{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T14:52:43Z","timestamp":1779375163280,"version":"3.53.1"},"reference-count":34,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2010,3,1]],"date-time":"2010-03-01T00:00:00Z","timestamp":1267401600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2010,3]]},"DOI":"10.1016\/j.bbrc.2010.02.079","type":"journal-article","created":{"date-parts":[[2010,2,19]],"date-time":"2010-02-19T04:17:40Z","timestamp":1266553060000},"page":"773-778","source":"Crossref","is-referenced-by-count":56,"title":["Protective effects of methyl gallate on H2O2-induced apoptosis in PC12 cells"],"prefix":"10.1016","volume":"393","author":[{"given":"James A.G.","family":"Crispo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Pich\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique R.","family":"Ansell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph K.","family":"Eibl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabella T.","family":"Tai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aseem","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory M.","family":"Ross","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.C.","family":"Tai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2010.02.079_bib1","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1007\/s00221-007-1100-3","article-title":"Protection against hydrogen peroxide-induced injury by Z-ligustilide in PC12 cells","volume":"184","author":"Yu","year":"2008","journal-title":"Exp. Brain Res."},{"key":"10.1016\/j.bbrc.2010.02.079_bib2","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.cellbi.2006.10.001","article-title":"Neuroprotective effects of tetramethylpyrazine on hydrogen peroxide-induced apoptosis in PC12 cells","volume":"31","author":"Cheng","year":"2007","journal-title":"Cell Biol. Int."},{"key":"10.1016\/j.bbrc.2010.02.079_bib3","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.mrfmmm.2008.10.021","article-title":"Attenuation of oxidative neuronal cell death by coffee phenolic phytochemicals","volume":"661","author":"Cho","year":"2009","journal-title":"Mutat. Res."},{"key":"10.1016\/j.bbrc.2010.02.079_bib4","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1046\/j.1471-4159.1997.69020514.x","article-title":"BCL-2-related protein expression in apoptosis: oxidative stress versus serum deprivation in PC12 cells","volume":"69","author":"Maroto","year":"1997","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbrc.2010.02.079_bib5","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1021\/jf072826r","article-title":"Neuroprotective effects of the citrus flavanones against H2O2-induced cytotoxicity in PC12 cells","volume":"56","author":"Hwang","year":"2008","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.bbrc.2010.02.079_bib6","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1093\/abbs\/40.9.796","article-title":"Salidroside inhibits H2O2-induced apoptosis in PC12 cells by preventing cytochrome c release and inactivating of caspase cascade","volume":"40","author":"Cai","year":"2008","journal-title":"Acta Biochim. Biophys. Sin. (Shanghai)"},{"key":"10.1016\/j.bbrc.2010.02.079_bib7","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1080\/10715760601134459","article-title":"Reactive oxygen, nitrogen species are involved in sorbitol-induced apoptosis of human erithroleukaemia cells K562","volume":"41","author":"Aquilano","year":"2007","journal-title":"Free Radic. Res."},{"key":"10.1016\/j.bbrc.2010.02.079_bib8","first-page":"425","article-title":"Role of N-acetylcysteine in the management of COPD","volume":"1","author":"Sadowska","year":"2006","journal-title":"Int. J. Chron. Obstruct. Pulm. Dis."},{"key":"10.1016\/j.bbrc.2010.02.079_bib9","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1007\/s000180300001","article-title":"Molecular mechanisms of N-acetylcysteine actions","volume":"60","author":"Zafarullah","year":"2003","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.bbrc.2010.02.079_bib10","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1093\/carcin\/22.7.999","article-title":"Mechanisms of N-acetylcysteine in the prevention of DNA damage and cancer, with special reference to smoking-related end-points","volume":"22","author":"De Flora","year":"2001","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.bbrc.2010.02.079_bib11","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1177\/153537020623100201","article-title":"Targeting apoptosis with dietary bioactive agents","volume":"231","author":"Martin","year":"2006","journal-title":"Exp. Biol. Med. (Maywood)"},{"key":"10.1016\/j.bbrc.2010.02.079_bib12","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1248\/bpb.30.682","article-title":"Quercetin-induced PC12 cell death accompanied by caspase-mediated DNA fragmentation","volume":"30","author":"Sasaki","year":"2007","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.bbrc.2010.02.079_bib13","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.abb.2008.01.028","article-title":"Are polyphenols antioxidants or pro-oxidants? What do we learn from cell culture and in vivo studies?","volume":"476","author":"Halliwell","year":"2008","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.bbrc.2010.02.079_bib14","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.neuro.2006.07.006","article-title":"Cytotoxic effects of various stressors on PC12 cells: involvement of oxidative stress and effect of antioxidants","volume":"28","author":"Piga","year":"2007","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.bbrc.2010.02.079_bib15","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.ijdevneu.2007.09.010","article-title":"Effects of ginkgolide B on 6-OHDA-induced apoptosis and calcium over load in cultured PC12","volume":"25","author":"Meng","year":"2007","journal-title":"Int. J. Dev. Neurosci."},{"key":"10.1016\/j.bbrc.2010.02.079_bib16","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1248\/bpb.25.1093","article-title":"Flavonoids suppress the cytotoxicity of linoleic acid hydroperoxide toward PC12 cells","volume":"25","author":"Sasaki","year":"2002","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.bbrc.2010.02.079_bib17","doi-asserted-by":"crossref","unstructured":"J.A. Crispo, D.R. Ansell, M. Pich\u00e9, J.K. Eibl, N. Khaper, G.M. Ross, T.C. Tai, Protective effects of polyphenolic compounds on oxidative stress-induced cytotoxicity in PC12 cells, Can. J. Physiol. Pharmacol., accepted for publication.","DOI":"10.1139\/Y09-137"},{"key":"10.1016\/j.bbrc.2010.02.079_bib18","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1532\/LH96.04020","article-title":"Evaluation of an automated instrument for viability and concentration measurements of cryopreserved hematopoietic cells","volume":"10","author":"Szabo","year":"2004","journal-title":"Lab. Hematol."},{"key":"10.1016\/j.bbrc.2010.02.079_bib19","doi-asserted-by":"crossref","first-page":"34457","DOI":"10.1074\/jbc.M704459200","article-title":"A novel interaction between procaspase 8 and SPARC enhances apoptosis and potentiates chemotherapy sensitivity in colorectal cancers","volume":"282","author":"Tang","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2010.02.079_bib20","doi-asserted-by":"crossref","first-page":"42619","DOI":"10.1074\/jbc.M508416200","article-title":"Human serum from patients with septic shock activates transcription factors STAT1, IRF1, and NF-kappaB and induces apoptosis in human cardiac myocytes","volume":"280","author":"Kumar","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2010.02.079_bib21","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1080\/01616412.2000.11740718","article-title":"Activation of caspase-9 and -3 during H2O2-induced apoptosis of PC12 cells independent of ceramide formation","volume":"22","author":"Yamakawa","year":"2000","journal-title":"Neurol. Res."},{"key":"10.1016\/j.bbrc.2010.02.079_bib22","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1006\/excr.1999.4657","article-title":"Changes in elemental content during apoptotic cell death studied by electron probe X-ray microanalysis","volume":"253","author":"Fernandez-Segura","year":"1999","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.bbrc.2010.02.079_bib23","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/34112","article-title":"A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD","volume":"391","author":"Enari","year":"1998","journal-title":"Nature"},{"issue":"Suppl. 3","key":"10.1016\/j.bbrc.2010.02.079_bib24","doi-asserted-by":"crossref","first-page":"S26","DOI":"10.1002\/ana.10483","article-title":"Oxidative stress in Parkinson\u2019s disease","volume":"53","author":"Jenner","year":"2003","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.bbrc.2010.02.079_bib25","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1016\/j.bbagen.2008.07.010","article-title":"Molecular mechanism for neuro-protective effect of prosaposin against oxidative stress: its regulation of dimeric transcription factor formation","volume":"1780","author":"Ochiai","year":"2008","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbrc.2010.02.079_bib26","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1016\/j.phytochem.2006.06.020","article-title":"Epigallocatechin-3-gallate (EGCG): chemical and biomedical perspectives","volume":"67","author":"Nagle","year":"2006","journal-title":"Phytochemistry"},{"key":"10.1016\/j.bbrc.2010.02.079_bib27","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1196\/annals.1338.056","article-title":"Antioxidant N-acetylcysteine blocks nerve growth factor-induced H2O2\/ERK signaling in PC12 cells","volume":"1042","author":"Yang","year":"2005","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.bbrc.2010.02.079_bib28","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1016\/j.lfs.2006.11.033","article-title":"Inhibition by epigallocatechin gallate of CoCl2-induced apoptosis in rat PC12 cells","volume":"80","author":"Jung","year":"2007","journal-title":"Life Sci."},{"key":"10.1016\/j.bbrc.2010.02.079_bib29","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/emm.2005.44","article-title":"Methyl gallate and chemicals structurally related to methyl gallate protect human umbilical vein endothelial cells from oxidative stress","volume":"37","author":"Whang","year":"2005","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.bbrc.2010.02.079_bib30","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.cellbi.2007.08.007","article-title":"Neuroprotective effects of (\u2212)-epigallocatechin-3-gallate (EGCG) on paraquat-induced apoptosis in PC12 cells","volume":"32","author":"Hou","year":"2008","journal-title":"Cell Biol. Int."},{"key":"10.1016\/j.bbrc.2010.02.079_bib31","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.neulet.2006.09.089","article-title":"Epigallocatechin gallate inhibits nitric oxide-induced apoptosis in rat PC12 cells","volume":"411","author":"Jung","year":"2007","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.bbrc.2010.02.079_bib32","first-page":"1190","article-title":"Protection against hydrogen peroxide-induced cytotoxicity in PC12 cells by guggulsterone","volume":"43","author":"Xu","year":"2008","journal-title":"Yao Xue Xue Bao"},{"key":"10.1016\/j.bbrc.2010.02.079_bib33","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.tox.2008.04.006","article-title":"Effects of epigallocatechin-3-gallate on lead-induced oxidative damage","volume":"249","author":"Yin","year":"2008","journal-title":"Toxicology"},{"key":"10.1016\/j.bbrc.2010.02.079_bib34","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/s00210-005-0025-2","article-title":"Pramipexole protects against H2O2-induced PC12 cell death","volume":"372","author":"Fujita","year":"2006","journal-title":"Naunyn Schmiedebergs Arch. Pharmacol."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X10002998?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X10002998?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,2,8]],"date-time":"2019-02-08T03:31:13Z","timestamp":1549596673000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X10002998"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,3]]},"references-count":34,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2010,3]]}},"alternative-id":["S0006291X10002998"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2010.02.079","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2010,3]]}}}