{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T23:28:34Z","timestamp":1776295714383,"version":"3.50.1"},"reference-count":30,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2012,7,1]],"date-time":"2012-07-01T00:00:00Z","timestamp":1341100800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2012,7]]},"DOI":"10.1016\/j.bbrc.2012.06.100","type":"journal-article","created":{"date-parts":[[2012,6,23]],"date-time":"2012-06-23T10:19:21Z","timestamp":1340446761000},"page":"170-175","source":"Crossref","is-referenced-by-count":62,"title":["TNF-\u03b1 mediates the stimulation of sclerostin expression in an estrogen-deficient condition"],"prefix":"10.1016","volume":"424","author":[{"given":"Beom-Jun","family":"Kim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung Jin","family":"Bae","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sun-Young","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young-Sun","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji-Eun","family":"Baek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sook-Young","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung Hun","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung-Min","family":"Koh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ghi Su","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2012.06.100_b0005","doi-asserted-by":"crossref","first-page":"3318","DOI":"10.1172\/JCI27071","article-title":"Pathogenesis of osteoporosis: concepts, conflicts, and prospects","volume":"115","author":"Raisz","year":"2005","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbrc.2012.06.100_b0010","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/S8756-3282(01)00501-4","article-title":"Mechanisms by which high-dose estrogen therapy produces anabolic skeletal effects in postmenopausal women: role of locally produced growth factors","volume":"29","author":"Bord","year":"2001","journal-title":"Bone"},{"key":"10.1016\/j.bbrc.2012.06.100_b0015","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1146\/annurev-pathol-011110-130203","article-title":"Disorders of bone remodeling","volume":"6","author":"Feng","year":"2011","journal-title":"Annu. Rev. Pathol."},{"key":"10.1016\/j.bbrc.2012.06.100_b0020","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1111\/j.0105-2896.2005.00324.x","article-title":"The role of T lymphocytes in bone metabolism","volume":"208","author":"Weitzmann","year":"2005","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.bbrc.2012.06.100_b0025","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1172\/JCI28550","article-title":"Estrogen deficiency and bone loss: an inflammatory tale","volume":"116","author":"Weitzmann","year":"2006","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbrc.2012.06.100_b0030","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1038\/46303","article-title":"Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand","volume":"402","author":"Kong","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2012.06.100_b0035","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1210\/er.21.2.115","article-title":"Birth and death of bone cells: basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis","volume":"21","author":"Manolagas","year":"2000","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.bbrc.2012.06.100_b0040","doi-asserted-by":"crossref","first-page":"2478","DOI":"10.4049\/jimmunol.136.7.2478","article-title":"Actions of recombinant interleukin 1, interleukin 2, and interferon-gamma on bone resorption in vitro","volume":"136","author":"Gowen","year":"1986","journal-title":"J. Immunol."},{"key":"10.1016\/j.bbrc.2012.06.100_b0045","doi-asserted-by":"crossref","first-page":"19883","DOI":"10.1074\/jbc.M413274200","article-title":"Sclerostin binds to LRP5\/6 and antagonizes canonical Wnt signaling","volume":"280","author":"Li","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2012.06.100_b0050","doi-asserted-by":"crossref","first-page":"26770","DOI":"10.1074\/jbc.M504308200","article-title":"SOST is a ligand for LRP5\/LRP6 and a Wnt signaling inhibitor","volume":"280","author":"Semenov","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2012.06.100_b0055","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1359\/jbmr.080216","article-title":"Targeted deletion of the sclerostin gene in mice results in increased bone formation and bone strength","volume":"23","author":"Li","year":"2008","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bbrc.2012.06.100_b0060","doi-asserted-by":"crossref","first-page":"6267","DOI":"10.1093\/emboj\/cdg599","article-title":"Osteocyte control of bone formation via sclerostin, a novel BMP antagonist","volume":"22","author":"Winkler","year":"2003","journal-title":"EMBO J."},{"key":"10.1016\/j.bbrc.2012.06.100_b0065","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1101\/gr.3437105","article-title":"Genomic deletion of a long-range bone enhancer misregulates sclerostin in Van Buchem disease","volume":"15","author":"Loots","year":"2005","journal-title":"Genome Res."},{"key":"10.1016\/j.bbrc.2012.06.100_b0070","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1093\/hmg\/10.5.537","article-title":"Increased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST)","volume":"10","author":"Balemans","year":"2001","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bbrc.2012.06.100_b0075","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1136\/jmg.39.2.91","article-title":"Identification of a 52kb deletion downstream of the SOST gene in patients with van Buchem disease","volume":"39","author":"Balemans","year":"2002","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.bbrc.2012.06.100_b0080","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1002\/jbmr.173","article-title":"Single-dose, placebo-controlled, randomized study of AMG 785, a sclerostin monoclonal antibody","volume":"26","author":"Padhi","year":"2011","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bbrc.2012.06.100_b0085","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1210\/jc.2009-2283","article-title":"Serum sclerostin levels negatively correlate with parathyroid hormone levels and free estrogen index in postmenopausal women","volume":"95","author":"Mirza","year":"2010","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bbrc.2012.06.100_b0090","doi-asserted-by":"crossref","first-page":"5056","DOI":"10.1210\/jc.2010-0720","article-title":"Effects of parathyroid hormone treatment on circulating sclerostin levels in postmenopausal women","volume":"95","author":"Drake","year":"2010","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bbrc.2012.06.100_b0095","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1002\/jbmr.128","article-title":"Regulation of circulating sclerostin levels by sex steroids in women and in men","volume":"26","author":"Modder","year":"2011","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bbrc.2012.06.100_b0100","article-title":"Long-term treatment with raloxifene, but not bisphosphonates, reduces circulating sclerostin levels in postmenopausal women","author":"Chung","year":"2011","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.bbrc.2012.06.100_b0105","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1359\/jbmr.090305","article-title":"Pro-inflammatory cytokines TNF-related weak inducer of apoptosis (TWEAK) and TNFalpha induce the mitogen-activated protein kinase (MAPK)-dependent expression of sclerostin in human osteoblasts","volume":"24","author":"Vincent","year":"2009","journal-title":"J. Bone. Miner. Res."},{"key":"10.1016\/j.bbrc.2012.06.100_b0110","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1359\/jbmr.070804","article-title":"Control of the SOST bone enhancer by PTH using MEF2 transcription factors","volume":"22","author":"Leupin","year":"2007","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bbrc.2012.06.100_b0115","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1111\/j.1600-0625.2005.00362.x","article-title":"Learning from nudity: lessons from the nude phenotype","volume":"14","author":"Mecklenburg","year":"2005","journal-title":"Exp. Dermatol."},{"key":"10.1016\/j.bbrc.2012.06.100_b0120","doi-asserted-by":"crossref","first-page":"13960","DOI":"10.1073\/pnas.251534698","article-title":"Up-regulation of TNF-producing T cells in the bone marrow: a key mechanism by which estrogen deficiency induces bone loss in vivo","volume":"98","author":"Roggia","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbrc.2012.06.100_b0125","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1359\/jbmr.1997.12.6.935","article-title":"The functional block of TNF but not of IL-6 prevents bone loss in ovariectomized mice","volume":"12","author":"Kimble","year":"1997","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bbrc.2012.06.100_b0130","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1172\/JCI11066","article-title":"Estrogen deficiency induces bone loss by enhancing T-cell production of TNF-alpha","volume":"106","author":"Cenci","year":"2000","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbrc.2012.06.100_b0135","doi-asserted-by":"crossref","first-page":"16735","DOI":"10.1073\/pnas.0505168102","article-title":"An IL-7-dependent rebound in thymic T cell output contributes to the bone loss induced by estrogen deficiency","volume":"102","author":"Ryan","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbrc.2012.06.100_b0140","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.bone.2005.03.018","article-title":"SOST is a target gene for PTH in bone","volume":"37","author":"Keller","year":"2005","journal-title":"Bone"},{"key":"10.1016\/j.bbrc.2012.06.100_b0145","doi-asserted-by":"crossref","first-page":"389","DOI":"10.3233\/BIR-2009-0550","article-title":"Modulation of sclerostin expression by mechanical loading and bone morphogenetic proteins in osteogenic cells","volume":"46","author":"Papanicolaou","year":"2009","journal-title":"Biorheology"},{"key":"10.1016\/j.bbrc.2012.06.100_b0150","doi-asserted-by":"crossref","first-page":"20764","DOI":"10.1073\/pnas.0805133106","article-title":"Regulation of bone formation by osteoclasts involves Wnt\/BMP signaling and the chemokine sphingosine-1-phosphate","volume":"105","author":"Pederson","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X12011953?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X12011953?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,6,23]],"date-time":"2023-06-23T21:28:48Z","timestamp":1687555728000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X12011953"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,7]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,7]]}},"alternative-id":["S0006291X12011953"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2012.06.100","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2012,7]]}}}