{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T01:03:30Z","timestamp":1768871010986,"version":"3.49.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2010,9,1]],"date-time":"2010-09-01T00:00:00Z","timestamp":1283299200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,9,1]],"date-time":"2010-09-01T00:00:00Z","timestamp":1283299200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2010,9,1]],"date-time":"2010-09-01T00:00:00Z","timestamp":1283299200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2010,9,1]],"date-time":"2010-09-01T00:00:00Z","timestamp":1283299200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2010,9,1]],"date-time":"2010-09-01T00:00:00Z","timestamp":1283299200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2010,9,1]],"date-time":"2010-09-01T00:00:00Z","timestamp":1283299200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2010,9,1]],"date-time":"2010-09-01T00:00:00Z","timestamp":1283299200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2010,9]]},"DOI":"10.1016\/j.bbrc.2010.07.125","type":"journal-article","created":{"date-parts":[[2010,8,4]],"date-time":"2010-08-04T04:50:11Z","timestamp":1280897411000},"page":"617-622","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"title":["The HPV-16 E5 protein represses expression of stress pathway genes XBP-1 and COX-2 in genital keratinocytes"],"prefix":"10.1016","volume":"399","author":[{"given":"Sawali R.","family":"Sudarshan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Schlegel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuefeng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2010.07.125_b0005","first-page":"74","article-title":"Global cancer statistics, 2002","volume":"55","author":"Parkin","year":"2005","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.bbrc.2010.07.125_b0195","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1056\/NEJMoa021641","article-title":"Epidemiologic classification of human papillomavirus types associated with cervical cancer","volume":"348","author":"Munoz","year":"2003","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbrc.2010.07.125_b0015","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.virol.2008.11.017","article-title":"Papillomavirus E6 proteins","volume":"384","author":"Howie","year":"2009","journal-title":"Virology"},{"key":"10.1016\/j.bbrc.2010.07.125_b0020","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.virol.2008.10.006","article-title":"The human papillomavirus E7 oncoprotein","volume":"384","author":"McLaughlin-Drubin","year":"2009","journal-title":"Virology"},{"key":"10.1016\/j.bbrc.2010.07.125_b0025","doi-asserted-by":"crossref","first-page":"18780","DOI":"10.1073\/pnas.0906357106","article-title":"HPV E6 protein interacts physically and functionally with the cellular telomerase complex","volume":"106","author":"Liu","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbrc.2010.07.125_b0030","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1038\/sj.onc.1210725","article-title":"HPV-16 E5 oncoprotein upregulates lipid raft components caveolin-1 and ganglioside GM1 at the plasma membrane of cervical cells","volume":"27","author":"Suprynowicz","year":"2008","journal-title":"Oncogene"},{"key":"10.1016\/j.bbrc.2010.07.125_b0035","doi-asserted-by":"crossref","first-page":"4521","DOI":"10.1128\/jvi.67.8.4521-4532.1993","article-title":"The E5 oncoprotein of human papillomavirus type 16 transforms fibroblasts and effects the downregulation of the epidermal growth factor receptor in keratinocytes","volume":"67","author":"Straight","year":"1993","journal-title":"J. Virol."},{"key":"10.1016\/j.bbrc.2010.07.125_b0040","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1006\/viro.1996.0475","article-title":"The E5 gene of HPV-16 enhances keratinocyte immortalization by full-length DNA","volume":"223","author":"Stoppler","year":"1996","journal-title":"Virology"},{"key":"10.1016\/j.bbrc.2010.07.125_b0045","doi-asserted-by":"crossref","first-page":"6534","DOI":"10.1158\/0008-5472.CAN-05-0083","article-title":"Requirement of epidermal growth factor receptor for hyperplasia induced by E5, a high-risk human papillomavirus oncogene","volume":"65","author":"Genther Williams","year":"2005","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbrc.2010.07.125_b0050","doi-asserted-by":"crossref","first-page":"682","DOI":"10.2353\/ajpath.2008.080280","article-title":"Koilocytosis: a cooperative interaction between the human papillomavirus E5 and E6 oncoproteins","volume":"173","author":"Krawczyk","year":"2008","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.bbrc.2010.07.125_b0055","doi-asserted-by":"crossref","first-page":"6170","DOI":"10.1128\/jvi.67.10.6170-6178.1993","article-title":"The human papillomavirus type 6 and 16 E5 proteins are membrane-associated proteins which associate with the 16-kilodalton pore-forming protein","volume":"67","author":"Conrad","year":"1993","journal-title":"J. Virol."},{"key":"10.1016\/j.bbrc.2010.07.125_b0060","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1006\/viro.2000.0376","article-title":"A mutagenic analysis of the E5 protein of human papillomavirus type 16 reveals that E5 binding to the vacuolar H+-ATPase is not sufficient for biological activity, using mammalian and yeast expression systems","volume":"272","author":"Adam","year":"2000","journal-title":"Virology"},{"key":"10.1016\/j.bbrc.2010.07.125_b0065","doi-asserted-by":"crossref","first-page":"6830","DOI":"10.1074\/jbc.270.12.6830","article-title":"Vacuolar H(+)-ATPase mutants transform cells and define a binding site for the papillomavirus E5 oncoprotein","volume":"270","author":"Andresson","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2010.07.125_b0070","doi-asserted-by":"crossref","first-page":"10042","DOI":"10.1128\/JVI.01240-08","article-title":"Bap31 is a novel target of the human papillomavirus E5 protein","volume":"82","author":"Regan","year":"2008","journal-title":"J. Virol."},{"key":"10.1016\/j.bbrc.2010.07.125_b0075","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.1002\/ijc.22089","article-title":"E5 protein of human papillomavirus 16 downregulates HLA class I and interacts with the heavy chain via its first hydrophobic domain","volume":"119","author":"Ashrafi","year":"2006","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.bbrc.2010.07.125_b0080","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1186\/1743-422X-4-116","article-title":"The E5 protein of the human papillomavirus type 16 down-regulates HLA-I surface expression in calnexin-expressing but not in calnexin-deficient cells","volume":"4","author":"Gruener","year":"2007","journal-title":"Virol. J."},{"key":"10.1016\/j.bbrc.2010.07.125_b0085","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1038\/sj.onc.1209768","article-title":"ErbB4 (JM-b\/CYT-1)-induced expression and phosphorylation of c-Jun is abrogated by human papillomavirus type 16 E5 protein","volume":"26","author":"Chen","year":"2007","journal-title":"Oncogene"},{"key":"10.1016\/j.bbrc.2010.07.125_b0090","doi-asserted-by":"crossref","first-page":"12833","DOI":"10.1128\/JVI.01003-09","article-title":"The canine papillomavirus E5 protein signals from the endoplasmic reticulum","volume":"83","author":"Condjella","year":"2009","journal-title":"J. Virol."},{"key":"10.1016\/j.bbrc.2010.07.125_b0095","doi-asserted-by":"crossref","first-page":"4343","DOI":"10.1128\/JVI.02054-07","article-title":"XBP-1, a novel human T-lymphotropic virus type 1 (HTLV-1) tax binding protein, activates HTLV-1 basal and tax-activated transcription","volume":"82","author":"Ku","year":"2008","journal-title":"J. Virol."},{"key":"10.1016\/j.bbrc.2010.07.125_b0100","doi-asserted-by":"crossref","first-page":"17158","DOI":"10.1074\/jbc.M312144200","article-title":"Hepatitis C virus suppresses the IRE1-XBP1 pathway of the unfolded protein response","volume":"279","author":"Tardif","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2010.07.125_b0105","doi-asserted-by":"crossref","first-page":"11868","DOI":"10.1128\/JVI.00879-06","article-title":"Flavivirus infection activates the XBP1 pathway of the unfolded protein response to cope with endoplasmic reticulum stress","volume":"80","author":"Yu","year":"2006","journal-title":"J. Virol."},{"key":"10.1016\/j.bbrc.2010.07.125_b0110","doi-asserted-by":"crossref","first-page":"2532","DOI":"10.1038\/sj.onc.1210916","article-title":"Genes involved in cell adhesion, cell motility and mitogenic signaling are altered due to HPV 16 E5 protein expression","volume":"27","author":"Kivi","year":"2008","journal-title":"Oncogene"},{"key":"10.1016\/j.bbrc.2010.07.125_b0115","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0042-6822(03)00129-6","article-title":"Codon optimization of the HPV-16 E5 gene enhances protein expression","volume":"311","author":"Disbrow","year":"2003","journal-title":"Virology"},{"key":"10.1016\/j.bbrc.2010.07.125_b0120","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1016\/S0002-9440(10)62552-7","article-title":"Cervical epithelial cells transduced with the papillomavirus E6\/E7 oncogenes maintain stable levels of oncoprotein expression but exhibit progressive, major increases in hTERT gene expression and telomerase activity","volume":"160","author":"Baege","year":"2002","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.bbrc.2010.07.125_b0125","doi-asserted-by":"crossref","first-page":"8392","DOI":"10.1073\/pnas.90.18.8392","article-title":"Production of high-titer helper-free retroviruses by transient transfection","volume":"90","author":"Pear","year":"1993","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbrc.2010.07.125_b0130","doi-asserted-by":"crossref","first-page":"46384","DOI":"10.1074\/jbc.M403568200","article-title":"Endoplasmic reticulum stress stimulates the expression of cyclooxygenase-2 through activation of NF-kappaB and pp38 mitogen-activated protein kinase","volume":"279","author":"Hung","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2010.07.125_b0135","doi-asserted-by":"crossref","first-page":"4162","DOI":"10.1128\/JVI.76.9.4162-4171.2002","article-title":"Japanese encephalitis virus infection initiates endoplasmic reticulum stress and an unfolded protein response","volume":"76","author":"Su","year":"2002","journal-title":"J. Virol."},{"key":"10.1016\/j.bbrc.2010.07.125_b0140","doi-asserted-by":"crossref","first-page":"2101","DOI":"10.1056\/NEJMp058171","article-title":"The promise of global cervical-cancer prevention","volume":"353","author":"Schiffman","year":"2005","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbrc.2010.07.125_b0145","doi-asserted-by":"crossref","first-page":"6155","DOI":"10.1158\/1078-0432.CCR-04-2664","article-title":"Epidermal growth factor-induced cyclooxygenase-2 expression is mediated through phosphatidylinositol-3 kinase, not mitogen-activated protein\/extracellular signal-regulated kinase kinase, in recurrent respiratory papillomas","volume":"11","author":"Wu","year":"2005","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.bbrc.2010.07.125_b0150","doi-asserted-by":"crossref","first-page":"143","DOI":"10.2119\/2007-00005.Wu","article-title":"Up-regulation of Rac1 by epidermal growth factor mediates COX-2 expression in recurrent respiratory papillomas","volume":"13","author":"Wu","year":"2007","journal-title":"Mol. Med."},{"key":"10.1016\/j.bbrc.2010.07.125_b0155","doi-asserted-by":"crossref","first-page":"3976","DOI":"10.1158\/0008-5472.CAN-06-4273","article-title":"Cyclooxygenase-2 transcription is regulated by human papillomavirus 16 E6 and E7 oncoproteins: evidence of a corepressor\/coactivator exchange","volume":"67","author":"Subbaramaiah","year":"2007","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbrc.2010.07.125_b0160","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1093\/carcin\/bgp066","article-title":"Involvement of NF-kappaB and AP-1 in COX-2 upregulation by human papillomavirus 16 E5 oncoprotein","volume":"30","author":"Kim","year":"2009","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.bbrc.2010.07.125_b0165","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1111\/j.1440-1746.2008.05509.x","article-title":"Early upregulation of cyclooxygenase-2 in human papillomavirus type 16 and telomerase-induced immortalization of human esophageal epithelial cells","volume":"23","author":"Zhuang","year":"2008","journal-title":"J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.bbrc.2010.07.125_b0170","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1097\/MEG.0b013e32832c7e76","article-title":"The relationship between HPV16 and expression of cyclooxygenase-2, P53 and their prognostic roles in esophageal squamous cell carcinoma","volume":"22","author":"Liu","year":"2010","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.bbrc.2010.07.125_b0175","doi-asserted-by":"crossref","first-page":"2009","DOI":"10.1111\/j.1525-1438.2006.00727.x","volume":"16","author":"Song","year":"2006","journal-title":"Int. J. Gynecol. Cancer"},{"key":"10.1016\/j.bbrc.2010.07.125_b0180","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.ygyno.2006.01.052","article-title":"Expression of cyclooxygenase-2 (COX-2) and Ki67 as related to disease severity and HPV detection in squamous lesions of the cervix","volume":"102","author":"Sarian","year":"2006","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.bbrc.2010.07.125_b0185","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0090-8258(03)00224-5","article-title":"Expression of cyclooxygenase-1 and -2 associated with expression of VEGF in primary cervical cancer and at metastatic lymph nodes","volume":"90","author":"Kim","year":"2003","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.bbrc.2010.07.125_b0190","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1159\/000081727","article-title":"Evaluation of expression of apoptosis-related proteins and their correlation with HPV, telomerase activity, and apoptotic index in cervical cancer","volume":"71","author":"Singh","year":"2004","journal-title":"Pathobiology"}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X10014580?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X10014580?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T10:51:46Z","timestamp":1757760706000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X10014580"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,9]]},"references-count":38,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2010,9]]}},"alternative-id":["S0006291X10014580"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2010.07.125","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2010,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The HPV-16 E5 protein represses expression of stress pathway genes XBP-1 and COX-2 in genital keratinocytes","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2010.07.125","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}