{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:11:48Z","timestamp":1790788308714,"version":"4.1.0"},"reference-count":32,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2008,8,1]],"date-time":"2008-08-01T00:00:00Z","timestamp":1217548800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,8,1]],"date-time":"2008-08-01T00:00:00Z","timestamp":1217548800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2008,8,1]],"date-time":"2008-08-01T00:00:00Z","timestamp":1217548800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2008,8,1]],"date-time":"2008-08-01T00:00:00Z","timestamp":1217548800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2008,8,1]],"date-time":"2008-08-01T00:00:00Z","timestamp":1217548800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2008,8,1]],"date-time":"2008-08-01T00:00:00Z","timestamp":1217548800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2008,8,1]],"date-time":"2008-08-01T00:00:00Z","timestamp":1217548800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001868","name":"National Science Council","doi-asserted-by":"publisher","award":["NSC96-2313-B-007-001"],"award-info":[{"award-number":["NSC96-2313-B-007-001"]}],"id":[{"id":"10.13039\/501100001868","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001868","name":"National Science Council","doi-asserted-by":"publisher","award":["NSC96-3112-B-007-002"],"award-info":[{"award-number":["NSC96-3112-B-007-002"]}],"id":[{"id":"10.13039\/501100001868","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2008,8]]},"DOI":"10.1016\/j.bbrc.2008.05.070","type":"journal-article","created":{"date-parts":[[2008,5,28]],"date-time":"2008-05-28T12:53:29Z","timestamp":1211979209000},"page":"1-7","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"title":["Structure-based inhibitor discovery of Helicobacter pylori dehydroquinate synthase"],"prefix":"10.1016","volume":"373","author":[{"given":"Jai-Shin","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Chi","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hung-Jung","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yen-Cheng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Ching","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2008.05.070_bib1","first-page":"1273","article-title":"Unidentified curved bacilli on gastric epithelium in active chronic gastritis","volume":"1","author":"Warren","year":"1983","journal-title":"Lancet"},{"key":"10.1016\/j.bbrc.2008.05.070_bib2","doi-asserted-by":"crossref","first-page":"147","DOI":"10.7861\/clinmedicine.2-2-147","article-title":"Helicobacter pylori: 20 years on","volume":"2","author":"Marshall","year":"2002","journal-title":"Clin. Med."},{"key":"10.1016\/j.bbrc.2008.05.070_bib3","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1111\/j.1523-5378.1996.tb00027.x","article-title":"Eradication of Helicobacter pylori using one-week triple therapies combining omeprazole with two antimicrobials: the MACH I Study","volume":"1","author":"Lind","year":"1996","journal-title":"Helicobacter"},{"key":"10.1016\/j.bbrc.2008.05.070_bib4","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1016\/S0016-5085(98)70100-3","article-title":"Antibiotic resistance in Helicobacter pylori: implications for therapy","volume":"115","author":"Graham","year":"1998","journal-title":"Gastroenterology"},{"issue":"Suppl. 3","key":"10.1016\/j.bbrc.2008.05.070_bib5","doi-asserted-by":"crossref","first-page":"S171","DOI":"10.1086\/519473","article-title":"Epidemiology of staphylococcal resistance","volume":"45","author":"Shorr","year":"2007","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.bbrc.2008.05.070_bib6","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.2174\/1381612023394818","article-title":"Comprehensive essential gene identification as a platform for novel anti-infective drug discovery","volume":"8","author":"Haselbeck","year":"2002","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.bbrc.2008.05.070_bib7","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1016\/0006-291X(80)90547-1","article-title":"The herbicide glyphosate is a potent inhibitor of 5-enolpyruvyl-shikimic acid-3-phosphate synthase","volume":"94","author":"Steinrucken","year":"1980","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2008.05.070_bib8","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1006\/mpat.1997.0157","article-title":"Salmonella typhimurium aroB mutants are attentuated in BALB\/c mice","volume":"23","author":"Gunel-Ozcan","year":"1997","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.bbrc.2008.05.070_bib9","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1038\/28431","article-title":"Structure of dehydroquinate synthase reveals an active site capable of multistep catalysis","volume":"394","author":"Carpenter","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2008.05.070_bib10","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0022-2836(03)00086-X","article-title":"Ligand-induced conformational changes and a mechanism for domain closure in Aspergillus nidulans dehydroquinate synthase","volume":"327","author":"Nichols","year":"2003","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.bbrc.2008.05.070_bib11","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.jmb.2004.08.039","article-title":"Comparison of ligand-induced conformational changes domain closure mechanisms, between prokaryotic and eukaryotic dehydroquinate synthases","volume":"343","author":"Nichols","year":"2004","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.bbrc.2008.05.070_bib12","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1002\/prot.20281","article-title":"Crystal structure of dehydroquinate synthase from Thermus thermophilus HB8 showing functional importance of the dimeric state","volume":"58","author":"Sugahara","year":"2005","journal-title":"Proteins"},{"key":"10.1016\/j.bbrc.2008.05.070_bib13","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1111\/j.1574-6968.1993.tb06034.x","article-title":"The cloning and nucleotide sequence of a Corynebacterium glutamicum 3-deoxy-d-arabinoheptulosonate-7-phosphate synthase gene","volume":"107","author":"Chen","year":"1993","journal-title":"FEMS Microbiol. Lett."},{"key":"10.1016\/j.bbrc.2008.05.070_bib14","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/S0076-6879(87)42041-7","article-title":"Dehydroquinate synthase from Escherichia coli, and its substrate 3-deoxy-d-arabino-heptulosonic acid 7-phosphate","volume":"142","author":"Mehdi","year":"1987","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.bbrc.2008.05.070_bib15","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1042\/bj2260817","article-title":"The 3-dehydroquinate synthase activity of the pentafunctional arom enzyme complex of Neurospora crassa is Zn2+-dependent","volume":"226","author":"Lambert","year":"1985","journal-title":"Biochem. J."},{"key":"10.1016\/j.bbrc.2008.05.070_bib16","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1002\/bit.20772","article-title":"The kinetic model of the shikimate pathway as a tool to optimize enzyme assays for high-throughput screening","volume":"95","author":"Noble","year":"2006","journal-title":"Biotechnol. Bioeng."},{"key":"10.1016\/j.bbrc.2008.05.070_bib17","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/S0021-9258(18)70161-0","article-title":"2-Keto-3-deoxy-d-arabo-heptonic acid 7-phosphate synthetase","volume":"234","author":"Srinivasan","year":"1959","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2008.05.070_bib18","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0076-6879(97)76066-X","article-title":"Processing of X-ray diffraction data collected in oscillation mode","volume":"276","author":"Otwinowski","year":"1997","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.bbrc.2008.05.070_bib19","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1107\/S0108767393007597","article-title":"AMoRE: an automated package for molecular replacement","volume":"50","author":"Navaza","year":"1994","journal-title":"Acta Crystallogr. A"},{"key":"10.1016\/j.bbrc.2008.05.070_bib20","first-page":"240","article-title":"Refinement of macromolecular structures by the maximum-likelihood method","volume":"D53","author":"Murshudov","year":"1997","journal-title":"Acta Crystallogr."},{"key":"10.1016\/j.bbrc.2008.05.070_bib21","first-page":"127","article-title":"Automated refinement of protein models","volume":"D49","author":"Lamzin","year":"1993","journal-title":"Acta Crystallogr."},{"key":"10.1016\/j.bbrc.2008.05.070_bib22","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1107\/S0108767390010224","article-title":"Improved methods for building protein models in electron density maps and the location of errors in these models","volume":"47","author":"Jones","year":"1991","journal-title":"Acta Crystallogr. A"},{"key":"10.1016\/j.bbrc.2008.05.070_bib23","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1107\/S0021889892009944","article-title":"PROCHECK: a program to check the stereochemical quality of protein structures","volume":"26","author":"Laskowski","year":"1993","journal-title":"J. Appl. Crystallogr."},{"key":"10.1016\/j.bbrc.2008.05.070_bib24","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1093\/bioinformatics\/15.4.305","article-title":"ESPript: analysis of multiple sequence alignments in PostScript","volume":"15","author":"Gouet","year":"1999","journal-title":"Bioinformatics"},{"key":"10.1016\/j.bbrc.2008.05.070_bib25","doi-asserted-by":"crossref","first-page":"4673","DOI":"10.1093\/nar\/22.22.4673","article-title":"CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice","volume":"22","author":"Thompson","year":"1994","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bbrc.2008.05.070_bib26","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1006\/jmbi.1993.1626","article-title":"Comparative protein modelling by satisfaction of spatial restraints","volume":"234","author":"Sali","year":"1993","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.bbrc.2008.05.070_bib27","doi-asserted-by":"crossref","first-page":"3553","DOI":"10.1021\/jm060092o","article-title":"Finding a needle in a haystack: development of a combinatorial virtual screening approach for identifying high specificity heparin\/heparan sulfate sequence(s)","volume":"49","author":"Raghuraman","year":"2006","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bbrc.2008.05.070_bib28","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/356083a0","article-title":"Assessment of protein models with three-dimensional profiles","volume":"356","author":"Luthy","year":"1992","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2008.05.070_bib29","first-page":"187","article-title":"ANOLEA: a www server to assess protein structures","volume":"5","author":"Melo","year":"1997","journal-title":"Proc. Int. Conf. Intell. Syst. Mol. Biol."},{"key":"10.1016\/j.bbrc.2008.05.070_bib30","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S1359-0278(97)00024-2","article-title":"Direct evaluation of thermal fluctuations in proteins using a single-parameter harmonic potential","volume":"2","author":"Bahar","year":"1997","journal-title":"Fold Des."},{"key":"10.1016\/j.bbrc.2008.05.070_bib31","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/j.jmb.2006.03.063","article-title":"Structure\u2013stability\u2013activity relationship in covalently cross-linked N-carbamoyl d-amino acid amidohydrolase and N-acylamino acid racemase","volume":"359","author":"Chiu","year":"2006","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.bbrc.2008.05.070_bib32","doi-asserted-by":"crossref","first-page":"7645","DOI":"10.1021\/ja961771z","article-title":"Cyclohexenyl and cyclohexylidene inhibitors of 3-dehydroquinate synthase: active site interactions relevant to enzyme mechanism and inhibitor design","volume":"119","author":"Montchamp","year":"1997","journal-title":"J. Am. Chem. Soc."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X08009704?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X08009704?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T10:38:51Z","timestamp":1757759931000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X08009704"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,8]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,8]]}},"alternative-id":["S0006291X08009704"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2008.05.070","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2008,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Structure-based inhibitor discovery of Helicobacter pylori dehydroquinate synthase","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2008.05.070","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}