{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T16:37:34Z","timestamp":1773247054866,"version":"3.50.1"},"reference-count":34,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2010,3,1]],"date-time":"2010-03-01T00:00:00Z","timestamp":1267401600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"crossref","award":["2009-0084163"],"award-info":[{"award-number":["2009-0084163"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"crossref","award":["2006-2005412"],"award-info":[{"award-number":["2006-2005412"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"crossref"}]},{"name":"The Regional Core Research Program\/Medical Convergence Technology Development Consortium for Anti-aging and Well-being"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2010,3]]},"DOI":"10.1016\/j.bbrc.2010.02.050","type":"journal-article","created":{"date-parts":[[2010,2,13]],"date-time":"2010-02-13T04:24:16Z","timestamp":1266035056000},"page":"536-541","source":"Crossref","is-referenced-by-count":51,"title":["Alpha-lipoic acid inhibits hepatic PAI-1 expression and fibrosis by inhibiting the TGF-\u03b2 signaling pathway"],"prefix":"10.1016","volume":"393","author":[{"given":"Ae-Kyung","family":"Min","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mi-Kyung","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hye-Young","family":"Seo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hye-Soon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Byoung Kuk","family":"Jang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae Seok","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hueng-Sik","family":"Choi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ki-Up","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keun-Gyu","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"In-Kyu","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2010.02.050_bib1","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1007\/BF02934504","article-title":"Molecular mechanisms of hepatic fibrosis and principles of therapy","volume":"32","author":"Friedman","year":"1997","journal-title":"J. Gastroenterol."},{"key":"10.1016\/j.bbrc.2010.02.050_bib2","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/S1089-3261(05)70168-9","article-title":"Hepatic fibrosis. Pathogenesis and principles of therapy","volume":"5","author":"Albanis","year":"2001","journal-title":"Clin. Liver Dis."},{"key":"10.1016\/j.bbrc.2010.02.050_bib3","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1002\/hep.20973","article-title":"Nonalcoholic fatty liver disease: from steatosis to cirrhosis","volume":"43","author":"Farrell","year":"2006","journal-title":"Hepatology"},{"key":"10.1016\/j.bbrc.2010.02.050_bib4","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1186\/1471-230X-9-81","article-title":"Liver fibrosis secondary to bile duct injury: correlation of Smad7 with TGF-beta and extracellular matrix proteins","volume":"31","author":"del Pilar Alatorre-Carranza","year":"2009","journal-title":"BMC Gastroenterol."},{"key":"10.1016\/j.bbrc.2010.02.050_bib5","doi-asserted-by":"crossref","first-page":"7017","DOI":"10.4049\/jimmunol.167.12.7017","article-title":"Regulation of hepatic fibrosis and extracellular matrix genes by the th response: new insight into the role of tissue inhibitors of matrix metalloproteinases","volume":"167","author":"Vaillant","year":"2001","journal-title":"J. Immunol."},{"key":"10.1016\/j.bbrc.2010.02.050_bib6","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.1074\/jbc.275.4.2247","article-title":"Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury","volume":"275","author":"Friedman","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2010.02.050_bib7","doi-asserted-by":"crossref","first-page":"793","DOI":"10.2741\/A812","article-title":"Roles of TGF-beta in hepatic fibrosis","volume":"7","author":"Gressner","year":"2002","journal-title":"Front. Biosci."},{"key":"10.1016\/j.bbrc.2010.02.050_bib8","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/j.1478-3231.2005.01192.x","article-title":"Therapeutic strategies against TGF-beta signaling pathway in hepatic fibrosis","volume":"26","author":"Liu","year":"2006","journal-title":"Liver Int."},{"key":"10.1016\/j.bbrc.2010.02.050_bib9","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1097\/01.alc.0000189284.98684.22","article-title":"Anti-TGF-beta strategies for the treatment of chronic liver disease","volume":"29","author":"Breitkopf","year":"2005","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.bbrc.2010.02.050_bib10","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1016\/j.jhep.2004.08.015","article-title":"Suppression of transforming growth factor-beta results in upregulation of transcription of regeneration factors after chronic liver injury","volume":"41","author":"Nakamura","year":"2004","journal-title":"J. Hepatol."},{"key":"10.1016\/j.bbrc.2010.02.050_bib11","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1053\/jhep.2000.9109","article-title":"Inhibition of transforming growth factor beta prevents progression of liver fibrosis and enhances hepatocyte regeneration in dimethylnitrosamine-treated rats","volume":"32","author":"Nakamura","year":"2000","journal-title":"Hepatology"},{"key":"10.1016\/j.bbrc.2010.02.050_bib12","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1111\/j.1472-8206.2008.00611.x","article-title":"Curcumin prevents and reverses cirrhosis induced by bile duct obstruction or CCl4 in rats: role of TGF-beta modulation and oxidative stress","volume":"22","author":"Reyes-Gordillo","year":"2008","journal-title":"Fundam. Clin. Pharmacol."},{"key":"10.1016\/j.bbrc.2010.02.050_bib13","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1053\/gast.2003.50012","article-title":"Liver fibrosis: insights into migration of hepatic stellate cells in response to extracellular matrix and growth factors","volume":"124","author":"Yang","year":"2003","journal-title":"Gastroenterology"},{"key":"10.1016\/j.bbrc.2010.02.050_bib14","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1160\/TH08-05-0294","article-title":"Transcriptional regulation of the plasminogen activator inhibitor type 1-with an emphasis on negative regulation","volume":"100","author":"Nagamine","year":"2008","journal-title":"Thromb. Haemost."},{"key":"10.1016\/j.bbrc.2010.02.050_bib15","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1002\/hep.21613","article-title":"Tissue-type plasminogen activator deficiency exacerbates cholestatic liver injury in mice","volume":"45","author":"Wang","year":"2007","journal-title":"Hepatology"},{"key":"10.1016\/j.bbrc.2010.02.050_bib16","first-page":"56","article-title":"Plasminogen activator inhibitor 1: physiological and pathophysiological roles","volume":"17","author":"Binder","year":"2002","journal-title":"News Physiol. Sci."},{"key":"10.1016\/j.bbrc.2010.02.050_bib17","first-page":"1159","article-title":"Liver fibrosis, the hepatic stellate cell and tissue inhibitors of metalloproteinases","volume":"15","author":"McCrudden","year":"2000","journal-title":"Histol. Histopathol."},{"key":"10.1016\/j.bbrc.2010.02.050_bib18","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/jgh.1998.13.s1.33","article-title":"Tissue inhibitors of metalloproteinases, hepatic stellate cells and liver fibrosis","volume":"13","author":"Arthur","year":"1998","journal-title":"J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.bbrc.2010.02.050_bib19","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1124\/jpet.105.095042","article-title":"Critical role of plasminogen activator inhibitor-1 in cholestatic liver injury and fibrosis","volume":"316","author":"Bergheim","year":"2006","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.bbrc.2010.02.050_bib20","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1002\/hep.20903","article-title":"Transcriptional profiling after bile duct ligation identifies PAI-1 as a contributor to cholestatic injury in mice","volume":"42","author":"Wang","year":"2005","journal-title":"Hepatology"},{"key":"10.1016\/j.bbrc.2010.02.050_bib21","doi-asserted-by":"crossref","first-page":"3098","DOI":"10.1016\/j.febslet.2007.05.049","article-title":"PAI-1 deficiency reduces liver fibrosis after bile duct ligation in mice through activation of tPA","volume":"581","author":"Wang","year":"2007","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bbrc.2010.02.050_bib22","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.jhep.2009.02.025","article-title":"Adenovirus-mediated transfer of siRNA against PAI-1 mRNA ameliorates hepatic fibrosis in rats","volume":"51","author":"Hu","year":"2009","journal-title":"J. Hepatol."},{"key":"10.1016\/j.bbrc.2010.02.050_bib23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1034\/j.1600-0676.2001.210101.x","article-title":"Involvement of reactive oxygen species and nitric oxide radicals in activation and proliferation of rat hepatic stellate cells","volume":"21","author":"Svegliati-Baroni","year":"2001","journal-title":"Liver"},{"key":"10.1016\/j.bbrc.2010.02.050_bib24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1017\/S1462399403005684","article-title":"Molecular basis of hepatic fibrosis","volume":"5","author":"Hui","year":"2003","journal-title":"Expert Rev. Mol. Med."},{"key":"10.1016\/j.bbrc.2010.02.050_bib25","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1101\/gad.13.7.804","article-title":"A mechanism of repression of TGFbeta\/Smad signaling by oncogenic Ras","volume":"13","author":"Kretzschmar","year":"1999","journal-title":"Genes Dev."},{"key":"10.1016\/j.bbrc.2010.02.050_bib26","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1093\/emboj\/19.8.1745","article-title":"Transcriptional control by the TGF-beta\/Smad signaling system","volume":"19","author":"Massagu\u00e9","year":"2000","journal-title":"EMBO J."},{"key":"10.1016\/j.bbrc.2010.02.050_bib27","doi-asserted-by":"crossref","first-page":"5742","DOI":"10.1038\/sj.onc.1208928","article-title":"Crosstalk mechanisms between the mitogen-activated protein kinase pathways and Smad signaling downstream of TGF-beta: implications for carcinogenesis","volume":"24","author":"Javelaud","year":"2005","journal-title":"Oncogene"},{"key":"10.1016\/j.bbrc.2010.02.050_bib28","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1152\/ajplung.00128.2007","article-title":"Glutathione suppresses TGF-beta-induced PAI-1 expression by inhibiting p38 and JNK MAPK and the binding of AP-1, SP-1, and Smad to the PAI-1 promoter","volume":"293","author":"Vayalil","year":"2007","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.bbrc.2010.02.050_bib29","doi-asserted-by":"crossref","first-page":"2488","DOI":"10.1161\/01.ATV.0000190667.33224.4c","article-title":"Alpha-lipoic acid prevents endothelial dysfunction in obese rats via activation of AMP-activated protein kinase","volume":"25","author":"Lee","year":"2005","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.bbrc.2010.02.050_bib30","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1002\/hep.22496","article-title":"Alpha-lipoic acid decreases hepatic lipogenesis through adenosine monophosphate-activated protein kinase (AMPK)-dependent and AMPK-independent pathways","volume":"48","author":"Park","year":"2008","journal-title":"Hepatology"},{"key":"10.1016\/j.bbrc.2010.02.050_bib31","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1111\/j.1523-1755.2005.00491.x","article-title":"MAPK\/AP-1-dependent regulation of PAI-1 gene expression by TGF-beta in rat mesangial cells","volume":"68","author":"Guo","year":"2005","journal-title":"Kidney Int."},{"key":"10.1016\/j.bbrc.2010.02.050_bib32","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1016\/S0140-6736(08)60383-9","article-title":"Liver cirrhosis","volume":"371","author":"Schuppan","year":"2008","journal-title":"Lancet"},{"key":"10.1016\/j.bbrc.2010.02.050_bib33","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1152\/ajprenal.00032.2002","article-title":"Plasminogen activator inhibitor-1 and kidney","volume":"283","author":"Eddy","year":"2002","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.1016\/j.bbrc.2010.02.050_bib34","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1002\/hep.20903","article-title":"Transcriptional profiling after bile duct ligation identifies PAI-1 as a contributor to cholestatic injury in mice","volume":"42","author":"Wang","year":"2005","journal-title":"Hepatology"}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X10002615?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X10002615?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,2,8]],"date-time":"2019-02-08T03:30:18Z","timestamp":1549596618000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X10002615"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,3]]},"references-count":34,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2010,3]]}},"alternative-id":["S0006291X10002615"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2010.02.050","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2010,3]]}}}