{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T07:12:41Z","timestamp":1788246761881,"version":"build-2803163510"},"reference-count":23,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2013,8,1]],"date-time":"2013-08-01T00:00:00Z","timestamp":1375315200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,5,13]],"date-time":"2014-05-13T00:00:00Z","timestamp":1399939200000},"content-version":"vor","delay-in-days":285,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"Wellcome Trust"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2013,8]]},"DOI":"10.1016\/j.bbrc.2013.07.005","type":"journal-article","created":{"date-parts":[[2013,7,11]],"date-time":"2013-07-11T09:17:11Z","timestamp":1373534231000},"page":"597-602","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"title":["Propranolol, a \u03b2-adrenoceptor antagonist, worsens liver injury in a model of non-alcoholic steatohepatitis"],"prefix":"10.1016","volume":"437","author":[{"given":"Chad","family":"McKee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junpei","family":"Soeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esra","family":"Asilmaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Sigalla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maelle","family":"Morgan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicoletta","family":"Sinelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tania","family":"Roskams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jude A.","family":"Oben","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2013.07.005_b0005","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1002\/hep.20466","article-title":"Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity","volume":"40","author":"Browning","year":"2004","journal-title":"Hepatology"},{"issue":"Suppl. 1","key":"10.1016\/j.bbrc.2013.07.005_b0010","doi-asserted-by":"crossref","first-page":"S104","DOI":"10.1016\/j.jhep.2008.01.009","article-title":"Non-alcoholic fatty liver disease: the mist gradually clears","volume":"48","author":"de Alwis","year":"2008","journal-title":"J. Hepatol."},{"key":"10.1016\/j.bbrc.2013.07.005_b0015","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.2337\/dc06-2247","article-title":"Prevalence of nonalcoholic fatty liver disease and its association with cardiovascular disease among type 2 diabetic patients","volume":"30","author":"Targher","year":"2007","journal-title":"Diabetes Care"},{"key":"10.1016\/j.bbrc.2013.07.005_b0020","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.1467-789X.2005.00164.x","article-title":"Prevalence of obesity in Great Britain","volume":"6","author":"Rennie","year":"2005","journal-title":"Obes. Rev."},{"issue":"Suppl. 1","key":"10.1016\/j.bbrc.2013.07.005_b0025","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/j.1467-789X.2007.00311.x","article-title":"Health risks associated with overweight and obesity","volume":"8","author":"Kopelman","year":"2007","journal-title":"Obes. Rev."},{"key":"10.1016\/j.bbrc.2013.07.005_b0030","doi-asserted-by":"crossref","first-page":"3000","DOI":"10.1001\/jama.289.22.3000","article-title":"Nonalcoholic fatty liver disease: an underrecognized cause of cryptogenic cirrhosis","volume":"289","author":"Clark","year":"2003","journal-title":"JAMA"},{"key":"10.1016\/j.bbrc.2013.07.005_b0035","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1053\/jhep.2003.50371","article-title":"Sympathetic nervous system inhibition increases hepatic progenitors and reduces liver injury","volume":"38","author":"Oben","year":"2003","journal-title":"Hepatology"},{"key":"10.1016\/j.bbrc.2013.07.005_b0040","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/S0006-291X(03)01360-3","article-title":"Norepinephrine induces hepatic fibrogenesis in leptin deficient ob\/ob mice","volume":"308","author":"Oben","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2013.07.005_b0045","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/S0006-291X(03)00232-8","article-title":"Norepinephrine and neuropeptide Y promote proliferation and collagen gene expression of hepatic myofibroblastic stellate cells","volume":"302","author":"Oben","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2013.07.005_b0050","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1002\/ar.a.20081","article-title":"Sympathetic nervous system regulation of liver repair","volume":"280","author":"Oben","year":"2004","journal-title":"Anat. Rec. A: Discov. Mol. Cell. Evol. Biol."},{"key":"10.1016\/j.bbrc.2013.07.005_b0055","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1056\/NEJM198312223092502","article-title":"Controlled trial of propranolol for the prevention of recurrent variceal hemorrhage in patients with cirrhosis","volume":"309","author":"Burroughs","year":"1983","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbrc.2013.07.005_b0060","doi-asserted-by":"crossref","first-page":"2254","DOI":"10.1056\/NEJMoa044456","article-title":"Beta-blockers to prevent gastroesophageal varices in patients with cirrhosis","volume":"353","author":"Groszmann","year":"2005","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbrc.2013.07.005_b0065","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1038\/nature730","article-title":"Bone marrow cells adopt the phenotype of other cells by spontaneous cell fusion","volume":"416","author":"Terada","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2013.07.005_b0070","doi-asserted-by":"crossref","first-page":"8078","DOI":"10.1073\/pnas.122210699","article-title":"In vitro trans-differentiation of adult hepatic stem cells into pancreatic endocrine hormone-producing cells","volume":"99","author":"Yang","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbrc.2013.07.005_b0075","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1053\/jhep.2001.26751","article-title":"A modified choline-deficient, ethionine-supplemented diet protocol effectively induces oval cells in mouse liver","volume":"34","author":"Akhurst","year":"2001","journal-title":"Hepatology"},{"key":"10.1016\/j.bbrc.2013.07.005_b0080","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1053\/jhep.2001.20793","article-title":"Human and rat hepatic stellate cells express neurotrophins and neurotrophin receptors","volume":"33","author":"Cassiman","year":"2001","journal-title":"Hepatology"},{"key":"10.1016\/j.bbrc.2013.07.005_b0085","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1002\/path.1257","article-title":"Liver pathology and hepatocarcinogenesis in a long-term mouse model of erythropoietic protoporphyria","volume":"199","author":"Libbrecht","year":"2003","journal-title":"J. Pathol."},{"key":"10.1016\/j.bbrc.2013.07.005_b0090","doi-asserted-by":"crossref","first-page":"G55","DOI":"10.1152\/ajpgi.00360.2005","article-title":"Roles of phosphatidylinositol 3-kinase and osteopontin in steatosis and aminotransferase release by hepatocytes treated with methionine-choline-deficient medium","volume":"291","author":"Sahai","year":"2006","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.bbrc.2013.07.005_b0095","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1210\/endo-129-2-1116","article-title":"Tissue-specific regulation of alpha 1B, beta 1, and beta 2-adrenergic receptor mRNAs by thyroid state in the rat","volume":"129","author":"Lazar-Wesley","year":"1991","journal-title":"Endocrinology"},{"key":"10.1016\/j.bbrc.2013.07.005_b0100","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1002\/jcp.1041520111","article-title":"Rapid inverse changes in alpha 1B- and beta 2-adrenergic receptors and gene transcripts in acutely isolated rat liver cells","volume":"152","author":"Ishac","year":"1992","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.bbrc.2013.07.005_b0105","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S1044-5323(03)00031-9","article-title":"The CD95 type I\/type II model","volume":"15","author":"Barnhart","year":"2003","journal-title":"Semin. Immunol."},{"key":"10.1016\/j.bbrc.2013.07.005_b0110","doi-asserted-by":"crossref","first-page":"2237","DOI":"10.1007\/s10495-006-0288-1","article-title":"Testicular germ cell sensitivity to TRAIL-induced apoptosis is dependent upon p53 expression and is synergistically enhanced by DR5 agonistic antibody treatment","volume":"11","author":"McKee","year":"2006","journal-title":"Apoptosis"},{"key":"10.1016\/j.bbrc.2013.07.005_b0115","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1136\/gut.2003.026658","article-title":"Hepatic fibrogenesis requires sympathetic neurotransmitters","volume":"53","author":"Oben","year":"2004","journal-title":"Gut"}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X13011455?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X13011455?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T17:57:36Z","timestamp":1588960656000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X13011455"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8]]},"references-count":23,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,8]]}},"alternative-id":["S0006291X13011455"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2013.07.005","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2013,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Propranolol, a \u03b2-adrenoceptor antagonist, worsens liver injury in a model of non-alcoholic steatohepatitis","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2013.07.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}