{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T11:00:41Z","timestamp":1791198041541,"version":"4.1.0"},"reference-count":23,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2010,3,1]],"date-time":"2010-03-01T00:00:00Z","timestamp":1267401600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2010,3]]},"DOI":"10.1016\/j.bbrc.2010.02.086","type":"journal-article","created":{"date-parts":[[2010,2,19]],"date-time":"2010-02-19T09:17:40Z","timestamp":1266571060000},"page":"800-805","source":"Crossref","is-referenced-by-count":53,"title":["Activation of the hypoxia-inducible factor-1 in overloaded temporomandibular joint, and induction of osteoclastogenesis"],"prefix":"10.1016","volume":"393","author":[{"given":"Maya","family":"Shirakura","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiji","family":"Tanimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidetaka","family":"Eguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mutsumi","family":"Miyauchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideaki","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiko","family":"Hiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kotaro","family":"Tanimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eiji","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Takata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuo","family":"Tanne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2010.02.086_bib1","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1016\/j.berh.2006.06.003","article-title":"Update on the biology of the chondrocyte and new approaches to treating cartilage diseases","volume":"20","author":"Goldring","year":"2006","journal-title":"Best Pract. Res. Clin. Rheumatol."},{"key":"10.1016\/j.bbrc.2010.02.086_bib2","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1093\/rheumatology\/ken199","article-title":"Osteoarthritis: a problem of growth not decay?","volume":"47","author":"Aspden","year":"2008","journal-title":"Rheumatology"},{"key":"10.1016\/j.bbrc.2010.02.086_bib3","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1016\/j.joca.2009.04.025","article-title":"Biomechanical and biomedical characteristics of the mandibular condylar cartilage","volume":"11","author":"Kuroda","year":"2009","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.bbrc.2010.02.086_bib4","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1007\/s00418-005-0773-6","article-title":"Vascular endothelial growth factor plays an important autocrine\/paracrine role in the progression of osteoarthritis","volume":"123","author":"Tanaka","year":"2005","journal-title":"Histochem. Cell Biol."},{"key":"10.1016\/j.bbrc.2010.02.086_bib5","doi-asserted-by":"crossref","first-page":"4604","DOI":"10.1128\/MCB.16.9.4604","article-title":"Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1","volume":"16","author":"Forsythe","year":"1996","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.bbrc.2010.02.086_bib6","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0002-9440(10)63109-4","article-title":"Mechanical overload induces VEGF in cartilage discs via hypoxia-inducible factor","volume":"164","author":"Pufe","year":"2004","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.bbrc.2010.02.086_bib7","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1084\/jem.190.2.293","article-title":"Vascular endothelial growth factor can substitute for macrophage colony-stimulating factor in the support of osteoclastic bone resorption","volume":"190","author":"Niida","year":"1999","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.bbrc.2010.02.086_bib8","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1083\/jcb.151.4.879","article-title":"Matrix metalloproteinase 9 and vascular endothelial growth factor are essential for osteoclast recruitment into developing long bones","volume":"151","author":"Engsig","year":"2000","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.bbrc.2010.02.086_bib9","first-page":"871","article-title":"Differential regulation of DEC2 among hypoxia-inducible genes in endometrial carcinomas","volume":"17","author":"Yunokawa","year":"2007","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.bbrc.2010.02.086_bib10","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/0169-6009(91)90068-B","article-title":"Calcitonin receptor expression and its regulation by 1 alpha-25-dihydroxyvitamin D3 during de novo osteoclast formation in organ cultures of fetal mouse metatarsals","volume":"13","author":"Minkin","year":"1991","journal-title":"Bone Miner."},{"key":"10.1016\/j.bbrc.2010.02.086_bib11","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1083\/jcb.133.2.457","article-title":"Chondrogenic differentiation of clonal mouse embryonic cell line ATDC5 in vitro: differentiation-dependent gene expression of parathyroid hormone (PTH)\/PTH-related peptide receptor","volume":"133","author":"Shukunami","year":"1996","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.bbrc.2010.02.086_bib12","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1359\/jbmr.1997.12.8.1174","article-title":"Cellular hypertrophy and calcification of embryonal carcinoma-derived chondrogenic cell line ATDC5 in vitro","volume":"12","author":"Shukunami","year":"1997","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bbrc.2010.02.086_bib13","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.archoralbio.2007.12.007","article-title":"Expression and activity of Runx2 mediated by hyaluronan during chondrocyte differentiation","volume":"53","author":"Tanne","year":"2008","journal-title":"Arch. Oral Biol."},{"key":"10.1016\/j.bbrc.2010.02.086_bib14","doi-asserted-by":"crossref","first-page":"4200","DOI":"10.1038\/onc.2008.58","article-title":"Human mismatch repair gene, MLH1, is transcriptionally repressed by the hypoxia-inducible factors, DEC1 and DEC2","volume":"27","author":"Nakamura","year":"2008","journal-title":"Oncogene"},{"key":"10.1016\/j.bbrc.2010.02.086_bib15","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1016\/S0003-9969(00)00085-6","article-title":"Quantitative changes in the mRNA for contractile proteins and metabolic enzymes in masseter muscle of bite-opened rats","volume":"45","author":"Ohnuki","year":"2000","journal-title":"Arch. Oral Biol."},{"key":"10.1016\/j.bbrc.2010.02.086_bib16","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1038\/nnano.2008.410","article-title":"Early detection of aging cartilage and osteoarthritis in mice and patient samples using atomic force microscopy","volume":"4","author":"Stolz","year":"2009","journal-title":"Nat. Nanotechnol."},{"key":"10.1016\/j.bbrc.2010.02.086_bib17","doi-asserted-by":"crossref","first-page":"R904","DOI":"10.1186\/ar1765","article-title":"Catabolic stress induces expression of hypoxia-inducible factor (HIF)-1\u03b1 in articular chondrocytes: involvement of HIF-1\u03b1 in the pathogenesis of osteoarthritis","volume":"7","author":"Yudoh","year":"2005","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.bbrc.2010.02.086_bib18","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1152\/physiol.00045.2008","article-title":"Regulation of oxygen homeostasis by hypoxia-inducible factor 1","volume":"24","author":"Semenza","year":"2009","journal-title":"Physiology"},{"key":"10.1016\/j.bbrc.2010.02.086_bib19","doi-asserted-by":"crossref","first-page":"3478","DOI":"10.1210\/endo.141.9.7634","article-title":"Osteoprotegerin produced by osteoblasts is an important regulator in osteoclast development and function","volume":"141","author":"Udagawa","year":"2000","journal-title":"Endocrinology"},{"key":"10.1016\/j.bbrc.2010.02.086_bib20","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1359\/JBMR.0301226","article-title":"PTH differentially regulates expression of RANKL and OPG","volume":"19","author":"Huang","year":"2004","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bbrc.2010.02.086_bib21","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1002\/jcp.20036","article-title":"Roles of stromal cell RANKL, OPG, and M-CSF expression in biphasic TGF-beta regulation of osteoclast differentiation","volume":"200","author":"Karst","year":"2004","journal-title":"J. Cell Physiol."},{"key":"10.1016\/j.bbrc.2010.02.086_bib22","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.jnutbio.2006.03.002","article-title":"Effects of arachidonic acid, docosahexaenoic acid, prostaglandin E2 and parathyroid hormone on osteoprotegerin and RANKL secretion by MC3T3-E1 osteoblast-like cells","volume":"18","author":"Coetzee","year":"2007","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.bbrc.2010.02.086_bib23","doi-asserted-by":"crossref","first-page":"2397","DOI":"10.1002\/art.23653","article-title":"Cytokine-controlled RANKL and osteoprotegerin expression by human and mouse synovial fibroblasts: fibroblast-mediated pathologic bone resorption","volume":"58","author":"Tunyogi-Csapo","year":"2009","journal-title":"Arthritis Rheum."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X10003062?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X10003062?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,2,8]],"date-time":"2019-02-08T08:31:27Z","timestamp":1549614687000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X10003062"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,3]]},"references-count":23,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2010,3]]}},"alternative-id":["S0006291X10003062"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2010.02.086","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2010,3]]}}}