{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:00:01Z","timestamp":1791273601273,"version":"4.1.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2012,4,1]],"date-time":"2012-04-01T00:00:00Z","timestamp":1333238400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Spanish Ministerio de Ciencia y Tecnolog\u00eda, with FEDER co-financing","award":["BFU2007-67740"],"award-info":[{"award-number":["BFU2007-67740"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2012,4]]},"DOI":"10.1016\/j.bbrc.2012.02.145","type":"journal-article","created":{"date-parts":[[2012,3,5]],"date-time":"2012-03-05T14:32:07Z","timestamp":1330957927000},"page":"257-262","source":"Crossref","is-referenced-by-count":25,"title":["L-type voltage-operated calcium channels, N-methyl-d-aspartate receptors and neuronal nitric-oxide synthase form a calcium\/redox nano-transducer within lipid rafts"],"prefix":"10.1016","volume":"420","author":[{"given":"D.","family":"Marques-da-Silva","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Gutierrez-Merino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2012.02.145_b0005","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0896-6273(00)80510-3","article-title":"Neuronal calcium signalling","volume":"21","author":"Berridge","year":"1998","journal-title":"Neuron"},{"key":"10.1016\/j.bbrc.2012.02.145_b0010","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1007\/PL00000698","article-title":"Calcium signalling: a historical account, recent developments and future perspectives","volume":"57","author":"Brini","year":"2000","journal-title":"Cell Mol. Life Sci."},{"key":"10.1016\/j.bbrc.2012.02.145_b0015","doi-asserted-by":"crossref","first-page":"3043","DOI":"10.1113\/jphysiol.2008.153460","article-title":"Ca2+ microdomains near plasma membrane Ca2+ channels: impact on cell function","volume":"586","author":"Parekh","year":"2008","journal-title":"J. Physiol."},{"key":"10.1016\/j.bbrc.2012.02.145_b0020","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/0306-4522(88)90279-5","article-title":"N-methyl-d-aspartate promotes the survival of cerebellar granule cells in culture","volume":"27","author":"Balazs","year":"1988","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbrc.2012.02.145_b0025","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/0166-2236(92)90103-F","article-title":"Suppression of programmed neuronal death by sustained elevation of cytoplasmic calcium","volume":"15","author":"Franklin","year":"1992","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.bbrc.2012.02.145_b0030","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1111\/j.1471-4159.2004.02964.x","article-title":"Alteration of cytosolic free calcium homeostasis by SIN-1: high sensitivity of L-type Ca2+ channels to extracellular oxidative\/nitrosative stress in cerebellar granule cells","volume":"92","author":"Gutierrez-Martin","year":"2005","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbrc.2012.02.145_b0035","doi-asserted-by":"crossref","first-page":"2366","DOI":"10.1046\/j.1471-4159.1995.65052366.x","article-title":"Peroxynitrite-mediated inhibition of DOPA synthesis in PC12 cells","volume":"65","author":"Ischiropoulos","year":"1995","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbrc.2012.02.145_b0040","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1046\/j.1471-4159.2001.00584.x","article-title":"SIN-1-induced cytotoxicity in mixed cortical cell culture: peroxynitrite-dependent and -independent induction of excitotoxic cell death","volume":"79","author":"Trackey","year":"2001","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbrc.2012.02.145_b0045","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1089\/ars.2007.1656","article-title":"Hydrogen sulfide raises cytosolic calcium in neurons through activation of L-type Ca2+ channels","volume":"10","author":"Garcia-Bereguiain","year":"2008","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.bbrc.2012.02.145_b0050","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1089\/ars.2007.1886","article-title":"Crosstalk between calcium and redox signalling: from molecular mechanisms to health implications","volume":"10","author":"Hidalgo","year":"2008","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.bbrc.2012.02.145_b0055","series-title":"Free Radicals in Biology and Medicine","first-page":"67","article-title":"Redox modulation of neuronal calcium homeostasis and its deregulation by reactive oxygen species","author":"Gutierrez-Merino","year":"2008"},{"key":"10.1016\/j.bbrc.2012.02.145_b0195","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.tcm.2003.10.002","article-title":"Localization of ion channels to lipid raft domains within the cardiovascular system","volume":"14","author":"O\u00b4Connell","year":"2004","journal-title":"Trends Cardiovasc. Med."},{"key":"10.1016\/j.bbrc.2012.02.145_b0065","doi-asserted-by":"crossref","first-page":"7500","DOI":"10.1073\/pnas.0503465103","article-title":"Localization of cardiac L-type Ca2+ channels to a caveolar macromolecular signaling complex is required for \u03b22-adrenergic regulation","volume":"103","author":"Balijepalli","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbrc.2012.02.145_b0070","doi-asserted-by":"crossref","first-page":"8748","DOI":"10.1523\/JNEUROSCI.2764-06.2006","article-title":"The calcium channel 22 subunit partitions with CaV2.1 into lipid rafts in cerebellum: implications for localization and function","volume":"26","author":"Davies","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbrc.2012.02.145_b0075","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1016\/j.jprot.2010.02.014","article-title":"L-type calcium channels and cytochrome b5 reductase are components of protein complexes tightly associated with lipid rafts microdomains of the neuronal plasma membrane","volume":"73","author":"Marques-da-Silva","year":"2010","journal-title":"J. Proteomics"},{"key":"10.1016\/j.bbrc.2012.02.145_b0080","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.tcb.2006.11.008","article-title":"Do caveolins regulate cells by actions outside of caveolae?","volume":"17","author":"Head","year":"2007","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.bbrc.2012.02.145_b0085","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1096\/fj.07-9299com","article-title":"Caveolin-1 expression is essential for N-methyl-D-aspartate receptor-mediated Src and extracellular signal-regulated kinase 1\/2 activation and protection of primary neurons from ischemic cell death","volume":"22","author":"Head","year":"2008","journal-title":"Faseb J."},{"key":"10.1016\/j.bbrc.2012.02.145_b0090","doi-asserted-by":"crossref","first-page":"2443","DOI":"10.1529\/biophysj.105.065623","article-title":"Caveolin-1 expression and membrane cholesterol content modulate N-type calcium channel activity in NG108-15 cells","volume":"89","author":"Toselli","year":"2005","journal-title":"Biophys. J."},{"key":"10.1016\/j.bbrc.2012.02.145_b0095","doi-asserted-by":"crossref","first-page":"8827","DOI":"10.1074\/jbc.M310327200","article-title":"Identification of Caveolin-1-interacting sites in neuronal nitric-oxide synthase. Molecular mechanism for inhibition of NO formation","volume":"279","author":"Sato","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2012.02.145_b0100","doi-asserted-by":"crossref","first-page":"2484","DOI":"10.1046\/j.1471-4159.1996.67062484.x","article-title":"Cytoskeletal breakdown and apoptosis elicited by NO donors in cerebellar granule cells require NMDA receptor activation","volume":"67","author":"Bonfoco","year":"1996","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbrc.2012.02.145_b0105","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1194\/jlr.E600002-JLR200","article-title":"Rafts defined: a report on the keystone symposium on lipid rafts and cell function","volume":"47","author":"Pike","year":"2006","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.bbrc.2012.02.145_b0110","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1146\/annurev.bi.47.070178.004131","article-title":"Fluorescence energy transfer as a spectroscopic ruler","volume":"47","author":"Stryer","year":"1978","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.bbrc.2012.02.145_b0115","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1042\/bst0220784","article-title":"Fluorescence energy transfer as a tool to locate functional sites in membrane proteins","volume":"22","author":"Gutierrez-Merino","year":"1994","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.bbrc.2012.02.145_b0200","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.mcn.2008.08.013","article-title":"Clustering of plasma membrane-bound cytochrome b5 reductase within \u2018lipid rafts\u2019 microdomains of the neuronal plasma membrane","volume":"40","author":"Samhan-Arias","year":"2009","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.bbrc.2012.02.145_b0125","doi-asserted-by":"crossref","unstructured":"A.K. Samhan-Arias, D. Marques-da-Silva, N. Yanamala, C. Gutierrez-Merino, Stimulation and clustering of cytochrome b5 reductase in caveolin-rich lipid microdomains is an early event in oxidative stress-mediated apoptosis of cerebellar granule neurons, J. Proteomics, in press. doi:10.1016\/j.jprot.2011.12.007.","DOI":"10.1016\/j.jprot.2011.12.007"},{"key":"10.1016\/j.bbrc.2012.02.145_b0130","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1046\/j.1471-4159.2002.01023.x","article-title":"Inhibition of the oxidative stress produced by plasma membrane NADH oxidase delays low-potassium induced apoptosis of cerebellar granule cells","volume":"82","author":"Martin-Romero","year":"2002","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbrc.2012.02.145_b0135","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.freeradbiomed.2004.04.002","article-title":"Kaempferol blocks oxidative stress in cerebellar granule cells and reveals a key role for the plasma membrane NADH oxidase activity in the commitment of apoptosis","volume":"37","author":"Samhan-Arias","year":"2004","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbrc.2012.02.145_b0140","doi-asserted-by":"crossref","first-page":"2947","DOI":"10.1091\/mbc.12.10.2947","article-title":"Lipid rafts act as specialized domains for tetanus toxin binding and internalization into neurons","volume":"12","author":"Herreros","year":"2001","journal-title":"Mol. Biol. Cell."},{"key":"10.1016\/j.bbrc.2012.02.145_b0145","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1194\/jlr.D400041-JLR200","article-title":"A simplified method for the preparation of detergent-free lipid rafts","volume":"46","author":"MacDonald","year":"2005","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.bbrc.2012.02.145_b0150","first-page":"168","article-title":"Crystallization and preliminary structure determination of an intact human immunoglobulin, b12: an antibody that broadly neutralizes primary isolates of HIV-1","volume":"D57","author":"Saphire","year":"2001","journal-title":"Acta Crystallogr."},{"key":"10.1016\/j.bbrc.2012.02.145_b0155","doi-asserted-by":"crossref","first-page":"22119","DOI":"10.1074\/jbc.270.38.22119","article-title":"Molecular determinants of high affinity phenylalkylamine block of L-type calcium channels","volume":"270","author":"Hockerman","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2012.02.145_b0160","doi-asserted-by":"crossref","first-page":"3625","DOI":"10.1021\/bi9613584","article-title":"L-type calcium channels: binding domains for dihydropyridines and benzothiazepines are located in close proximity to each other","volume":"36","author":"Brauns","year":"1997","journal-title":"Biochemistry"},{"key":"10.1016\/j.bbrc.2012.02.145_b0165","doi-asserted-by":"crossref","first-page":"3586","DOI":"10.1073\/pnas.89.8.3586","article-title":"In vivo labeling of L-type Ca2+ channels by fluorescent dihydropyridines: evidence for a functional, extracellular heparin-binding site","volume":"89","author":"Knaus","year":"1992","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbrc.2012.02.145_b0170","doi-asserted-by":"crossref","first-page":"11875","DOI":"10.1021\/bi00205a025","article-title":"Complex molecular mechanism for dihydropyridine binding to L-type Ca2+-channels as revealed by fluorescence energy transfer","volume":"33","author":"Berger","year":"1994","journal-title":"Biochemistry"},{"key":"10.1016\/j.bbrc.2012.02.145_b0175","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/S0959-4388(97)80065-7","article-title":"Synaptic signalling by nitric-oxide","volume":"7","author":"Brenman","year":"1997","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.bbrc.2012.02.145_b0180","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/j.neuron.2005.08.016","article-title":"The synaptic localization of NR2B-containing NMDA receptors is controlled by interactions with PDZ proteins and AP-2","volume":"47","author":"Prybylowski","year":"2005","journal-title":"Neuron"},{"key":"10.1016\/j.bbrc.2012.02.145_b0185","series-title":"The Handbook: a Guide to Fluorescent Probes and Labeling Techniques","author":"Haugland","year":"2005"},{"key":"10.1016\/j.bbrc.2012.02.145_b0190","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1146\/annurev.bi.63.070194.001135","article-title":"Nitric-oxide: a physiologic messenger molecule","volume":"63","author":"Bredt","year":"1994","journal-title":"Annu. Rev. Biochem."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X12004044?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X12004044?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,11,25]],"date-time":"2018-11-25T10:20:59Z","timestamp":1543141259000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X12004044"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4]]},"references-count":38,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,4]]}},"alternative-id":["S0006291X12004044"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2012.02.145","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2012,4]]}}}