{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T09:10:03Z","timestamp":1789377003160,"version":"build-2803163510"},"reference-count":35,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2013,9,1]],"date-time":"2013-09-01T00:00:00Z","timestamp":1377993600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Chang-Gung University, Taoyuan, Taiwan","award":["CMRPD 34013, NMRP 140511"],"award-info":[{"award-number":["CMRPD 34013, NMRP 140511"]}]},{"name":"National Science Council of the ROC","award":["NSC 94-2320-B-182-052"],"award-info":[{"award-number":["NSC 94-2320-B-182-052"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2013,9]]},"DOI":"10.1016\/j.bbrc.2013.08.028","type":"journal-article","created":{"date-parts":[[2013,8,16]],"date-time":"2013-08-16T10:30:52Z","timestamp":1376649052000},"page":"60-65","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"title":["Thyroid hormone receptor inhibits hepatoma cell migration through transcriptional activation of Dickkopf 4"],"prefix":"10.1016","volume":"439","author":[{"given":"Hsiang-Cheng","family":"Chi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen-Hsin","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-Hui","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng-Ming","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chung-Ying","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia-Jung","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Hsin","family":"Tseng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang-Hsiang","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-Yi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I-Hsiao","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tzu-I","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Jan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwang-Huei","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2013.08.028_b0005","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1152\/physrev.2001.81.3.1269","article-title":"Nuclear hormone receptors and gene expression","volume":"81","author":"Aranda","year":"2001","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.bbrc.2013.08.028_b0010","first-page":"325","article-title":"Thyroid hormone dependent regulation of target genes and their physiological significance","volume":"31","author":"Huang","year":"2008","journal-title":"Chang Gung Med. J."},{"key":"10.1016\/j.bbrc.2013.08.028_b0015","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1023\/A:1010052101214","article-title":"Multiple mechanisms for regulation of the transcriptional activity of thyroid hormone receptors","volume":"1","author":"Cheng","year":"2000","journal-title":"Rev. Endocr. Metab. Disord."},{"key":"10.1016\/j.bbrc.2013.08.028_b0020","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1158\/0008-5472.CAN-08-2198","article-title":"Thyroid hormone receptor beta1 acts as a potent suppressor of tumor invasiveness and metastasis","volume":"69","author":"Martinez-Iglesias","year":"2009","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbrc.2013.08.028_b0025","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1038\/onc.2009.476","article-title":"Thyroid hormone receptors are tumor suppressors in a mouse model of metastatic follicular thyroid carcinoma","volume":"29","author":"Zhu","year":"2010","journal-title":"Oncogene"},{"key":"10.1016\/j.bbrc.2013.08.028_b0030","doi-asserted-by":"crossref","first-page":"4241","DOI":"10.1002\/j.1460-2075.1994.tb06744.x","article-title":"Thyroid abnormalities and hepatocellular carcinoma in mice transgenic for v-erbA","volume":"13","author":"Barlow","year":"1994","journal-title":"EMBO J."},{"key":"10.1016\/j.bbrc.2013.08.028_b0035","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1038\/324635a0","article-title":"The c-erb-A protein is a high-affinity receptor for thyroid hormone","volume":"324","author":"Sap","year":"1986","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2013.08.028_b0040","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1002\/(SICI)1098-2744(199909)26:1<53::AID-MC7>3.0.CO;2-Z","article-title":"Expression of mutant thyroid hormone nuclear receptors in human hepatocellular carcinoma cells","volume":"26","author":"Lin","year":"1999","journal-title":"Mol. Carcinog."},{"key":"10.1016\/j.bbrc.2013.08.028_b0045","doi-asserted-by":"crossref","first-page":"3576","DOI":"10.1038\/sj.onc.1209389","article-title":"Thyroid hormone receptors mutated in liver cancer function as distorted antimorphs","volume":"25","author":"Chan","year":"2006","journal-title":"Oncogene"},{"key":"10.1016\/j.bbrc.2013.08.028_b0050","doi-asserted-by":"crossref","first-page":"4162","DOI":"10.1038\/onc.2009.265","article-title":"Thyroid hormone receptor mutants implicated in human hepatocellular carcinoma display an altered target gene repertoire","volume":"28","author":"Chan","year":"2009","journal-title":"Oncogene"},{"key":"10.1016\/j.bbrc.2013.08.028_b0055","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/S0378-1119(99)00365-0","article-title":"Functional and structural diversity of the human Dickkopf gene family","volume":"238","author":"Krupnik","year":"1999","journal-title":"Gene"},{"key":"10.1016\/j.bbrc.2013.08.028_b0060","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1038\/sj.onc.1208303","article-title":"The Wnt antagonist DICKKOPF-1 gene is a downstream target of beta-catenin\/TCF and is downregulated in human colon cancer","volume":"24","author":"Gonzalez-Sancho","year":"2005","journal-title":"Oncogene"},{"key":"10.1016\/j.bbrc.2013.08.028_b0065","doi-asserted-by":"crossref","first-page":"2702","DOI":"10.3748\/wjg.14.2702","article-title":"Transcriptional silencing of Dickkopf gene family by CpG island hypermethylation in human gastrointestinal cancer","volume":"14","author":"Maehata","year":"2008","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.bbrc.2013.08.028_b0070","doi-asserted-by":"crossref","first-page":"2459","DOI":"10.1093\/carcin\/bgm178","article-title":"Frequent epigenetic inactivation of DICKKOPF family genes in human gastrointestinal tumors","volume":"28","author":"Sato","year":"2007","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.bbrc.2013.08.028_b0075","doi-asserted-by":"crossref","first-page":"2540","DOI":"10.1210\/endo.141.7.7570","article-title":"Negative regulation of the antimetastatic gene Nm23-H1 by thyroid hormone receptors","volume":"141","author":"Lin","year":"2000","journal-title":"Endocrinology"},{"key":"10.1016\/j.bbrc.2013.08.028_b0080","doi-asserted-by":"crossref","first-page":"3485","DOI":"10.1210\/en.2006-1239","article-title":"Direct regulation of androgen receptor-associated protein 70 by thyroid hormone and its receptors","volume":"148","author":"Tai","year":"2007","journal-title":"Endocrinology"},{"key":"10.1016\/j.bbrc.2013.08.028_b0085","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1677\/ERC-09-0050","article-title":"Positive regulation of spondin 2 by thyroid hormone is associated with cell migration and invasion","volume":"17","author":"Liao","year":"2010","journal-title":"Endocr. Relat. Cancer"},{"key":"10.1016\/j.bbrc.2013.08.028_b0090","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.mce.2009.04.013","article-title":"Regulation of AKR1B1 by thyroid hormone and its receptors","volume":"307","author":"Liao","year":"2009","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.bbrc.2013.08.028_b0095","doi-asserted-by":"crossref","first-page":"2481","DOI":"10.1210\/en.2005-1166","article-title":"Indirect regulation of human dehydroepiandrosterone sulfotransferase family 1A member 2 by thyroid hormones","volume":"147","author":"Huang","year":"2006","journal-title":"Endocrinology"},{"key":"10.1016\/j.bbrc.2013.08.028_b0180","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1007\/s00018-010-0281-2","article-title":"Thyroid hormone receptor-mediated regulation of the methionine adenosyltransferase 1 gene is associated with cell invasion in hepatoma cell lines","volume":"20","author":"Wu","year":"2010","journal-title":"Cell Mol. Life Sci."},{"key":"10.1016\/j.bbrc.2013.08.028_b0105","doi-asserted-by":"crossref","first-page":"3817","DOI":"10.1210\/en.2007-0989","article-title":"Thyroid hormone promotes cell invasion through activation of furin expression in human hepatoma cell lines","volume":"149","author":"Chen","year":"2008","journal-title":"Endocrinology"},{"key":"10.1016\/j.bbrc.2013.08.028_b0110","doi-asserted-by":"crossref","first-page":"2036","DOI":"10.1038\/onc.2009.496","article-title":"Wnt5a signaling is involved in the aggressiveness of prostate cancer and expression of metalloproteinase","volume":"29","author":"Yamamoto","year":"2010","journal-title":"Oncogene"},{"key":"10.1016\/j.bbrc.2013.08.028_b0115","first-page":"701","article-title":"Redundant expression of canonical Wnt ligands in human breast cancer cell lines","volume":"15","author":"Benhaj","year":"2006","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.bbrc.2013.08.028_b0120","doi-asserted-by":"crossref","first-page":"2627","DOI":"10.1242\/jcs.00623","article-title":"Secreted antagonists of the Wnt signalling pathway","volume":"116","author":"Kawano","year":"2003","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.bbrc.2013.08.028_b0125","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1146\/annurev.cellbio.17.1.463","article-title":"How matrix metalloproteinases regulate cell behavior","volume":"17","author":"Sternlicht","year":"2001","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.bbrc.2013.08.028_b0130","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0304-3835(02)00614-6","article-title":"Thyroid hormone receptors\/THR genes in human cancer","volume":"192","author":"Gonzalez-Sancho","year":"2003","journal-title":"Cancer Lett."},{"key":"10.1016\/j.bbrc.2013.08.028_b0135","doi-asserted-by":"crossref","first-page":"5308","DOI":"10.1210\/endo.138.12.5625","article-title":"Dominant negative activity of mutant thyroid hormone alpha1 receptors from patients with hepatocellular carcinoma","volume":"138","author":"Lin","year":"1997","journal-title":"Endocrinology"},{"key":"10.1016\/j.bbrc.2013.08.028_b0140","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.mce.2003.10.051","article-title":"Thyroid hormone receptor mutations in cancer","volume":"213","author":"Cheng","year":"2003","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.bbrc.2013.08.028_b0145","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.jhep.2009.11.015","article-title":"Risk of HCC: genetic heterogeneity and complex genetics","volume":"52","author":"Dragani","year":"2010","journal-title":"J. Hepatol."},{"key":"10.1016\/j.bbrc.2013.08.028_b0150","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1002\/hep.22793","article-title":"Association between hypothyroidism and hepatocellular carcinoma: a case-control study in the United States","volume":"49","author":"Hassan","year":"2009","journal-title":"Hepatology"},{"key":"10.1016\/j.bbrc.2013.08.028_b0155","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.cgh.2006.07.011","article-title":"Hypothyroidism: a possible risk factor for liver cancer in patients with no known underlying cause of liver disease","volume":"5","author":"Reddy","year":"2007","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"10.1016\/j.bbrc.2013.08.028_b0160","doi-asserted-by":"crossref","first-page":"4467","DOI":"10.1038\/onc.2008.88","article-title":"DICKKOPF-4 is induced by TCF\/beta-catenin and upregulated in human colon cancer, promotes tumour cell invasion and angiogenesis and is repressed by 1alpha,25-dihydroxyvitamin D3","volume":"27","author":"Pendas-Franco","year":"2008","journal-title":"Oncogene"},{"key":"10.1016\/j.bbrc.2013.08.028_b0165","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.canlet.2008.11.003","article-title":"Dickkopf-4 is frequently down-regulated and inhibits growth of colorectal cancer cells","volume":"276","author":"Baehs","year":"2009","journal-title":"Cancer Lett."},{"key":"10.1016\/j.bbrc.2013.08.028_b0170","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1002\/hep.24740","article-title":"Dickkopf 4 positively regulated by the thyroid hormone receptor suppresses cell invasion in human hepatoma cells","volume":"55","author":"Liao","year":"2012","journal-title":"Hepatology"},{"key":"10.1016\/j.bbrc.2013.08.028_b0175","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1146\/annurev.cellbio.17.1.463","article-title":"How matrix metalloproteinases regulate cell behavior","volume":"17","author":"Sternlicht","year":"2001","journal-title":"Annu. Rev. Cell Dev. Biol."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X13013545?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X13013545?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,7,21]],"date-time":"2019-07-21T02:24:20Z","timestamp":1563675860000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X13013545"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,9]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,9]]}},"alternative-id":["S0006291X13013545"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2013.08.028","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2013,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Thyroid hormone receptor inhibits hepatoma cell migration through transcriptional activation of Dickkopf 4","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2013.08.028","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Inc. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}