{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T15:22:30Z","timestamp":1789658550317,"version":"4.0.1"},"reference-count":35,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2012,10,1]],"date-time":"2012-10-01T00:00:00Z","timestamp":1349049600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2012,10]]},"DOI":"10.1016\/j.bbrc.2012.08.119","type":"journal-article","created":{"date-parts":[[2012,9,7]],"date-time":"2012-09-07T00:19:24Z","timestamp":1346977164000},"page":"528-532","source":"Crossref","is-referenced-by-count":36,"title":["ATP activates P2X receptors to mediate gap junctional coupling in the cochlea"],"prefix":"10.1016","volume":"426","author":[{"given":"Yan","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Bo","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2012.08.119_b0005","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1038\/387080a0","article-title":"Connexin 26 mutations in hereditary non-syndromic sensorineural deafness","volume":"387","author":"Kelsell","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2012.08.119_b0010","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/BF00186783","article-title":"Gap junctions in the rat cochlea: immunohistochemical and ultrastructural analysis","volume":"191","author":"Kikuchi","year":"1995","journal-title":"Anat. Embryol."},{"key":"10.1016\/j.bbrc.2012.08.119_b0015","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s002320001051","article-title":"Voltage gating of gap junctions in cochlear supporting cells: evidence for nonhomotypic channels","volume":"175","author":"Zhao","year":"2000","journal-title":"J. Membr. Biol."},{"key":"10.1016\/j.bbrc.2012.08.119_b0020","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1002\/cne.10916","article-title":"Gap junctions in the inner ear: comparison of distribution patterns in different vertebrates and assessement of connexin composition in mammals","volume":"467","author":"Forge","year":"2003","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.bbrc.2012.08.119_b0025","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1002\/cne.21113","article-title":"Distinct and gradient distributions of connexin26 and connexin30 in the cochlear sensory epithelium of guinea pigs","volume":"499","author":"Zhao","year":"2006","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.bbrc.2012.08.119_b0030","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1038\/20686","article-title":"Auditory collusion and a coupled couple of outer hair cells","volume":"399","author":"Zhao","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2012.08.119_b0035","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0304-3940(00)01626-8","article-title":"Directional rectification of gap junctional voltage gating between dieters cells in the inner ear of guinea pig","volume":"296","author":"Zhao","year":"2000","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.bbrc.2012.08.119_b0040","doi-asserted-by":"crossref","first-page":"e7923","DOI":"10.1371\/journal.pone.0007923","article-title":"Modulation of outer hair cell electromotility by cochlear supporting cells and gap junctions","volume":"4","author":"Yu","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.bbrc.2012.08.119_b0045","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/0378-5955(91)90190-K","article-title":"Isolated supporting cells from the organ of Corti: some whole cell electrical characteristics and estimates of gap junctional conductance","volume":"52","author":"Santos-Sacchi","year":"1991","journal-title":"Hear. Res."},{"key":"10.1016\/j.bbrc.2012.08.119_b0050","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/s11302-010-9184-9","article-title":"ATP-mediated potassium recycling in the cochlear supporting cells","volume":"6","author":"Zhu","year":"2010","journal-title":"Purinergic Signal"},{"key":"10.1016\/j.bbrc.2012.08.119_b0055","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/ncb1205","article-title":"Impaired permeability to Ins (1,4,5) P3 in a mutant connexin underlies recessive hereditary deafness","volume":"7","author":"Beltramello","year":"2005","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.bbrc.2012.08.119_b0060","doi-asserted-by":"crossref","first-page":"15201","DOI":"10.1073\/pnas.0501859102","article-title":"Gap junction-mediated intercellular biochemical coupling in cochlear supporting cells is required for normal cochlear functions","volume":"102","author":"Zhang","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbrc.2012.08.119_b0065","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1080\/15419060802357217","article-title":"Hemichannel-mediated inositol 1, 4, 5-trisphosphate (IP3) release in the cochlea: a novel mechanism of IP3 intercellular signaling","volume":"15","author":"Gossman","year":"2008","journal-title":"Cell Commun. Adhes."},{"key":"10.1016\/j.bbrc.2012.08.119_b0180","unstructured":"H.B. Zhao, Biophysical properties and functional analysis of inner ear gap junctions for deafness mechanisms of nonsyndromic hearing loss, in: Proceedings of the 9th International Meeting on Gap Junctions, August 2003, Cambridge, UK, pp. 23\u201328."},{"key":"10.1016\/j.bbrc.2012.08.119_b0075","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1111\/j.1460-9568.2005.04031.x","article-title":"Connexin26 is responsible for anionic molecule permeability in the cochlea for intercellular signaling and metabolic communications","volume":"21","author":"Zhao","year":"2005","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.bbrc.2012.08.119_b0080","doi-asserted-by":"crossref","first-page":"18724","DOI":"10.1073\/pnas.0506481102","article-title":"Gap junctional hemichannel-mediated ATP release and hearing controls in the inner ear","volume":"102","author":"Zhao","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbrc.2012.08.119_b0085","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1007\/s00424-008-0522-5","article-title":"ATP activates P2x receptors and requires extracellular Ca2+ participation to modify outer hair cell nonlinear capacitance","volume":"457","author":"Yu","year":"2008","journal-title":"Pflugers Arch."},{"key":"10.1016\/j.bbrc.2012.08.119_b0090","doi-asserted-by":"crossref","first-page":"4057","DOI":"10.1021\/jm020046y","article-title":"Purine and pyrimidine (P2) receptors as drug targets","volume":"45","author":"Jacobson","year":"2002","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bbrc.2012.08.119_b0095","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1152\/physrev.00015.2002","article-title":"Molecular physiology of P2X receptors","volume":"82","author":"North","year":"2002","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.bbrc.2012.08.119_b0100","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.tins.2009.01.001","article-title":"Purinergic signaling in special senses","volume":"32","author":"Housley","year":"2009","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.bbrc.2012.08.119_b0105","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/0378-5955(95)00153-5","article-title":"Adenosine 5\u2019-triphosphate (ATP) concentrations in the endolymph and perilymph of the guinea-pig cochlea","volume":"90","author":"Munoz","year":"1995","journal-title":"Hear. Res."},{"key":"10.1016\/j.bbrc.2012.08.119_b0110","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1113\/jphysiol.1990.sp018203","article-title":"Control of intracellular calcium by ATP in isolated outer hair cells of the guinea-pig cochlea","volume":"428","author":"Ashmore","year":"1990","journal-title":"J. Physiol."},{"key":"10.1016\/j.bbrc.2012.08.119_b0115","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1097\/00001756-199102000-00001","article-title":"Extracellular ATP elevates cytosolic Ca2+ in cochlear inner hair cells","volume":"2","author":"Dulon","year":"1991","journal-title":"Neuroreport"},{"key":"10.1016\/j.bbrc.2012.08.119_b0120","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1113\/jphysiol.1996.sp021251","article-title":"ATP activates non-selective cation channels and calcium release in inner hair cells of the guinea-pig cochlea","volume":"491","author":"Sugasawa","year":"1996","journal-title":"J. Physiol."},{"key":"10.1016\/j.bbrc.2012.08.119_b0125","doi-asserted-by":"crossref","first-page":"8377","DOI":"10.1523\/JNEUROSCI.19-19-08377.1999","article-title":"Expression of the P2X2 receptor subunit of the ATP-gated ion channel in the cochlea: implications for sound transduction and auditory neurotransmission","volume":"19","author":"Housley","year":"1999","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbrc.2012.08.119_b0130","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1007\/s10162-003-4003-4","article-title":"Purinergic modulation of cochlear partition resistance and its effect on the endocochlear potential in the Guinea pig","volume":"5","author":"Thorne","year":"2004","journal-title":"J. Assoc. Res. Otolaryngol."},{"key":"10.1016\/j.bbrc.2012.08.119_b0135","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/s11302-010-9195-6","article-title":"Reduced P2x(2) receptor-mediated regulation of endocochlear potential in the ageing mouse cochlea","volume":"6","author":"Telang","year":"2010","journal-title":"Purinergic Signal"},{"key":"10.1016\/j.bbrc.2012.08.119_b0140","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/nature06233","article-title":"The origin of spontaneous activity in the developing auditory system","volume":"450","author":"Tritsch","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2012.08.119_b0145","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1038\/nature08487","article-title":"The postsynaptic function of type II cochlear afferents","volume":"461","author":"Weisz","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2012.08.119_b0150","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.ceca.2006.05.005","article-title":"Purinergic signalling and intercellular Ca2+ wave propagation in the organ of Corti","volume":"41","author":"Piazza","year":"2007","journal-title":"Cell Calcium"},{"key":"10.1016\/j.bbrc.2012.08.119_b0155","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1111\/j.1469-7793.2001.0693h.x","article-title":"Purinergic control of intercellular communication between Hensen\u2019s cells of the guinea-pig cochlea","volume":"531","author":"Lagostena","year":"2001","journal-title":"J. Physiol."},{"key":"10.1016\/j.bbrc.2012.08.119_b0160","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1085\/jgp.112.4.447","article-title":"Effect of membrane tension on gap junctional conductance of supporting cells in Corti\u2019s organ","volume":"112","author":"Zhao","year":"1998","journal-title":"J. Gen. Physiol."},{"key":"10.1016\/j.bbrc.2012.08.119_b0165","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1085\/jgp.106.4.705","article-title":"Estimation of the junctional resistance between electrically coupled receptor cells in Necturus taste buds","volume":"106","author":"Bigiani","year":"1995","journal-title":"J. Gen. Physiol."},{"key":"10.1016\/j.bbrc.2012.08.119_b0170","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/0378-5955(94)90004-3","article-title":"Cell coupling in the supporting cells of Corti\u2019s organ: sensitivity to intracellular H+ and Ca2+","volume":"80","author":"Sato","year":"1994","journal-title":"Hear. Res."},{"key":"10.1016\/j.bbrc.2012.08.119_b0175","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1073\/pnas.79.2.441","article-title":"Gap junctional conductance: comparison of sensitivities to H and Ca ions","volume":"79","author":"Spray","year":"1982","journal-title":"Proc. Natl. Acad. Sci. USA"}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X12016877?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X12016877?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,7,3]],"date-time":"2019-07-03T15:06:47Z","timestamp":1562166407000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X12016877"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10]]},"references-count":35,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,10]]}},"alternative-id":["S0006291X12016877"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2012.08.119","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2012,10]]}}}