{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:57:03Z","timestamp":1791928623917,"version":"4.3.4"},"reference-count":42,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2013,7,1]],"date-time":"2013-07-01T00:00:00Z","timestamp":1372636800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,10,10]],"date-time":"2013-10-10T00:00:00Z","timestamp":1381363200000},"content-version":"vor","delay-in-days":101,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100004731","name":"Zhejiang Natural Science Foundation","doi-asserted-by":"crossref","award":["Y2100486"],"award-info":[{"award-number":["Y2100486"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2013,7]]},"DOI":"10.1016\/j.bbrc.2013.05.079","type":"journal-article","created":{"date-parts":[[2013,5,30]],"date-time":"2013-05-30T00:38:34Z","timestamp":1369874314000},"page":"578-584","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":48,"title":["MicroRNA-214 provokes cardiac hypertrophy via repression of EZH2"],"prefix":"10.1016","volume":"436","author":[{"given":"Tao","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo-fei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-fan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai-hua","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shao-zi","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-feng","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Ming","family":"Ni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.bbrc.2013.05.079_b0005","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1161\/ATVBAHA.112.300137","article-title":"MicroRNAs in Myocardial Infarction","volume":"33","author":"Fiedler","year":"2013","journal-title":"Arterios. Thromb. Vas. Biol."},{"key":"10.1016\/j.bbrc.2013.05.079_b0010","unstructured":"Y.R. Fujii, The xenotropic microRNA gene information for stem cell researches and clinical applications (2013)."},{"issue":"1","key":"10.1016\/j.bbrc.2013.05.079_b0015","first-page":"93","article-title":"A computational prediction of conserved microRNA targets of ion channels in vertebrates","volume":"8","author":"Kathirvel","year":"2013","journal-title":"Curr. Bioinform."},{"key":"10.1016\/j.bbrc.2013.05.079_b0020","article-title":"Regenerative medicine approach to repair the failing heart","author":"Vincenzo","year":"2013","journal-title":"Vas. pharmacol."},{"key":"10.1016\/j.bbrc.2013.05.079_b0025","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/978-1-4614-5203-4_2","article-title":"Molecular mechanisms of cardiac development","author":"Roche","year":"2013","journal-title":"Car. Adapt."},{"key":"10.1016\/j.bbrc.2013.05.079_b0030","first-page":"017","article-title":"MicroRNAs and cardiovascular disease","volume":"6","author":"Shijun","year":"2011","journal-title":"Int. J. Pathol. Clin. Med."},{"key":"10.1016\/j.bbrc.2013.05.079_b0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.yjmcc.2013.01.005","article-title":"MiRNA expression in pediatric failing human heart","author":"Stauffer","year":"2013","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"1","key":"10.1016\/j.bbrc.2013.05.079_b0040","doi-asserted-by":"crossref","first-page":"e52442","DOI":"10.1371\/journal.pone.0052442","article-title":"Heart structure-specific transcriptomic atlas reveals conserved microRNA\u2013mRNA interactions","volume":"8","author":"Vacchi-Suzzi","year":"2013","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.bbrc.2013.05.079_b0045","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.ccr.2012.11.019","article-title":"Suppression of miRNA-708 by polycomb group promotes metastases by calcium-induced cell migration","volume":"23","author":"Ryu","year":"2013","journal-title":"Cancer Cell"},{"key":"10.1016\/j.bbrc.2013.05.079_b0050","doi-asserted-by":"crossref","DOI":"10.1038\/ng.1068","article-title":"Epigenetic repression of cardiac progenitor gene expression by Ezh2 is required for postnatal cardiac homeostasis","author":"Delgado-Olgu\u00edn","year":"2012","journal-title":"Nat. Gene."},{"issue":"4","key":"10.1016\/j.bbrc.2013.05.079_b0055","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.vph.2011.08.001","article-title":"MicroRNAs as peripheral blood biomarkers of cardiovascular disease","volume":"55","author":"Di Stefano","year":"2011","journal-title":"Vas. Pharmacol."},{"key":"10.1016\/j.bbrc.2013.05.079_b0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbrc.2012.01.030","article-title":"Tumor suppressive <i> microRNA-133a\/<i> regulates novel targets Moesin contributes to cancer cell proliferation and invasion in head and neck squamous cell carcinoma","author":"Kinoshita","year":"2012","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"6","key":"10.1016\/j.bbrc.2013.05.079_b0065","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1073\/pnas.0710228105","article-title":"Targeted deletion of Dicer in the heart leads to dilated cardiomyopathy and heart failure","volume":"105","author":"Chen","year":"2008","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"5","key":"10.1016\/j.bbrc.2013.05.079_b0070","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1038\/nm1582","article-title":"MicroRNA-133 controls cardiac hypertrophy","volume":"13","author":"Care","year":"2007","journal-title":"Nat. Med."},{"issue":"1","key":"10.1016\/j.bbrc.2013.05.079_b0075","doi-asserted-by":"crossref","first-page":"i1","DOI":"10.1085\/JGP1411OIA1","article-title":"Mutual antagonism between IP3RII and miRNA-133a regulates calcium signals and cardiac hypertrophy","volume":"141","author":"Drawnel","year":"2013","journal-title":"J. General Physiol."},{"issue":"2","key":"10.1016\/j.bbrc.2013.05.079_b0080","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1161\/CIRCRESAHA.108.182535","article-title":"MiR-133 and miR-30 regulate connective tissue growth factor implications for a role of microRNAs in myocardial matrix remodeling","volume":"104","author":"Duisters","year":"2009","journal-title":"Circul. Res."},{"issue":"1","key":"10.1016\/j.bbrc.2013.05.079_b0085","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1002\/dmrr.1054","article-title":"MiR133a regulates cardiomyocyte hypertrophy in diabetes","volume":"26","author":"Feng","year":"2010","journal-title":"Diab.\/Metab. Res. Rev."},{"issue":"2","key":"10.1016\/j.bbrc.2013.05.079_b0090","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.bbrc.2009.08.136","article-title":"MicroRNA-133 regulates the expression of GLUT4 by targeting KLF15 and is involved in metabolic control in cardiac myocytes","volume":"389","author":"Horie","year":"2009","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"5","key":"10.1016\/j.bbrc.2013.05.079_b0095","doi-asserted-by":"crossref","first-page":"H1340","DOI":"10.1152\/ajpheart.00592.2009","article-title":"NFATc4 is negatively regulated in miR-133a-mediated cardiomyocyte hypertrophic repression","volume":"298","author":"Li","year":"2010","journal-title":"Am. J. Physiol.-Heart Circul. Physiol."},{"issue":"5","key":"10.1016\/j.bbrc.2013.05.079_b0100","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1016\/j.devcel.2009.10.013","article-title":"A family of microRNAs encoded by myosin genes governs myosin expression and muscle performance","volume":"17","author":"van Rooij","year":"2009","journal-title":"Develop. Cell"},{"issue":"5824","key":"10.1016\/j.bbrc.2013.05.079_b0105","first-page":"575","article-title":"Control of stress-dependent cardiac growth and gene expression by a microRNA","volume":"316","author":"van Rooij","year":"2007","journal-title":"Sci. Signal."},{"issue":"6","key":"10.1016\/j.bbrc.2013.05.079_b0110","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1016\/j.yjmcc.2007.04.004","article-title":"Expression of microRNAs is dynamically regulated during cardiomyocyte hypertrophy","volume":"42","author":"Tatsuguchi","year":"2007","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"6","key":"10.1016\/j.bbrc.2013.05.079_b0115","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.2353\/ajpath.2007.061170","article-title":"MicroRNAs are aberrantly expressed in hypertrophic heart: do they play a role in cardiac hypertrophy?","volume":"170","author":"Cheng","year":"2007","journal-title":"Am. J. Pathol."},{"issue":"15","key":"10.1016\/j.bbrc.2013.05.079_b0120","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1161\/CIRCULATIONAHA.108.769984","article-title":"Conditional dicer gene deletion in the postnatal myocardium provokes spontaneous cardiac remodeling","volume":"118","author":"Costa da Martins","year":"2008","journal-title":"Circulation"},{"issue":"48","key":"10.1016\/j.bbrc.2013.05.079_b0125","doi-asserted-by":"crossref","first-page":"18255","DOI":"10.1073\/pnas.0608791103","article-title":"A signature pattern of stress-responsive microRNAs that can evoke cardiac hypertrophy and heart failure","volume":"103","author":"Van Rooij","year":"2006","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"1","key":"10.1016\/j.bbrc.2013.05.079_b0130","doi-asserted-by":"crossref","first-page":"e53950","DOI":"10.1371\/journal.pone.0053950","article-title":"MiR-30-regulated autophagy mediates angiotensin II-induced myocardial hypertrophy","volume":"8","author":"Pan","year":"2013","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.bbrc.2013.05.079_b0135","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1161\/CIRCRESAHA.110.228437","article-title":"Thioredoxin 1 negatively regulates angiotensin II\u2013induced cardiac hypertrophy through upregulation of miR-98\/let-7 novelty and significance","volume":"108","author":"Yang","year":"2011","journal-title":"Circul. Res."},{"issue":"3","key":"10.1016\/j.bbrc.2013.05.079_b0140","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1038\/cr.2011.132","article-title":"Cardiomyocyte overexpression of miR-27b induces cardiac hypertrophy and dysfunction in mice","volume":"22","author":"Wang","year":"2011","journal-title":"Cell Res."},{"issue":"29","key":"10.1016\/j.bbrc.2013.05.079_b0145","doi-asserted-by":"crossref","first-page":"12103","DOI":"10.1073\/pnas.0811371106","article-title":"MiR-23a functions downstream of NFATc3 to regulate cardiac hypertrophy","volume":"106","author":"Lin","year":"2009","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"8","key":"10.1016\/j.bbrc.2013.05.079_b0150","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1016\/j.biocel.2009.03.002","article-title":"MicroRNAs 1, 133, and 206: critical factors of skeletal and cardiac muscle development, function, and disease","volume":"42","author":"Townley-Tilson","year":"2010","journal-title":"Int. J. Biochem. Cell Biol."},{"issue":"1","key":"10.1016\/j.bbrc.2013.05.079_b0155","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.jacc.2012.08.1003","article-title":"The circulating level of FABP3 is an indirect biomarker of microRNA-1","volume":"61","author":"Varrone","year":"2013","journal-title":"J. Am. College Cardiol."},{"issue":"2","key":"10.1016\/j.bbrc.2013.05.079_b0160","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1159\/000172616","article-title":"MicroRNA: novel regulators involved in the remodeling and reverse remodeling of the heart","volume":"113","author":"Wang","year":"2009","journal-title":"Cardiology"},{"key":"10.1016\/j.bbrc.2013.05.079_b0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbrc.2012.12.133","article-title":"MicroRNA-181b regulates articular chondrocytes differentiation and cartilage integrity","author":"Song","year":"2013","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"3","key":"10.1016\/j.bbrc.2013.05.079_b0170","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.jjcc.2011.01.009","article-title":"Altered microRNA expression associated with reduced catecholamine sensitivity in patients with chronic heart failure","volume":"57","author":"Funahashi","year":"2011","journal-title":"J. Cardiol."},{"issue":"3","key":"10.1016\/j.bbrc.2013.05.079_b0175","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1152\/physiolgenomics.00144.2007","article-title":"Altered microRNA expression in human heart disease","volume":"31","author":"Ikeda","year":"2007","journal-title":"Physiol. Gen."},{"issue":"2","key":"10.1016\/j.bbrc.2013.05.079_b0180","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1161\/CIRCULATIONAHA.110.012237","article-title":"Signature microRNA expression profile of essential hypertension and its novel link to human cytomegalovirus infection clinical perspective","volume":"124","author":"Li","year":"2011","journal-title":"Circulation"},{"issue":"3","key":"10.1016\/j.bbrc.2013.05.079_b0185","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1161\/01.RES.0000257913.42552.23","article-title":"MicroRNAs play an essential role in the development of cardiac hypertrophy","volume":"100","author":"Sayed","year":"2007","journal-title":"Circul. Res."},{"issue":"11","key":"10.1016\/j.bbrc.2013.05.079_b0190","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1152\/physiolgenomics.00145.2010","article-title":"MicroRNAs 29 are involved in the improvement of ventricular compliance promoted by aerobic exercise training in rats","volume":"43","author":"Soci","year":"2011","journal-title":"Physiol. Gen."},{"issue":"4","key":"10.1016\/j.bbrc.2013.05.079_b0195","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1093\/cvr\/cvn137","article-title":"MicroRNAs: novel regulators in cardiac development and disease","volume":"79","author":"Thum","year":"2008","journal-title":"Cardiovas. Res."},{"issue":"5","key":"10.1016\/j.bbrc.2013.05.079_b0200","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1161\/CIRCGENETICS.109.934281","article-title":"Dynamic microRNA expression programs during cardiac differentiation of human embryonic stem cells clinical perspective role for miR-499","volume":"3","author":"Wilson","year":"2010","journal-title":"Circul. Cardiovas. Gene."},{"key":"10.1016\/j.bbrc.2013.05.079_b0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.yjmcc.2012.04.012","article-title":"Combined deep microRNA and mRNA sequencing identifies protective transcriptomal signature of enhanced PI3K\u03b1 signaling in cardiac hypertrophy","author":"Yang","year":"2012","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"1","key":"10.1016\/j.bbrc.2013.05.079_b0210","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.molcel.2009.08.008","article-title":"Mir-214-dependent regulation of the polycomb protein Ezh2 in skeletal muscle and embryonic stem cells","volume":"36","author":"Juan","year":"2009","journal-title":"Mol. Cell"}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X13008760?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X13008760?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T16:25:34Z","timestamp":1588955134000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X13008760"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7]]},"references-count":42,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,7]]}},"alternative-id":["S0006291X13008760"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2013.05.079","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2013,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"MicroRNA-214 provokes cardiac hypertrophy via repression of EZH2","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2013.05.079","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}