{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T04:13:24Z","timestamp":1784261604256,"version":"3.55.0"},"reference-count":27,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2013,6,1]],"date-time":"2013-06-01T00:00:00Z","timestamp":1370044800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2013,6]]},"DOI":"10.1016\/j.bbrc.2013.05.088","type":"journal-article","created":{"date-parts":[[2013,5,30]],"date-time":"2013-05-30T16:48:52Z","timestamp":1369932532000},"page":"259-264","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"title":["Synergistically killing activity of aspirin and histone deacetylase inhibitor valproic acid (VPA) on hepatocellular cancer cells"],"prefix":"10.1016","volume":"436","author":[{"given":"Xiaofei","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanshuang","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huabin","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianqing","family":"Lou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiwei","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongxin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinghe","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2013.05.088_b0005","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1136\/gut.2010.208413","article-title":"Liver dysfunction related to hepatitis B and C in patients with inflammatory bowel disease treated with immunosuppressive therapy","volume":"59","author":"Loras","year":"2010","journal-title":"Gut"},{"key":"10.1016\/j.bbrc.2013.05.088_b0010","doi-asserted-by":"crossref","first-page":"e48208","DOI":"10.1371\/journal.pone.0048208","article-title":"Aspirin inhibits colon cancer cell and tumor growth and downregulates specificity protein (Sp) transcription factors","volume":"7","author":"Pathi","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.bbrc.2013.05.088_b0015","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1186\/1477-7819-10-200","article-title":"Cyclooxygenase\/lipoxygenase shunting lowers the anti-cancer effect of cyclooxygenase-2 inhibition in colorectal cancer cells","volume":"10","author":"Ganesh","year":"2012","journal-title":"World J. Surg. Oncol."},{"key":"10.1016\/j.bbrc.2013.05.088_b0020","doi-asserted-by":"crossref","first-page":"2260","DOI":"10.3892\/ijo.2012.1636","article-title":"Chemoprevention of pancreatic cancer using solid-lipid nanoparticulate delivery of a novel aspirin, curcumin and sulforaphane drug combination regimen","volume":"41","author":"Sutaria","year":"2012","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.bbrc.2013.05.088_b0025","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1158\/1940-6207.CAPR-12-0171","article-title":"Aspirin use after a prostate cancer diagnosis and cancer survival in a prospective cohort","volume":"5","author":"Dhillon","year":"2012","journal-title":"Cancer Prev. Res. (Phila)"},{"key":"10.1016\/j.bbrc.2013.05.088_b0030","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s11010-012-1421-9","article-title":"Priming effect of aspirin for tumor cells to augment cytotoxic action of cisplatin against tumor cells: implication of altered constitution of tumor microenvironment, expression of cell cycle, apoptosis, and survival regulatory molecules","volume":"371","author":"Kumar","year":"2012","journal-title":"Mol. Cell Biochem."},{"key":"10.1016\/j.bbrc.2013.05.088_b0035","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.taap.2012.07.029","article-title":"Effects of nitric oxide-releasing nonsteroidal anti-inflammatory drugs (NONO\u2013NSAIDs) on melanoma cell adhesion","volume":"264","author":"Cheng","year":"2012","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.bbrc.2013.05.088_b0040","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.bbrc.2012.06.067","article-title":"Aspirin enhances TRAIL-induced apoptosis via regulation of ERK1\/2 activation in human cervical cancer cells","volume":"424","author":"Im","year":"2012","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2013.05.088_b0045","doi-asserted-by":"crossref","DOI":"10.1021\/mp300073j","article-title":"Inducing apoptosis in rolling cancer cells: a combined therapy with aspirin and immobilized trail and E-selectin","author":"Rana","year":"2012","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.bbrc.2013.05.088_b0050","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/j.bcp.2011.12.019","article-title":"Hydrogen sulfide-releasing aspirin suppresses NF-\u03baB signaling in estrogen receptor negative breast cancer cells in vitro and in vivo","volume":"83","author":"Chattopadhyay","year":"2012","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bbrc.2013.05.088_b0055","first-page":"180363","article-title":"Mechanism of growth inhibition of prostate cancer xenografts by valproic acid","author":"Sidana","year":"2012","journal-title":"J. Biomed. Biotechnol."},{"key":"10.1016\/j.bbrc.2013.05.088_b0060","doi-asserted-by":"crossref","first-page":"2487","DOI":"10.3109\/10428194.2012.698273","article-title":"Synergistic\/additive interaction of valproic acid with bortezomib on proliferation and apoptosis of acute myeloid leukemia cells","volume":"53","author":"Nie","year":"2012","journal-title":"Leuk. Lymphoma"},{"key":"10.1016\/j.bbrc.2013.05.088_b0065","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1002\/pbc.24152","article-title":"Valproic acid synergistically enhances the cytotoxicity of clofarabine in pediatric acute myeloid leukemia cells","volume":"59","author":"Xie","year":"2012","journal-title":"Pediatr. Blood Cancer"},{"key":"10.1016\/j.bbrc.2013.05.088_b0070","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.bbrc.2011.05.149","article-title":"Lovastatin and valproic acid additively attenuate cell invasion in ACC-MESO-1 cells","volume":"410","author":"Yamauchi","year":"2011","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2013.05.088_b0075","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1093\/jnci\/83.11.775","article-title":"Tumor cell invasion inhibited by TIMP-2","volume":"83","author":"Albini","year":"1991","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.bbrc.2013.05.088_b0080","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.1038\/sj.bjc.6602221","article-title":"A new superinvasive in vitro phenotype induced by selection of human breast carcinoma cells with the chemotherapeutic drugs paclitaxel and doxorubicin","volume":"91","author":"Glynn","year":"2004","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.bbrc.2013.05.088_b0085","doi-asserted-by":"crossref","first-page":"e1000410","DOI":"10.1371\/journal.pbio.1000410","article-title":"HSP72 protects cells from ER stress-induced apoptosis via enhancement of IRE1alpha-XBP1 signaling through a physical interaction","volume":"8","author":"Gupta","year":"2010","journal-title":"PLoS Biol."},{"key":"10.1016\/j.bbrc.2013.05.088_b0090","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1038\/35019501","article-title":"Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome","volume":"2","author":"Beere","year":"2000","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.bbrc.2013.05.088_b0095","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1038\/bjc.2011.289","article-title":"Aspirin and cancer: has aspirin been overlooked as an adjuvant therapy?","volume":"105","author":"Langley","year":"2011","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.bbrc.2013.05.088_b0100","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1158\/2159-8290.CD-12-0329","article-title":"The initial hours of metastasis: the importance of cooperative host\u2013tumor cell interactions during hematogenous dissemination","volume":"2","author":"Labelle","year":"2012","journal-title":"Cancer Discov."},{"key":"10.1016\/j.bbrc.2013.05.088_b0105","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1111\/j.1523-1755.2004.00387.x","article-title":"Chronic COX-2 inhibition reduces medullary HSP70 expression and induces papillary apoptosis in dehydrated rats","volume":"65","author":"Neuhofer","year":"2004","journal-title":"Kidney Int."},{"key":"10.1016\/j.bbrc.2013.05.088_b0110","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.bbrc.2004.02.105","article-title":"Modulation of angiogenesis-related protein synthesis by valproic acid","volume":"316","author":"Zgouras","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2013.05.088_b0115","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1158\/0008-5472.CAN-03-0799","article-title":"Histone deacetylase is a target of valproic acidmediated cellular differentiation","volume":"64","author":"Gurvich","year":"2004","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbrc.2013.05.088_b0120","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1007\/s11306-009-0159-1","article-title":"Single valproic acid treatment inhibits glycogen and RNA ribose turnover while disrupting glucose-derived cholesterol synthesis in liver as revealed by the [U-13C6]-d-glucose tracer in mice","volume":"5","author":"Beger","year":"2009","journal-title":"Metabolomics"},{"key":"10.1016\/j.bbrc.2013.05.088_b0125","doi-asserted-by":"crossref","first-page":"2734","DOI":"10.1016\/j.fct.2011.08.012","article-title":"Anti-inflammatory effects of [6]-shogaol: potential roles of HDAC inhibition and HSP70 induction","volume":"49","author":"Shim","year":"2011","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.bbrc.2013.05.088_b0130","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1111\/j.1471-4159.2009.06385.x","article-title":"Valproic acid induces functional heat-shock protein 70 via Class I histone deacetylase inhibition in cortical neurons: a potential role of Sp1 acetylation","volume":"111","author":"Marinova","year":"2009","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbrc.2013.05.088_b0135","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1002\/ijc.28029","article-title":"Elevated levels of mitochondrial mortalin and cytosolic HSP70 in blood as risk factors in patients with colorectal cancer","volume":"133","author":"Rozenberg","year":"2013","journal-title":"Int. J. Cancer"}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X13008954?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X13008954?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,7,14]],"date-time":"2019-07-14T07:55:12Z","timestamp":1563090912000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X13008954"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6]]},"references-count":27,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,6]]}},"alternative-id":["S0006291X13008954"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2013.05.088","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2013,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Synergistically killing activity of aspirin and histone deacetylase inhibitor valproic acid (VPA) on hepatocellular cancer cells","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2013.05.088","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Crown copyright \u00a9 2013 Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}