{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T08:46:31Z","timestamp":1772354791252,"version":"3.50.1"},"reference-count":53,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2012,6,1]],"date-time":"2012-06-01T00:00:00Z","timestamp":1338508800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2012,6]]},"DOI":"10.1016\/j.bbrc.2012.05.102","type":"journal-article","created":{"date-parts":[[2012,5,24]],"date-time":"2012-05-24T21:06:39Z","timestamp":1337893599000},"page":"147-151","source":"Crossref","is-referenced-by-count":27,"title":["Curative and protective effects of l-arginine on carbon tetrachloride-induced hepatotoxicity in mice"],"prefix":"10.1016","volume":"423","author":[{"given":"Entsar A.","family":"Saad","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2012.05.102_b0005","unstructured":"M.P.H. Cooper, H. Kenneth, Advanced Nutritional Therapies, Thomas Nelson, Inc., Nashville, 1996."},{"issue":"4","key":"10.1016\/j.bbrc.2012.05.102_b0010","doi-asserted-by":"crossref","first-page":"600","DOI":"10.3748\/wjg.v11.i4.600","article-title":"Potential effects of L-NAME on alcohol-induced oxidative stress","volume":"11","author":"Uzun","year":"2005","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.bbrc.2012.05.102_b0015","series-title":"Prescription for Nutritional Healing","author":"Balch","year":"1997"},{"key":"10.1016\/j.bbrc.2012.05.102_b0020","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/1472-6882-6-33","article-title":"Aqueous extract of Terminalia arjuna prevents carbon tetrachloride induced hepatic and renal disorders","volume":"6","author":"Manna","year":"2006","journal-title":"BMC Complement Altern. Med."},{"key":"10.1016\/j.bbrc.2012.05.102_b0025","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/bj2220001","article-title":"Free radical mechanisms in tissue injury","volume":"222","author":"Slater","year":"1984","journal-title":"Biochem. J."},{"key":"10.1016\/j.bbrc.2012.05.102_b0030","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.1016\/S0021-9258(17)43327-8","article-title":"Oxygen- and carbon-centered free radical formation during carbon tetrachloride metabolism. Observation of lipid radicals in vivo and in vitro","volume":"259","author":"McCay","year":"1984","journal-title":"J. Biol. Chem."},{"issue":"12","key":"10.1016\/j.bbrc.2012.05.102_b0035","doi-asserted-by":"crossref","first-page":"2027","DOI":"10.1016\/0006-2952(90)90625-U","article-title":"Mechanism for the protective effects of silymarin against carbon tetrachloride-induced lipid peroxidation and hepatotoxicity in mice. Evidence that silymarin acts both as an inhibitor of metabolic activation and as a chain-breaking antioxidant","volume":"39","author":"Letteron","year":"1990","journal-title":"Biochem. Pharmacol."},{"issue":"1","key":"10.1016\/j.bbrc.2012.05.102_b0040","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF01318880","article-title":"Plasma amino acid levels after carbon tetrachloride induced acute liver damage. A dose-response and time-response study in rats","volume":"16","author":"Holecek","year":"1999","journal-title":"Amino Acids"},{"key":"10.1016\/j.bbrc.2012.05.102_b0045","first-page":"412","article-title":"Biology of disease: free radicals and tissue injury","volume":"47","author":"Freeman","year":"1982","journal-title":"Lab. Invest."},{"issue":"6","key":"10.1016\/j.bbrc.2012.05.102_b0050","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1006\/phrs.2002.0968","article-title":"Protective effect of l-arginine against nephrotoxicity induced by cyclosporine in normal rats","volume":"45","author":"Mansour","year":"2002","journal-title":"Pharmacol. Res."},{"issue":"1\u20132","key":"10.1016\/j.bbrc.2012.05.102_b0055","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.cccn.2004.11.029","article-title":"Counteraction of oxalate induced nitrosative stress by supplementation of l-arginine, a potent antilithic agent","volume":"354","author":"Pragasam","year":"2005","journal-title":"Clinica Chimica Acta"},{"issue":"1","key":"10.1016\/j.bbrc.2012.05.102_b0060","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.jss.2005.04.023","article-title":"Renal protective effect of molsidomine and l-arginine in ischemia-reperfusion induced injury in rats","volume":"128","author":"Chander","year":"2005","journal-title":"J. Surg. Res."},{"key":"10.1016\/j.bbrc.2012.05.102_b0065","unstructured":"NIH [National Institutes of Health], Guide for the Care and Use of Laboratory Animals, seventh ed., National Academy Press, Washington, DC, 1996."},{"key":"10.1016\/j.bbrc.2012.05.102_b0070","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1016\/j.lfs.2003.07.020","article-title":"Protective effect of acteoside on carbon tetrachloride-induced hepatotoxicity","volume":"74","author":"Lee","year":"2004","journal-title":"Life Sci."},{"key":"10.1016\/j.bbrc.2012.05.102_b0075","doi-asserted-by":"crossref","first-page":"2118","DOI":"10.1016\/j.fct.2007.05.010","article-title":"Hepatoprotective and antioxidant effects of the coffee diterpenes kahweol and cafestol on carbon tetrachloride-induced liver damage in mice","volume":"45","author":"Lee","year":"2007","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.bbrc.2012.05.102_b0080","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","article-title":"Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction","volume":"95","author":"Ohkawa","year":"1979","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.bbrc.2012.05.102_b0085","first-page":"882","article-title":"Improved method for the determination of blood glutathione","volume":"61","author":"Beutler","year":"1963","journal-title":"J. Lab. Clin. Med."},{"key":"10.1016\/j.bbrc.2012.05.102_b0090","unstructured":"E. Beutler, Glutathione peroxidase, in: Red Cell Metabolism: A Manual of Biochemical Methods, Grune & Stratton, New York, 1975, p. 71:3."},{"key":"10.1016\/j.bbrc.2012.05.102_b0095","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1172\/JCI106162","article-title":"Effect of flavin compounds on glutathione reductase activity: in vivo and in vitro studies","volume":"48","author":"Beutler","year":"1969","journal-title":"J. Clin. Invest."},{"issue":"22","key":"10.1016\/j.bbrc.2012.05.102_b0100","doi-asserted-by":"crossref","first-page":"7130","DOI":"10.1016\/S0021-9258(19)42083-8","article-title":"Glutathione-S-transferase. The first enzymatic step in mercapturic formation","volume":"249","author":"Habig","year":"1974","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2012.05.102_b0105","doi-asserted-by":"crossref","unstructured":"L.R. Dechaatelet, C.E. McCall, L.C. McPhail, R.B. Johnston Jr., Superoxide dismutase activity in leukocytes, J. Clin. Invest. 53 (1974) 1197\u20131201.","DOI":"10.1172\/JCI107659"},{"key":"10.1016\/j.bbrc.2012.05.102_b0110","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1016\/S0076-6879(55)02300-8","article-title":"Assays of catalases and peroxides","volume":"2","author":"Chance","year":"1955","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.bbrc.2012.05.102_b0115","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.bbrc.2012.05.102_b0120","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1055\/s-2006-958032","article-title":"Effect of lignan enriched Fructus schisandrae extract on hepatic glutathione status in rats: protection against carbon tetrachloride toxicity","volume":"61","author":"Ko","year":"1995","journal-title":"Planta Med."},{"issue":"5","key":"10.1016\/j.bbrc.2012.05.102_b0125","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1007\/BF02877719","article-title":"Duration-dependent hepatoprotective effects of propolis extract against carbon tetrachloride-induced acute liver damage in rats","volume":"24","author":"Bhadauria","year":"2007","journal-title":"Adv. Ther."},{"issue":"8","key":"10.1016\/j.bbrc.2012.05.102_b0130","doi-asserted-by":"crossref","first-page":"2703","DOI":"10.1016\/j.fct.2008.04.025","article-title":"Multiple treatment of propolis extract ameliorates carbon tetrachloride induced liver injury in rats","volume":"46","author":"Bhadauria","year":"2008","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.bbrc.2012.05.102_b0135","first-page":"30","article-title":"Hepatoprotective effect of Epaltes divaricata extract on carbon tetrachloride induced hepatotoxicity in mice","volume":"120","author":"Hewawasam","year":"2004","journal-title":"Indian J. Med. Res."},{"issue":"2","key":"10.1016\/j.bbrc.2012.05.102_b0140","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.bbrc.2012.05.022","article-title":"Protective effect of L-theanine on carbon tetrachloride-induced acute liver injury in mice","volume":"422","author":"Jiang","year":"2012","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"9","key":"10.1016\/j.bbrc.2012.05.102_b0145","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1016\/S0891-5849(00)00396-8","article-title":"The roles played by crucial free radicals like lipid free radicals, nitric oxide, and enzymes NOS and NADPH in CCl(4)-induced acute liver injury of mice","volume":"29","author":"Zhu","year":"2000","journal-title":"Free Radic. Biol. Med."},{"issue":"6","key":"10.1016\/j.bbrc.2012.05.102_b0150","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/S0006-2952(98)00220-2","article-title":"Nitric oxide protection of rat liver from lipid peroxidation, collagen accumulation, and liver damage induced by carbon tetrachloride","volume":"56","author":"Muriel","year":"1998","journal-title":"Biochem. Pharmacol."},{"issue":"3","key":"10.1016\/j.bbrc.2012.05.102_b0155","first-page":"832","article-title":"Arginine reverses ethanol-induced inflammatory and fibrotic changes in liver despite continued ethanol administration","volume":"299","author":"Nanji","year":"2001","journal-title":"Pharmacology"},{"key":"10.1016\/j.bbrc.2012.05.102_b0160","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/0378-8741(90)90020-T","article-title":"Effect of Melothria maderspatana on carbon tetrachloride induced changes in rat hepatic microsomal drug metabolizing enzyme activity","volume":"30","author":"Jayatilaka","year":"1990","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.bbrc.2012.05.102_b0165","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1055\/s-2006-962691","article-title":"A comparative study of the efficacy of Pavetta indica and Osbeckia octandra in the treatment of liver dysfunction","volume":"53","author":"Thabrew","year":"1987","journal-title":"Planta Med."},{"issue":"5","key":"10.1016\/j.bbrc.2012.05.102_b0170","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1124\/mol.61.5.1081","article-title":"Functional and analytical evidence for scavenging of oxygen radicals by L\u2013arginine","volume":"61","author":"Lass","year":"2002","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.bbrc.2012.05.102_b0175","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1159\/000084657","article-title":"Protective effect of l-arginine intake on the impaired renal vascular responses in the gentamicin-treated rats","volume":"100","author":"Se\u00e7ilmis","year":"2005","journal-title":"Nephron Physiol."},{"key":"10.1016\/j.bbrc.2012.05.102_b0180","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1006\/abbi.1996.9765","article-title":"Inhibition of rat and human cytochrome P4502E1 catalytic activity and reactive oxygen radical formation by nitric oxide","volume":"337","author":"Gergel","year":"1997","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.bbrc.2012.05.102_b0185","first-page":"833","article-title":"Interactions between nitric oxide and cytochrome P450 in the liver","volume":"63","author":"Khatsenko","year":"1998","journal-title":"Biochemistry"},{"issue":"5","key":"10.1016\/j.bbrc.2012.05.102_b0190","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1007\/s12272-001-1203-8","article-title":"The effects of fucoidan extracts on CCl(4)-induced liver injury","volume":"31","author":"Kang","year":"2008","journal-title":"Arch. Pharm. Res."},{"issue":"4","key":"10.1016\/j.bbrc.2012.05.102_b0195","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.phrs.2011.12.005","article-title":"Preventive and therapeutic effects of oleuropein against carbon tetrachloride-induced liver damage in mice","volume":"65","author":"Domitrovi\u0107","year":"2012","journal-title":"Pharmacol. Res."},{"issue":"3","key":"10.1016\/j.bbrc.2012.05.102_b0200","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1152\/physrev.1979.59.3.527","article-title":"Hydroperoxide metabolism in mammalian organs","volume":"59","author":"Chance","year":"1979","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.bbrc.2012.05.102_b0205","first-page":"87","article-title":"The glutathione peroxidase activity of glutathione-S-transferases","volume":"611","author":"Prohaska","year":"1980","journal-title":"Biochem. Biophys. Acta"},{"key":"10.1016\/j.bbrc.2012.05.102_b0210","doi-asserted-by":"crossref","unstructured":"G.M. Rosen, B.E. Britigan, H.J. Halpern, S. Pou, The oxygen paradox, in: Free Radicals, Biology and Detection by Spin Trapping, Oxford university press, Oxford, 1999, p. 34.","DOI":"10.1093\/oso\/9780195095050.001.0001"},{"key":"10.1016\/j.bbrc.2012.05.102_b0215","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1146\/annurev.bi.52.070183.003431","article-title":"Glutathione","volume":"52","author":"Meister","year":"1983","journal-title":"Ann. Rev. Biochem."},{"key":"10.1016\/j.bbrc.2012.05.102_b0220","doi-asserted-by":"crossref","unstructured":"Z.M. Wu, T. Wen, Y.F. Tan, Y. Liu, F. Ren, H. Wu, Effects of salvianolic acid a on oxidative stress and liver injury induced by carbon tetrachloride in rats, Basic Clin. Pharmacol. Toxicol. 100 (2) (2007) 115\u2013120.","DOI":"10.1111\/j.1742-7835.2007.00020.x"},{"issue":"5","key":"10.1016\/j.bbrc.2012.05.102_b0225","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1055\/s-2008-1074501","article-title":"Protective effects of amburoside A, a phenol glucoside from Amburana cearensis, against CCl4-induced hepatotoxicity in rats","volume":"74","author":"Leal","year":"2008","journal-title":"Planta Med."},{"key":"10.1016\/j.bbrc.2012.05.102_b0230","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1016\/j.fct.2012.01.037","article-title":"Protective effects of lotus (Nelumbo nucifera Gaertn) germ oil against carbon tetrachloride-induced injury in mice and cultured PC-12 cells","volume":"50","author":"Lv","year":"2012","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.bbrc.2012.05.102_b0235","doi-asserted-by":"crossref","unstructured":"P. Srilaxmi, G.R. Sareddy, P.B. Kavi Kishor, O.H. Setty, P.P. Babu, Protective efficacy of natansnin, a dibenzoyl glycoside from Salvinia natans against CCl4 induced oxidative stress and cellular degeneration in rat liver, BMC Pharmacol. 10 (2010) 13.","DOI":"10.1186\/1471-2210-10-13"},{"issue":"7","key":"10.1016\/j.bbrc.2012.05.102_b0240","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1177\/0960327108096851","article-title":"A nutrient mixture suppresses carbon tetrachloride-induced acute hepatic toxicity in ICR mice","volume":"27","author":"Roomi","year":"2008","journal-title":"Hum. Exp. Toxicol."},{"issue":"7\u20138","key":"10.1016\/j.bbrc.2012.05.102_b0245","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/S0899-9007(96)91731-1","article-title":"Oral arginine supplementation in acute liver injury","volume":"12","author":"Adawi","year":"1996","journal-title":"Nutrition"},{"issue":"6","key":"10.1016\/j.bbrc.2012.05.102_b0250","first-page":"656","article-title":"Influence of l-arginine and inhibitors of NO-synthase on generation of nitric oxide and nitrosothiols at toxic damage of liver","volume":"51","author":"Bliznetsova","year":"2005","journal-title":"Biomed. Khim."},{"key":"10.1016\/j.bbrc.2012.05.102_b0255","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/S0026-895X(25)09701-9","article-title":"Nitric oxide production during endotoxic shock in carbon tetrachloride\u2013treated rats","volume":"46","author":"Chamulitrat","year":"1994","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.bbrc.2012.05.102_b0260","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1002\/hep.1840200427","article-title":"Endogenous nitric oxide attenuates ethanol-induced perturbation of hepatic circulation in the isolated perfused rat liver","volume":"20","author":"Oshita","year":"1994","journal-title":"Hepatology"},{"key":"10.1016\/j.bbrc.2012.05.102_b0265","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1016\/S0891-5849(99)00179-3","article-title":"Cellular antioxidant and pro-oxidant actions of nitric oxide","volume":"27","author":"Joshi","year":"1999","journal-title":"Free Rad. Biol. Med."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X12009928?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X12009928?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T19:46:10Z","timestamp":1743191170000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X12009928"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6]]},"references-count":53,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,6]]}},"alternative-id":["S0006291X12009928"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2012.05.102","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2012,6]]}}}