{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T09:14:05Z","timestamp":1761988445913,"version":"3.37.3"},"reference-count":42,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2012,2,1]],"date-time":"2012-02-01T00:00:00Z","timestamp":1328054400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100001962","name":"A-T Children\u2019s Project","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100001962","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Longevity Foundation"},{"name":"NIEHS Center","award":["ES07784"],"award-info":[{"award-number":["ES07784"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2012,2]]},"DOI":"10.1016\/j.bbrc.2012.01.008","type":"journal-article","created":{"date-parts":[[2012,1,11]],"date-time":"2012-01-11T01:09:51Z","timestamp":1326244191000},"page":"267-272","source":"Crossref","is-referenced-by-count":21,"title":["Activation of AMP-activated protein kinase in cerebella of Atm\u2212\/\u2212 mice is attributable to accumulation of reactive oxygen species"],"prefix":"10.1016","volume":"418","author":[{"given":"Xianghong","family":"Kuang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingshan","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanne M.","family":"Ajmo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Virginia L.","family":"Scofield","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Stoica","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul K.Y.","family":"Wong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2012.01.008_b0005","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0167-8140(98)00027-9","article-title":"Radiosensitivity and oxidative signalling in ataxia telangiectasia: an update","volume":"47","author":"Lavin","year":"1998","journal-title":"Radiother. Oncol."},{"key":"10.1016\/j.bbrc.2012.01.008_b0010","series-title":"Neurodegeneration: Theory, Disorder and Treatment","article-title":"Oxidative stress-mediated neurodegeneration: a tale of two models","author":"Wong","year":"2011"},{"key":"10.1016\/j.bbrc.2012.01.008_b0015","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0092-8674(00)80086-0","article-title":"Atm-deficient mice: a paradigm of ataxia telangiectasia","volume":"86","author":"Barlow","year":"1996","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2012.01.008_b0020","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S1568-7864(01)00007-6","article-title":"ATM deficiency and oxidative stress: a new dimension of defective response to DNA damage","volume":"1","author":"Barzilai","year":"2002","journal-title":"DNA Repair (Amst.)"},{"key":"10.1016\/j.bbrc.2012.01.008_b0025","doi-asserted-by":"crossref","first-page":"9915","DOI":"10.1073\/pnas.96.17.9915","article-title":"Loss of the ataxia-telangiectasia gene product causes oxidative damage in target organs","volume":"96","author":"Barlow","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbrc.2012.01.008_b0030","doi-asserted-by":"crossref","first-page":"14396","DOI":"10.1074\/jbc.M808116200","article-title":"Oxidative stress is linked to ERK1\/2-p16 signaling-mediated growth defect in ATM-deficient astrocytes","volume":"284","author":"Kim","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2012.01.008_b0035","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1038\/labinvest.3700354","article-title":"ATM deficiency induces oxidative stress and endoplasmic reticulum stress in astrocytes","volume":"85","author":"Liu","year":"2005","journal-title":"Lab. Invest."},{"key":"10.1016\/j.bbrc.2012.01.008_b0040","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1002\/stem.125","article-title":"Loss of ATM impairs proliferation of neural stem cells through oxidative stress-mediated p38 MAPK signaling","volume":"27","author":"Kim","year":"2009","journal-title":"Stem cells"},{"key":"10.1016\/j.bbrc.2012.01.008_b0045","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/j.1748-1716.2009.01971.x","article-title":"The regulation and function of mammalian AMPK-related kinases","volume":"196","author":"Bright","year":"2009","journal-title":"Acta. Physiol. (Oxf.)"},{"key":"10.1016\/j.bbrc.2012.01.008_b0050","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/978-3-642-17214-4_13","article-title":"AMP-activated protein kinase and metabolic control","volume":"203","author":"Viollet","year":"2011","journal-title":"Handb. Exp. Pharmacol."},{"key":"10.1016\/j.bbrc.2012.01.008_b0055","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.1172\/JCI32975","article-title":"\u201cAMPing up\u201d our understanding of the hypothalamic control of energy balance","volume":"117","author":"Williams","year":"2007","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbrc.2012.01.008_b0060","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1002\/bies.200900003","article-title":"Expanding roles for AMP-activated protein kinase in neuronal survival and autophagy","volume":"31","author":"Poels","year":"2009","journal-title":"Bioassays"},{"key":"10.1016\/j.bbrc.2012.01.008_b0065","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0079-6123(06)53007-9","article-title":"The selfish brain: competition for energy resources","volume":"153","author":"Fehm","year":"2006","journal-title":"Prog. Brain. Res."},{"key":"10.1016\/j.bbrc.2012.01.008_b0070","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1046\/j.1471-4159.1999.721707.x","article-title":"Cellular distribution and developmental expression of AMP-activated protein kinase isoforms in mouse central nervous system","volume":"72","author":"Turnley","year":"1999","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbrc.2012.01.008_b0075","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1385\/JMN:17:1:45","article-title":"AMP-activated protein kinase is highly expressed in neurons in the developing rat brain and promotes neuronal survival following glucose deprivation","volume":"17","author":"Culmsee","year":"2001","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.bbrc.2012.01.008_b0080","doi-asserted-by":"crossref","first-page":"127","DOI":"10.3988\/jcn.2010.6.3.127","article-title":"Melatonin potentiates the neuroprotective properties of resveratrol against beta-amyloid-induced neurodegeneration by modulating AMP-activated protein kinase pathways","volume":"6","author":"Kwon","year":"2010","journal-title":"J. Clin. Neurol."},{"key":"10.1016\/j.bbrc.2012.01.008_b0085","doi-asserted-by":"crossref","first-page":"20493","DOI":"10.1074\/jbc.M409985200","article-title":"Pharmacological inhibition of AMP-activated protein kinase provides neuroprotection in stroke","volume":"280","author":"McCullough","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2012.01.008_b0090","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.neuron.2006.12.015","article-title":"Phospho-dependent functional modulation of GABA(B) receptors by the metabolic sensor AMP-dependent protein kinase","volume":"53","author":"Kuramoto","year":"2007","journal-title":"Neuron"},{"key":"10.1016\/j.bbrc.2012.01.008_b0095","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.bbrc.2008.04.102","article-title":"Activation of AMP-activated protein kinase by kainic acid mediates brain-derived neurotrophic factor expression through a NF-kappaB dependent mechanism in C6 glioma cells","volume":"371","author":"Yoon","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2012.01.008_b0100","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1038\/nm1061","article-title":"Anti-obesity effects of alpha-lipoic acid mediated by suppression of hypothalamic AMP-activated protein kinase","volume":"10","author":"Kim","year":"2004","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbrc.2012.01.008_b0105","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1016\/j.bbrc.2004.09.145","article-title":"IGF-1 phosphorylates AMPK-alpha subunit in ATM-dependent and LKB1-independent manner","volume":"324","author":"Suzuki","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2012.01.008_b0110","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/s11010-007-9575-6","article-title":"AICAR induces phosphorylation of AMPK in an ATM-dependent, LKB1-independent manner","volume":"306","author":"Sun","year":"2007","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.bbrc.2012.01.008_b0115","first-page":"1849","article-title":"Increased oxidative stress in ataxia telangiectasia evidenced by alterations in redox state of brains from Atm-deficient mice","volume":"61","author":"Kamsler","year":"2001","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbrc.2012.01.008_b0120","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1016\/j.freeradbiomed.2009.02.019","article-title":"Hypoxic activation of AMPK is dependent on mitochondrial ROS but independent of an increase in AMP\/ATP ratio","volume":"46","author":"Emerling","year":"2009","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbrc.2012.01.008_b0125","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.bbrc.2009.04.019","article-title":"Deregulation of mTOR signaling is involved in thymic lymphoma development in Atm\u2212\/\u2212 mice","volume":"383","author":"Kuang","year":"2009","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2012.01.008_b0130","doi-asserted-by":"crossref","first-page":"3095","DOI":"10.1128\/MCB.19.4.3095","article-title":"Atm is dispensable for p53 apoptosis and tumor suppression triggered by cell cycle dysfunction","volume":"19","author":"Liao","year":"1999","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.bbrc.2012.01.008_b0135","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.freeradbiomed.2004.09.025","article-title":"N-acetylcysteine amide, a novel cell-permeating thiol, restores cellular glutathione and protects human red blood cells from oxidative stress","volume":"38","author":"Grinberg","year":"2005","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbrc.2012.01.008_b0140","doi-asserted-by":"crossref","first-page":"4557","DOI":"10.1128\/JVI.80.9.4557-4569.2006","article-title":"Retrovirus-induced oxidative stress with neuroimmunodegeneration is suppressed by antioxidant treatment with a refined monosodium alpha-luminol (Galavit)","volume":"80","author":"Jiang","year":"2006","journal-title":"J. Virol."},{"key":"10.1016\/j.bbrc.2012.01.008_b0145","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1016\/j.freeradbiomed.2006.05.008","article-title":"ATM controls c-Myc and DNA synthesis during postnatal thymocyte development through regulation of redox state","volume":"41","author":"Yan","year":"2006","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbrc.2012.01.008_b0150","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1038\/nature02989","article-title":"Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells","volume":"431","author":"Ito","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2012.01.008_b0155","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1096\/fj.00-0601com","article-title":"The ataxia-telangiectasia gene product may modulate DNA turnover and control cell fate by regulating cellular redox in lymphocytes","volume":"15","author":"Yan","year":"2001","journal-title":"FASEB J."},{"key":"10.1016\/j.bbrc.2012.01.008_b0160","doi-asserted-by":"crossref","first-page":"2154","DOI":"10.1093\/hmg\/ddm166","article-title":"Intrinsic mitochondrial dysfunction in ATM-deficient lymphoblastoid cells","volume":"16","author":"Ambrose","year":"2007","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bbrc.2012.01.008_b0165","doi-asserted-by":"crossref","first-page":"2651","DOI":"10.1021\/pr101243j","article-title":"Integrated analysis of ATM mediated gene and protein expression impacting cellular metabolism","volume":"10","author":"Cheema","year":"2011","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.bbrc.2012.01.008_b0170","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1111\/j.1471-4159.2011.07331.x","article-title":"AMP-activated protein kinase: a potential player in Alzheimer\u2019s disease","volume":"118","author":"Salminen","year":"2011","journal-title":"J Neurochem."},{"key":"10.1016\/j.bbrc.2012.01.008_b0175","first-page":"54","article-title":"Oxidative stress and cell membranes in the pathogenesis of Alzheimer\u2019s disease","volume":"26","author":"Axelsen","year":"2011","journal-title":"Physiology (Bethesda)"},{"key":"10.1016\/j.bbrc.2012.01.008_b0180","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3233\/JAD-2011-110524","article-title":"Statins: the role in the treatment and prevention of Alzheimer\u2019s neurodegeneration","volume":"27","author":"Pac-Soo","year":"2011","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.bbrc.2012.01.008_b0185","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1600-079X.2011.00916.x","article-title":"Melatonin as a natural ally against oxidative stress: a physicochemical examination","volume":"51","author":"Galano","year":"2011","journal-title":"J. Pineal. Res."},{"key":"10.1016\/j.bbrc.2012.01.008_b0190","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.tox.2010.04.008","article-title":"Melatonin: action as antioxidant and potential applications in human disease and aging","volume":"278","author":"Bonnefont-Rousselot","year":"2010","journal-title":"Toxicology"},{"key":"10.1016\/j.bbrc.2012.01.008_b0195","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1089\/jop.2010.0144","article-title":"Antioxidant effect of trans-resveratrol in cultured human retinal pigment epithelial cells","volume":"27","author":"Pintea","year":"2011","journal-title":"J. Ocul. Pharmacol. Ther."},{"key":"10.1016\/j.bbrc.2012.01.008_b0200","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.molcel.2005.03.027","article-title":"AMP-activated protein kinase induces a p53-dependent metabolic checkpoint","volume":"18","author":"Jones","year":"2005","journal-title":"Mol. Cell"},{"key":"10.1016\/j.bbrc.2012.01.008_b0205","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1016\/j.neuint.2010.02.017","article-title":"Neuroprotective effects of the drug GVT (monosodium luminol) are mediated by the stabilization of Nrf2 in astrocytes","volume":"56","author":"Reddy","year":"2010","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.bbrc.2012.01.008_b0210","doi-asserted-by":"crossref","first-page":"11926","DOI":"10.1128\/JVI.78.21.11926-11938.2004","article-title":"Activation of transcription factor Nrf-2 and its downstream targets in response to moloney murine leukemia virus ts1-induced thiol depletion and oxidative stress in astrocytes","volume":"78","author":"Qiang","year":"2004","journal-title":"J. Virol."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X12000319?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X12000319?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,2,8]],"date-time":"2019-02-08T20:38:46Z","timestamp":1549658326000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X12000319"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2]]},"references-count":42,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,2]]}},"alternative-id":["S0006291X12000319"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2012.01.008","relation":{},"ISSN":["0006-291X"],"issn-type":[{"type":"print","value":"0006-291X"}],"subject":[],"published":{"date-parts":[[2012,2]]}}}