{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T10:54:47Z","timestamp":1772794487860,"version":"3.50.1"},"reference-count":30,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2010,6,1]],"date-time":"2010-06-01T00:00:00Z","timestamp":1275350400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"crossref","award":["KFO 196"],"award-info":[{"award-number":["KFO 196"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]},{"name":"HOMFOR"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2010,6]]},"DOI":"10.1016\/j.bbrc.2010.05.086","type":"journal-article","created":{"date-parts":[[2010,5,21]],"date-time":"2010-05-21T08:34:26Z","timestamp":1274430866000},"page":"208-213","source":"Crossref","is-referenced-by-count":23,"title":["Integrin-linked kinase is a central mediator in angiotensin II type 1- and chemokine receptor CXCR4 signaling in myocardial hypertrophy"],"prefix":"10.1016","volume":"397","author":[{"given":"Stephanie I.","family":"Bettink","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Werner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chia-Hui","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephan H.","family":"Schirmer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katrin L.","family":"Walenta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"B\u00f6hm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrich","family":"Laufs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erik B.","family":"Friedrich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2010.05.086_bib1","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1016\/j.ejheart.2008.08.005","volume":"10","author":"Dickstein","year":"2008","journal-title":"Eur. J. Heart Fail."},{"key":"10.1016\/j.bbrc.2010.05.086_bib2","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1161\/01.CIR.0000120390.68287.BB","article-title":"Hypertrophy of the heart: a new therapeutic target?","volume":"109","author":"Frey","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.bbrc.2010.05.086_bib3","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1056\/NEJM199005313222203","article-title":"Prognostic implications of echocardiographically determined left ventricular mass in the Framingham Heart Study","volume":"322","author":"Levy","year":"1990","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbrc.2010.05.086_bib4","doi-asserted-by":"crossref","first-page":"7432","DOI":"10.1073\/pnas.0510444103","article-title":"Requirement of Rac1 in the development of cardiac hypertrophy","volume":"103","author":"Satoh","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbrc.2010.05.086_bib5","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1093\/eurjhf\/hfn043","article-title":"Inflammation as a therapeutic target in heart failure? A scientific statement from the Translational Research Committee of the Heart Failure Association of the European Society of Cardiology","volume":"11","author":"Heymans","year":"2009","journal-title":"Eur. J. Heart Fail."},{"key":"10.1016\/j.bbrc.2010.05.086_bib6","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1007\/BF02938356","article-title":"Role of inflammation in the progression of heart failure","volume":"9","author":"Yndestad","year":"2007","journal-title":"Curr. Cardiol. Rep."},{"key":"10.1016\/j.bbrc.2010.05.086_bib7","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1016\/S0008-6363(00)00142-5","article-title":"Myocardial expression of CC- and CXC-chemokines and their receptors in human end-stage heart failure","volume":"47","author":"Damas","year":"2000","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.bbrc.2010.05.086_bib8","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1016\/j.yjmcc.2006.08.008","article-title":"CXCR4 modulates contractility in adult cardiac myocytes","volume":"41","author":"Pyo","year":"2006","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.bbrc.2010.05.086_bib9","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/s00424-007-0284-5","article-title":"Antagonism of stromal cell-derived factor-1alpha reduces infarct size and improves ventricular function after myocardial infarction","volume":"455","author":"Proulx","year":"2007","journal-title":"Pflug. Arch."},{"key":"10.1016\/j.bbrc.2010.05.086_bib10","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1161\/01.RES.0000265233.40455.62","article-title":"Integrin-linked kinase at the heart of cardiac contractility, repair, and disease","volume":"100","author":"Hannigan","year":"2007","journal-title":"Circ. Res."},{"key":"10.1016\/j.bbrc.2010.05.086_bib11","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/379091a0","article-title":"Regulation of cell adhesion and anchorage-dependent growth by a new beta 1-integrin-linked protein kinase","volume":"379","author":"Hannigan","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2010.05.086_bib12","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/j.bbrc.2006.07.217","article-title":"Role of integrin-linked kinase in vascular smooth muscle cells: regulation by statins and angiotensin II","volume":"349","author":"Friedrich","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2010.05.086_bib13","doi-asserted-by":"crossref","first-page":"8134","DOI":"10.1128\/MCB.24.18.8134-8144.2004","article-title":"Integrin-linked kinase regulates endothelial cell survival and vascular development","volume":"24","author":"Friedrich","year":"2004","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.bbrc.2010.05.086_bib14","doi-asserted-by":"crossref","first-page":"16371","DOI":"10.1074\/jbc.M201240200","article-title":"Role of integrin-linked kinase in leukocyte recruitment","volume":"277","author":"Friedrich","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2010.05.086_bib15","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.bbrc.2008.09.081","article-title":"Role of integrin-linked kinase for functional capacity of endothelial progenitor cells in patients with stable coronary artery disease","volume":"377","author":"Werner","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2010.05.086_bib16","doi-asserted-by":"crossref","first-page":"2361","DOI":"10.1101\/gad.1448306","article-title":"Integrin-linked kinase, a novel component of the cardiac mechanical stretch sensor, controls contractility in the zebrafish heart","volume":"20","author":"Bendig","year":"2006","journal-title":"Genes Dev."},{"key":"10.1016\/j.bbrc.2010.05.086_bib17","doi-asserted-by":"crossref","first-page":"2355","DOI":"10.1101\/gad.1458906","article-title":"Targeted ablation of ILK from the murine heart results in dilated cardiomyopathy and spontaneous heart failure","volume":"20","author":"White","year":"2006","journal-title":"Genes Dev."},{"key":"10.1016\/j.bbrc.2010.05.086_bib18","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1161\/CIRCULATIONAHA.107.689984","article-title":"Laminin-alpha4 and integrin-linked kinase mutations cause human cardiomyopathy via simultaneous defects in cardiomyocytes and endothelial cells","volume":"116","author":"Knoll","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.bbrc.2010.05.086_bib19","doi-asserted-by":"crossref","first-page":"2271","DOI":"10.1161\/CIRCULATIONAHA.106.642330","article-title":"Integrin-linked kinase expression is elevated in human cardiac hypertrophy and induces hypertrophy in transgenic mice","volume":"114","author":"Lu","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.bbrc.2010.05.086_bib20","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1038\/nature03000","article-title":"Thymosin beta4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repair","volume":"432","author":"Bock-Marquette","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2010.05.086_bib21","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1161\/CIRCULATIONAHA.109.870725","article-title":"Increased expression of integrin-linked kinase attenuates left ventricular remodeling and improves cardiac function after myocardial infarction","volume":"120","author":"Ding","year":"2009","journal-title":"Circulation"},{"key":"10.1016\/j.bbrc.2010.05.086_bib22","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.yjmcc.2005.10.007","article-title":"17Beta-estradiol inhibits monocyte adhesion via down-regulation of Rac1 GTPase","volume":"40","author":"Friedrich","year":"2006","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.bbrc.2010.05.086_bib23","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1161\/01.CIR.0000091084.46500.BB","article-title":"Oxygen free radical release in human failing myocardium is associated with increased activity of rac1-GTPase and represents a target for statin treatment","volume":"108","author":"Maack","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.bbrc.2010.05.086_bib24","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.jacc.2007.03.041","article-title":"Role of Rac1 GTPase activation in atrial fibrillation","volume":"50","author":"Adam","year":"2007","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.bbrc.2010.05.086_bib25","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.cardiores.2006.04.005","article-title":"Association of RhoGDIalpha with Rac1 GTPase mediates free radical production during myocardial hypertrophy","volume":"71","author":"Custodis","year":"2006","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.bbrc.2010.05.086_bib26","doi-asserted-by":"crossref","first-page":"32562","DOI":"10.1074\/jbc.M801904200","article-title":"Metabolic switch and hypertrophy of cardiomyocytes following treatment with angiotensin II are prevented by AMP-activated protein kinase","volume":"283","author":"Stuck","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2010.05.086_bib27","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1172\/JCI8497","article-title":"Altered focal adhesion regulation correlates with cardiomyopathy in mice expressing constitutively active rac1","volume":"105","author":"Sussman","year":"2000","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbrc.2010.05.086_bib28","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1096\/fj.05-4579fje","article-title":"Regulation of cell\u2013matrix adhesion dynamics and Rac-1 by integrin linked kinase","volume":"20","author":"Boulter","year":"2006","journal-title":"FASEB J."},{"key":"10.1016\/j.bbrc.2010.05.086_bib29","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1161\/HYPERTENSIONAHA.109.136572","article-title":"Pressure-induced vascular oxidative stress is mediated through activation of integrin-linked kinase 1\/{beta}PIX\/Rac-1 pathway","volume":"54","author":"Vecchione","year":"2009","journal-title":"Hypertension"},{"key":"10.1016\/j.bbrc.2010.05.086_bib30","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1007\/s00392-008-0668-3","article-title":"RAS blockade with ARB and ACE inhibitors: current perspective on rationale and patient selection","volume":"97","author":"Werner","year":"2008","journal-title":"Clin. Res. Cardiol."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X10009861?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X10009861?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,11]],"date-time":"2018-12-11T01:54:38Z","timestamp":1544493278000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X10009861"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,6]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2010,6]]}},"alternative-id":["S0006291X10009861"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2010.05.086","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2010,6]]}}}