{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T02:02:05Z","timestamp":1792202525736,"version":"4.4.0"},"reference-count":17,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2013,8,1]],"date-time":"2013-08-01T00:00:00Z","timestamp":1375315200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,8,1]],"date-time":"2013-08-01T00:00:00Z","timestamp":1375315200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["17109007"],"award-info":[{"award-number":["17109007"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["22249020"],"award-info":[{"award-number":["22249020"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2013,8]]},"DOI":"10.1016\/j.bbrc.2013.07.004","type":"journal-article","created":{"date-parts":[[2013,7,11]],"date-time":"2013-07-11T23:17:32Z","timestamp":1373584652000},"page":"13-19","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":126,"title":["Downregulation of Securin by the variant RNF213 R4810K (rs112735431, G>A) reduces angiogenic activity of induced pluripotent stem cell-derived vascular endothelial cells from moyamoya patients"],"prefix":"10.1016","volume":"438","author":[{"given":"Toshiaki","family":"Hitomi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiyuki","family":"Habu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hatasu","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroko","family":"Okuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kouji H.","family":"Harada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Osafune","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Taura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masakatsu","family":"Sone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isao","family":"Asaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomonaga","family":"Ameku","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoko","family":"Kasahara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomomi","family":"Sudo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumihiko","family":"Shiota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirokuni","family":"Hashikata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasushi","family":"Takagi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Morito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susumu","family":"Miyamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuwa","family":"Nakao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akio","family":"Koizumi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2013.07.004_b0005","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1001\/archneur.1969.00480090076012","article-title":"Cerebrovascular \u201cmoyamoya\u201d disease. Disease showing abnormal net-like vessels in base of brain","volume":"20","author":"Suzuki","year":"1969","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.bbrc.2013.07.004_b0010","first-page":"37","article-title":"Hypogenesis of bilateral internal carotid arteries","volume":"9","author":"Takeuchi","year":"1957","journal-title":"Brain Nerve"},{"key":"10.1016\/j.bbrc.2013.07.004_b0015","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1016\/S1474-4422(08)70240-0","article-title":"Moyamoya disease: current concepts and future perspectives","volume":"7","author":"Kuroda","year":"2008","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.bbrc.2013.07.004_b0020","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.clineuro.2009.11.009","article-title":"Epidemiological and clinical features of moyamoya disease in Nanjing, China","volume":"112","author":"Miao","year":"2010","journal-title":"Clin. Neurol. Neurosurg."},{"key":"10.1016\/j.bbrc.2013.07.004_b0025","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1056\/NEJMra0804622","article-title":"Moyamoya disease and moyamoya syndrome","volume":"360","author":"Scott","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbrc.2013.07.004_b0030","doi-asserted-by":"crossref","first-page":"E16","DOI":"10.3171\/FOC\/2008\/24\/2\/E16","article-title":"Moyamoya disease in pediatric patients: outcomes of neurosurgical interventions","volume":"24","author":"Veeravagu","year":"2008","journal-title":"Neurosurg. Focus"},{"key":"10.1016\/j.bbrc.2013.07.004_b0035","doi-asserted-by":"crossref","first-page":"e22542","DOI":"10.1371\/journal.pone.0022542","article-title":"Identification of RNF213 as a susceptibility gene for moyamoya disease and its possible role in vascular development","volume":"6","author":"Liu","year":"2011","journal-title":"PLoS ONE"},{"key":"10.1016\/j.bbrc.2013.07.004_b0090","doi-asserted-by":"crossref","first-page":"299","DOI":"10.2176\/nmc.52.299","article-title":"Distribution of moyamoya disease susceptibility polymorphism p.R4810K in RNF213 in East and Southeast Asian Populations","volume":"52","author":"Liu","year":"2012","journal-title":"Neurol. Med. Chir."},{"key":"10.1016\/j.bbrc.2013.07.004_b0045","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1002\/jnr.22228","article-title":"Decreased level and defective function of circulating endothelial progenitor cells in children with moyamoya disease","volume":"88","author":"Kim","year":"2010","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.bbrc.2013.07.004_b0050","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/j.cell.2007.11.019","article-title":"Induction of pluripotent stem cells from adult human fibroblasts by defined factors","volume":"131","author":"Takahashi","year":"2007","journal-title":"Cell"},{"issue":"Suppl. 2","key":"10.1016\/j.bbrc.2013.07.004_b0055","doi-asserted-by":"crossref","first-page":"S238","DOI":"10.1016\/S0303-8467(97)00082-6","article-title":"Guidelines for the diagnosis and treatment of spontaneous occlusion of the circle of Willis (\u2018moyamoya\u2019 disease). Research Committee on Spontaneous Occlusion of the Circle of Willis (Moyamoya Disease) of the Ministry of Health and Welfare, Japan","volume":"99","author":"Fukui","year":"1997","journal-title":"Clin. Neurol. Neurosurg."},{"key":"10.1016\/j.bbrc.2013.07.004_b0060","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1038\/nbt.2051","article-title":"Screening ethnically diverse human embryonic stem cells identifies a chromosome 20 minimal amplicon conferring growth advantage","volume":"29","author":"Amps","year":"2011","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.bbrc.2013.07.004_b0065","doi-asserted-by":"crossref","first-page":"2644","DOI":"10.1101\/gad.435107","article-title":"SIRT1 controls endothelial angiogenic functions during vascular growth","volume":"21","author":"Potente","year":"2007","journal-title":"Genes Dev."},{"key":"10.1016\/j.bbrc.2013.07.004_b0070","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0022-1759(83)90303-4","article-title":"Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays","volume":"65","author":"Mosmann","year":"1983","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/j.bbrc.2013.07.004_b0075","first-page":"867","article-title":"Human pituitary tumor-transforming gene induces angiogenesis","volume":"86","author":"Ishikawa","year":"2001","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bbrc.2013.07.004_b0080","doi-asserted-by":"crossref","first-page":"4302","DOI":"10.1091\/mbc.e10-10-0838","article-title":"PTTG1\/securin modulates microtubule nucleation and cell migration","volume":"22","author":"Moreno-Mateos","year":"2011","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.bbrc.2013.07.004_b0085","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.2353\/ajpath.2006.060116","article-title":"Influence of endothelial cells on vascular smooth muscle cells phenotype after irradiation: implication in radiation-induced vascular damages","volume":"169","author":"Milliat","year":"2006","journal-title":"Am. J. Pathol."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X13011443?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X13011443?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T11:05:22Z","timestamp":1757761522000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X13011443"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8]]},"references-count":17,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,8]]}},"alternative-id":["S0006291X13011443"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2013.07.004","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2013,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Downregulation of Securin by the variant RNF213 R4810K (rs112735431, G>A) reduces angiogenic activity of induced pluripotent stem cell-derived vascular endothelial cells from moyamoya patients","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2013.07.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}