{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T08:19:00Z","timestamp":1779092340835,"version":"3.51.4"},"reference-count":26,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2011,3,1]],"date-time":"2011-03-01T00:00:00Z","timestamp":1298937600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2011,3]]},"DOI":"10.1016\/j.bbrc.2011.02.040","type":"journal-article","created":{"date-parts":[[2011,2,16]],"date-time":"2011-02-16T16:35:15Z","timestamp":1297874115000},"page":"341-347","source":"Crossref","is-referenced-by-count":45,"title":["Cloning and characterization of the biosynthetic gene cluster of the bacterial RNA polymerase inhibitor tirandamycin from marine-derived Streptomyces sp. SCSIO1666"],"prefix":"10.1016","volume":"406","author":[{"given":"Xuhua","family":"Mo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhongwen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junying","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongbo","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinpeng","family":"Tian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Si","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changsheng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianhua","family":"Ju","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2011.02.040_b0005","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1021\/cr00038a009","article-title":"Naturally-occurring tetramic acids \u2013 structure, isolation, and synthesis","volume":"95","author":"Royles","year":"1995","journal-title":"Chem. Rev."},{"key":"10.1016\/j.bbrc.2011.02.040_b0010","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1128\/AAC.10.4.618","article-title":"Tirandamycin, an inhibitor of bacterial ribonucleic-acid polymerase","volume":"10","author":"Reusser","year":"1976","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.bbrc.2011.02.040_b0015","doi-asserted-by":"crossref","first-page":"558","DOI":"10.7164\/antibiotics.24.558","article-title":"Tirandamycin, a new antibiotic isolation and characterization","volume":"24","author":"Meyer","year":"1971","journal-title":"J. Antibiot."},{"key":"10.1016\/j.bbrc.2011.02.040_b0020","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/BF00425114","article-title":"Metabolic products of microorganisms .158. Tirandamycin-B","volume":"109","author":"Hagenmaier","year":"1976","journal-title":"Arch. Microbiol."},{"key":"10.1016\/j.bbrc.2011.02.040_b0025","doi-asserted-by":"crossref","first-page":"2076","DOI":"10.1021\/np9005597","article-title":"Isolation and characterization of tirandamycins from a marine-derived Streptomyces sp.","volume":"72","author":"Carlson","year":"2009","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.bbrc.2011.02.040_b0030","first-page":"12","article-title":"Fermentation optimization, isolation and identification of tirandamycins A and B from marine-derived Streptomyces sp. SCSIO 1666","volume":"29","author":"Duan","year":"2010","journal-title":"Chin. J. Mar. Drugs"},{"key":"10.1016\/j.bbrc.2011.02.040_b0035","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/j.molcel.2005.07.020","article-title":"Structural basis of transcription inhibition by antibiotic streptolydigin","volume":"19","author":"Temiakov","year":"2005","journal-title":"Mol. Cell"},{"key":"10.1016\/j.bbrc.2011.02.040_b0040","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1016\/j.chembiol.2009.09.015","article-title":"Deciphering biosynthesis of the RNA polymerase inhibitor streptolydigin and generation of glycosylated derivatives","volume":"16","author":"Olano","year":"2009","journal-title":"Chem. Biol."},{"key":"10.1016\/j.bbrc.2011.02.040_b0045","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1002\/cbic.200900658","article-title":"Identification of the tirandamycin biosynthetic gene cluster from Streptomyces sp. 307-9","volume":"11","author":"Carlson","year":"2010","journal-title":"ChemBioChem."},{"key":"10.1016\/j.bbrc.2011.02.040_b0050","doi-asserted-by":"crossref","first-page":"2113","DOI":"10.1128\/AAC.00007-06","article-title":"Biosynthetic gene cluster for the polyenoyltetramic acid a-lipomycin","volume":"50","author":"Bihlmaier","year":"2006","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.bbrc.2011.02.040_b0055","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1007\/s00248-004-0249-6","article-title":"New PCR primers for the screening of NRPS and PKS-I systems in actinomycetes: detection and distribution of these biosynthetic gene sequences in major taxonomic groups","volume":"49","author":"Ayuso-Sacido","year":"2005","journal-title":"Microb. Ecol."},{"key":"10.1016\/j.bbrc.2011.02.040_b0060","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1002\/cbic.200300581","article-title":"Conserved amino acid residues correlating with ketoreductase stereospecificity in modular polyketide synthases","volume":"4","author":"Caffrey","year":"2003","journal-title":"ChemBioChem."},{"key":"10.1016\/j.bbrc.2011.02.040_b0065","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1021\/bi0268706","article-title":"A model of structure and catalysis for ketoreductase domains in modular polyketide synthases","volume":"42","author":"Reid","year":"2003","journal-title":"Biochemistry"},{"key":"10.1016\/j.bbrc.2011.02.040_b0070","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.chembiol.2007.12.009","article-title":"Molecular analysis of the kirromycin biosynthetic gene cluster revealed beta-alanine as precursor of the pyridone moiety","volume":"15","author":"Weber","year":"2008","journal-title":"Chem. Biol."},{"key":"10.1016\/j.bbrc.2011.02.040_b0075","doi-asserted-by":"crossref","first-page":"5799","DOI":"10.1093\/nar\/gki885","article-title":"Specificity prediction of adenylation domains in nonribosomal peptide synthetases (NRPS) using transductive support vector machines (TSVMS)","volume":"33","author":"Rausch","year":"2005","journal-title":"Nucl. Acids Res."},{"key":"10.1016\/j.bbrc.2011.02.040_b0080","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1039\/B912037H","article-title":"PKS and NRPS release mechanisms","volume":"27","author":"Du","year":"2010","journal-title":"Nat. Prod. Rep."},{"key":"10.1016\/j.bbrc.2011.02.040_b0085","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1099\/13500872-145-6-1287","article-title":"A subfamily of malt-related ATP-dependent regulators in the LuxR family","volume":"145","author":"De Schrijver","year":"1999","journal-title":"Microbiology"},{"key":"10.1016\/j.bbrc.2011.02.040_b0090","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1007\/s00203-007-0346-2","article-title":"The LuxR family members GdmRI and GdmRII are positive regulators of geldanamycin biosynthesis in Streptomyces hygroscopicus 17997","volume":"189","author":"He","year":"2008","journal-title":"Arch. Microbiol."},{"key":"10.1016\/j.bbrc.2011.02.040_b0095","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1128\/MMBR.69.2.326-356.2005","article-title":"The TetR family of transcriptional repressors","volume":"69","author":"Ramos","year":"2005","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"10.1016\/j.bbrc.2011.02.040_b0100","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1099\/mic.0.2007\/014381-0","article-title":"Conditionally positive effect of the TetR-family transcriptional regulator AtrA on streptomycin production by Streptomyces griseus","volume":"154","author":"Hirano","year":"2008","journal-title":"Microbiology"},{"key":"10.1016\/j.bbrc.2011.02.040_b0105","doi-asserted-by":"crossref","first-page":"48028","DOI":"10.1074\/jbc.M207770200","article-title":"Biochemical evidence for an editing role of thioesterase II in the biosynthesis of the polyketide pikromycin","volume":"277","author":"Kim","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2011.02.040_b0110","doi-asserted-by":"crossref","first-page":"29660","DOI":"10.1074\/jbc.M604895200","article-title":"A dedicated phosphopantetheinyl transferase for the fredericamycin polyketide synthase from Streptomyces griseus","volume":"281","author":"Huang","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2011.02.040_b0115","doi-asserted-by":"crossref","first-page":"4172","DOI":"10.1128\/AEM.00734-06","article-title":"Isolation, characterization, and heterologous expression of the biosynthesis gene cluster for the antitumor anthracycline steffimycin","volume":"72","author":"Gull\u00f3n","year":"2006","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.bbrc.2011.02.040_b0120","doi-asserted-by":"crossref","first-page":"28607","DOI":"10.1074\/jbc.M804279200","article-title":"Characterization of the tautomycin biosynthetic gene cluster from Streptomyces spiroverticillatus unveiling new insights into dialkylmaleic anhydride and polyketide biosynthesis","volume":"283","author":"Li","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2011.02.040_b0125","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.chembiol.2006.11.013","article-title":"Spiroketal polyketide formation in sorangium: identification and analysis of the biosynthetic gene cluster for the highly cytotoxic spirangienes","volume":"14","author":"Frank","year":"2007","journal-title":"Chem. Biol."},{"key":"10.1016\/j.bbrc.2011.02.040_b0130","doi-asserted-by":"crossref","first-page":"3468","DOI":"10.1128\/JB.183.11.3468-3475.2001","article-title":"Characterization and analysis of the PikD regulatory factor in the pikromycin biosynthetic pathway of Streptomyces venezuelae","volume":"183","author":"Wilson","year":"2001","journal-title":"J. Bacteriol."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X11002324?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X11002324?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,4]],"date-time":"2018-12-04T20:26:55Z","timestamp":1543955215000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X11002324"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,3]]},"references-count":26,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2011,3]]}},"alternative-id":["S0006291X11002324"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2011.02.040","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2011,3]]}}}