{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T16:38:42Z","timestamp":1771000722724,"version":"3.50.1"},"reference-count":24,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2010,5,1]],"date-time":"2010-05-01T00:00:00Z","timestamp":1272672000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,5,1]],"date-time":"2010-05-01T00:00:00Z","timestamp":1272672000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2010,5,1]],"date-time":"2010-05-01T00:00:00Z","timestamp":1272672000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2010,5,1]],"date-time":"2010-05-01T00:00:00Z","timestamp":1272672000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2010,5,1]],"date-time":"2010-05-01T00:00:00Z","timestamp":1272672000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2010,5,1]],"date-time":"2010-05-01T00:00:00Z","timestamp":1272672000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2010,5,1]],"date-time":"2010-05-01T00:00:00Z","timestamp":1272672000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2010,5]]},"DOI":"10.1016\/j.bbrc.2010.04.063","type":"journal-article","created":{"date-parts":[[2010,4,14]],"date-time":"2010-04-14T04:26:12Z","timestamp":1271219172000},"page":"547-552","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Development and characterization of a novel anti-IgE monoclonal antibody"],"prefix":"10.1016","volume":"395","author":[{"given":"Weizhu","family":"Qian","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xunmin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bohua","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dapeng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing","family":"Tong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geng","family":"Kou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheng","family":"Hou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yajun","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2010.04.063_bib1","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1038\/72601","article-title":"The pharmacological basis of anti-IgE therapy","volume":"18","author":"Chang","year":"2000","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.bbrc.2010.04.063_bib2","first-page":"3","article-title":"Epidemiology of rhinitis and asthma","volume":"28","author":"Lundb\u00e4ck","year":"1998","journal-title":"Clin. Exp. Allergy"},{"key":"10.1016\/j.bbrc.2010.04.063_bib3","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1146\/annurev.iy.04.040186.002223","article-title":"The receptor with high affinity for immunoglobulin E","volume":"4","author":"Metzger","year":"1986","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.bbrc.2010.04.063_bib4","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/BF00204626","article-title":"Can anti-IgE be used to treat allergy?","volume":"15","author":"Davis","year":"1993","journal-title":"Springer Semin. Immunopathol."},{"key":"10.1016\/j.bbrc.2010.04.063_bib5","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.pharmthera.2006.07.003","article-title":"Immunoglobulin E: role in asthma and allergic disease: lessons from the clinic","volume":"113","author":"Owen","year":"2007","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.bbrc.2010.04.063_bib6","doi-asserted-by":"crossref","first-page":"26368","DOI":"10.1016\/S0021-9258(18)47203-1","article-title":"The binding site on human immunoglobulin E for its high affinity receptor","volume":"269","author":"Presta","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2010.04.063_bib7","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/35018500","article-title":"Structure of the Fc fragment of human IgE bound to its high-affinity receptor Fc epsilonRI alpha","volume":"406","author":"Garman","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2010.04.063_bib8","doi-asserted-by":"crossref","first-page":"2623","DOI":"10.4049\/jimmunol.151.5.2623","article-title":"Humanization of an antibody directed against IgE","volume":"151","author":"Presta","year":"1993","journal-title":"J. Immunol."},{"key":"10.1016\/j.bbrc.2010.04.063_bib9","first-page":"613","article-title":"A review of anti-IgE monoclonal antibody (omalizumab) as add on therapy for severe allergic (IgE-mediated) asthma","volume":"3","author":"D\u2019Amato","year":"2007","journal-title":"Ther. Clin. Risk Manag."},{"key":"10.1016\/j.bbrc.2010.04.063_bib10","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1016\/j.rmed.2005.10.004","article-title":"Management of asthma with anti-immunoglobulin E: a review of clinical trials of omalizumab","volume":"100","author":"Nowak","year":"2006","journal-title":"Respir. Med."},{"key":"10.1016\/j.bbrc.2010.04.063_bib11","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1248\/bpb.26.252","article-title":"Application of human Fc epsilon RI alpha-chain-transfected RBL-2H3 cells for estimation of active serum IgE","volume":"26","author":"Takagi","year":"2003","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.bbrc.2010.04.063_bib12","doi-asserted-by":"crossref","first-page":"3842","DOI":"10.4049\/jimmunol.145.11.3842","article-title":"Recombinant human IgG1-murine IgE chimeric Ig. Construction, expression, and binding to human Fc gamma receptors","volume":"145","author":"Shopes","year":"1990","journal-title":"J. Immunol."},{"key":"10.1016\/j.bbrc.2010.04.063_bib13","doi-asserted-by":"crossref","first-page":"3683","DOI":"10.1016\/j.molimm.2008.06.008","article-title":"A novel functional motif of osteopontin for human lymphocyte migration and survival","volume":"45","author":"Cao","year":"2008","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.bbrc.2010.04.063_bib14","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1111\/j.1365-2567.2007.02705.x","article-title":"Neuropeptides activate human mast cell degranulation and chemokine production","volume":"123","author":"Kulka","year":"2008","journal-title":"Immunology"},{"key":"10.1016\/j.bbrc.2010.04.063_bib15","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.imlet.2007.02.003","article-title":"Inhibition of human cord blood-derived mast cell responses by anti-Fc epsilon RI mAb 15\/1 versus anti-IgE omalizumab","volume":"109","author":"Mirkina","year":"2007","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.bbrc.2010.04.063_bib16","doi-asserted-by":"crossref","first-page":"3518","DOI":"10.1158\/0008-5472.CAN-06-3919","article-title":"Identification of their epitope reveals the structural basis for the mechanism of action of the immunosuppressive antibodies basiliximab and daclizumab","volume":"67","author":"Binder","year":"2007","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbrc.2010.04.063_bib17","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1182\/blood-2005-04-1769","article-title":"Generation of biologically active linear and cyclic peptides has revealed a unique fine specificity of rituximab and its possible cross-reactivity with acid sphingomyelinase-like phosphodiesterase 3b precursor","volume":"107","author":"Perosa","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.bbrc.2010.04.063_bib18","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.bbrc.2008.08.055","article-title":"Fine epitope mapping of humanized anti-IgE monoclonal antibody omalizumab","volume":"375","author":"Zheng","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2010.04.063_bib19","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.4049\/jimmunol.179.2.1353","article-title":"Omalizumab reverses the phenotypic and functional effects of IgE-enhanced Fc epsilonRI on human skin mast cells","volume":"179","author":"Gomez","year":"2007","journal-title":"J. Immunol."},{"key":"10.1016\/j.bbrc.2010.04.063_bib20","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.jaci.2004.06.032","article-title":"Omalizumab-induced reductions in mast cell Fce psilon RI expression and function","volume":"114","author":"Beck","year":"2004","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.bbrc.2010.04.063_bib21","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.jaci.2003.11.044","article-title":"Omalizumab rapidly decreases nasal allergic response and FcepsilonRI on basophils","volume":"113","author":"Lin","year":"2004","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.bbrc.2010.04.063_bib22","doi-asserted-by":"crossref","first-page":"5624","DOI":"10.4049\/jimmunol.162.9.5624","article-title":"Down-regulation of human basophil IgE and FC epsilon RI alpha surface densities and mediator release by anti-IgE-infusions is reversible in vitro and in vivo","volume":"162","author":"Saini","year":"1999","journal-title":"J. Immunol."},{"key":"10.1016\/j.bbrc.2010.04.063_bib23","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1067\/mai.2003.56","article-title":"Treatment with omalizumab normalizes the number of myeloid dendritic cells during the grass pollen season","volume":"111","author":"Feuchtinger","year":"2003","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.bbrc.2010.04.063_bib24","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1016\/j.jaci.2003.10.003","article-title":"Omalizumab treatment downregulates dendritic cell FcepsilonRI expression","volume":"112","author":"Prussin","year":"2003","journal-title":"J. Allergy Clin. Immunol."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X10007321?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X10007321?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T14:22:03Z","timestamp":1762093323000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X10007321"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,5]]},"references-count":24,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2010,5]]}},"alternative-id":["S0006291X10007321"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2010.04.063","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2010,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Development and characterization of a novel anti-IgE monoclonal antibody","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2010.04.063","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}