{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T00:23:13Z","timestamp":1779927793020,"version":"3.53.1"},"reference-count":28,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2012,4,1]],"date-time":"2012-04-01T00:00:00Z","timestamp":1333238400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,4,1]],"date-time":"2012-04-01T00:00:00Z","timestamp":1333238400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2012,4,1]],"date-time":"2012-04-01T00:00:00Z","timestamp":1333238400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2012,4,1]],"date-time":"2012-04-01T00:00:00Z","timestamp":1333238400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2012,4,1]],"date-time":"2012-04-01T00:00:00Z","timestamp":1333238400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2012,4,1]],"date-time":"2012-04-01T00:00:00Z","timestamp":1333238400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2012,4,1]],"date-time":"2012-04-01T00:00:00Z","timestamp":1333238400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81000725"],"award-info":[{"award-number":["81000725"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2012,4]]},"DOI":"10.1016\/j.bbrc.2012.03.067","type":"journal-article","created":{"date-parts":[[2012,3,17]],"date-time":"2012-03-17T20:06:55Z","timestamp":1332014815000},"page":"755-761","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Expression and immunogenicity of novel subunit enterovirus 71 VP1 antigens"],"prefix":"10.1016","volume":"420","author":[{"given":"Juan","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shixia","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weihua","family":"Gan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liwen","family":"Ju","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuhu","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2012.03.067_b0005","first-page":"1","article-title":"Enterovirus infections with special reference to enterovirus 71","volume":"33","author":"Hsiung","year":"2000","journal-title":"J. Microbiol. Immunol. Infect."},{"key":"10.1016\/j.bbrc.2012.03.067_b0010","doi-asserted-by":"crossref","first-page":"7732","DOI":"10.1128\/JVI.75.16.7732-7738.2001","article-title":"Phylogenetic analysis of enterovirus 71 strains isolated during linked epidemics in Malaysia, Singapore, and Western Australia","volume":"75","author":"McMinn","year":"2001","journal-title":"J. Virol."},{"key":"10.1016\/j.bbrc.2012.03.067_b0015","doi-asserted-by":"crossref","first-page":"461","DOI":"10.3201\/eid0904.020395","article-title":"Molecular epidemiology of human enterovirus 71 strains and recent outbreaks in the Asia\u2013Pacific region: comparative analysis of the VP1 and VP4 genes","volume":"9","author":"Cardosa","year":"2003","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.bbrc.2012.03.067_b0020","first-page":"43","article-title":"The hand, foot and mouth disease virus capsid: sequence analysis and prediction of antigenic sites from homology modelling","volume":"1","author":"Ranganathan","year":"2002","journal-title":"Appl. Bioinformatics"},{"key":"10.1016\/j.bbrc.2012.03.067_b0025","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1016\/S0969-2126(00)88343-4","article-title":"The crystal structure of coxsackievirus A9: new insights into the uncoating mechanisms of enteroviruses","volume":"7","author":"Hendry","year":"1999","journal-title":"Structure"},{"key":"10.1016\/j.bbrc.2012.03.067_b0030","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/0168-1702(95)00087-9","article-title":"Complete nucleotide sequence of enterovirus 71 is distinct from poliovirus","volume":"39","author":"Brown","year":"1995","journal-title":"Virus Res."},{"key":"10.1016\/j.bbrc.2012.03.067_b0150","series-title":"Virology","first-page":"507","article-title":"Picornaviruses and their replication","author":"Rueckert","year":"1990"},{"key":"10.1016\/j.bbrc.2012.03.067_b0040","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1111\/j.1469-0691.2007.01745.x","article-title":"Genetic and antigenic analyses of enterovirus 71 isolates in Taiwan during 1998\u20132005","volume":"13","author":"Kung","year":"2007","journal-title":"Clin. Microbiol. Infect."},{"key":"10.1016\/j.bbrc.2012.03.067_b0045","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1099\/0022-1317-82-1-79","article-title":"Molecular strategy for \u2018serotyping\u2019 of human enteroviruses","volume":"82","author":"Caro","year":"2001","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.bbrc.2012.03.067_b0050","doi-asserted-by":"crossref","first-page":"9969","DOI":"10.1128\/JVI.73.12.9969-9975.1999","article-title":"Molecular epidemiology and evolution of enterovirus 71 strains isolated from 1970 to 1998","volume":"73","author":"Brown","year":"1999","journal-title":"J. Virol."},{"key":"10.1016\/j.bbrc.2012.03.067_b0055","doi-asserted-by":"crossref","first-page":"847","DOI":"10.2174\/092986707780363032","article-title":"The efficacy of viral capsid inhibitors in human enterovirus infection and associated diseases","volume":"14","author":"Li","year":"2007","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.bbrc.2012.03.067_b0060","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.1099\/vir.0.83676-0","article-title":"The molecular basis of mouse adaptation by human enterovirus 71","volume":"89","author":"Chua","year":"2008","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.bbrc.2012.03.067_b0065","doi-asserted-by":"crossref","first-page":"3523","DOI":"10.1128\/AAC.48.9.3523-3529.2004","article-title":"Mutation in enterovirus 71 capsid protein VP1 confers resistance to the inhibitory effects of pyridyl imidazolidinone","volume":"48","author":"Shih","year":"2004","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.bbrc.2012.03.067_b0070","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/s11373-007-9228-5","article-title":"Antiviral activity of pyridyl imidazolidinones against enterovirus 71 variants","volume":"15","author":"Chen","year":"2008","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.bbrc.2012.03.067_b0075","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/S0264-410X(01)00385-1","article-title":"Protection against lethal enterovirus 71 infection in newborn mice by passive immunization with subunit VP1 vaccines and inactivated virus","volume":"20","author":"Wu","year":"2001","journal-title":"Vaccine"},{"key":"10.1016\/j.bbrc.2012.03.067_b0080","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0168-1702(95)00048-U","article-title":"Antibody recognition of picornaviruses and escape from neutralization: a structural view","volume":"38","author":"Mateu","year":"1995","journal-title":"Virus Res."},{"key":"10.1016\/j.bbrc.2012.03.067_b0085","first-page":"121","article-title":"Antigenic structure of picornaviruses","volume":"161","author":"Minor","year":"1990","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"10.1016\/j.bbrc.2012.03.067_b0090","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1007\/s00705-007-0941-1","article-title":"High-titred neutralizing antibodies to human enterovirus 71 preferentially bind to the N-terminal portion of the capsid protein VP1","volume":"152","author":"Tan","year":"2007","journal-title":"Arch. Virol."},{"key":"10.1016\/j.bbrc.2012.03.067_b0095","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1002\/jmv.20668","article-title":"Recombinant Newcastle disease virus capsids displaying enterovirus 71 VP1 fragment induce a strong immune response in rabbits","volume":"78","author":"Sivasamugham","year":"2006","journal-title":"J. Med. Virol."},{"key":"10.1016\/j.bbrc.2012.03.067_b0100","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.vaccine.2006.06.083","article-title":"High immunogenic enterovirus 71 strain and its production using serum-free microcarrier Vero cell culture","volume":"25","author":"Liu","year":"2007","journal-title":"Vaccine"},{"key":"10.1016\/j.bbrc.2012.03.067_b0105","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1128\/JVI.00999-09","article-title":"Formaldehyde-inactivated whole-virus vaccine protects a murine model of enterovirus 71 encephalomyelitis against disease","volume":"84","author":"Ong","year":"2010","journal-title":"J. Virol."},{"key":"10.1016\/j.bbrc.2012.03.067_b0110","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.1016\/j.vaccine.2008.01.058","article-title":"Immunization with virus-like particles of enterovirus 71 elicits potent immune responses and protects mice against lethal challenge","volume":"26","author":"Chung","year":"2008","journal-title":"Vaccine"},{"key":"10.1016\/j.bbrc.2012.03.067_b0115","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1479-0556-5-6","article-title":"DNA vaccine constructs against enterovirus 71 elicit immune response in mice","volume":"5","author":"Tung","year":"2007","journal-title":"Genet. Vaccines Ther."},{"key":"10.1016\/j.bbrc.2012.03.067_b0120","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1016\/j.micinf.2006.01.021","article-title":"Protection of neonatal mice from lethal enterovirus 71 infection by maternal immunization with attenuated Salmonella enterica serovar Typhimurium expressing VP1 of enterovirus 71","volume":"8","author":"Chiu","year":"2006","journal-title":"Microbes Infect."},{"key":"10.1016\/j.bbrc.2012.03.067_b0125","doi-asserted-by":"crossref","first-page":"2485","DOI":"10.1016\/S0264-410X(02)00182-2","article-title":"Characterization of a vero cell-adapted virulent strain of enterovirus 71 suitable for use as a vaccine candidate","volume":"20","author":"Lin","year":"2002","journal-title":"Vaccine"},{"key":"10.1016\/j.bbrc.2012.03.067_b0130","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1016\/j.micinf.2007.06.002","article-title":"Passive protection against lethal enterovirus 71 infection in newborn mice by neutralizing antibodies elicited by a synthetic peptide","volume":"9","author":"Foo","year":"2007","journal-title":"Microbes Infect."},{"key":"10.1016\/j.bbrc.2012.03.067_b0135","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.coi.2009.05.016","article-title":"Heterologous prime-boost vaccination","volume":"21","author":"Lu","year":"2009","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.bbrc.2012.03.067_b0140","first-page":"2339","article-title":"Immunogenicities of env glycoproteins from circulating HIV-1 isolates in China focusing on the strategy of \u201cDNA prime plus protein boost\u201d","volume":"122","author":"Wang","year":"2009","journal-title":"Chin. Med. J. (Engl.)"}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X12005141?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X12005141?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T11:00:37Z","timestamp":1757761237000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X12005141"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4]]},"references-count":28,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,4]]}},"alternative-id":["S0006291X12005141"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2012.03.067","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2012,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Expression and immunogenicity of novel subunit enterovirus 71 VP1 antigens","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2012.03.067","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}