{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T13:14:23Z","timestamp":1792329263167,"version":"4.4.0"},"reference-count":93,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2010,5,1]],"date-time":"2010-05-01T00:00:00Z","timestamp":1272672000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,5,1]],"date-time":"2010-05-01T00:00:00Z","timestamp":1272672000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100011102","name":"Seventh Framework Programme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011102","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003514","name":"Kommunfullm\u00e4ktige, Stockholms Stad","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003514","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007464","name":"Torsten S\u00f6derbergs Stiftelse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007464","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001858","name":"VINNOVA","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2010,5]]},"DOI":"10.1016\/j.bbrc.2010.02.136","type":"journal-article","created":{"date-parts":[[2010,5,22]],"date-time":"2010-05-22T04:48:07Z","timestamp":1274503687000},"page":"39-45","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":136,"title":["NO-synthase independent NO generation in mammals"],"prefix":"10.1016","volume":"396","author":[{"given":"Jon O.","family":"Lundberg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eddie","family":"Weitzberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2010.02.136_bib1","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1038\/nrmicro929","article-title":"Nitrate, bacteria and human health","volume":"2","author":"Lundberg","year":"2004","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.bbrc.2010.02.136_bib2","doi-asserted-by":"crossref","first-page":"2002","DOI":"10.1056\/NEJM199312303292706","article-title":"The l-arginine\u2013nitric oxide pathway","volume":"329","author":"Moncada","year":"1993","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbrc.2010.02.136_bib3","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/S0008-6363(98)00259-4","article-title":"Serum nitrite sensitively reflects endothelial NO formation in human forearm vasculature: evidence for biochemical assessment of the endothelial l-arginine\u2013NO pathway","volume":"41","author":"Kelm","year":"1999","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.bbrc.2010.02.136_bib4","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.freeradbiomed.2003.11.011","article-title":"Circulating NO pool: assessment of nitrite and nitroso species in blood and tissues","volume":"36","author":"Rassaf","year":"2004","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbrc.2010.02.136_bib5","doi-asserted-by":"crossref","first-page":"11482","DOI":"10.1073\/pnas.97.21.11482","article-title":"Role of circulating nitrite and S-nitrosohemoglobin in the regulation of regional blood flow in humans","volume":"97","author":"Gladwin","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbrc.2010.02.136_bib6","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.freeradbiomed.2004.04.027","article-title":"Inorganic nitrate is a possible source for systemic generation of nitric oxide","volume":"37","author":"Lundberg","year":"2004","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbrc.2010.02.136_bib7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1113\/jphysiol.2004.068197","article-title":"Effect of exercise training on endothelium-derived nitric oxide function in humans","volume":"561","author":"Green","year":"2004","journal-title":"J. Physiol."},{"key":"10.1016\/j.bbrc.2010.02.136_bib8","doi-asserted-by":"crossref","first-page":"2782","DOI":"10.1161\/01.ATV.19.11.2782","article-title":"Exercise training increases basal nitric oxide production from the forearm in hypercholesterolemic patients","volume":"19","author":"Lewis","year":"1999","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.bbrc.2010.02.136_bib9","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1152\/jappl.1997.82.3.760","article-title":"Both physical fitness and acute exercise regulate nitric oxide formation in healthy humans","volume":"82","author":"Jungersten","year":"1997","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.bbrc.2010.02.136_bib10","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1182\/blood-2004-03-0880","article-title":"Transduction of NO-bioactivity by the red blood cell in sepsis: novel mechanisms of vasodilation during acute inflammatory disease","volume":"104","author":"Crawford","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.bbrc.2010.02.136_bib11","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1086\/314908","article-title":"Increased nitric oxide in infective gastroenteritis","volume":"180","author":"Herulf","year":"1999","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.bbrc.2010.02.136_bib12","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1016\/S0891-5849(03)00406-4","article-title":"Plasma nitrite reflects constitutive nitric oxide synthase activity in mammals","volume":"35","author":"Kleinbongard","year":"2003","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbrc.2010.02.136_bib13","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.freeradbiomed.2005.08.025","article-title":"Plasma nitrite concentrations reflect the degree of endothelial dysfunction in humans","volume":"40","author":"Kleinbongard","year":"2006","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbrc.2010.02.136_bib14","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1111\/j.1749-6632.1994.tb12040.x","article-title":"Nitric oxide synthesis and metabolism in man","volume":"714","author":"Wennmalm","year":"1994","journal-title":"Ann. NY Acad. Sci."},{"key":"10.1016\/j.bbrc.2010.02.136_bib15","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/S0015-6264(76)80005-3","article-title":"Influence of dietary nitrate on nitrite content of human saliva: possible relevance to in vivo formation of N-nitroso compounds","volume":"14","author":"Spiegelhalder","year":"1976","journal-title":"Food Cosmet. Toxicol."},{"key":"10.1016\/j.bbrc.2010.02.136_bib16","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1136\/gut.35.11.1543","article-title":"Intragastric nitric oxide production in humans: measurements in expelled air","volume":"35","author":"Lundberg","year":"1994","journal-title":"Gut"},{"key":"10.1016\/j.bbrc.2010.02.136_bib17","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1038\/368502a0","article-title":"Stomach NO synthesis","volume":"368","author":"Benjamin","year":"1994","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2010.02.136_bib18","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1128\/AAC.40.6.1422","article-title":"Antimicrobial effect of acidified nitrite on gut pathogens: importance of dietary nitrate in host defence","volume":"40","author":"Dykhuizen","year":"1996","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.bbrc.2010.02.136_bib19","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1136\/gut.42.3.334","article-title":"Helicobacter pylori is killed by nitrite under acidic conditions","volume":"42","author":"Dykhuizen","year":"1998","journal-title":"Gut"},{"key":"10.1016\/j.bbrc.2010.02.136_bib20","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1016\/j.freeradbiomed.2006.07.020","article-title":"Intragastric generation of antimicrobial nitrogen oxides from saliva \u2013 physiological and therapeutic considerations","volume":"41","author":"Bjorne","year":"2006","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbrc.2010.02.136_bib21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/niox.1997.0162","article-title":"Nonenzymatic nitric oxide production in humans","volume":"2","author":"Weitzberg","year":"1998","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.bbrc.2010.02.136_bib22","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1172\/JCI19019","article-title":"Nitrite in saliva increases gastric mucosal blood flow and mucus thickness","volume":"113","author":"Bjorne","year":"2004","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbrc.2010.02.136_bib23","doi-asserted-by":"crossref","first-page":"G718","DOI":"10.1152\/ajpgi.00435.2006","article-title":"Dietary nitrate increases gastric mucosal blood flow and mucosal defense","volume":"292","author":"Petersson","year":"2007","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.bbrc.2010.02.136_bib24","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/j.freeradbiomed.2006.11.018","article-title":"Protection from nonsteroidal anti-inflammatory drug (NSAID)-induced gastric ulcers by dietary nitrate","volume":"42","author":"Jansson","year":"2007","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbrc.2010.02.136_bib25","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1080\/1071576021000086632","article-title":"Dietary nitrate inhibits stress-induced gastric mucosal injury in the rat","volume":"37","author":"Miyoshi","year":"2003","journal-title":"Free Radic. Res."},{"key":"10.1016\/j.bbrc.2010.02.136_bib26","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1016\/S0024-3205(03)00480-6","article-title":"Effect of dietary nitric oxide on gastric mucosal mast cells in absence or presence of an experimental gastritis in rats","volume":"73","author":"Larauche","year":"2003","journal-title":"Life Sci."},{"key":"10.1016\/j.bbrc.2010.02.136_bib27","doi-asserted-by":"crossref","first-page":"G993","DOI":"10.1152\/ajpgi.00203.2004","article-title":"Gastrointestinal nitric oxide generation in germ-free and conventional rats","volume":"287","author":"Sobko","year":"2004","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.bbrc.2010.02.136_bib28","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.1097\/01.CCM.0000171204.59502.AA","article-title":"Intragastric nitric oxide is abolished in intubated patients and restored by nitrite","volume":"33","author":"Bjorne","year":"2005","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.bbrc.2010.02.136_bib29","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1038\/nm0895-804","article-title":"Enzyme-independent formation of nitric oxide in biological tissues","volume":"1","author":"Zweier","year":"1995","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbrc.2010.02.136_bib30","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1002\/med.20151","article-title":"Nitrite as regulator of hypoxic signaling in mammalian physiology","volume":"29","author":"van Faassen","year":"2009","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.bbrc.2010.02.136_bib31","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1006\/niox.2001.0371","article-title":"Effects of pH, nitrite, and ascorbic acid on nonenzymatic nitric oxide generation and bacterial growth in urine","volume":"5","author":"Carlsson","year":"2001","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.bbrc.2010.02.136_bib32","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1016\/j.freeradbiomed.2007.06.007","article-title":"Red wine-dependent reduction of nitrite to nitric oxide in the stomach","volume":"43","author":"Gago","year":"2007","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbrc.2010.02.136_bib33","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1038\/nm0695-546","article-title":"Chemical generation of nitric oxide in the mouth from the enterosalivary circulation of dietary nitrate [see comments]","volume":"1","author":"Duncan","year":"1995","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbrc.2010.02.136_bib34","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1038\/nm954","article-title":"Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation","volume":"9","author":"Cosby","year":"2003","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbrc.2010.02.136_bib35","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.1172\/JCI24650","article-title":"Enzymatic function of hemoglobin as a nitrite reductase that produces NO under allosteric control","volume":"115","author":"Huang","year":"2005","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbrc.2010.02.136_bib36","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1161\/01.RES.0000260171.52224.6b","article-title":"Deoxymyoglobin is a nitrite reductase that generates nitric oxide and regulates mitochondrial respiration","volume":"100","author":"Shiva","year":"2007","journal-title":"Circ. Res."},{"key":"10.1016\/j.bbrc.2010.02.136_bib37","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1161\/CIRCRESAHA.107.152488","article-title":"Nitrite reductase function of deoxymyoglobin: oxygen sensor and regulator of cardiac energetics and function","volume":"100","author":"Rassaf","year":"2007","journal-title":"Circ. Res."},{"key":"10.1016\/j.bbrc.2010.02.136_bib38","first-page":"1714","article-title":"Nitrate and nitrite reductase activity of milk xanthine oxidase","volume":"45","author":"Alikulov","year":"1980","journal-title":"Biokhimiia"},{"key":"10.1016\/j.bbrc.2010.02.136_bib39","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/S0014-5793(98)00430-X","article-title":"Xanthine oxidoreductase catalyses the reduction of nitrates and nitrite to nitric oxide under hypoxic conditions","volume":"427","author":"Millar","year":"1998","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bbrc.2010.02.136_bib40","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1006\/bbrc.1998.9226","article-title":"Generation of nitric oxide by a nitrite reductase activity of xanthine oxidase: a potential pathway for nitric oxide formation in the absence of nitric oxide synthase activity","volume":"249","author":"Zhang","year":"1998","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2010.02.136_bib41","doi-asserted-by":"crossref","first-page":"524S","DOI":"10.1042\/bst025524s","article-title":"Human xanthine oxidase converts nitrite ions into nitric oxide (NO)","volume":"25","author":"Zhang","year":"1997","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.bbrc.2010.02.136_bib42","doi-asserted-by":"crossref","first-page":"7757","DOI":"10.1074\/jbc.275.11.7757","article-title":"Reduction of nitrite to nitric oxide catalyzed by xanthine oxidoreductase","volume":"275","author":"Godber","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2010.02.136_bib43","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.niox.2009.12.004","article-title":"Mechanisms of nitrite reduction to nitric oxide in the heart and vessel wall","volume":"22","author":"Zweier","year":"2010","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.bbrc.2010.02.136_bib44","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0014-5793(99)00788-7","article-title":"Nitrite reductase activity is a novel function of mammalian mitochondria","volume":"454","author":"Kozlov","year":"1999","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bbrc.2010.02.136_bib45","doi-asserted-by":"crossref","first-page":"913","DOI":"10.18388\/abp.2000_3946","article-title":"Mitochondria recycle nitrite back to the bioregulator nitric monoxide","volume":"47","author":"Nohl","year":"2000","journal-title":"Acta Biochim. Pol."},{"key":"10.1016\/j.bbrc.2010.02.136_bib46","first-page":"874","article-title":"NO-synthase and nitrite-reductase components of nitric oxide cycle","volume":"63","author":"Reutov","year":"1998","journal-title":"Biochemistry (Mosc)"},{"key":"10.1016\/j.bbrc.2010.02.136_bib47","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.febslet.2004.09.004","article-title":"Mitochondrial electron transport as a source for nitric oxide in the unicellular green alga Chlorella sorokiniana","volume":"576","author":"Tischner","year":"2004","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bbrc.2010.02.136_bib48","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1038\/sj.bjp.0705323","article-title":"Various intracellular compartments cooperate in the release of nitric oxide from glycerol trinitrate in liver","volume":"139","author":"Kozlov","year":"2003","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.bbrc.2010.02.136_bib49","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1111\/j.1749-6632.2000.tb06181.x","article-title":"Regulation of mitochondrial respiration by oxygen and nitric oxide","volume":"899","author":"Boveris","year":"2000","journal-title":"Ann. NY Acad. Sci."},{"key":"10.1016\/j.bbrc.2010.02.136_bib50","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1038\/nrm762","article-title":"Does nitric oxide modulate mitochondrial energy generation and apoptosis?","volume":"3","author":"Moncada","year":"2002","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bbrc.2010.02.136_bib51","doi-asserted-by":"crossref","first-page":"14602","DOI":"10.1073\/pnas.97.26.14602","article-title":"The effect of nitric oxide on cell respiration: a key to understanding its role in cell survival or death","volume":"97","author":"Beltran","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbrc.2010.02.136_bib52","doi-asserted-by":"crossref","first-page":"16507","DOI":"10.1073\/pnas.0405432101","article-title":"Mitochondrial biogenesis by NO yields functionally active mitochondria in mammals","volume":"101","author":"Nisoli","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbrc.2010.02.136_bib53","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0022-3565(25)05163-8","article-title":"Reactions of strips of rabbit aorta to epinephrine, isopropylarterenol, sodium nitrite and other drugs","volume":"108","author":"Furchgott","year":"1953","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.bbrc.2010.02.136_bib54","first-page":"9","article-title":"Nitrite-derived nitric oxide: a possible mediator of \u2018acidic-metabolic\u2019 vasodilation","volume":"171","author":"Modin","year":"2001","journal-title":"Acta Physiol. Scand."},{"key":"10.1016\/j.bbrc.2010.02.136_bib55","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.niox.2009.11.004","article-title":"The biological role of nitrate and nitrite: the times they are a-changin\u2019","volume":"22","author":"Lundberg","year":"2009","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.bbrc.2010.02.136_bib56","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1161\/01.ATV.0000161048.72004.c2","article-title":"NO generation from nitrite and its role in vascular control","volume":"25","author":"Lundberg","year":"2005","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.bbrc.2010.02.136_bib57","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.bcmd.2004.02.002","article-title":"Emerging role of nitrite in human biology","volume":"32","author":"Dejam","year":"2004","journal-title":"Blood Cells Mol. Dis."},{"key":"10.1016\/j.bbrc.2010.02.136_bib58","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/978-0-387-34817-9_17","article-title":"Role of the red blood cell in nitric oxide homeostasis and hypoxic vasodilation","volume":"588","author":"Gladwin","year":"2006","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.bbrc.2010.02.136_bib59","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1172\/JCI22493","article-title":"Cytoprotective effects of nitrite during in vivo ischemia\u2013reperfusion of the heart and liver","volume":"115","author":"Duranski","year":"2005","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbrc.2010.02.136_bib60","first-page":"350","article-title":"Nitrite-derived nitric oxide by xanthine oxidoreductase protects the liver against ischemia\u2013reperfusion injury","volume":"4","author":"Lu","year":"2005","journal-title":"Hepatobiliary Pancreat. Dis. Int."},{"key":"10.1016\/j.bbrc.2010.02.136_bib61","doi-asserted-by":"crossref","first-page":"2986","DOI":"10.1161\/CIRCULATIONAHA.107.748814","article-title":"Nitrite provides potent cytoprotective and anti-apoptotic effects as adjuvant therapy to reperfusion for acute myocardial infarction","volume":"117","author":"Gonzales","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.bbrc.2010.02.136_bib62","doi-asserted-by":"crossref","first-page":"13683","DOI":"10.1073\/pnas.0402927101","article-title":"Reduction of nitrite to nitric oxide during ischemia protects against myocardial ischemia\u2013reperfusion damage","volume":"101","author":"Webb","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbrc.2010.02.136_bib63","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.yjmcc.2007.07.057","article-title":"Nitrite confers protection against myocardial infarction: role of xanthine oxidoreductase, NADPH oxidase and K(ATP) channels","volume":"43","author":"Baker","year":"2007","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.bbrc.2010.02.136_bib64","doi-asserted-by":"crossref","first-page":"2744","DOI":"10.1161\/01.STR.0000245116.40163.1c","article-title":"Early intravenous infusion of sodium nitrite protects brain against in vivo ischemia\u2013reperfusion injury","volume":"37","author":"Jung","year":"2006","journal-title":"Stroke"},{"key":"10.1016\/j.bbrc.2010.02.136_bib65","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1681\/ASN.2006050450","article-title":"Nitrite-derived nitric oxide protects the rat kidney against ischemia\/reperfusion injury in vivo: role for xanthine oxidoreductase","volume":"18","author":"Tripatara","year":"2007","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.bbrc.2010.02.136_bib66","doi-asserted-by":"crossref","first-page":"7540","DOI":"10.1073\/pnas.0711480105","article-title":"Chronic sodium nitrite therapy augments ischemia-induced angiogenesis and arteriogenesis","volume":"105","author":"Kumar","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbrc.2010.02.136_bib67","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.1084\/jem.20070198","article-title":"Nitrite augments tolerance to ischemia\/reperfusion injury via the modulation of mitochondrial electron transfer","volume":"204","author":"Shiva","year":"2007","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.bbrc.2010.02.136_bib68","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.niox.2006.01.013","article-title":"Cardioprotective effects of vegetables: is nitrate the answer?","volume":"15","author":"Lundberg","year":"2006","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.bbrc.2010.02.136_bib69","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1080\/07315724.1990.10720407","article-title":"Hypothesis: the effect of oral nitrite on blood pressure in the spontaneously hypertensive rat. Does dietary nitrate mitigate hypertension after conversion to nitrite?","volume":"9","author":"Classen","year":"1990","journal-title":"J. Am. Coll. Nutr."},{"key":"10.1016\/j.bbrc.2010.02.136_bib70","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1038\/nchembio1105-308","article-title":"The emerging biology of the nitrite anion","volume":"1","author":"Gladwin","year":"2005","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.bbrc.2010.02.136_bib71","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1038\/nchembio.260","article-title":"Nitrate and nitrite in biology, nutrition and therapeutics","volume":"5","author":"Lundberg","year":"2009","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.bbrc.2010.02.136_bib72","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.cmet.2006.02.011","article-title":"Mitochondrial cytochrome oxidase produces nitric oxide under hypoxic conditions: implications for oxygen sensing and hypoxic signaling in eukaryotes","volume":"3","author":"Castello","year":"2006","journal-title":"Cell Metab."},{"key":"10.1016\/j.bbrc.2010.02.136_bib73","doi-asserted-by":"crossref","first-page":"32590","DOI":"10.1074\/jbc.M806934200","article-title":"Nitrite reductase activity of cytochrome c","volume":"283","author":"Basu","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2010.02.136_bib74","doi-asserted-by":"crossref","first-page":"2497","DOI":"10.1172\/JCI2736","article-title":"Inhaled NO as a viable antiadhesive therapy for ischemia\/reperfusion injury of distal microvascular beds","volume":"101","author":"Fox-Robichaud","year":"1998","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbrc.2010.02.136_bib75","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1172\/JCI200112761","article-title":"Effects of inhaled nitric oxide on regional blood flow are consistent with intravascular nitric oxide delivery","volume":"108","author":"Cannon","year":"2001","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbrc.2010.02.136_bib76","doi-asserted-by":"crossref","first-page":"H379","DOI":"10.1152\/ajpheart.01172.2005","article-title":"Inhaled nitric oxide decreases infarction size and improves left ventricular function in a murine model of myocardial ischemia\u2013reperfusion injury","volume":"291","author":"Hataishi","year":"2006","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.bbrc.2010.02.136_bib77","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1016\/j.jacc.2007.04.069","article-title":"Nitric oxide inhalation improves microvascular flow and decreases infarction size after myocardial ischemia and reperfusion","volume":"50","author":"Liu","year":"2007","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.bbrc.2010.02.136_bib78","doi-asserted-by":"crossref","first-page":"2583","DOI":"10.1172\/JCI31892","article-title":"Inhaled NO accelerates restoration of liver function in adults following orthotopic liver transplantation","volume":"117","author":"Lang","year":"2007","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbrc.2010.02.136_bib79","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1038\/nrd2466","article-title":"The nitrate\u2013nitrite\u2013nitric oxide pathway in physiology and therapeutics","volume":"7","author":"Lundberg","year":"2008","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.bbrc.2010.02.136_bib80","first-page":"123","article-title":"Nitrate reduction in germfree rats","volume":"181","author":"Ward","year":"1985","journal-title":"Prog. Clin. Biol. Res."},{"key":"10.1016\/j.bbrc.2010.02.136_bib81","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/nchembio.92","article-title":"A mammalian functional nitrate reductase that regulates nitrite and nitric oxide homeostasis","volume":"4","author":"Jansson","year":"2008","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.bbrc.2010.02.136_bib82","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1021\/bi026385a","article-title":"Characterization of the magnitude and kinetics of xanthine oxidase-catalyzed nitrate reduction: evaluation of its role in nitrite and nitric oxide generation in anoxic tissues","volume":"42","author":"Li","year":"2003","journal-title":"Biochemistry"},{"key":"10.1016\/j.bbrc.2010.02.136_bib83","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.niox.2008.08.003","article-title":"The increase in plasma nitrite after a dietary nitrate load is markedly attenuated by an antibacterial mouthwash","volume":"19","author":"Govoni","year":"2008","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.bbrc.2010.02.136_bib84","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1016\/j.freeradbiomed.2009.01.011","article-title":"Gastroprotective and blood pressure lowering effects of dietary nitrate are abolished by an antiseptic mouthwash","volume":"46","author":"Petersson","year":"2009","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbrc.2010.02.136_bib85","doi-asserted-by":"crossref","first-page":"2792","DOI":"10.1056\/NEJMc062800","article-title":"Effects of dietary nitrate on blood pressure in healthy volunteers","volume":"355","author":"Larsen","year":"2006","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbrc.2010.02.136_bib86","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/j.1748-1716.2007.01713.x","article-title":"Effects of dietary nitrate on oxygen cost during exercise","volume":"191","author":"Larsen","year":"2007","journal-title":"Acta Physiol. (Oxf.)"},{"key":"10.1016\/j.bbrc.2010.02.136_bib87","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.freeradbiomed.2009.11.006","article-title":"Dietary nitrate reduces maximal oxygen consumption while maintaining work performance at maximal exercise","volume":"48","author":"Larsen","year":"2009","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbrc.2010.02.136_bib88","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1152\/japplphysiol.00722.2009","article-title":"Dietary nitrate supplementation reduces the O2 cost of low-intensity exercise and enhances tolerance to high-intensity exercise in humans","volume":"107","author":"Bailey","year":"2009","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.bbrc.2010.02.136_bib89","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1161\/HYPERTENSIONAHA.107.103523","article-title":"Acute blood pressure lowering, vasoprotective, and antiplatelet properties of dietary nitrate via bioconversion to nitrite","volume":"51","author":"Webb","year":"2008","journal-title":"Hypertension"},{"key":"10.1016\/j.bbrc.2010.02.136_bib90","doi-asserted-by":"crossref","first-page":"19144","DOI":"10.1073\/pnas.0706579104","article-title":"Dietary nitrite supplementation protects against myocardial ischemia\u2013reperfusion injury","volume":"104","author":"Bryan","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbrc.2010.02.136_bib91","doi-asserted-by":"crossref","first-page":"F1457","DOI":"10.1152\/ajprenal.00621.2007","article-title":"Dietary doses of nitrite restore circulating nitric oxide level and improve renal injury in l-NAME-induced hypertensive rats","volume":"295","author":"Kanematsu","year":"2008","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.1016\/j.bbrc.2010.02.136_bib92","doi-asserted-by":"crossref","first-page":"2560","DOI":"10.1001\/jama.289.19.2560","article-title":"The seventh report of the joint national committee on prevention, detection, evaluation, and treatment of high blood pressure: the JNC 7 report","volume":"289","author":"Chobanian","year":"2003","journal-title":"JAMA"},{"key":"10.1016\/j.bbrc.2010.02.136_bib93","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1056\/NEJM199704173361601","article-title":"A clinical trial of the effects of dietary patterns on blood pressure. DASH Collaborative Research Group","volume":"336","author":"Appel","year":"1997","journal-title":"N. Engl. J. Med."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X10003700?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X10003700?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T14:22:00Z","timestamp":1762093320000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X10003700"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,5]]},"references-count":93,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,5]]}},"alternative-id":["S0006291X10003700"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2010.02.136","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2010,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"NO-synthase independent NO generation in mammals","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2010.02.136","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}