{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T06:12:47Z","timestamp":1777443167408,"version":"3.51.4"},"reference-count":31,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2008,5,1]],"date-time":"2008-05-01T00:00:00Z","timestamp":1209600000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2008,5]]},"DOI":"10.1016\/j.bbrc.2008.03.012","type":"journal-article","created":{"date-parts":[[2008,3,12]],"date-time":"2008-03-12T14:29:45Z","timestamp":1205332185000},"page":"33-37","source":"Crossref","is-referenced-by-count":19,"title":["Regulation of pancreatic duct cell differentiation by phosphatidylinositol-3 kinase"],"prefix":"10.1016","volume":"370","author":[{"given":"Hiroaki","family":"Watanabe","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Saito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junji","family":"Ueda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B. Mark","family":"Evers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"Suppl. 1","key":"10.1016\/j.bbrc.2008.03.012_bib1","doi-asserted-by":"crossref","first-page":"S154","DOI":"10.2337\/diabetes.50.2007.S154","article-title":"Beta-cell adaptation and decompensation during the progression of diabetes","volume":"50","author":"Weir","year":"2001","journal-title":"Diabetes"},{"key":"10.1016\/j.bbrc.2008.03.012_bib2","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1679\/aohc.66.163","article-title":"Differentiation and proliferation of endocrine cells in the regenerating rat pancreas after 90% pancreatectomy","volume":"66","author":"Hayashi","year":"2003","journal-title":"Arch. Histol. Cytol."},{"key":"10.1016\/j.bbrc.2008.03.012_bib3","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/S0039-6060(96)80270-4","article-title":"Pancreatic regeneration (reg) gene expression in a rat model of islet hyperplasia","volume":"119","author":"Zenilman","year":"1996","journal-title":"Surgery"},{"issue":"Suppl. 3","key":"10.1016\/j.bbrc.2008.03.012_bib4","doi-asserted-by":"crossref","first-page":"S320","DOI":"10.2337\/diabetes.51.2007.S320","article-title":"Regulation of pdx-1 gene expression","volume":"51","author":"Melloul","year":"2002","journal-title":"Diabetes"},{"key":"10.1016\/j.bbrc.2008.03.012_bib5","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1530\/eje.0.1460129","article-title":"Pancreas duodenum homeobox-1 regulates pancreas development during embryogenesis and islet cell function in adulthood","volume":"146","author":"Hui","year":"2002","journal-title":"Eur. J. Endocrinol."},{"key":"10.1016\/j.bbrc.2008.03.012_bib6","doi-asserted-by":"crossref","first-page":"785","DOI":"10.2337\/diabetes.50.4.785","article-title":"Glucagon-like peptide 1 induces differentiation of islet duodenal homeobox-1-positive pancreatic ductal cells into insulin-secreting cells","volume":"50","author":"Hui","year":"2001","journal-title":"Diabetes"},{"key":"10.1016\/j.bbrc.2008.03.012_bib7","doi-asserted-by":"crossref","first-page":"10465","DOI":"10.1073\/pnas.91.22.10465","article-title":"Transcriptional regulation of the human insulin gene is dependent on the homeodomain protein STF1\/IPF1 acting through the CT boxes","volume":"91","author":"Petersen","year":"1994","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbrc.2008.03.012_bib8","doi-asserted-by":"crossref","first-page":"507","DOI":"10.2337\/diabetes.48.3.507","article-title":"The homeodomain protein IDX-1 increases after an early burst of proliferation during pancreatic regeneration","volume":"48","author":"Sharma","year":"1999","journal-title":"Diabetes"},{"issue":"Suppl. 2","key":"10.1016\/j.bbrc.2008.03.012_bib9","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1007\/s001250051387","article-title":"The insulin signalling system and the IRS proteins","volume":"40","author":"White","year":"1997","journal-title":"Diabetologia"},{"key":"10.1016\/j.bbrc.2008.03.012_bib10","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1677\/joe.0.1740247","article-title":"Inhibitors of phosphatidylinositol 3-kinase amplify insulin release from islets of lean but not obese mice","volume":"174","author":"Zawalich","year":"2002","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.bbrc.2008.03.012_bib11","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1146\/annurev.biochem.70.1.535","article-title":"Synthesis and function of 3-phosphorylated inositol lipids","volume":"70","author":"Vanhaesebroeck","year":"2001","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.bbrc.2008.03.012_bib12","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1053\/j.gastro.2005.03.016","article-title":"Aging is associated with decreased pancreatic acinar cell regeneration and phosphatidylinositol 3-kinase\/Akt activation","volume":"128","author":"Watanabe","year":"2005","journal-title":"Gastroenterology"},{"key":"10.1016\/j.bbrc.2008.03.012_bib13","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1097\/MPA.0b013e318157753e","article-title":"Activation of phosphatidylinositol-3 kinase regulates pancreatic duodenal homeobox-1 in duct cells during pancreatic regeneration","volume":"36","author":"Watanabe","year":"2008","journal-title":"Pancreas"},{"key":"10.1016\/j.bbrc.2008.03.012_bib14","doi-asserted-by":"crossref","first-page":"1892","DOI":"10.1073\/pnas.0308698100","article-title":"Short interfering RNAs can induce unexpected and divergent changes in the levels of untargeted proteins in mammalian cells","volume":"101","author":"Scacheri","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbrc.2008.03.012_bib15","doi-asserted-by":"crossref","first-page":"18961","DOI":"10.1016\/S0021-9258(17)32260-3","article-title":"Neurite outgrowth of PC12 cells is suppressed by wortmannin, a specific inhibitor of phosphatidylinositol 3-kinase","volume":"269","author":"Kimura","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2008.03.012_bib16","doi-asserted-by":"crossref","first-page":"G1197","DOI":"10.1152\/ajpgi.00177.2002","article-title":"Phorbol ester-mediated neurotensin secretion is dependent on the PKC-alpha and -delta isoforms","volume":"283","author":"Li","year":"2002","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.bbrc.2008.03.012_bib17","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1177\/44.9.8773559","article-title":"Islet morphogenesis and stem cell markers in rat pancreas","volume":"44","author":"Bouwens","year":"1996","journal-title":"J. Histochem. Cytochem."},{"key":"10.1016\/j.bbrc.2008.03.012_bib18","doi-asserted-by":"crossref","first-page":"e85","DOI":"10.1097\/00006676-200410000-00017","article-title":"Stem cells and regenerative medicine for diabetes mellitus","volume":"29","author":"Sumi","year":"2004","journal-title":"Pancreas"},{"key":"10.1016\/j.bbrc.2008.03.012_bib19","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1038\/73128","article-title":"Reversal of insulin-dependent diabetes using islets generated in vitro from pancreatic stem cells","volume":"6","author":"Ramiya","year":"2000","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbrc.2008.03.012_bib20","doi-asserted-by":"crossref","first-page":"7999","DOI":"10.1073\/pnas.97.14.7999","article-title":"In vitro cultivation of human islets from expanded ductal tissue","volume":"97","author":"Bonner-Weir","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbrc.2008.03.012_bib21","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1242\/dev.121.6.1569","article-title":"Developmental biology of the pancreas","volume":"121","author":"Slack","year":"1995","journal-title":"Development"},{"key":"10.1016\/j.bbrc.2008.03.012_bib22","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1073\/pnas.0237371100","article-title":"Expression of Pax4 in embryonic stem cells promotes differentiation of nestin-positive progenitor and insulin-producing cells","volume":"100","author":"Blyszczuk","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbrc.2008.03.012_bib23","doi-asserted-by":"crossref","first-page":"5034","DOI":"10.1073\/pnas.0936260100","article-title":"Glucagon-like peptide 1 (1\u201337) converts intestinal epithelial cells into insulin-producing cells","volume":"100","author":"Suzuki","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbrc.2008.03.012_bib24","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1126\/science.1077838","article-title":"Insulin staining of ES cell progeny from insulin uptake","volume":"299","author":"Rajagopal","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.bbrc.2008.03.012_bib25","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1093\/intimm\/dxh180","article-title":"Altered splenic B cell subset development in mice lacking phosphoinositide 3-kinase p85\u03b1","volume":"16","author":"Donahue","year":"2004","journal-title":"Int. Immunol."},{"key":"10.1016\/j.bbrc.2008.03.012_bib26","article-title":"Akt1\/Akt2 and mTOR\/Bim play critical roles in osteoclast differentiation and survival, respectively, while Akt is dispensable for cell survival in isolated osteoclast precursors","author":"Sugatani","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2008.03.012_bib27","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1002\/jcb.20185","article-title":"Involvement of phosphoinositide 3-kinase signaling pathway in chondrocytic differentiation of ATDC5 cells: application of a gene-trap mutagenesis","volume":"93","author":"Ihara-Watanabe","year":"2004","journal-title":"J. Cell Biochem."},{"key":"10.1016\/j.bbrc.2008.03.012_bib28","doi-asserted-by":"crossref","first-page":"3590","DOI":"10.1210\/endo.137.8.8754791","article-title":"Expression of a constitutively activated form of protein kinase B (c-Akt) in 3T3-L1 preadipose cells causes spontaneous differentiation","volume":"137","author":"Magun","year":"1996","journal-title":"Endocrinology"},{"key":"10.1016\/j.bbrc.2008.03.012_bib29","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1083\/jcb.137.5.1127","article-title":"Phosphatidylinositol 3-kinase is a negative regulator of cellular differentiation","volume":"137","author":"Ptasznik","year":"1997","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.bbrc.2008.03.012_bib30","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1128\/MCB.25.5.1596-1607.2005","article-title":"Phosphoinositide 3-kinase catalytic subunit deletion and regulatory subunit deletion have opposite effects on insulin sensitivity in mice","volume":"25","author":"Brachmann","year":"2005","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.bbrc.2008.03.012_bib31","first-page":"1","article-title":"Pancreas and islet transplantation","volume":"75","author":"Hakim","year":"2004","journal-title":"Ann. Ital. Chir."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X08004531?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X08004531?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T00:42:28Z","timestamp":1684284148000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X08004531"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,5]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,5]]}},"alternative-id":["S0006291X08004531"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2008.03.012","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2008,5]]}}}