{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T11:27:10Z","timestamp":1775042830350,"version":"3.50.1"},"reference-count":36,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2013,7,1]],"date-time":"2013-07-01T00:00:00Z","timestamp":1372636800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,10,21]],"date-time":"2013-10-21T00:00:00Z","timestamp":1382313600000},"content-version":"vor","delay-in-days":112,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"funder":[{"name":"NCI","award":["R01CA151354"],"award-info":[{"award-number":["R01CA151354"]}]},{"DOI":"10.13039\/501100001809","name":"NNSFC","doi-asserted-by":"crossref","award":["81250110552"],"award-info":[{"award-number":["81250110552"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Hyundai Hope on Wheels Research Scholar"},{"name":"Roy J. Carver Charitable Trust Collaborative Pilot"},{"name":"Iowa City Veterans Affairs Medical Center"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2013,7]]},"DOI":"10.1016\/j.bbrc.2013.06.012","type":"journal-article","created":{"date-parts":[[2013,6,11]],"date-time":"2013-06-11T15:32:55Z","timestamp":1370964775000},"page":"660-665","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"title":["Piperlongumine inhibits LMP1\/MYC-dependent mouse B-lymphoma cells"],"prefix":"10.1016","volume":"436","author":[{"given":"Seong-Su","family":"Han","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Van S.","family":"Tompkins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong-Ju","family":"Son","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalie L.","family":"Kamberos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura L.","family":"Stunz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmad","family":"Halwani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gail A.","family":"Bishop","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siegfried","family":"Janz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2013.06.012_b0005","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.phymed.2007.06.007","article-title":"Piper longum Linn. extract inhibits TNF-\u03b1-induced expression of cell adhesion molecules by inhibiting NF-\u03baB activation and microsomal lipid peroxidation","volume":"15","author":"Singh","year":"2008","journal-title":"Phytomedicine"},{"key":"10.1016\/j.bbrc.2013.06.012_b0010","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.leukres.2012.11.009","article-title":"Piperlongumine inhibits proliferation and survival of Burkitt lymphoma in vitro","volume":"37","author":"Han","year":"2013","journal-title":"Leuk. Res."},{"key":"10.1016\/j.bbrc.2013.06.012_b0015","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/nature10167","article-title":"Selective killing of cancer cells by a small molecule targeting the stress response to ROS","volume":"475","author":"Raj","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2013.06.012_b0020","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/0092-8674(85)90256-9","article-title":"An EBV membrane protein expressed in immortalized lymphocytes transforms established rodent cells","volume":"43","author":"Wang","year":"1985","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2013.06.012_b0025","doi-asserted-by":"crossref","first-page":"7824","DOI":"10.1073\/pnas.79.24.7824","article-title":"Human c-myc onc gene is located on the region of chromosome 8 that is translocated in Burkitt lymphoma cells","volume":"79","author":"Dalla-Favera","year":"1982","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.bbrc.2013.06.012_b0030","doi-asserted-by":"crossref","first-page":"3056","DOI":"10.1158\/1078-0432.CCR-10-2578","article-title":"Epstein-Barr virus-associated B-cell lymphomas: pathogenesis and clinical outcomes","volume":"17","author":"Saha","year":"2011","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.bbrc.2013.06.012_b0035","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1101\/gad.1095203","article-title":"Reconstructing myc","volume":"17","author":"Levens","year":"2003","journal-title":"Genes Dev."},{"key":"10.1016\/j.bbrc.2013.06.012_b0040","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1038\/nri910","article-title":"NF-[kappa] B regulation in the immune system","volume":"2","author":"Li","year":"2002","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.bbrc.2013.06.012_b0045","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1593\/neo.06274","article-title":"Molecular cross-talk between the NF kappa B and STAT3 signaling pathways in head and neck squamous cell carcinoma","volume":"8","author":"Squarize","year":"2006","journal-title":"Neoplasia"},{"key":"10.1016\/j.bbrc.2013.06.012_b0050","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1111\/j.1365-2559.2008.03139.x","article-title":"Activation of the NF-\u03baB signalling pathway in diffuse large B-cell lymphoma: clinical implications","volume":"53","author":"Espinosa","year":"2008","journal-title":"Histopathology"},{"key":"10.1016\/j.bbrc.2013.06.012_b0055","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1038\/nature04870","article-title":"Nuclear factor-\u03baB in cancer development and progression","volume":"441","author":"Karin","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2013.06.012_b0060","doi-asserted-by":"crossref","first-page":"e166","DOI":"10.1371\/journal.ppat.0030166","article-title":"EBV latent membrane protein 1 activates Akt, NF\u03baB, and Stat3 in B cell lymphomas","volume":"3","author":"Shair","year":"2007","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.bbrc.2013.06.012_b0065","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1084\/jem.181.3.1169","article-title":"Role of Rel-related factors in control of c-myc gene transcription in receptor-mediated apoptosis of the murine B cell WEHI 231 line","volume":"181","author":"Lee","year":"1995","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.bbrc.2013.06.012_b0070","doi-asserted-by":"crossref","first-page":"5015","DOI":"10.1128\/MCB.16.9.5015","article-title":"Inhibition of c-myc expression induces apoptosis of WEHI 231 murine B cells","volume":"16","author":"Wu","year":"1996","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.bbrc.2013.06.012_b0075","doi-asserted-by":"crossref","first-page":"5014","DOI":"10.1128\/JVI.02264-08","article-title":"c-Myc and Rel\/NF-\u03baB are the two mMaster transcriptional systems activated in the latency III program of Epstein-Barr virus-immortalized B cells","volume":"83","author":"Faumont","year":"2009","journal-title":"J. Virol."},{"key":"10.1016\/j.bbrc.2013.06.012_b0080","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1158\/0008-5472.CAN-04-0268","article-title":"Insertion of c-Myc into Igh induces B-cell and plasma-cell neoplasms in mice","volume":"65","author":"Park","year":"2005","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbrc.2013.06.012_b0085","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.immuni.2004.07.008","article-title":"Expression of the cytoplasmic tail of LMP1 in mice induces hyperactivation of B lymphocytes and disordered lymphoid architecture","volume":"21","author":"Stunz","year":"2004","journal-title":"Immunity"},{"key":"10.1016\/j.bbrc.2013.06.012_b0090","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/1476-4598-4-40","article-title":"Molecular and cytological features of the mouse B-cell lymphoma line iMycEmu-1","volume":"4","author":"Su Han","year":"2005","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.bbrc.2013.06.012_b0095","doi-asserted-by":"crossref","first-page":"7722","DOI":"10.1038\/sj.onc.1204868","article-title":"Transcription of the RelB gene is regulated by NF-kappaB","volume":"20","author":"Bren","year":"2001","journal-title":"Oncogene"},{"key":"10.1016\/j.bbrc.2013.06.012_b0100","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1182\/blood-2009-11-251074","article-title":"Aurora kinases A and B are up-regulated by Myc and are essential for maintenance of the malignant state","volume":"116","author":"den Hollander","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.bbrc.2013.06.012_b0105","doi-asserted-by":"crossref","first-page":"5884","DOI":"10.3748\/wjg.v12.i36.5884","article-title":"ECA39 is a novel distant metastasis-related biomarker in colorectal cancer","volume":"12","author":"Yoshikawa","year":"2006","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.bbrc.2013.06.012_b0110","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/jmv.22214","article-title":"Screening and functional analysis of differentially expressed genes in EBV-transformed lymphoblasts","volume":"9","author":"Dai","year":"2012","journal-title":"Virol. J."},{"key":"10.1016\/j.bbrc.2013.06.012_b0115","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1158\/0008-5472.CAN-12-1408","article-title":"MYC regulation of CHK1 and CHK2 promotes radioresistance in a stem cell-like population of nasopharyngeal carcinoma cells","volume":"73","author":"Wang","year":"2013","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbrc.2013.06.012_b0120","doi-asserted-by":"crossref","first-page":"2373","DOI":"10.1128\/MCB.26.6.2373-2386.2006","article-title":"Activation of transferrin receptor 1 by c-Myc enhances cellular proliferation and tumorigenesis","volume":"26","author":"O\u2019Donnell","year":"2006","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.bbrc.2013.06.012_b0125","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1002\/gcc.22030","article-title":"Analysis of 20 genes at chromosome band 12q13: RACGAP1 and MCRS1 overexpression in nonsmall-cell lung cancer","volume":"52","author":"Liang","year":"2013","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1016\/j.bbrc.2013.06.012_b0130","doi-asserted-by":"crossref","first-page":"6040","DOI":"10.1158\/1078-0432.CCR-11-0557","article-title":"Upregulation of Rac GTPase-activating protein 1 is significantly associated with the early recurrence of human hepatocellular carcinoma","volume":"17","author":"Wang","year":"2011","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.bbrc.2013.06.012_b0135","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s00280-012-2002-z","article-title":"Prognostic significance of RACGAP1 mRNA expression in high-risk early breast cancer: a study in primary tumors of breast cancer patients participating in a randomized Hellenic Cooperative Oncology Group trial","volume":"71","author":"Pliarchopoulou","year":"2013","journal-title":"Cancer Chemother. Pharmacol."},{"key":"10.1016\/j.bbrc.2013.06.012_b0140","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S1534-5807(01)00110-1","article-title":"Central spindle assembly and cytokinesis require a kinesin-like protein\/RhoGAP complex with microtubule bundling activity","volume":"2","author":"Mishima","year":"2002","journal-title":"Dev. Cell"},{"key":"10.1016\/j.bbrc.2013.06.012_b0145","doi-asserted-by":"crossref","first-page":"3550","DOI":"10.1182\/blood-2004-03-1066","article-title":"A GTPase-activating protein binds STAT3 and is required for IL-6-induced STAT3 activation and for differentiation of a leukemic cell line","volume":"104","author":"Tonozuka","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.bbrc.2013.06.012_b0150","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1161\/01.RES.0000204727.46710.5e","article-title":"Regulation of NADPH oxidases: the role of Rac proteins","volume":"98","author":"Hordijk","year":"2006","journal-title":"Circ. Res."},{"key":"10.1016\/j.bbrc.2013.06.012_b0155","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/nature07618","article-title":"Cell-cycle restriction limits DNA damage and maintains self-renewal of leukaemia stem cells","volume":"457","author":"Viale","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2013.06.012_b0160","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1038\/nrc2657","article-title":"P21 in cancer: intricate networks and multiple activities","volume":"9","author":"Abbas","year":"2009","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.bbrc.2013.06.012_b0165","first-page":"262","volume":"1","author":"Basile","year":"2003","journal-title":"Mol. Cancer Res."},{"key":"10.1016\/j.bbrc.2013.06.012_b0170","doi-asserted-by":"crossref","first-page":"46093","DOI":"10.1074\/jbc.M206603200","article-title":"Expression of Ku70 and Ku80 mediated by NF-\u03baB and cyclooxygenase-2 is related to proliferation of human gastric cancer cells","volume":"277","author":"Lim","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2013.06.012_b0175","doi-asserted-by":"crossref","first-page":"9367","DOI":"10.1158\/0008-5472.CAN-09-2616","article-title":"Targeting the Fanconi anemia\/BRCA pathway circumvents drug resistance in multiple myeloma","volume":"69","author":"Yarde","year":"2009","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbrc.2013.06.012_b0180","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","article-title":"Hallmarks of cancer: the next generation","volume":"144","author":"Hanahan","year":"2011","journal-title":"Cell"}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X13009868?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X13009868?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T16:44:59Z","timestamp":1588956299000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X13009868"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7]]},"references-count":36,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,7]]}},"alternative-id":["S0006291X13009868"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2013.06.012","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2013,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Piperlongumine inhibits LMP1\/MYC-dependent mouse B-lymphoma cells","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2013.06.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}