{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T13:28:56Z","timestamp":1791120536367,"version":"4.1.0"},"reference-count":30,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"BRNS, Department of Atomic Energy, Mumbai","award":["2002\/37\/19\/BRNS"],"award-info":[{"award-number":["2002\/37\/19\/BRNS"]}]},{"name":"BRNS, Department of Atomic Energy, Mumbai","award":["2008\/37\/30\/BRNS"],"award-info":[{"award-number":["2008\/37\/30\/BRNS"]}]},{"name":"University Grants Commission, New Delhi, India"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2012,1]]},"DOI":"10.1016\/j.bbrc.2011.12.072","type":"journal-article","created":{"date-parts":[[2011,12,23]],"date-time":"2011-12-23T16:15:41Z","timestamp":1324656941000},"page":"903-909","source":"Crossref","is-referenced-by-count":30,"title":["Diospyrin derivative, an anticancer quinonoid, regulates apoptosis at endoplasmic reticulum as well as mitochondria by modulating cytosolic calcium in human breast carcinoma cells"],"prefix":"10.1016","volume":"417","author":[{"given":"Binod","family":"Kumar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subhalakshmi","family":"Ghosh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Badri N.","family":"Pandey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaushala P.","family":"Mishra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Banasri","family":"Hazra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2011.12.072_b0005","series-title":"Calcium: The Molecular Basis of Calcium Action in Biology and Medicine","author":"Pochet","year":"2000"},{"key":"10.1016\/j.bbrc.2011.12.072_b0010","first-page":"235","article-title":"Calcium transport and signaling in the mammary gland: targets for breast cancer","volume":"1765","author":"Lee","year":"2006","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbrc.2011.12.072_b0015","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1038\/nrm1155","article-title":"Calcium signalling: dynamics, homeostasis and remodeling","volume":"4","author":"Berridge","year":"2003","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bbrc.2011.12.072_b0020","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.jsbmb.2005.06.007","article-title":"Calcium signaling in cancer and vitamin D","volume":"97","author":"Sargeev","year":"2005","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.bbrc.2011.12.072_b0025","doi-asserted-by":"crossref","first-page":"3672","DOI":"10.1016\/j.bmc.2007.03.050","article-title":"Synthesis and antiproliferative activity of some novel derivatives of diospyrin, a plant-derived naphthoquinonoid","volume":"15","author":"Sarma","year":"2007","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bbrc.2011.12.072_b0030","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1159\/000100514","article-title":"Cytotoxicity of diospyrin and its derivatives in relation to the generation of reactive oxygen species in tumour cells in vitro and in vivo","volume":"53","author":"Hazra","year":"2007","journal-title":"Chemotherapy"},{"key":"10.1016\/j.bbrc.2011.12.072_b0035","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0304-3835(02)00494-9","article-title":"Induction of apoptosis in human cancer cell lines by diospyrin, a plant-derived bisnaphthoquinonoid, and its synthetic derivatives","volume":"188","author":"Chakrabarty","year":"2002","journal-title":"Cancer Lett."},{"key":"10.1016\/j.bbrc.2011.12.072_b0040","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.toxlet.2005.01.016","article-title":"Enhancement of the tumor inhibitory activity, in vivo, of diospyrin, a plant-derived quinonoid, through liposomal encapsulation","volume":"157","author":"Hazra","year":"2005","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.bbrc.2011.12.072_b0045","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/s11010-007-9511-9","article-title":"Radiosensitization by diospyrin diethylether in MCF7 breast carcinoma cell line","volume":"304","author":"Kumar","year":"2007","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.bbrc.2011.12.072_b0050","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1080\/09553000802030736","article-title":"Increased cytotoxicity by the combination of radiation and diospyrin diethylether in fibrosarcoma in culture and in tumor","volume":"84","author":"Kumar","year":"2008","journal-title":"Int. J. Radiat. Biol."},{"key":"10.1016\/j.bbrc.2011.12.072_b0055","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/s11010-008-9920-4","article-title":"Role of mitochondrial oxidative stress in the apoptosis induced by diospyrin diethylether in human breast carcinoma (MCF-7) cells","volume":"320","author":"Kumar","year":"2009","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.bbrc.2011.12.072_b0060","doi-asserted-by":"crossref","unstructured":"P.J. O\u2019Brien, Molecular mechanisms of quinone cytotoxicity, Chem. Biol. Interact. 80 (1991) 1\u201341.","DOI":"10.1016\/0009-2797(91)90029-7"},{"key":"10.1016\/j.bbrc.2011.12.072_b0065","doi-asserted-by":"crossref","unstructured":"W.C. Chiang, Y.M. Chen, S.L. Lin, K.D. Wu, T.J. Tsai, Bradykinin enhances reactive oxygen species generation, mitochondrial injury, and cell death induced by ATP depletion\u2014a role of the phospholipase C\u2013Ca2+ pathway, Free Radical Biol. Med. 43 (2007) 702\u2013710.","DOI":"10.1016\/j.freeradbiomed.2007.04.032"},{"key":"10.1016\/j.bbrc.2011.12.072_b0075","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0162-0134(03)00284-8","article-title":"Both calcium and ROS as common signals mediate Na2SeO3-induced apoptosis in SW480 human colonic carcinoma cells","volume":"97","author":"Wang","year":"2003","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.bbrc.2011.12.072_b0080","doi-asserted-by":"crossref","unstructured":"J.R. Nofer, M. Tepel, M. Walter, U. Seedorf, G. Assmann, W. Zidek, Phosphatidylcholine-specific phospholipase C regulates thapsigargin-induced calcium influx in human lymphocytes, J. Biol. Chem. 272 (1997) 32861\u201332868.","DOI":"10.1074\/jbc.272.52.32861"},{"key":"10.1016\/j.bbrc.2011.12.072_b0085","doi-asserted-by":"crossref","first-page":"a004010","DOI":"10.1101\/cshperspect.a004010","article-title":"IP3 receptors: toward understanding their activation","volume":"2","author":"Taylor","year":"2010","journal-title":"Cold Spring Harbor Perspect. Biol."},{"key":"10.1016\/j.bbrc.2011.12.072_b0090","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/j.ceca.2006.08.016","article-title":"Mitochondrial calcium signalling and cell death: approaches for assessing the role of mitochondrial Ca2+ uptake in apoptosis","volume":"40","author":"Hajn\u00f3czky","year":"2006","journal-title":"Cell Calcium"},{"key":"10.1016\/j.bbrc.2011.12.072_b0095","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1152\/physrev.00029.2002","article-title":"The calpain system","volume":"83","author":"Goll","year":"2003","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.bbrc.2011.12.072_b0100","doi-asserted-by":"crossref","first-page":"3440","DOI":"10.1016\/S0021-9258(19)83641-4","article-title":"A new generation of Ca2+ indicators with greatly improved fluorescence properties","volume":"260","author":"Grynkiewicz","year":"1985","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2011.12.072_b0105","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1038\/74994","article-title":"Mitochondrial control of cell death","volume":"6","author":"Kroemer","year":"2000","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbrc.2011.12.072_b0110","doi-asserted-by":"crossref","unstructured":"X.M. Wang, P.I. Terasaki, J.W. Rankin, D. Chia, H.P. Zhong, S. Hardy, A new microcellular cytotoxicity test based on calcein-AM release, Hum. Immumnol. 37 (1993) 264\u2013270.","DOI":"10.1016\/0198-8859(93)90510-8"},{"key":"10.1016\/j.bbrc.2011.12.072_b0115","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1016\/j.cell.2007.11.028","article-title":"Calcium signalling","volume":"131","author":"Clapham","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2011.12.072_b0120","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S1535-6108(04)00059-5","article-title":"Selective estrogen receptor modulation: concept and consequences in cancer","volume":"5","author":"Jordan","year":"2004","journal-title":"Cancer Cell"},{"key":"10.1016\/j.bbrc.2011.12.072_b0125","doi-asserted-by":"crossref","unstructured":"T. Nakagawa, H. Zhu, N. Morishima, E. Li, J. Xu, B.A. Yankner, J. Yuan, Caspase-mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta, Nature 403 (2000) 98\u2013103.","DOI":"10.1038\/47513"},{"key":"10.1016\/j.bbrc.2011.12.072_b0130","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1016\/j.bbabio.2009.06.009","article-title":"Mitochondrial calcium and the permeability transition in cell death","author":"Lemasters","year":"2009","journal-title":"Biochim. Biophys. Acta Bioenergetics"},{"key":"10.1016\/j.bbrc.2011.12.072_b0135","doi-asserted-by":"crossref","unstructured":"A.V. Kuznetsov, R. Margreiter, A. Amberger, V. Saks, M. Grimm, Changes in mitochondrial redox state, membrane potential and calcium precede mitochondrial dysfunction in doxorubicin-induced cell death, Biochim. Biophys. Acta 1813 (2011) 1152.","DOI":"10.1016\/j.bbamcr.2011.03.002"},{"key":"10.1016\/j.bbrc.2011.12.072_b0140","doi-asserted-by":"crossref","first-page":"141","DOI":"10.4161\/cbt.2.2.237","article-title":"Calpain activation in \u03b2-lapachone-mediated apoptosis","volume":"2","author":"Tagliarino","year":"2003","journal-title":"Cancer Biol. Ther."},{"key":"10.1016\/j.bbrc.2011.12.072_b0145","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.radphyschem.2005.09.011","article-title":"Modification of radiation-induced oxidative damage in liposomal and microsomal membrane by eugenol","volume":"75","author":"Pandey","year":"2006","journal-title":"Radiat. Phys. Chem."},{"key":"10.1016\/j.bbrc.2011.12.072_b0150","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1038\/nrm1150","article-title":"Regulation of cell death: the calcium apoptosis link","volume":"4","author":"Orrenius","year":"2003","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"key":"10.1016\/j.bbrc.2011.12.072_b0155","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1146\/annurev.pharmtox.44.101802.121804","article-title":"The role of calpain in oncotic cell death","volume":"44","author":"Liu","year":"2006","journal-title":"Annu. Rev. Pharmacol. Toxicol."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X11022819?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X11022819?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,12,22]],"date-time":"2021-12-22T00:21:26Z","timestamp":1640132486000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X11022819"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,1]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,1]]}},"alternative-id":["S0006291X11022819"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2011.12.072","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2012,1]]}}}