{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T19:26:28Z","timestamp":1780514788894,"version":"3.54.1"},"reference-count":24,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T00:00:00Z","timestamp":1314835200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2011,9]]},"DOI":"10.1016\/j.bbrc.2011.07.087","type":"journal-article","created":{"date-parts":[[2011,8,2]],"date-time":"2011-08-02T23:34:05Z","timestamp":1312328045000},"page":"419-424","source":"Crossref","is-referenced-by-count":27,"title":["Impedance measurement: A new method to detect ligand-biased receptor signaling"],"prefix":"10.1016","volume":"412","author":[{"given":"M.","family":"Kammermann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Denelavas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Imbach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"U.","family":"Grether","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Dehmlow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.M.","family":"Apfel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Hertel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2011.07.087_b0005","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/j.1365-201X.2007.01696.x","article-title":"Novel aspects of G-protein-coupled receptor signalling \u2013 different ways to achieve specificity","volume":"190","author":"Schulte","year":"2007","journal-title":"Acta Physiologica"},{"key":"10.1016\/j.bbrc.2011.07.087_b0010","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.tips.2007.06.008","article-title":"Allosteric enhancers, allosteric agonists and ago-allosteric modulators: where do they bind and how do they act?","volume":"28","author":"Schwartz","year":"2007","journal-title":"Trends in Pharmacological Sciences"},{"key":"10.1016\/j.bbrc.2011.07.087_b0015","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1126\/science.1063866","article-title":"Regulation of receptor fate by ubiquitination of activated \u03b22-adrenergic receptor and \u03b2-arrestin","volume":"294","author":"Shenoy","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.bbrc.2011.07.087_b0020","doi-asserted-by":"crossref","first-page":"5669","DOI":"10.1074\/jbc.M708118200","article-title":"\u03b2-arrestin-biased agonism at the \u03b22-adrenergic receptor","volume":"283","author":"Drake","year":"2008","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.bbrc.2011.07.087_b0025","doi-asserted-by":"crossref","first-page":"16657","DOI":"10.1073\/pnas.0707936104","article-title":"A unique mechanism of \u03b2-blocker action: carvedilol stimulates \u03b2-arrestin signaling","volume":"104","author":"Wisler","year":"2007","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"10.1016\/j.bbrc.2011.07.087_b0030","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/j.tips.2007.06.006","article-title":"\u03b2-arrestin-biased ligands at seven-transmembrane receptors","volume":"28","author":"Violin","year":"2007","journal-title":"Trends in Pharmacological Sciences"},{"key":"10.1016\/j.bbrc.2011.07.087_b0035","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1172\/JCI36806","article-title":"\u03b2-arrestin1 mediates nicotinic acid-induced flushing but not its antilipolytic effect, in mice","volume":"119","author":"Walters","year":"2009","journal-title":"The Journal of Clinical Investigation"},{"key":"10.1016\/j.bbrc.2011.07.087_b0040","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1080\/10799890903047437","article-title":"An optical dynamic mass redistribution assay reveals biased signaling of dualsteric GPCR activators","volume":"29","author":"Kebig","year":"2009","journal-title":"Journal of Receptor and Signal Transduction"},{"key":"10.1016\/j.bbrc.2011.07.087_b0045","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1177\/1087057108330115","article-title":"Evaluating cellular impedance assays for detection of GPCR pleiotropic signaling and functional selectivity","volume":"14","author":"Peters","year":"2009","journal-title":"Journal of Biomolecular Screening"},{"key":"10.1016\/j.bbrc.2011.07.087_b0050","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/j.coph.2009.06.015","article-title":"7TM pharmacology measured by label-free: a holistic approach to cell signalling","volume":"9","author":"Rocheville","year":"2009","journal-title":"Current Opinion in Pharmacology"},{"key":"10.1016\/j.bbrc.2011.07.087_b0055","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1021\/ac051695v","article-title":"Real-time monitoring of morphological changes in living cells by electronic cell sensor arrays: an approach to study G protein-coupled receptors","volume":"78","author":"Yu","year":"2006","journal-title":"Analytical Chemistry"},{"key":"10.1016\/j.bbrc.2011.07.087_b0060","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1016\/j.chembiol.2009.05.011","article-title":"Kinetic cell-based morphological screening: prediction of mechanism of compound action and off-target effects","volume":"16","author":"Abassi","year":"2009","journal-title":"Chemistry and Biology"},{"key":"10.1016\/j.bbrc.2011.07.087_b0065","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1038\/nbt.1671","article-title":"Deconvolution of complex G protein-coupled receptor signaling in live cells using dynamic mass redistribution measurements","volume":"28","author":"Schroder","year":"2010","journal-title":"Nature Biotechnology"},{"key":"10.1016\/j.bbrc.2011.07.087_b0070","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1177\/1087057105279635","article-title":"Dynamic monitoring of cell adhesion and spreading on microelectronic sensor arrays","volume":"10","author":"Atienza","year":"2005","journal-title":"Journal of Biomolecular Screening"},{"key":"10.1016\/j.bbrc.2011.07.087_b0075","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1177\/1087057106289334","article-title":"Label-free and real-time cell-based assay for screening selective and potent receptor tyrosine kinase inhibitors using microelectronic sensor array","volume":"11","author":"Atienza","year":"2006","journal-title":"Journal of Biomolecular Screening"},{"key":"10.1016\/j.bbrc.2011.07.087_b0080","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1021\/tx049721s","article-title":"Dynamic monitoring of cytotoxicity on microelectronic sensors","volume":"18","author":"Xing","year":"2005","journal-title":"Chemical Research in Toxicology"},{"key":"10.1016\/j.bbrc.2011.07.087_b0085","unstructured":"D.P. Behan, D.T. Connolly, J.G. Richman, Compositions for treating flushing and lipid-associated disorders comprising pyrazole compounds as niacin receptor partial agonists, WO 2006052569, 2006."},{"key":"10.1016\/j.bbrc.2011.07.087_b0090","unstructured":"G. Semple, T. Schrader, P.J. Skinner, S.L. Colletti, T. Gharbaoui, J.E. Imbriglio, J.K. Jung, R. Liang, S. Raghavan, D. Schmidt, J.R. Tata, A preparation of tetrazole derivatives, useful as a modulators of RUP25 receptor, WO 2005044816, 2005."},{"key":"10.1016\/j.bbrc.2011.07.087_b0095","doi-asserted-by":"crossref","first-page":"1844","DOI":"10.1124\/mol.106.030833","article-title":"Nicotinic acid-induced flushing is mediated by activation of epidermal langerhans cells","volume":"70","author":"Beny\u00f3","year":"2006","journal-title":"Molecular Pharmacology"},{"key":"10.1016\/j.bbrc.2011.07.087_b0100","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/0014-5793(80)80432-7","article-title":"A probe for the organization of the [beta]-adrenergic receptor-regulated adenylate cyclase system in turkey erythrocyte membranes by the use of a complementation assay","volume":"122","author":"Lad","year":"1980","journal-title":"FEBS Letters"},{"key":"10.1016\/j.bbrc.2011.07.087_b0105","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/0014-5793(87)81521-1","article-title":"A new GTP-binding protein in brain tissues serving as the specific substrate of islet-activating protein Pertussis toxin","volume":"213","author":"Katada","year":"1987","journal-title":"FEBS Letters"},{"key":"10.1016\/j.bbrc.2011.07.087_b0110","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/S0898-6568(98)00012-6","article-title":"The sevenfold way of PKC regulation","volume":"10","author":"Liu","year":"1998","journal-title":"Cellular Signalling"},{"key":"10.1016\/j.bbrc.2011.07.087_b0115","doi-asserted-by":"crossref","first-page":"18028","DOI":"10.1074\/jbc.M701866200","article-title":"Nicotinic acid receptor agonists differentially activate downstream effectors","volume":"282","author":"Richman","year":"2007","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.bbrc.2011.07.087_b0120","doi-asserted-by":"crossref","first-page":"5101","DOI":"10.1021\/jm800258p","article-title":"3-(1H-Tetrazol-5-yl)-1, 4, 5, 6-tetrahydro-cyclopentapyrazole (MK-0354): a partial agonist of the nicotinic acid receptor, G-Protein coupled receptor 109a, with antilipolytic but no vasodilatory activity in mice","volume":"51","author":"Semple","year":"2008","journal-title":"Journal of Medicinal Chemistry"}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X11013222?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X11013222?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,11,30]],"date-time":"2018-11-30T19:52:10Z","timestamp":1543607530000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X11013222"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,9]]},"references-count":24,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2011,9]]}},"alternative-id":["S0006291X11013222"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2011.07.087","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2011,9]]}}}