{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T03:48:55Z","timestamp":1773632935488,"version":"3.50.1"},"reference-count":34,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2008,5,1]],"date-time":"2008-05-01T00:00:00Z","timestamp":1209600000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,5,1]],"date-time":"2008-05-01T00:00:00Z","timestamp":1209600000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100008732","name":"Uehara Memorial Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008732","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007449","name":"Takeda Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007449","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008608","name":"Sumitomo Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008608","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2008,5]]},"DOI":"10.1016\/j.bbrc.2008.03.020","type":"journal-article","created":{"date-parts":[[2008,3,15]],"date-time":"2008-03-15T10:35:28Z","timestamp":1205577328000},"page":"1155-1159","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"title":["Glyoxal causes inflammatory injury in human vascular endothelial cells"],"prefix":"10.1016","volume":"369","author":[{"given":"Hideyuki","family":"Yamawaki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukio","family":"Hara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2008.03.020_bib1","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1111\/j.1365-2796.2007.01831.x","article-title":"Hyperglycaemia and cardiovascular disease","volume":"262","author":"Bartnik","year":"2007","journal-title":"J. Intern. Med."},{"key":"10.1016\/j.bbrc.2008.03.020_bib2","doi-asserted-by":"crossref","first-page":"292","DOI":"10.4103\/0019-5359.32098","article-title":"Atherosclerosis in diabetes mellitus: role of inflammation","volume":"61","author":"Maiti","year":"2007","journal-title":"Ind. J. Med. Sci."},{"key":"10.1016\/j.bbrc.2008.03.020_bib3","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1056\/NEJM199901143400207","article-title":"Atherosclerosis\u2014an inflammatory disease","volume":"340","author":"Ross","year":"1999","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbrc.2008.03.020_bib4","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1038\/nature01323","article-title":"Inflammation in atherosclerosis","volume":"420","author":"Libby","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2008.03.020_bib5","doi-asserted-by":"crossref","first-page":"84","DOI":"10.3132\/dvdr.2007.025","article-title":"The endothelium and vascular inflammation in diabetes","volume":"4","author":"Hartge","year":"2007","journal-title":"Diab. Vasc. Dis. Res."},{"key":"10.1016\/j.bbrc.2008.03.020_bib6","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0168-8227(98)00074-6","article-title":"Increased serum levels of advanced glycation end-products and diabetic complications","volume":"41","author":"Ono","year":"1998","journal-title":"Diabetes Res. Clin. Pract."},{"key":"10.1016\/j.bbrc.2008.03.020_bib7","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.2337\/diacare.22.9.1543","article-title":"Serum levels of advanced glycation end products are increased in patients with type 2 diabetes and coronary heart disease","volume":"22","author":"Kilhovd","year":"1999","journal-title":"Diabetes Care"},{"key":"10.1016\/j.bbrc.2008.03.020_bib8","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s005920070025","article-title":"Serum concentrations of advanced glycation endproducts are associated with the development of atherosclerosis as well as diabetic microangiopathy in patients with type 2 diabetes","volume":"37","author":"Aso","year":"2000","journal-title":"Acta Diabetol."},{"key":"10.1016\/j.bbrc.2008.03.020_bib9","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1161\/01.ATV.0000155462.24263.e4","article-title":"High glucose induces human endothelial cell apoptosis through a phosphoinositide 3-kinase-regulated cyclooxygenase-2 pathway","volume":"25","author":"Sheu","year":"2005","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.bbrc.2008.03.020_bib10","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.cellsig.2005.05.009","article-title":"High glucose-induced apoptosis in human vascular endothelial cells is mediated through NF-kappaB and c-Jun NH2-terminal kinase pathway and prevented by PI3K\/Akt\/eNOS pathway","volume":"18","author":"Ho","year":"2006","journal-title":"Cell Signal"},{"key":"10.1016\/j.bbrc.2008.03.020_bib11","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1161\/01.CIR.0000080378.96063.23","article-title":"Diabetes-induced oxidative stress and low-grade inflammation in porcine coronary arteries","volume":"108","author":"Zhang","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.bbrc.2008.03.020_bib12","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1007\/s00125-004-1525-1","article-title":"Hyperglycaemia-induced superoxide production decreases eNOS expression via AP-1 activation in aortic endothelial cells","volume":"47","author":"Srinivasan","year":"2004","journal-title":"Diabetologia"},{"key":"10.1016\/j.bbrc.2008.03.020_bib13","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1161\/hc0702.104183","article-title":"Advanced glycation end products activate endothelium through signal-transduction receptor RAGE: a mechanism for amplification of inflammatory responses","volume":"105","author":"Basta","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.bbrc.2008.03.020_bib14","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1007\/s00125-004-1392-9","article-title":"Binding of receptor for advanced glycation end products (RAGE) ligands is not sufficient to induce inflammatory signals: lack of activity of endotoxin-free albumin-derived advanced glycation end products","volume":"47","author":"Valencia","year":"2004","journal-title":"Diabetologia"},{"key":"10.1016\/j.bbrc.2008.03.020_bib15","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1172\/JCI119885","article-title":"Overexpression of glyoxalase-I in bovine endothelial cells inhibits intracellular advanced glycation endproduct formation and prevents hyperglycemia-induced increases in macromolecular endocytosis","volume":"101","author":"Shinohara","year":"1998","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbrc.2008.03.020_bib16","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1016\/S0891-5849(01)00702-X","article-title":"Glyoxal and methylglyoxal induce lyoxal and methyglyoxal induce aggregation and inactivation of ERK in human endothelial cells","volume":"31","author":"Akhand","year":"2001","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbrc.2008.03.020_bib17","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/S0891-5849(01)00550-0","article-title":"Glyoxal and methylglyoxal trigger distinct signals for map family kinases and caspase activation in human endothelial cells","volume":"31","author":"Akhand","year":"2001","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbrc.2008.03.020_bib18","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1515\/CCLM.2003.180","article-title":"Glyoxal and methylglyoxal levels in diabetic patients: quantitative determination by a new GC\/MS method","volume":"41","author":"Lapolla","year":"2003","journal-title":"Clin. Chem. Lab Med."},{"key":"10.1016\/j.bbrc.2008.03.020_bib19","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1172\/JCI200523001","article-title":"Fluid shear stress inhibits vascular inflammation by decreasing thioredoxin-interacting protein in endothelial cells","volume":"115","author":"Yamawaki","year":"2005","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbrc.2008.03.020_bib20","doi-asserted-by":"crossref","first-page":"C1495","DOI":"10.1152\/ajpcell.00481.2005","article-title":"Cytotoxicity of water-soluble fullerene in vascular endothelial cells","volume":"290","author":"Yamawaki","year":"2006","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.bbrc.2008.03.020_bib21","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0031-6997(25)06663-3","article-title":"Nitric oxide: physiology, pathophysiology, and pharmacology","volume":"43","author":"Moncada","year":"1991","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.bbrc.2008.03.020_bib22","doi-asserted-by":"crossref","first-page":"9897","DOI":"10.1073\/pnas.96.17.9897","article-title":"EUK-134, a synthetic superoxide dismutase and catalase mimetic, prevents oxidative stress and attenuates kainate-induced neuropathology","volume":"96","author":"Rong","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbrc.2008.03.020_bib23","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/j.freeradbiomed.2007.05.014","article-title":"Comparison of the effects of the superoxide dismutase mimetics EUK-134 and tempol on paraquat-induced nephrotoxicity","volume":"43","author":"Samai","year":"2007","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbrc.2008.03.020_bib24","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1038\/sj.bjp.0706660","article-title":"Substance P-induced cyclooxygenase-2 expression in human umbilical vein endothelial cells","volume":"147","author":"Gallicchio","year":"2006","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.bbrc.2008.03.020_bib25","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/j.cardiores.2005.09.019","article-title":"Involvement of COX-2 in VEGF-induced angiogenesis via P38 and JNK pathways in vascular endothelial cells","volume":"69","author":"Wu","year":"2006","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.bbrc.2008.03.020_bib26","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1161\/ATVBAHA.106.132837","article-title":"Acrolein induces cyclooxygenase-2 and prostaglandin production in human umbilical vein endothelial cells: roles of p38 MAP kinase","volume":"27","author":"Park","year":"2007","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.bbrc.2008.03.020_bib27","doi-asserted-by":"crossref","first-page":"11792","DOI":"10.1074\/jbc.M509292200","article-title":"Cyclooxygenase-2 induction and prostacyclin release by protease-activated receptors in endothelial cells require cooperation between mitogen-activated protein kinase and NF-kappaB pathways","volume":"281","author":"Syeda","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2008.03.020_bib28","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/j.cardiores.2004.10.024","article-title":"Diversity and similarity in signaling events leading to rapid Cox-2 induction by tumor necrosis factor-alpha and phorbol ester in human endothelial cells","volume":"65","author":"Eligini","year":"2005","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.bbrc.2008.03.020_bib29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainres.2005.12.003","article-title":"Activation of the JAK-STAT signaling pathz in the rat basilar artery after subarachnoid hemorrhage","volume":"1072","author":"Osuka","year":"2006","journal-title":"Brain Res."},{"key":"10.1016\/j.bbrc.2008.03.020_bib30","doi-asserted-by":"crossref","first-page":"5050","DOI":"10.4049\/jimmunol.176.8.5050","article-title":"Substance P stimulates cyclooxygenase-2 and prostaglandin E2 expression through JAK-STAT activation in human colonic epithelial cells","volume":"176","author":"Koon","year":"2006","journal-title":"J. Immunol."},{"key":"10.1016\/j.bbrc.2008.03.020_bib31","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.1161\/01.CIR.94.7.1682","article-title":"Fluid flow inhibits endothelial adhesiveness. Nitric oxide and transcriptional regulation of VCAM-1","volume":"94","author":"Tsao","year":"1996","journal-title":"Circulation"},{"key":"10.1016\/j.bbrc.2008.03.020_bib32","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1172\/JCI114081","article-title":"Nitric oxide-generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells","volume":"83","author":"Garg","year":"1989","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbrc.2008.03.020_bib33","doi-asserted-by":"crossref","first-page":"L450","DOI":"10.1152\/ajplung.2001.280.3.L450","article-title":"NO regulates LPS-stimulated cyclooxygenase gene expression and activity in pulmonary artery endothelium","volume":"280","author":"Chen","year":"2001","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"10.1016\/j.bbrc.2008.03.020_bib34","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1161\/CIRCULATIONAHA.105.602532","article-title":"Endothelial nitric oxide synthase in vascular disease: from marvel to menace","volume":"113","author":"Forstermann","year":"2006","journal-title":"Circulation"}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X08004658?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X08004658?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T10:37:07Z","timestamp":1757759827000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X08004658"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,5]]},"references-count":34,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2008,5]]}},"alternative-id":["S0006291X08004658"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2008.03.020","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2008,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Glyoxal causes inflammatory injury in human vascular endothelial cells","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2008.03.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}