{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:55:52Z","timestamp":1788872152238,"version":"build-2803163510"},"reference-count":29,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2013,7,1]],"date-time":"2013-07-01T00:00:00Z","timestamp":1372636800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"National Basic Science and Development Program","award":["2012CB518103"],"award-info":[{"award-number":["2012CB518103"]}]},{"name":"National Basic Science and Development Program","award":["2012CB518105"],"award-info":[{"award-number":["2012CB518105"]}]},{"name":"863 Projects of Ministry of Science and Technology of China","award":["2011AA020113"],"award-info":[{"award-number":["2011AA020113"]}]},{"name":"863 Projects of Ministry of Science and Technology of China","award":["2013AA020105"],"award-info":[{"award-number":["2013AA020105"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81121004"],"award-info":[{"award-number":["81121004"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81230041"],"award-info":[{"award-number":["81230041"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2013,7]]},"DOI":"10.1016\/j.bbrc.2013.05.117","type":"journal-article","created":{"date-parts":[[2013,6,11]],"date-time":"2013-06-11T13:53:33Z","timestamp":1370958813000},"page":"418-423","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":91,"title":["Multiple intravenous infusions of bone marrow mesenchymal stem cells reverse hyperglycemia in experimental type 2 diabetes rats"],"prefix":"10.1016","volume":"436","author":[{"given":"Haojie","family":"Hao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiejie","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yali","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huilin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuan","family":"Tong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongdong","family":"Ti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiming","family":"Mu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianping","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaobing","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weidong","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2013.05.117_b0005","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.diabres.2009.10.007","article-title":"Global estimates of the prevalence of diabetes for 2010 and 2030","volume":"87","author":"Shaw","year":"2010","journal-title":"Diabetes Res. Clin. Pract."},{"key":"10.1016\/j.bbrc.2013.05.117_b0010","doi-asserted-by":"crossref","unstructured":"American Diabetes Association, Diagnosis and classification of diabetes mellitus, Diabetes Care 31 (Suppl. 1) (2008) S55\u2013S60.","DOI":"10.2337\/dc08-S055"},{"key":"10.1016\/j.bbrc.2013.05.117_b0015","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.blre.2004.03.001","article-title":"Stem cell plasticity","volume":"19","author":"Lakshmipathy","year":"2005","journal-title":"Blood Rev."},{"key":"10.1016\/j.bbrc.2013.05.117_b0020","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/S0301-472X(00)00482-3","article-title":"Mesenchymal stem cells: biology and potential clinical uses","volume":"28","author":"Deans","year":"2000","journal-title":"Exp. Hematol."},{"key":"10.1016\/j.bbrc.2013.05.117_b0025","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1002\/jcp.20959","article-title":"From the laboratory bench to the patient\u2019s bedside: an update on clinical trials with mesenchymal stem cells","volume":"211","author":"Giordano","year":"2007","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.bbrc.2013.05.117_b0030","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.bbmt.2008.01.006","article-title":"Systemic administration of multipotent mesenchymal stromal cells reverts hyperglycemia and prevents nephropathy in type 1 diabetic mice","volume":"14","author":"Ezquer","year":"2008","journal-title":"Biol. Blood Marrow Transplant."},{"key":"10.1016\/j.bbrc.2013.05.117_b0035","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.arr.2010.08.005","article-title":"MSCs: biological characteristics, clinical applications and their outstanding concerns","volume":"10","author":"Si","year":"2011","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.bbrc.2013.05.117_b0040","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1517\/14712590903455997","article-title":"Modification of mesenchymal stem cells for cardiac regeneration","volume":"10","author":"Song","year":"2010","journal-title":"Expert Opin. Biol. Ther."},{"key":"10.1016\/j.bbrc.2013.05.117_b0045","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1002\/stem.1132","article-title":"The antidiabetic effect of mesenchymal stem cells is unrelated to their transdifferentiation potential but to their capability to restore Th1\/Th2 balance and to modify the pancreatic microenvironment","volume":"30","author":"Ezquer","year":"2012","journal-title":"Stem Cells"},{"key":"10.1016\/j.bbrc.2013.05.117_b0050","doi-asserted-by":"crossref","first-page":"17438","DOI":"10.1073\/pnas.0608249103","article-title":"Multipotent stromal cells from human marrow home to and promote repair of pancreatic islets and renal glomeruli in diabetic NOD\/scid mice","volume":"103","author":"Lee","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbrc.2013.05.117_b0055","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1007\/s00125-009-1374-z","article-title":"Mesenchymal stem cells protect NOD mice from diabetes by inducing regulatory T cells","volume":"52","author":"Madec","year":"2009","journal-title":"Diabetologia"},{"key":"10.1016\/j.bbrc.2013.05.117_b0060","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1097\/TP.0b013e3181c7dc99","article-title":"Trophic molecules derived from human mesenchymal stem cells enhance survival, function, and angiogenesis of isolated islets after transplantation","volume":"89","author":"Park","year":"2010","journal-title":"Transplantation"},{"key":"10.1016\/j.bbrc.2013.05.117_b0065","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.2337\/db11-1141","article-title":"Infusion of mesenchymal stem cells ameliorates hyperglycemia in type 2 diabetic rats: identification of a novel role in improving insulin sensitivity","volume":"61","author":"Si","year":"2012","journal-title":"Diabetes"},{"key":"10.1016\/j.bbrc.2013.05.117_b0070","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1634\/stemcells.2007-0267","article-title":"Mesenchymal stem cells cooperate with bone marrow cells in therapy of diabetes","volume":"26","author":"Urban","year":"2008","journal-title":"Stem Cells"},{"key":"10.1016\/j.bbrc.2013.05.117_b0075","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1053\/meta.2000.17721","article-title":"A new rat model of type 2 diabetes: the fat-fed, streptozotocin-treated rat","volume":"49","author":"Reed","year":"2000","journal-title":"Metabolism"},{"key":"10.1016\/j.bbrc.2013.05.117_b0080","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1097\/01.tp.0000259752.13304.0b","article-title":"Isolation of large numbers of mesenchymal stem cells from the washings of bone marrow collection bags: characterization of fresh mesenchymal stem cells","volume":"83","author":"Mageed","year":"2007","journal-title":"Transplantation"},{"key":"10.1016\/j.bbrc.2013.05.117_b0085","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1634\/stemcells.22-4-625","article-title":"Critical parameters for the isolation of mesenchymal stem cells from umbilical cord blood","volume":"22","author":"Bieback","year":"2004","journal-title":"Stem Cells"},{"key":"10.1016\/j.bbrc.2013.05.117_b0090","doi-asserted-by":"crossref","first-page":"997","DOI":"10.3727\/096368911X603611","article-title":"Multiple intravenous transplantations of mesenchymal stem cells effectively restore long-term blood glucose homeostasis by hepatic engraftment and beta-cell differentiation in streptozocin-induced diabetic mice","volume":"21","author":"Ho","year":"2012","journal-title":"Cell Transplant."},{"key":"10.1016\/j.bbrc.2013.05.117_b0095","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1016\/j.bbrc.2007.09.058","article-title":"The cardioprotective effect of mesenchymal stem cells is mediated by IGF-1 and VEGF","volume":"363","author":"Sadat","year":"2007","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2013.05.117_b0100","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.mehy.2008.03.046","article-title":"Mesenchymal stem cell therapy for diabetes through paracrine mechanisms","volume":"71","author":"Xu","year":"2008","journal-title":"Med. Hypotheses"},{"key":"10.1016\/j.bbrc.2013.05.117_b0105","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1373\/clinchem.2010.148270","article-title":"Is diabetes mellitus a continuous spectrum?","volume":"57","author":"Brooks-Worrell","year":"2011","journal-title":"Clin. Chem."},{"key":"10.1016\/j.bbrc.2013.05.117_b0110","doi-asserted-by":"crossref","first-page":"168","DOI":"10.2337\/dc10-0579","article-title":"Identification of autoantibody-negative autoimmune type 2 diabetic patients","volume":"34","author":"Brooks-Worrell","year":"2011","journal-title":"Diabetes Care"},{"key":"10.1016\/j.bbrc.2013.05.117_b0115","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1373\/clinchem.2010.148833","article-title":"Therapeutic approaches to target inflammation in type 2 diabetes","volume":"57","author":"Goldfine","year":"2011","journal-title":"Clin. Chem."},{"key":"10.1016\/j.bbrc.2013.05.117_b0120","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/nri2922","article-title":"Immunometabolism: an emerging frontier","volume":"11","author":"Mathis","year":"2011","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.bbrc.2013.05.117_b0125","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1023\/A:1025148211587","article-title":"Latent autoimmune diabetes in adults (LADA)","volume":"4","author":"Naik","year":"2003","journal-title":"Rev. Endocr. Metab. Disord."},{"key":"10.1016\/j.bbrc.2013.05.117_b0130","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1172\/JCI29069","article-title":"Inflammation and insulin resistance","volume":"116","author":"Shoelson","year":"2006","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbrc.2013.05.117_b0135","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1007\/s11684-011-0116-z","article-title":"Transplantation of placenta-derived mesenchymal stem cells in type 2 diabetes: a pilot study","volume":"5","author":"Jiang","year":"2011","journal-title":"Front. Med."},{"key":"10.1016\/j.bbrc.2013.05.117_b0140","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.2337\/db12-0355","article-title":"Mesenchymal stem cells for the treatment of diabetes","volume":"61","author":"Pileggi","year":"2012","journal-title":"Diabetes"},{"key":"10.1016\/j.bbrc.2013.05.117_b0145","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1038\/78693","article-title":"Targeted disruption of the glucose transporter 4 selectively in muscle causes insulin resistance and glucose intolerance","volume":"6","author":"Zisman","year":"2000","journal-title":"Nat. Med."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X13009352?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X13009352?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,2,24]],"date-time":"2022-02-24T16:58:03Z","timestamp":1645721883000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X13009352"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7]]},"references-count":29,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,7]]}},"alternative-id":["S0006291X13009352"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2013.05.117","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2013,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Multiple intravenous infusions of bone marrow mesenchymal stem cells reverse hyperglycemia in experimental type 2 diabetes rats","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2013.05.117","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}