{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T04:09:19Z","timestamp":1791173359468,"version":"4.1.0"},"reference-count":32,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2010,4,1]],"date-time":"2010-04-01T00:00:00Z","timestamp":1270080000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2010,4]]},"DOI":"10.1016\/j.bbrc.2010.03.138","type":"journal-article","created":{"date-parts":[[2010,3,30]],"date-time":"2010-03-30T17:27:45Z","timestamp":1269970065000},"page":"1098-1104","source":"Crossref","is-referenced-by-count":178,"title":["Salinomycin overcomes ABC transporter-mediated multidrug and apoptosis resistance in human leukemia stem cell-like KG-1a cells"],"prefix":"10.1016","volume":"394","author":[{"given":"Dominik","family":"Fuchs","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Volker","family":"Daniel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud","family":"Sadeghi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhard","family":"Opelz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cord","family":"Naujokat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2010.03.138_bib1","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1146\/annurev.pathol.2.010506.091847","article-title":"Cancer stem cells: at the headwater of tumor development","volume":"2","author":"Ward","year":"2007","journal-title":"Annu. Rev. Pathol."},{"key":"10.1016\/j.bbrc.2010.03.138_bib2","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.copbio.2007.10.007","article-title":"Cancer stem cells in solid tumors","volume":"18","author":"Ailles","year":"2007","journal-title":"Curr. Opin. Biotechnol."},{"key":"10.1016\/j.bbrc.2010.03.138_bib3","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1038\/367645a0","article-title":"A cell initiating human acute myeloid leukemia after transplantation into SCID mice","volume":"367","author":"Lapidot","year":"1994","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2010.03.138_bib4","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1038\/nm0797-730","article-title":"Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell","volume":"3","author":"Bonnet","year":"1997","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbrc.2010.03.138_bib5","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/nrc1590","article-title":"Tumor stem cells and drug resistance","volume":"5","author":"Dean","year":"2005","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.bbrc.2010.03.138_bib6","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/leu.2008.246","article-title":"Targeting the leukemic stem cell: the Holy Grail for leukemia therapy","volume":"23","author":"Misaghian","year":"2009","journal-title":"Leukemia"},{"key":"10.1016\/j.bbrc.2010.03.138_bib7","doi-asserted-by":"crossref","first-page":"2989","DOI":"10.1021\/cr9000226","article-title":"ABC efflux pump-based resistance to chemotherapy drugs","volume":"109","author":"Eckford","year":"2009","journal-title":"Chem. Rev."},{"key":"10.1016\/j.bbrc.2010.03.138_bib8","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1182\/blood.V98.4.1166","article-title":"A leukemic stem cell with intrinsic drug efflux capacity in acute myeloid leukemia","volume":"98","author":"Wulf","year":"2001","journal-title":"Blood"},{"key":"10.1016\/j.bbrc.2010.03.138_bib9","doi-asserted-by":"crossref","first-page":"2436","DOI":"10.1158\/1078-0432.CCR-04-0212","article-title":"Breast cancer resistance protein in drug resistance of primitive CD34 cells in acute myeloid leukemia","volume":"11","author":"Raaijmakers","year":"2005","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.bbrc.2010.03.138_bib10","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.exphem.2007.11.014","article-title":"MDR1 and BCRP1 expression in leukemic progenitors correlates with chemotherapy response in acute myeloid leukemia","volume":"36","author":"Ho","year":"2008","journal-title":"Exp. Hematol."},{"key":"10.1016\/j.bbrc.2010.03.138_bib11","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s10911-009-9109-9","article-title":"ABC transporters, drug resistance, and cancer stem cells","volume":"14","author":"Dean","year":"2009","journal-title":"J. Mammary Gland Biol. Neoplasia"},{"key":"10.1016\/j.bbrc.2010.03.138_bib12","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1182\/blood.V56.2.265.265","article-title":"An undifferentiated variant derived from the human acute myelogenous leukemia cell line (KG-1)","volume":"56","author":"Koeffler","year":"1980","journal-title":"Blood"},{"key":"10.1016\/j.bbrc.2010.03.138_bib13","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/S0301-472X(99)00004-1","article-title":"Transforming growth factor beta inhibits growth of more differentiated myeloid leukemia cells and retinoblastoma protein phosphorylation at serine 795","volume":"27","author":"Hu","year":"1999","journal-title":"Exp. Hematol."},{"key":"10.1016\/j.bbrc.2010.03.138_bib14","first-page":"6363","article-title":"Effects of phorbol ester on translocation and down-regulation of protein kinase C and phosphorylation of endogenous proteins in human acute myeloid leukemia cell line KG-1 and its phorbol ester-resistant subline KG-1a","volume":"47","author":"Shoji","year":"1987","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbrc.2010.03.138_bib15","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1080\/1042819031000060564","article-title":"Retinoic acid induction of CD38 antigen expression on normal and leukemic human myeloid cells: relationship with cell differentiation","volume":"44","author":"Prus","year":"2003","journal-title":"Leuk. Lymphoma"},{"key":"10.1016\/j.bbrc.2010.03.138_bib16","doi-asserted-by":"crossref","first-page":"3705","DOI":"10.1158\/1078-0432.CCR-08-2048","article-title":"Histone deacetylase inhibitors induce a very broad, pleiotropic anticancer drug resistance phenotype in acute myeloid leukemia cells by modulation of multiple ABC transporter genes","volume":"15","author":"Hauswald","year":"2009","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.bbrc.2010.03.138_bib17","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1084\/jem.189.4.693","article-title":"CD34(+) hematopoietic stem cells exert accessory function in lipopolysaccharide-induced T cell stimulation and CD80 expression on monocytes","volume":"189","author":"Mattern","year":"1999","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.bbrc.2010.03.138_bib18","doi-asserted-by":"crossref","first-page":"814","DOI":"10.7164\/antibiotics.27.814","article-title":"Salinomycin, a new polyether antibiotic","volume":"27","author":"Miyazaki","year":"1974","journal-title":"J. Antibiot."},{"key":"10.1016\/j.bbrc.2010.03.138_bib19","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1128\/AAC.9.4.655","article-title":"Salinomycin effects on mitochondrial ion translocation and respiration","volume":"9","author":"Mitani","year":"1976","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.bbrc.2010.03.138_bib20","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.cell.2009.06.034","article-title":"Identification of selective inhibitors of cancer stem cells by high-throughput screening","volume":"138","author":"Gupta","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2010.03.138_bib21","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/j.bbrc.2009.10.042","article-title":"Salinomycin induces apoptosis and overcomes apoptosis resistance in human cancer cells","volume":"390","author":"Fuchs","year":"2009","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2010.03.138_bib22","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1038\/373438a0","article-title":"Autocrine T-cell suicide mediated by APO-1\/(Fas\/CD95)","volume":"373","author":"Dhein","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2010.03.138_bib23","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1002\/jcb.21405","article-title":"Increased expression and altered subunit composition of proteasomes induced by continuous proteasome inhibition establish apoptosis resistance and hyperproliferation of Burkitt lymphoma cells","volume":"103","author":"Fuchs","year":"2008","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.bbrc.2010.03.138_bib24","first-page":"1971","article-title":"Induction of histone acetylation and growth regulation in erythroleukemia cells by 4-phenylbutyrate and structural analogs","volume":"19","author":"Lea","year":"1999","journal-title":"Anticancer Res."},{"key":"10.1016\/j.bbrc.2010.03.138_bib25","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/978-1-59745-280-9_17","article-title":"Measurement of multiple drug resistance transporter activity in putative cancer stem\/progenitor cells","volume":"568","author":"Donnenberg","year":"2009","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.bbrc.2010.03.138_bib26","doi-asserted-by":"crossref","first-page":"2320","DOI":"10.1158\/1078-0432.CCR-04-1725","article-title":"Cyclosporin A is a broad-spectrum multidrug resistance modulator","volume":"11","author":"Qadir","year":"2005","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.bbrc.2010.03.138_bib27","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1159\/000077285","article-title":"Interference by anti-cancer chemotherapeutic agents in the MTT-tumor chemosensitivity assay","volume":"50","author":"Ulukaya","year":"2004","journal-title":"Chemotherapy"},{"key":"10.1016\/j.bbrc.2010.03.138_bib28","first-page":"865","article-title":"Vulnerability of multidrug-resistant tumor cells to the aromatic fatty acids phenylacetate and phenylbutyrate","volume":"2","author":"Shack","year":"1996","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.bbrc.2010.03.138_bib29","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.1158\/1078-0432.CCR-08-0442","article-title":"Expression of ABCC-type nucleotide exporters in blasts of adult acute myeloid leukemia: relation to long-term survival","volume":"15","author":"Guo","year":"2009","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.bbrc.2010.03.138_bib30","doi-asserted-by":"crossref","first-page":"7764","DOI":"10.1158\/1078-0432.CCR-04-1895","article-title":"MRP3, BCRP, and P-glycoprotein activities are prognostic factors in adult acute myeloid leukemia","volume":"11","author":"Benderra","year":"2005","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.bbrc.2010.03.138_bib31","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/0014-5793(95)00370-O","article-title":"Involvement of multiple proteases during Fas-mediated apoptosis in T lymphocytes","volume":"364","author":"Chow","year":"1995","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bbrc.2010.03.138_bib32","doi-asserted-by":"crossref","first-page":"14989","DOI":"10.1021\/ja075024l","article-title":"Conformation and location of membrane-bound salinomycin\u2013sodium complex deduced from NMR in isotropic bicelles","volume":"129","author":"Matsumori","year":"2007","journal-title":"J. Am. Chem. Soc."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X10006133?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X10006133?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,6,3]],"date-time":"2020-06-03T11:07:18Z","timestamp":1591182438000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X10006133"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,4]]},"references-count":32,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2010,4]]}},"alternative-id":["S0006291X10006133"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2010.03.138","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2010,4]]}}}