{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:06:51Z","timestamp":1791216411554,"version":"4.1.0"},"reference-count":35,"publisher":"Elsevier BV","issue":"3-4","license":[{"start":{"date-parts":[[2010,12,1]],"date-time":"2010-12-01T00:00:00Z","timestamp":1291161600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,12,1]],"date-time":"2010-12-01T00:00:00Z","timestamp":1291161600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100006380","name":"Rehabilitation Research and Development Service","doi-asserted-by":"publisher","award":["B3347K"],"award-info":[{"award-number":["B3347K"]}],"id":[{"id":"10.13039\/100006380","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006380","name":"Rehabilitation Research and Development Service","doi-asserted-by":"publisher","award":["B3522R"],"award-info":[{"award-number":["B3522R"]}],"id":[{"id":"10.13039\/100006380","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006380","name":"Rehabilitation Research and Development Service","doi-asserted-by":"publisher","award":["B4162C"],"award-info":[{"award-number":["B4162C"]}],"id":[{"id":"10.13039\/100006380","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2010,12]]},"DOI":"10.1016\/j.bbrc.2010.11.061","type":"journal-article","created":{"date-parts":[[2010,11,20]],"date-time":"2010-11-20T04:24:02Z","timestamp":1290227042000},"page":"473-478","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":62,"title":["Protection against dexamethasone-induced muscle atrophy is related to modulation by testosterone of FOXO1 and PGC-1\u03b1"],"prefix":"10.1016","volume":"403","author":[{"given":"Weiping","family":"Qin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangping","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William A.","family":"Bauman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Cardozo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2010.11.061_b0005","first-page":"E621","article-title":"Sensitivity of myofibrillar proteins to glucocorticoid-induced muscle proteolysis","volume":"252","author":"Kayali","year":"1987","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.bbrc.2010.11.061_b0010","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1042\/bj1560185","article-title":"The relative importance of muscle protein synthesis and breakdown in the regulation of muscle mass","volume":"156","author":"Millward","year":"1976","journal-title":"Biochem. J."},{"key":"10.1016\/j.bbrc.2010.11.061_b0015","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1126\/science.1065874","article-title":"Identification of ubiquitin ligases required for skeletal muscle atrophy","volume":"294","author":"Bodine","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.bbrc.2010.11.061_b0020","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/S0092-8674(04)00400-3","article-title":"Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy","volume":"117","author":"Sandri","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2010.11.061_b0025","doi-asserted-by":"crossref","first-page":"E785","DOI":"10.1152\/ajpendo.00646.2007","article-title":"The glucocorticoid receptor and FOXO1 synergistically activate the skeletal muscle atrophy-associated MuRF1 gene","volume":"295","author":"Waddell","year":"2008","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.bbrc.2010.11.061_b0030","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1096\/fj.03-0610com","article-title":"Multiple types of skeletal muscle atrophy involve a common program of changes in gene expression","volume":"18","author":"Lecker","year":"2004","journal-title":"FASEB J."},{"key":"10.1016\/j.bbrc.2010.11.061_b0035","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.cmet.2007.09.009","article-title":"The E3 Ligase MuRF1 degrades myosin heavy chain protein in dexamethasone-treated skeletal muscle","volume":"6","author":"Clarke","year":"2007","journal-title":"Cell Metab."},{"key":"10.1016\/j.bbrc.2010.11.061_b0040","doi-asserted-by":"crossref","first-page":"E76","DOI":"10.1152\/ajpendo.2000.278.1.E76","article-title":"Acute attenuation of translation initiation and protein synthesis by glucocorticoids in skeletal muscle","volume":"278","author":"Shah","year":"2000","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.bbrc.2010.11.061_b0045","doi-asserted-by":"crossref","first-page":"39128","DOI":"10.1074\/jbc.M610023200","article-title":"Dexamethasone represses signaling through the mammalian target of rapamycin in muscle cells by enhancing expression of REDD1","volume":"281","author":"Wang","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2010.11.061_b0050","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.ceb.2005.09.009","article-title":"Growing roles for the mTOR pathway","volume":"17","author":"Sarbassov","year":"2005","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.bbrc.2010.11.061_b0055","doi-asserted-by":"crossref","first-page":"5834","DOI":"10.1128\/MCB.25.14.5834-5845.2005","article-title":"Regulation of mTOR and cell growth in response to energy stress by REDD1","volume":"25","author":"Sofer","year":"2005","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.bbrc.2010.11.061_b0060","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1096\/fj.06-6604com","article-title":"Rapid disuse and denervation atrophy involve transcriptional changes similar to those of muscle wasting during systemic diseases","volume":"21","author":"Sacheck","year":"2007","journal-title":"FASEB J."},{"key":"10.1016\/j.bbrc.2010.11.061_b0065","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1210\/en.2009-0530","article-title":"REDD1 is a major target of testosterone action in preventing dexamethasone-induced muscle loss","volume":"151","author":"Wu","year":"2009","journal-title":"Endocrinology"},{"key":"10.1016\/j.bbrc.2010.11.061_b0070","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1677\/jme.0.0300253","article-title":"Nutritional and hormonal factors control the gene expression of FoxOs, the mammalian homologues of DAF-16","volume":"30","author":"Imae","year":"2003","journal-title":"J. Mol. Endocrinol."},{"key":"10.1016\/j.bbrc.2010.11.061_b0075","doi-asserted-by":"crossref","first-page":"41114","DOI":"10.1074\/jbc.M400674200","article-title":"Skeletal muscle FOXO1 (FKHR) transgenic mice have less skeletal muscle mass, down-regulated type I (slow twitch\/red muscle) fiber genes, and impaired glycemic control","volume":"279","author":"Kamei","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2010.11.061_b0080","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/S1097-2765(04)00211-4","article-title":"The IGF-1\/PI3K\/Akt pathway prevents expression of muscle atrophy-induced ubiquitin ligases by inhibiting FOXO transcription factors","volume":"14","author":"Stitt","year":"2004","journal-title":"Mol. Cell"},{"key":"10.1016\/j.bbrc.2010.11.061_b0085","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1101\/gad.1617608","article-title":"Hypoxia regulates TSC1\/2-mTOR signaling and tumor suppression through REDD1-mediated 14-3-3 shuttling","volume":"22","author":"DeYoung","year":"2008","journal-title":"Genes Dev."},{"key":"10.1016\/j.bbrc.2010.11.061_b0090","doi-asserted-by":"crossref","first-page":"21176","DOI":"10.1074\/jbc.M702039200","article-title":"FOXO1 regulates the expression of 4E-BP1 and inhibits mTOR signaling in mammalian skeletal muscle","volume":"282","author":"Southgate","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2010.11.061_b0095","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/j.bbrc.2008.11.123","article-title":"Dependence of dexamethasone-induced Akt\/FOXO1 signaling, upregulation of MAFbx, and protein catabolism upon the glucocorticoid receptor","volume":"378","author":"Zhao","year":"2009","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2010.11.061_b0100","doi-asserted-by":"crossref","first-page":"16260","DOI":"10.1073\/pnas.0607795103","article-title":"PGC-1alpha protects skeletal muscle from atrophy by suppressing FoxO3 action and atrophy-specific gene transcription","volume":"103","author":"Sandri","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbrc.2010.11.061_b0105","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1074\/jbc.M606116200","article-title":"Exercise-induced mitochondrial biogenesis begins before the increase in muscle PGC-1alpha expression","volume":"282","author":"Wright","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2010.11.061_b0110","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.bbrc.2005.12.011","article-title":"AMPK activation increases fatty acid oxidation in skeletal muscle by activating PPARalpha and PGC-1","volume":"340","author":"Lee","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2010.11.061_b0115","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1001\/archinte.1996.00440100065008","article-title":"Testosterone therapy in glucocorticoid-treated men","volume":"156","author":"Reid","year":"1996","journal-title":"Arch. Intern. Med."},{"key":"10.1016\/j.bbrc.2010.11.061_b0120","doi-asserted-by":"crossref","first-page":"3167","DOI":"10.1210\/jc.2002-021827","article-title":"Randomized placebo-controlled trial of androgen effects on muscle and bone in men requiring long-term systemic glucocorticoid treatment","volume":"88","author":"Crawford","year":"2003","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bbrc.2010.11.061_b0125","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.jsbmb.2008.03.024","article-title":"Testosterone protects against dexamethasone-induced muscle atrophy, protein degradation and MAFbx upregulation","volume":"110","author":"Zhao","year":"2008","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.bbrc.2010.11.061_b0135","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1002\/mus.20888","article-title":"Effects of nandrolone on denervation atrophy depend upon time after nerve transection","volume":"37","author":"Zhao","year":"2008","journal-title":"Muscle Nerve"},{"key":"10.1016\/j.bbrc.2010.11.061_b0140","doi-asserted-by":"crossref","first-page":"5449","DOI":"10.1210\/en.2008-0664","article-title":"Expression of the muscle arophy factor MAFbx is suppressed by testosterone","volume":"149","author":"Zhao","year":"2008","journal-title":"Endocrinology"},{"key":"10.1016\/j.bbrc.2010.11.061_b0145","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1152\/japplphysiol.01113.2002","article-title":"Atrophy responses to muscle inactivity. II. Molecular markers of protein deficits","volume":"95","author":"Haddad","year":"2003","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.bbrc.2010.11.061_b0150","doi-asserted-by":"crossref","first-page":"C1161","DOI":"10.1152\/ajpcell.00128.2003","article-title":"Nerve activity-independent regulation of skeletal muscle atrophy: role of MyoD and myogenin in satellite cells and myonuclei","volume":"285","author":"Hyatt","year":"2003","journal-title":"Am. J. Physiol. Cell. Physiol."},{"key":"10.1016\/j.bbrc.2010.11.061_b0155","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1172\/JCI27794","article-title":"PGC-1 coactivators: inducible regulators of energy metabolism in health and disease","volume":"116","author":"Finck","year":"2006","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbrc.2010.11.061_b0160","doi-asserted-by":"crossref","first-page":"25970","DOI":"10.1074\/jbc.M703634200","article-title":"Intramolecular control of protein stability, subnuclear compartmentalization, and coactivator function of peroxisome proliferator-activated receptor gamma coactivator 1alpha","volume":"282","author":"Sano","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2010.11.061_b0165","doi-asserted-by":"crossref","first-page":"E799","DOI":"10.1152\/ajpendo.00448.2009","article-title":"The microRNA miR-696 regulates PGC-1{alpha} in mouse skeletal muscle in response to physical activity","volume":"298","author":"Aoi","year":"2010","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.bbrc.2010.11.061_b0170","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1128\/MCB.21.3.771-780.2001","article-title":"Dexamethasone destabilizes cyclooxygenase 2 mRNA by inhibiting mitogen-activated protein kinase p38","volume":"21","author":"Lasa","year":"2001","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.bbrc.2010.11.061_b0175","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1677\/JOE-08-0476","article-title":"Mouse model of testosterone-induced muscle fiber hypertrophy: involvement of p38 mitogen-activated protein kinase-mediated Notch signaling","volume":"201","author":"Brown","year":"2009","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.bbrc.2010.11.061_b0180","doi-asserted-by":"crossref","first-page":"3706","DOI":"10.1210\/en.2010-0150","article-title":"Effects of a novel selective androgen receptor modulator on dexamethasone-induced and hypogonadism-induced muscle atrophy","volume":"151","author":"Jones","year":"2010","journal-title":"Endocrinology"}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X10021200?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X10021200?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T14:23:47Z","timestamp":1762093427000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X10021200"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,12]]},"references-count":35,"journal-issue":{"issue":"3-4","published-print":{"date-parts":[[2010,12]]}},"alternative-id":["S0006291X10021200"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2010.11.061","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2010,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Protection against dexamethasone-induced muscle atrophy is related to modulation by testosterone of FOXO1 and PGC-1\u03b1","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2010.11.061","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}