{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,4]],"date-time":"2025-05-04T05:47:25Z","timestamp":1746337645045},"reference-count":40,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2012,2,1]],"date-time":"2012-02-01T00:00:00Z","timestamp":1328054400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"crossref","award":["310000-122310\/1"],"award-info":[{"award-number":["310000-122310\/1"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Foundation for Research at the Medical Faculty, University of Zurich","award":["RO 957\/7-1, RO 957\/8-1"],"award-info":[{"award-number":["RO 957\/7-1, RO 957\/8-1"]}]},{"name":"University Medical Center Giessen\/Marburg","award":["10\/2010GI"],"award-info":[{"award-number":["10\/2010GI"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2012,2]]},"DOI":"10.1016\/j.bbrc.2012.01.036","type":"journal-article","created":{"date-parts":[[2012,1,19]],"date-time":"2012-01-19T16:16:24Z","timestamp":1326989784000},"page":"445-450","source":"Crossref","is-referenced-by-count":21,"title":["Complement factor C5 deficiency significantly delays the progression of biliary fibrosis in bile duct-ligated mice"],"prefix":"10.1016","volume":"418","author":[{"given":"Johannes","family":"Schmitt","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Roderfeld","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karim","family":"Sabrane","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yinghua","family":"Tian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joachim C.","family":"Mertens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pascal","family":"Frei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno","family":"Stieger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Achim","family":"Weber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beat","family":"M\u00fcllhaupt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elke","family":"Roeb","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Geier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"Suppl. 1","key":"10.1016\/j.bbrc.2012.01.036_b0005","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.1097\/01.mpg.0000226384.71859.16","article-title":"\u201cLet there be bile\u201d \u2013 understanding hepatic injury in cholestasis","volume":"43","author":"Sokol","year":"2006","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"10.1016\/j.bbrc.2012.01.036_b0010","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1056\/NEJMra043898","article-title":"Primary biliary cirrhosis","volume":"353","author":"Kaplan","year":"2005","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbrc.2012.01.036_b0015","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1002\/lt.21456","article-title":"Current diagnosis and management of primary sclerosing cholangitis","volume":"14","author":"Tischendorf","year":"2008","journal-title":"Liver Transpl."},{"key":"10.1016\/j.bbrc.2012.01.036_b0020","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1007\/s00281-009-0164-5","article-title":"Primary biliary cirrhosis","volume":"31","author":"Hohenester","year":"2009","journal-title":"Semin. Immunopathol."},{"key":"10.1016\/j.bbrc.2012.01.036_b0025","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1053\/j.gastro.2008.03.003","article-title":"Mechanisms of hepatic fibrogenesis","volume":"134","author":"Friedman","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1016\/j.bbrc.2012.01.036_b0030","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1172\/JCI24282","article-title":"Liver fibrosis","volume":"115","author":"Bataller","year":"2005","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbrc.2012.01.036_b0035","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1002\/hep.23274","article-title":"Bone marrow transplantation demonstrates medullar origin of CD34+ fibrocytes and ameliorates hepatic fibrosis in Abcb4\u2212\/\u2212 mice","volume":"51","author":"Roderfeld","year":"2010","journal-title":"Hepatology"},{"key":"10.1016\/j.bbrc.2012.01.036_b0040","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1053\/jhep.2002.36088","article-title":"Ursodeoxycholic acid in cholestatic liver disease: mechanisms of action and therapeutic use revisited","volume":"36","author":"Paumgartner","year":"2002","journal-title":"Hepatology"},{"key":"10.1016\/j.bbrc.2012.01.036_b0045","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1038\/ncpgasthep0521","article-title":"Drug insight: mechanisms and sites of action of ursodeoxycholic acid in cholestasis","volume":"3","author":"Beuers","year":"2006","journal-title":"Nat. Clin. Pract. Gastroenterol. Hepatol."},{"key":"10.1016\/j.bbrc.2012.01.036_b0050","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1053\/j.gastro.2005.10.018","article-title":"24-norUrsodeoxycholic acid is superior to ursodeoxycholic acid in the treatment of sclerosing cholangitis in Mdr2 (Abcb4) knockout mice","volume":"130","author":"Fickert","year":"2006","journal-title":"Gastroenterology"},{"key":"10.1016\/j.bbrc.2012.01.036_b0055","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1007\/s12016-008-8085-y","article-title":"Medical treatment of primary sclerosing cholangitis: a role for novel bile acids and other (post-)transcriptional modulators?","volume":"36","author":"Beuers","year":"2009","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"10.1016\/j.bbrc.2012.01.036_b0060","first-page":"333","article-title":"The complement system in liver diseases","volume":"3","author":"Qin","year":"2006","journal-title":"Cell Mol. Immunol."},{"key":"10.1016\/j.bbrc.2012.01.036_b0065","doi-asserted-by":"crossref","first-page":"2753","DOI":"10.1016\/j.molimm.2009.04.027","article-title":"The role of the anaphylatoxins in health and disease","volume":"46","author":"Klos","year":"2009","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.bbrc.2012.01.036_b0070","doi-asserted-by":"crossref","first-page":"151","DOI":"10.3109\/00365528609034640","article-title":"Relationship between secretory IgA, IgA-containing (C3-fixing) circulating immune complexes, and complement components (C3, C4) in patients with obstructive jaundice","volume":"21","author":"Ohshio","year":"1986","journal-title":"Scand. J. Gastroenterol."},{"key":"10.1016\/j.bbrc.2012.01.036_b0075","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1007\/BF02918614","article-title":"Complement profile in primary biliary cirrhosis","volume":"11","author":"Schlesinger","year":"1992","journal-title":"Immunol. Res."},{"key":"10.1016\/j.bbrc.2012.01.036_b0080","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1016\/0016-5085(89)90386-7","article-title":"Activation of the complement system in primary sclerosing cholangitis","volume":"97","author":"Senaldi","year":"1989","journal-title":"Gastroenterology"},{"key":"10.1016\/j.bbrc.2012.01.036_b0085","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1006\/clin.1998.4542","article-title":"Complement system is not activated in primary biliary cirrhosis","volume":"87","author":"Gardinali","year":"1998","journal-title":"Clin. Immunol. Immunopathol."},{"key":"10.1016\/j.bbrc.2012.01.036_b0090","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/s005340170042","article-title":"Primary sclerosing cholangitis successfully treated by resection of the confluence of the hepatic duct","volume":"8","author":"Hirai","year":"2001","journal-title":"J. Hepatobiliary Pancreat. Surg."},{"key":"10.1016\/j.bbrc.2012.01.036_b0095","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.3109\/00365528509088882","article-title":"Observations during long-term plasma exchange in primary biliary cirrhosis","volume":"20","author":"Lindgren","year":"1985","journal-title":"Scand. J. Gastroenterol."},{"key":"10.1016\/j.bbrc.2012.01.036_b0100","doi-asserted-by":"crossref","first-page":"7427","DOI":"10.1074\/jbc.M411473200","article-title":"Regulation of complement C3 expression by the bile acid receptor FXR","volume":"280","author":"Li","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2012.01.036_b0105","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1038\/ng1599","article-title":"Complement factor 5 is a quantitative trait gene that modifies liver fibrogenesis in mice and humans","volume":"37","author":"Hillebrandt","year":"2005","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bbrc.2012.01.036_b0110","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.jhep.2008.05.021","article-title":"Evaluation of complement factor 5 variants as genetic risk factors for the development of advanced fibrosis in chronic hepatitis C infection","volume":"49","author":"Halangk","year":"2008","journal-title":"J. Hepatol."},{"key":"10.1016\/j.bbrc.2012.01.036_b0115","doi-asserted-by":"crossref","unstructured":"D. van der Poorten, J. George, Disease-specific mechanisms of fibrosis: hepatitis C virus and nonalcoholic steatohepatitis, Clin. Liver Dis. 12 (2008) 805\u2013824, ix.","DOI":"10.1016\/j.cld.2008.07.003"},{"key":"10.1016\/j.bbrc.2012.01.036_b0120","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1002\/hep.20594","article-title":"Cytokine-independent repression of rodent Ntcp in obstructive cholestasis","volume":"41","author":"Geier","year":"2005","journal-title":"Hepatology"},{"key":"10.1016\/j.bbrc.2012.01.036_b0125","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1096\/fj.05-4828com","article-title":"Inhibition of hepatic fibrogenesis by matrix metalloproteinase-9 mutants in mice","volume":"20","author":"Roderfeld","year":"2006","journal-title":"FASEB J."},{"key":"10.1016\/j.bbrc.2012.01.036_b0130","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.3109\/00365521.2010.499961","article-title":"Cellular sources of MMP-7, MMP-13 and MMP-28 in ulcerative colitis","volume":"45","author":"Rath","year":"2010","journal-title":"Scand. J. Gastroenterol."},{"key":"10.1016\/j.bbrc.2012.01.036_b0135","doi-asserted-by":"crossref","first-page":"e7","DOI":"10.1017\/S1462399409000994","article-title":"Cholangiocyte proliferation and liver fibrosis","volume":"11","author":"Glaser","year":"2009","journal-title":"Expert. Rev. Mol. Med."},{"key":"10.1016\/j.bbrc.2012.01.036_b0140","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.gastro.2005.05.052","article-title":"Analysis of the biliary transcriptome in experimental biliary atresia","volume":"129","author":"Carvalho","year":"2005","journal-title":"Gastroenterology"},{"key":"10.1016\/j.bbrc.2012.01.036_b0145","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.bbamcr.2006.04.014","article-title":"Principles of hepatic organic anion transporter regulation during cholestasis, inflammation and liver regeneration","volume":"1773","author":"Geier","year":"2007","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbrc.2012.01.036_b0150","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1002\/bjs.6050","article-title":"Characterization of time-related changes after experimental bile duct ligation","volume":"95","author":"Georgiev","year":"2008","journal-title":"Br. J. Surg."},{"key":"10.1016\/j.bbrc.2012.01.036_b0155","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1053\/j.gastro.2008.04.009","article-title":"Inhibition of integrin alphavbeta6 on cholangiocytes blocks transforming growth factor-beta activation and retards biliary fibrosis progression","volume":"135","author":"Patsenker","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1016\/j.bbrc.2012.01.036_b0160","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1111\/j.1478-3231.2006.01271.x","article-title":"Cytokine blockade inhibits hepatic tissue inhibitor of metalloproteinase-1 expression and up-regulates matrix metalloproteinase-9 in toxic liver injury","volume":"26","author":"Roderfeld","year":"2006","journal-title":"Liver Int."},{"key":"10.1016\/j.bbrc.2012.01.036_b0165","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1002\/hep.22776","article-title":"An early complement-dependent and TLR-4-independent phase in the pathogenesis of ethanol-induced liver injury in mice","volume":"49","author":"Roychowdhury","year":"2009","journal-title":"Hepatology"},{"key":"10.1016\/j.bbrc.2012.01.036_b0170","first-page":"583","article-title":"The anti-fibrotic effect of liver growth factor is associated with decreased intrahepatic levels of matrix metalloproteinases 2 and 9 and transforming growth factor beta 1 in bile duct-ligated rats","volume":"23","author":"Diaz-Gil","year":"2008","journal-title":"Histol. Histopathol."},{"key":"10.1016\/j.bbrc.2012.01.036_b0175","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1053\/gast.2001.25480","article-title":"Angiotensin-converting enzyme inhibition attenuates the progression of rat hepatic fibrosis","volume":"121","author":"Jonsson","year":"2001","journal-title":"Gastroenterology"},{"key":"10.1016\/j.bbrc.2012.01.036_b0180","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1002\/hep.23228","article-title":"Activation of the complement system in human nonalcoholic fatty liver disease","volume":"50","author":"Rensen","year":"2009","journal-title":"Hepatology"},{"key":"10.1016\/j.bbrc.2012.01.036_b0185","doi-asserted-by":"crossref","unstructured":"J.I. Cohen, S. Roychowdhury, M.R. McMullen, et al., Complement and alcoholic liver disease: role of C1q in the pathogenesis of ethanol-induced liver injury in mice, Gastroenterology (2010).","DOI":"10.1053\/j.gastro.2010.04.041"},{"key":"10.1016\/j.bbrc.2012.01.036_b0190","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/j.clinbiochem.2007.02.001","article-title":"Gc-globulin concentrations and C5 haplotype-tagging polymorphisms contribute to variations in serum activity of complement factor C5","volume":"40","author":"Gressner","year":"2007","journal-title":"Clin. Biochem."},{"key":"10.1016\/j.bbrc.2012.01.036_b0195","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1053\/j.ajkd.2009.08.011","article-title":"Maintenance of kidney function following treatment with eculizumab and discontinuation of plasma exchange after a third kidney transplant for atypical hemolytic uremic syndrome associated with a CFH mutation","volume":"55","author":"Davin","year":"2010","journal-title":"Am. J. Kidney Dis."},{"key":"10.1016\/j.bbrc.2012.01.036_b0200","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.jcmg.2009.09.014","article-title":"Pexelizumab and infarct size in patients with acute myocardial infarction undergoing primary percutaneous coronary Intervention: a delayed enhancement cardiac magnetic resonance substudy from the APEX-AMI trial","volume":"3","author":"Patel","year":"2010","journal-title":"JACC Cardiovasc. Imag."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X12000599?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X12000599?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,11,27]],"date-time":"2018-11-27T01:22:22Z","timestamp":1543281742000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X12000599"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2]]},"references-count":40,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,2]]}},"alternative-id":["S0006291X12000599"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2012.01.036","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2012,2]]}}}