{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T09:34:22Z","timestamp":1790674462815,"version":"4.1.0"},"reference-count":32,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2008,6,1]],"date-time":"2008-06-01T00:00:00Z","timestamp":1212278400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2008,6]]},"DOI":"10.1016\/j.bbrc.2008.03.154","type":"journal-article","created":{"date-parts":[[2008,4,11]],"date-time":"2008-04-11T18:59:42Z","timestamp":1207940382000},"page":"39-43","source":"Crossref","is-referenced-by-count":19,"title":["Insulin-secreting L-cells for the treatment of insulin-dependent diabetes"],"prefix":"10.1016","volume":"371","author":[{"given":"Heather","family":"Bara","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Athanassios","family":"Sambanis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2008.03.154_bib1","doi-asserted-by":"crossref","first-page":"369","DOI":"10.2174\/156652406777435453","article-title":"Islet cell transplantation","volume":"6","author":"Bertuzzi","year":"2006","journal-title":"Curr. Mol. Med."},{"key":"10.1016\/j.bbrc.2008.03.154_bib2","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1007\/s001250051096","article-title":"Cellular characterization of pituitary adenoma cell line (AtT20 cell) transfected with insulin, glucose transporter type 2 (GLUT2) and glucokinase genes: insulin secretion in response to physiological concentrations of glucose","volume":"41","author":"Motoyoshi","year":"1998","journal-title":"Diabetologia"},{"key":"10.1016\/j.bbrc.2008.03.154_bib3","doi-asserted-by":"crossref","first-page":"15205","DOI":"10.1016\/S0021-9258(18)82457-7","article-title":"Transfection of AtT-20ins cells with GLUT-2 but not GLUT-1 confers glucose-stimulated insulin secretion. Relationship to glucose metabolism","volume":"268","author":"Hughes","year":"1993","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2008.03.154_bib4","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/S0014-5793(01)02352-3","article-title":"Gene therapy for streptozotocin-induced diabetic mice by electroporational transfer of naked human insulin precursor DNA into skeletal muscle in vivo","volume":"495","author":"Yin","year":"2001","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bbrc.2008.03.154_bib5","doi-asserted-by":"crossref","first-page":"2119","DOI":"10.1089\/ten.2006.0210","article-title":"Efficient production of bioactive insulin from human epidermal keratinocytes and tissue-engineered skin substitutes: implications for treatment of diabetes","volume":"13","author":"Lei","year":"2007","journal-title":"Tissue Eng."},{"key":"10.1016\/j.bbrc.2008.03.154_bib6","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1038\/35044106","article-title":"Remission in models of type 1 diabetes by gene therapy using a single-chain insulin analogue","volume":"408","author":"Lee","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2008.03.154_bib7","doi-asserted-by":"crossref","first-page":"6241","DOI":"10.1016\/S0021-9258(17)37593-2","article-title":"Genetically engineered proinsulin constitutively processed and secreted as mature, active insulin","volume":"269","author":"Groskreutz","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2008.03.154_bib8","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.1038\/sj.gt.3301297","article-title":"Regulated hepatic insulin gene therapy of STZ-diabetic rats","volume":"7","author":"Thule","year":"2000","journal-title":"Gene Ther."},{"key":"10.1016\/j.bbrc.2008.03.154_bib9","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1089\/104303403769211628","article-title":"Glucose-responsive hepatic insulin gene therapy of spontaneously diabetic BB\/Wor rats","volume":"14","author":"Olson","year":"2003","journal-title":"Hum. Gene Ther."},{"key":"10.1016\/j.bbrc.2008.03.154_bib10","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1210\/edrv.20.6.0385","article-title":"The glucagon-like peptides","volume":"20","author":"Kieffer","year":"1999","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.bbrc.2008.03.154_bib11","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1172\/JCI118411","article-title":"Gastric emptying and release of incretin hormones after glucose ingestion in humans","volume":"97","author":"Schirra","year":"1996","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbrc.2008.03.154_bib12","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1126\/science.290.5498.1959","article-title":"Glucose-dependent insulin release from genetically engineered K cells","volume":"290","author":"Cheung","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.bbrc.2008.03.154_bib13","doi-asserted-by":"crossref","first-page":"2610","DOI":"10.1210\/en.2004-1109","article-title":"Release of transgenic human insulin from gastric G cells: a novel approach for the amelioration of diabetes","volume":"146","author":"Lu","year":"2005","journal-title":"Endocrinology"},{"key":"10.1016\/j.bbrc.2008.03.154_bib14","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/S0006-291X(03)00399-1","article-title":"Development of genetically engineered human intestinal cells for regulated insulin secretion using rAAV-mediated gene transfer","volume":"303","author":"Tang","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2008.03.154_bib15","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1002\/jgm.587","article-title":"Differential rAAV2 transduction efficiencies and insulin secretion profiles in pure and co-culture models of human enteroendocrine L-cells and enterocytes","volume":"6","author":"Tang","year":"2004","journal-title":"J. Gene Med."},{"key":"10.1016\/j.bbrc.2008.03.154_bib16","doi-asserted-by":"crossref","first-page":"4108","DOI":"10.1210\/endo.139.10.6228","article-title":"Regulation of glucagon-like peptide-1 synthesis and secretion in the GLUTag enteroendocrine cell line","volume":"139","author":"Brubaker","year":"1998","journal-title":"Endocrinology"},{"key":"10.1016\/j.bbrc.2008.03.154_bib17","doi-asserted-by":"crossref","first-page":"6408","DOI":"10.1073\/pnas.84.18.6408","article-title":"A superactive insulin: [B10-aspartic acid]insulin(human)","volume":"84","author":"Schwartz","year":"1987","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbrc.2008.03.154_bib18","doi-asserted-by":"crossref","first-page":"4800","DOI":"10.1210\/endo.140.10.7068","article-title":"Proglucagon processing profile in canine L cells expressing endogenous prohormone convertase 1\/3 and prohormone convertase 2","volume":"140","author":"Damholt","year":"1999","journal-title":"Endocrinology"},{"key":"10.1016\/j.bbrc.2008.03.154_bib19","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1080\/15438600490424514","article-title":"C-peptide, Na+, K(+)-ATPase, and diabetes","volume":"5","author":"Vague","year":"2004","journal-title":"Exp. Diabetes Res."},{"key":"10.1016\/j.bbrc.2008.03.154_bib20","doi-asserted-by":"crossref","first-page":"S78","DOI":"10.2337\/db06-S010","article-title":"Signaling mechanisms underlying the release of glucagon-like peptide 1","volume":"55","author":"Reimann","year":"2006","journal-title":"Diabetes"},{"key":"10.1016\/j.bbrc.2008.03.154_bib21","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1113\/jphysiol.2004.076414","article-title":"Characterization and functional role of voltage gated cation conductances in the glucagon-like peptide-1 secreting GLUTag cell line","volume":"563","author":"Reimann","year":"2005","journal-title":"J. Physiol. Lond."},{"key":"10.1016\/j.bbrc.2008.03.154_bib22","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1007\/s00125-004-1498-0","article-title":"Glutamine potently stimulates glucagon-like peptide-1 secretion from GLUTag cells","volume":"47","author":"Reimann","year":"2004","journal-title":"Diabetologia"},{"key":"10.1016\/j.bbrc.2008.03.154_bib23","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.2337\/diabetes.52.5.1147","article-title":"A novel glucose-sensing mechanism contributing to glucagon-like peptide-1 secretion from the GLUTag cell line","volume":"52","author":"Gribble","year":"2003","journal-title":"Diabetes"},{"key":"10.1016\/j.bbrc.2008.03.154_bib24","doi-asserted-by":"crossref","first-page":"2757","DOI":"10.2337\/diabetes.51.9.2757","article-title":"Glucose-sensing in glucagon-like peptide-1-secreting cells","volume":"51","author":"Reimann","year":"2002","journal-title":"Diabetes"},{"key":"10.1016\/j.bbrc.2008.03.154_bib25","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1210\/endo.138.3.5023","article-title":"Peptones stimulate cholecystokinin secretion and gene transcription in the intestinal cell line STC-1","volume":"138","author":"Cordier-Bussat","year":"1997","journal-title":"Endocrinology"},{"key":"10.1016\/j.bbrc.2008.03.154_bib26","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.2337\/diabetes.47.7.1038","article-title":"Peptones stimulate both the secretion of the incretin hormone glucagon-like peptide 1 and the transcription of the proglucagon gene","volume":"47","author":"Cordier-Bussat","year":"1998","journal-title":"Diabetes"},{"key":"10.1016\/j.bbrc.2008.03.154_bib27","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1007\/s00125-004-1380-0","article-title":"Protein hydrolysates stimulate proglucagon gene transcription in intestinal endocrine cells via two elements related to cyclic AMP response element","volume":"47","author":"Gevrey","year":"2004","journal-title":"Diabetologia"},{"key":"10.1016\/j.bbrc.2008.03.154_bib28","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1210\/endo.142.1.7870","article-title":"Coregulation of glucagon-like peptide-1 synthesis with proglucagon and prohormone convertase 1 gene expression in enteroendocrine GLUTag cells","volume":"142","author":"Dhanvantari","year":"2001","journal-title":"Endocrinology"},{"key":"10.1016\/j.bbrc.2008.03.154_bib29","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1006\/bbrc.1995.1634","article-title":"Oxygen consumption rates of free and alginate entrapped bTC3 mouse insulinoma cells","volume":"210","author":"Mukundan","year":"1995","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2008.03.154_bib30","first-page":"E1100","article-title":"Glucose-stimulated insulin secretion is not obligatorily linked to an increase in O2 consumption in betaHC9 cells","volume":"275","author":"Papas","year":"1998","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.bbrc.2008.03.154_bib31","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1128\/JVI.72.1.180-190.1998","article-title":"Reactivation of the previously silenced cytomegalovirus major immediate-early promoter in the mouse liver: involvement of NFkappaB","volume":"72","author":"Loser","year":"1998","journal-title":"J. Virol."},{"key":"10.1016\/j.bbrc.2008.03.154_bib32","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1002\/bit.260350804","article-title":"Use of regulated secretion in protein-production from animal-cells - an evaluation with the att-20 model cell-line","volume":"35","author":"Sambanis","year":"1990","journal-title":"Biotechnol. Bioeng."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X08006165?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X08006165?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,9,7]],"date-time":"2021-09-07T23:01:39Z","timestamp":1631055699000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X08006165"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,6]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,6]]}},"alternative-id":["S0006291X08006165"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2008.03.154","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2008,6]]}}}