{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T18:08:17Z","timestamp":1790359697586,"version":"4.1.0"},"reference-count":24,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2008,9,1]],"date-time":"2008-09-01T00:00:00Z","timestamp":1220227200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2008,9]]},"DOI":"10.1016\/j.bbrc.2008.07.042","type":"journal-article","created":{"date-parts":[[2008,7,18]],"date-time":"2008-07-18T08:34:19Z","timestamp":1216370059000},"page":"479-484","source":"Crossref","is-referenced-by-count":41,"title":["IFN-\u03b3 acts as anti-angiogenic cytokine in the human cornea by regulating the expression of VEGF-A and sVEGF-R1"],"prefix":"10.1016","volume":"374","author":[{"given":"Vijay K.","family":"Kommineni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chandrasekharam N.","family":"Nagineni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abitha","family":"William","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Detrick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John J.","family":"Hooks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2008.07.042_bib1","first-page":"264","article-title":"Corneal angiogenic privilege: angiogenic and antiangiogenic factors in corneal avascularity vasculogenesis, and wound healing (an American Ophthalmological Society thesis)","volume":"104","author":"Azar","year":"2006","journal-title":"Trans. Am. Ophthalmol. Soc."},{"key":"10.1016\/j.bbrc.2008.07.042_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.preteyeres.2006.09.002","article-title":"Ocular neovascularization: implication of endogenous angiogenic inhibitors and potential therapy","volume":"26","author":"Zhang","year":"2007","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.bbrc.2008.07.042_bib3","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1136\/bjo.2006.107417","article-title":"Soluble vascular endothelial growth factor receptor-1 contributes to the corneal antiangiogenic barrier","volume":"91","author":"Ambati","year":"2007","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.bbrc.2008.07.042_bib4","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1097\/00003226-199811000-00008","article-title":"Angiogenesis in corneal diseases: histopathologic evaluation of 254 human corneal buttons with neovascularization","volume":"17","author":"Cursiefen","year":"1998","journal-title":"Cornea"},{"key":"10.1016\/j.bbrc.2008.07.042_bib5","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1097\/00003226-200007000-00025","article-title":"Immunohistochemical localization of vascular endothelial growth factor, transforming growth factor alpha, and transforming growth factor beta1 in human corneas with neovascularization","volume":"19","author":"Cursiefen","year":"2000","journal-title":"Cornea"},{"key":"10.1016\/j.bbrc.2008.07.042_bib6","first-page":"2514","article-title":"Expression of vascular endothelial growth factor and its receptors in inflamed and vascularized human corneas","volume":"41","author":"Philipp","year":"2000","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.bbrc.2008.07.042_bib7","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1089\/104303401750270959","article-title":"Inhibition of angiogenesis by adenovirus-mediated sFlt-1 expression in a rat model of corneal neovascularization","volume":"12","author":"Lai","year":"2001","journal-title":"Hum. Gene Ther."},{"key":"10.1016\/j.bbrc.2008.07.042_bib8","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1016\/j.bbrc.2007.07.114","article-title":"Inhibition of corneal neovascularization by recombinant adenovirus-mediated sFlk-1 expression","volume":"361","author":"Yu","year":"2007","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2008.07.042_bib9","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1038\/nm0603-669","article-title":"The biology of VEGF and its receptors","volume":"9","author":"Ferrara","year":"2003","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbrc.2008.07.042_bib10","first-page":"614","article-title":"An SV40-immortalized human corneal epithelial cell line and its characterization","volume":"36","author":"Araki-Sasaki","year":"1995","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.bbrc.2008.07.042_bib11","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1097\/01.ico.0000208815.02120.90","article-title":"Inhibition of inflammatory cytokine production in human corneal cells by dexamethasone, but not cyclosporin","volume":"25","author":"Djalilian","year":"2006","journal-title":"Cornea"},{"key":"10.1016\/j.bbrc.2008.07.042_bib12","doi-asserted-by":"crossref","first-page":"10705","DOI":"10.1073\/pnas.90.22.10705","article-title":"Inhibition of vascular endothelial cell growth factor activity by an endogenously encoded soluble receptor","volume":"90","author":"Kendall","year":"1993","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbrc.2008.07.042_bib13","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1002\/jcp.10378","article-title":"Transforming growth factor-beta induces expression of vascular endothelial growth factor in human retinal pigment epithelial cells: involvement of mitogen-activated protein kinases","volume":"197","author":"Nagineni","year":"2003","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.bbrc.2008.07.042_bib14","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1016\/S0960-894X(02)00106-3","article-title":"Photochemical preparation of a pyridone containing tetracycle: a Jak protein kinase inhibitor","volume":"12","author":"Thompson","year":"2002","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bbrc.2008.07.042_bib15","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1002\/jcp.20839","article-title":"Interferon-gamma differentially regulates TGF-beta1 and TGF-beta2 expression in human retinal pigment epithelial cells through JAK-STAT pathway","volume":"210","author":"Nagineni","year":"2007","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.bbrc.2008.07.042_bib16","doi-asserted-by":"crossref","first-page":"3953","DOI":"10.1021\/jm0205705","article-title":"Synthesis and activity of new aryl- and heteroaryl-substituted pyrazole inhibitors of the transforming growth factor-beta type I receptor kinase domain","volume":"46","author":"Sawyer","year":"2003","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bbrc.2008.07.042_bib17","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/j.micinf.2005.03.003","article-title":"Early events in HSV keratitis\u2014setting the stage for a blinding disease","volume":"7","author":"Biswas","year":"2005","journal-title":"Microbes Infect."},{"key":"10.1016\/j.bbrc.2008.07.042_bib18","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S0039-6257(98)00035-6","article-title":"Ocular neovascularization: an epidemiologic review","volume":"43","author":"Lee","year":"1998","journal-title":"Surv. Ophthalmol."},{"key":"10.1016\/j.bbrc.2008.07.042_bib19","first-page":"59","article-title":"A role of transforming growth factor-beta 1 in the control of corneal neovascularization","volume":"10","author":"Friling","year":"1996","journal-title":"In Vivo"},{"key":"10.1016\/j.bbrc.2008.07.042_bib20","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1038\/sj.gt.3301320","article-title":"Blockade of TGF-beta by in vivo gene transfer of a soluble TGF-beta type II receptor in the muscle inhibits corneal opacification, edema and angiogenesis","volume":"7","author":"Sakamoto","year":"2000","journal-title":"Gene Ther."},{"key":"10.1016\/j.bbrc.2008.07.042_bib21","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.2353\/ajpath.2007.070172","article-title":"Dexamethasone inhibits interleukin-1beta-induced corneal neovascularization: role of nuclear factor-kappaB-activated stromal cells in inflammatory angiogenesis","volume":"171","author":"Nakao","year":"2007","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.bbrc.2008.07.042_bib22","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/s10456-006-9055-8","article-title":"Vascular endothelial growth factor receptor-1 (VEGFR-1\/Flt-1): a dual regulator for angiogenesis","volume":"9","author":"Shibuya","year":"2006","journal-title":"Angiogenesis"},{"key":"10.1016\/j.bbrc.2008.07.042_bib23","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1002\/jlb.55.3.410","article-title":"Macrophages and angiogenesis","volume":"55","author":"Sunderkotter","year":"1994","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.bbrc.2008.07.042_bib24","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1093\/jnci\/87.8.581","article-title":"Inhibition of angiogenesis in vivo by interleukin 12","volume":"87","author":"Voest","year":"1995","journal-title":"J. Natl. Cancer Inst."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X08013673?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X08013673?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,12]],"date-time":"2019-05-12T18:57:32Z","timestamp":1557687452000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X08013673"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,9]]},"references-count":24,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2008,9]]}},"alternative-id":["S0006291X08013673"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2008.07.042","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2008,9]]}}}