":"Berendsen","year":"1984","journal-title":"J. Chem. Phys."},{"key":"10.1016\/j.bbrc.2007.10.011_bib18","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1002\/jcc.540130805","article-title":"Settle: an analytical version of the shake and rattle algorithms for rigid water molecules","volume":"13","author":"Miyamoto","year":"1992","journal-title":"J. Comp. Chem."},{"key":"10.1016\/j.bbrc.2007.10.011_bib19","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1002\/(SICI)1096-987X(199709)18:12<1463::AID-JCC4>3.0.CO;2-H","article-title":"LINCS: a linear constraint solver for molecular simulations","volume":"18","author":"Hess","year":"1997","journal-title":"J. Comp. Chem."},{"key":"10.1016\/j.bbrc.2007.10.011_bib20","doi-asserted-by":"crossref","first-page":"10089","DOI":"10.1063\/1.464397","article-title":"Particle mesh ewald: an N log (N) method for Ewald sums in large systems","volume":"98","author":"Darden","year":"1993","journal-title":"J. Chem. Phys."},{"key":"10.1016\/j.bbrc.2007.10.011_bib21","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1073\/pnas.97.1.145","article-title":"NMR solution structure of the human prion protein","volume":"97","author":"Zahn","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbrc.2007.10.011_bib22","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1002\/(SICI)1097-0134(20000215)38:3<327::AID-PROT8>3.0.CO;2-G","article-title":"Molecular dynamics of the mouse and Syrian hamster PrP: implications for activity","volume":"38","author":"Parchment","year":"2000","journal-title":"Proteins: Struct. Funct. Genet."},{"key":"10.1016\/j.bbrc.2007.10.011_bib23","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S1093-3263(01)00117-6","article-title":"Flexibility of the murine prion protein and its Asp178Asn mutant investigated by molecular dynamics simulations","volume":"20","author":"Gsponer","year":"2001","journal-title":"J. Mol. Graph. Model."},{"key":"10.1016\/j.bbrc.2007.10.011_bib24","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0065-3233(01)57020-5","article-title":"Simulations and computational analyses of prion protein conformations","volume":"57","author":"Alonso","year":"2001","journal-title":"Adv. Protein Chem."},{"key":"10.1016\/j.bbrc.2007.10.011_bib25","doi-asserted-by":"crossref","first-page":"15335","DOI":"10.1073\/pnas.0404235101","article-title":"Probing the instabilities in the dynamics of helical fragments from mouse PrPc","volume":"101","author":"Dima","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbrc.2007.10.011_bib26","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1002\/(SICI)1096-987X(199803)19:4<430::AID-JCC5>3.0.CO;2-T","article-title":"Derivation of class II force fields: V. Quantum force field for amides, peptides, and related compounds","volume":"19","author":"Maple","year":"1998","journal-title":"J. Comp. Chem."},{"key":"10.1016\/j.bbrc.2007.10.011_bib27","doi-asserted-by":"crossref","first-page":"12522","DOI":"10.1074\/jbc.M211599200","article-title":"The role of Helix 1 aspartates and salt bridges in the stability and conversion of prion protein","volume":"278","author":"Speare","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2007.10.011_bib28","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1016\/j.bbrc.2007.05.194","article-title":"A comparative molecular dynamics study on thermostability of human and chicken prion proteins","volume":"359","author":"Ji","year":"2007","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2007.10.011_bib29","doi-asserted-by":"crossref","first-page":"3908","DOI":"10.1529\/biophysj.105.075341","article-title":"Structural instability of the prion protein upon M205S\/R mutations revealed by molecular dynamics simulations","volume":"90","author":"Hirschberger","year":"2006","journal-title":"Biophys. J."},{"key":"10.1016\/j.bbrc.2007.10.011_bib30","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1006\/jmbi.2001.5329","article-title":"Effects of the N2144S mutation on backbone dynamics of a TB-cbEGF domain pair from human fibrillin-1","volume":"316","author":"Yuan","year":"2002","journal-title":"J. Mol. Biol."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X07021419?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X07021419?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,1,3]],"date-time":"2019-01-03T12:22:10Z","timestamp":1546518130000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X07021419"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,12]]},"references-count":30,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2007,12]]}},"alternative-id":["S0006291X07021419"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2007.10.011","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2007,12]]}}}