{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T10:23:19Z","timestamp":1789986199015,"version":"4.0.1"},"reference-count":28,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2008,3,1]],"date-time":"2008-03-01T00:00:00Z","timestamp":1204329600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2008,3]]},"DOI":"10.1016\/j.bbrc.2007.12.152","type":"journal-article","created":{"date-parts":[[2008,1,3]],"date-time":"2008-01-03T10:37:03Z","timestamp":1199356623000},"page":"674-679","source":"Crossref","is-referenced-by-count":24,"title":["Galantamine and carbon monoxide protect brain microvascular endothelial cells by heme oxygenase-1 induction"],"prefix":"10.1016","volume":"367","author":[{"given":"Atsunori","family":"Nakao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Kaczorowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian S.","family":"Zuckerbraun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaetano","family":"Faleo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kentaro","family":"Deguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth R.","family":"McCurry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy R.","family":"Billiar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinichi","family":"Kanno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2007.12.152_bib1","first-page":"1","article-title":"Agonist responses of neuronal nicotinic acetylcholine receptors are potentiated by a novel class of allosterically acting ligands","volume":"49","author":"Schrattenholz","year":"1996","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.bbrc.2007.12.152_bib2","doi-asserted-by":"crossref","first-page":"095","DOI":"10.2165\/00003495-200060050-00008","article-title":"Galantamine: a review of its use in Alzheimer\u2019s disease","volume":"60","author":"Scott","year":"2000","journal-title":"Drugs"},{"key":"10.1016\/j.bbrc.2007.12.152_bib3","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.1073\/pnas.98.4.2089","article-title":"Galantamine: effect on nicotinic receptor binding, acetylcholinesterase inhibition, and learning","volume":"98","author":"Woodruff-Pak","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbrc.2007.12.152_bib4","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S0165-0173(00)00043-6","article-title":"Evidence that Alzheimer\u2019s disease is a microvascular disorder: the role of constitutive nitric oxide","volume":"34","author":"de la Torre","year":"2000","journal-title":"Brain Res. Brain Res. Rev."},{"key":"10.1016\/j.bbrc.2007.12.152_bib5","first-page":"24","article-title":"The pharmacological rationale for treating vascular dementia with galantamine (Reminyl)","volume":"120","author":"Maelicke","year":"2001","journal-title":"Int. J. Clin. Pract. Suppl."},{"key":"10.1016\/j.bbrc.2007.12.152_bib6","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1034\/j.1600-0404.2000.00310.x","article-title":"Galantamine is an allosterically potentiating ligand of the human alpha4\/beta2 nAChR","volume":"176","author":"Samochocki","year":"2000","journal-title":"Acta Neurol. Scand. Suppl."},{"key":"10.1016\/j.bbrc.2007.12.152_bib7","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1046\/j.1468-1331.2003.00677.x","article-title":"Long-term safety and cognitive effects of galantamine in the treatment of probable vascular dementia or Alzheimer\u2019s disease with cerebrovascular disease","volume":"10","author":"Kurz","year":"2003","journal-title":"Eur. J. Neurol."},{"key":"10.1016\/j.bbrc.2007.12.152_bib8","doi-asserted-by":"crossref","first-page":"777","DOI":"10.2165\/00002512-200320100-00006","article-title":"A long-term comparison of galantamine and donepezil in the treatment of Alzheimer\u2019s disease","volume":"20","author":"Wilcock","year":"2003","journal-title":"Drugs. Aging"},{"key":"10.1016\/j.bbrc.2007.12.152_bib9","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1097\/01.wad.0000189052.48688.36","article-title":"Effects of galantamine versus donepezil on sleep in patients with mild to moderate Alzheimer disease and their caregivers: a double-blind, head-to-head, randomized pilot study","volume":"19","author":"Ancoli-Israel","year":"2005","journal-title":"Alzheimer. Dis. Assoc. Disord."},{"key":"10.1016\/j.bbrc.2007.12.152_bib10","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1046\/j.1471-4159.2000.0750304.x","article-title":"Neurons overexpressing heme oxygenase-1 resist oxidative stress-mediated cell death","volume":"75","author":"Chen","year":"2000","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbrc.2007.12.152_bib11","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.neulet.2004.03.033","article-title":"Glutamate-induced cell death of immortalized murine hippocampal neurons: neuroprotective activity of heme oxygenase-1, heat shock protein 70, and sodium selenite","volume":"362","author":"Rossler","year":"2004","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.bbrc.2007.12.152_bib12","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1002\/jnr.10582","article-title":"Oxidative stress in cultured cerebral endothelial cells induces chromosomal aberrations, micronuclei, and apoptosis","volume":"72","author":"Bresgen","year":"2003","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.bbrc.2007.12.152_bib13","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1097\/00004647-200302000-00006","article-title":"Ionotropic glutamate receptors in cerebral microvascular endothelium are functionally linked to heme oxygenase","volume":"23","author":"Parfenova","year":"2003","journal-title":"J. Cereb. Blood Flow. Metab."},{"key":"10.1016\/j.bbrc.2007.12.152_bib14","first-page":"177","article-title":"Nutritional antioxidants and the heme oxygenase pathway of stress tolerance: novel targets for neuroprotection in Alzheimer\u2019s disease","volume":"52","author":"Calabrese","year":"2003","journal-title":"Ital. J. Biochem."},{"key":"10.1016\/j.bbrc.2007.12.152_bib15","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/S0047-6374(01)00362-1","article-title":"The hippocampus in spontaneously hypertensive rats: an animal model of vascular dementia?","volume":"123","author":"Sabbatini","year":"2002","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.bbrc.2007.12.152_bib16","first-page":"H1485","article-title":"Prostanoid synthesis in response to high CO2 in newborn pig brain microvascular endothelial cells","volume":"264","author":"Hsu","year":"1993","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.bbrc.2007.12.152_bib17","doi-asserted-by":"crossref","first-page":"15148","DOI":"10.1074\/jbc.273.24.15148","article-title":"Multiple NF-kappaB enhancer elements regulate cytokine induction of the human inducible nitric oxide synthase gene","volume":"273","author":"Taylor","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2007.12.152_bib18","doi-asserted-by":"crossref","first-page":"17950","DOI":"10.1074\/jbc.M108317200","article-title":"Heme oxygenase-1-derived carbon monoxide requires the activation of transcription factor NF-kappa B to protect endothelial cells from tumor necrosis factor-alpha-mediated apoptosis","volume":"277","author":"Brouard","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2007.12.152_bib19","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1084\/jem.20031003","article-title":"Carbon monoxide protects against liver failure through nitric oxide-induced heme oxygenase 1","volume":"198","author":"Zuckerbraun","year":"2003","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.bbrc.2007.12.152_bib20","doi-asserted-by":"crossref","first-page":"2323","DOI":"10.1161\/01.STR.0000091396.95360.E1","article-title":"Efficacy and tolerability of donepezil in vascular dementia: positive results of a 24-week, multicenter, international, randomized, placebo-controlled clinical trial","volume":"34","author":"Black","year":"2003","journal-title":"Stroke"},{"key":"10.1016\/j.bbrc.2007.12.152_bib21","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1016\/S0140-6736(06)68350-5","article-title":"Donepezil in patients with severe Alzheimer\u2019s disease: double-blind, parallel-group, placebo-controlled study","volume":"367","author":"Winblad","year":"2006","journal-title":"Lancet"},{"key":"10.1016\/j.bbrc.2007.12.152_bib22","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1124\/jpet.105.090365","article-title":"Unequal neuroprotection afforded by the acetylcholinesterase inhibitors galantamine, donepezil, and rivastigmine in SH-SY5Y neuroblastoma cells: role of nicotinic receptors","volume":"315","author":"Arias","year":"2005","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.bbrc.2007.12.152_bib23","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/j.yjmcc.2007.08.003","article-title":"Heme-oxygenase-1-induced protection against hypoxia\/reoxygenation is dependent on biliverdin reductase and its interaction with PI3K\/Akt pathway","volume":"43","author":"Pachori","year":"2007","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.bbrc.2007.12.152_bib24","doi-asserted-by":"crossref","first-page":"2799","DOI":"10.1016\/S0028-3908(00)00127-1","article-title":"The alpha7 nicotinic acetylcholine receptor subtype mediates nicotine protection against NMDA excitotoxicity in primary hippocampal cultures through a Ca (2+) dependent mechanism","volume":"39","author":"Dajas-Bailador","year":"2000","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bbrc.2007.12.152_bib25","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1038\/sj.bjp.0705272","article-title":"Vascular endothelial growth factor increases heme oxygenase-1 protein expression in the chick embryo chorioallantoic membrane","volume":"139","author":"Fernandez","year":"2003","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.bbrc.2007.12.152_bib26","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1084\/jem.20051047","article-title":"Carbon monoxide ameliorates chronic murine colitis through a heme oxygenase 1-dependent pathway","volume":"202","author":"Hegazi","year":"2005","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.bbrc.2007.12.152_bib27","doi-asserted-by":"crossref","first-page":"111S","DOI":"10.1038\/jid.1993.33","article-title":"Role of microvascular endothelial cells in inflammation","volume":"100","author":"Swerlick","year":"1993","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.bbrc.2007.12.152_bib28","first-page":"673","article-title":"Antigenic heterogeneity of vascular endothelium","volume":"141","author":"Page","year":"1992","journal-title":"Am. J. Pathol."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X07028100?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X07028100?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T18:26:12Z","timestamp":1546367172000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X07028100"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,3]]},"references-count":28,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2008,3]]}},"alternative-id":["S0006291X07028100"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2007.12.152","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1122912.580012","asserted-by":"object"}]},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2008,3]]}}}