{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T13:30:09Z","timestamp":1758634209851,"version":"3.40.4"},"reference-count":34,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2013,10,1]],"date-time":"2013-10-01T00:00:00Z","timestamp":1380585600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"crossref","award":["2010CB529806"],"award-info":[{"award-number":["2010CB529806"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Nature Sciences Foundation of China","doi-asserted-by":"crossref","award":["31171064"],"award-info":[{"award-number":["31171064"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Shanghai science and technology commission","award":["11JC1404300","124119b0600"],"award-info":[{"award-number":["11JC1404300","124119b0600"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2013,10]]},"DOI":"10.1016\/j.bbrc.2013.09.071","type":"journal-article","created":{"date-parts":[[2013,9,21]],"date-time":"2013-09-21T21:38:13Z","timestamp":1379799493000},"page":"374-380","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Microglial activation of p38 contributes to scorpion envenomation-induced hyperalgesia"],"prefix":"10.1016","volume":"440","author":[{"given":"Qing-Shan","family":"Niu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li-Ming","family":"Hua","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin","family":"Fu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun-Lu","family":"Jiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong-Hua","family":"Ji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gang","family":"Ding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2013.09.071_b0005","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.ejphar.2006.09.018","article-title":"Rat pain-related responses induced by experimental scorpion BmK sting","volume":"552","author":"Bai","year":"2006","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.bbrc.2013.09.071_b0010","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1016\/0041-0101(96)00065-7","article-title":"Two neurotoxins (BmK I and BmK II) from the venom of the scorpion Buthus martensi Karsch: purification, amino acid sequences and assessment of specific activity","volume":"34","author":"Ji","year":"1996","journal-title":"Toxicon"},{"key":"10.1016\/j.bbrc.2013.09.071_b0015","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/S0166-2236(00)01854-3","article-title":"Glial activation: a driving force for pathological pain","volume":"24","author":"Watkins","year":"2001","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.bbrc.2013.09.071_b0020","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0304-3959(00)00490-5","article-title":"The role of neuroinflammation and neuroimmune activation in persistent pain","volume":"90","author":"DeLeo","year":"2001","journal-title":"Pain"},{"key":"10.1016\/j.bbrc.2013.09.071_b0025","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1038\/nrn1700","article-title":"Role of the immune system in chronic pain","volume":"6","author":"Marchand","year":"2005","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.bbrc.2013.09.071_b0030","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.expneurol.2004.11.001","article-title":"Immune and glial cell factors as pain mediators and modulators","volume":"192","author":"McMahon","year":"2005","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.bbrc.2013.09.071_b0035","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1016\/S0022-3565(24)29652-X","article-title":"Propentofylline, a glial modulating agent, exhibits antiallodynic properties in a rat model of neuropathic pain","volume":"297","author":"Sweitzer","year":"2001","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.bbrc.2013.09.071_b0040","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1038\/nn1997","article-title":"Microglia: active sensor and versatile effector cells in the normal and pathologic brain","volume":"10","author":"Hanisch","year":"2007","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.bbrc.2013.09.071_b0045","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.tins.2004.12.002","article-title":"Neuropathic pain and spinal microglia: a big problem from molecules in \u201csmall\u201d glia","volume":"28","author":"Tsuda","year":"2005","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.bbrc.2013.09.071_b0050","doi-asserted-by":"crossref","first-page":"2471","DOI":"10.2174\/138161209788682299","article-title":"Peptides as signaling inhibitors for mammalian MAP kinase cascades","volume":"15","author":"Gaestel","year":"2009","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.bbrc.2013.09.071_b0055","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1016\/j.toxicon.2008.01.005","article-title":"Activation of spinal ERK signaling pathway contributes to pain-related responses induced by scorpion Buthus martensi Karch venom","volume":"51","author":"Pang","year":"2008","journal-title":"Toxicon"},{"key":"10.1016\/j.bbrc.2013.09.071_b0060","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1152\/physrev.1999.79.1.143","article-title":"Mitogen-activated protein kinase: conservation of a three-kinase module from yeast to human","volume":"79","author":"Widmann","year":"1999","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.bbrc.2013.09.071_b0065","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1046\/j.1471-4159.2003.01969.x","article-title":"Activation of p38 mitogen-activated protein kinase in spinal microglia is a critical link in inflammation-induced spinal pain processing","volume":"86","author":"Svensson","year":"2003","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbrc.2013.09.071_b0070","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.pain.2007.11.019","article-title":"Low-dose methotrexate reduces peripheral nerve injury-evoked spinal microglial activation and neuropathic pain behavior in rats","volume":"138","author":"Scholz","year":"2008","journal-title":"Pain"},{"key":"10.1016\/j.bbrc.2013.09.071_b0075","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1038\/372739a0","article-title":"A protein kinase involved in the regulation of inflammatory cytokine biosynthesis","volume":"372","author":"Lee","year":"1994","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2013.09.071_b0080","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/0304-3959(83)90201-4","article-title":"Ethical guidelines for investigations of experimental pain in conscious animals","volume":"16","author":"Zimmermann","year":"1983","journal-title":"Pain"},{"key":"10.1016\/j.bbrc.2013.09.071_b0085","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/nbdi.2000.0360","article-title":"Neuronal plasticity and signal transduction in nociceptive neurons: implications for the initiation and maintenance of pathological pain","volume":"8","author":"Ji","year":"2001","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.bbrc.2013.09.071_b0090","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/1056-8719(94)90087-6","article-title":"A method to perform direct transcutaneous intrathecal injection in rats","volume":"32","author":"Mestre","year":"1994","journal-title":"J. Pharmacol. Toxicol. Methods."},{"key":"10.1016\/j.bbrc.2013.09.071_b0095","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/S0168-0102(02)00177-3","article-title":"C-Fos expression in rat spinal cord induced by scorpion BmK venom via plantar subcutaneous injection","volume":"44","author":"Bai","year":"2002","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.bbrc.2013.09.071_b0100","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/0304-3940(88)90346-1","article-title":"The glucose oxidase-DAB-nickel method in peroxidase histochemistry of the nervous system","volume":"85","author":"Shu","year":"1988","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.bbrc.2013.09.071_b0105","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0304-3940(98)00792-7","article-title":"Relationship between neuronal activity and substance P-immunoreactivity in the rat spinal cord during acute and persistent myositis","volume":"257","author":"Hoheisel","year":"1998","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.bbrc.2013.09.071_b0110","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.neulet.2003.12.003","article-title":"Effects of a chronic myositis on structural and functional features of spinal astrocytes in the rat","volume":"361","author":"Tenschert","year":"2004","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.bbrc.2013.09.071_b0115","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.expneurol.2010.08.018","article-title":"Phenotypes and peripheral mechanisms underlying inflammatory pain-related behaviors induced by BmK I, a modulator of sodium channels","volume":"226","author":"Bai","year":"2010","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.bbrc.2013.09.071_b0120","doi-asserted-by":"crossref","first-page":"4017","DOI":"10.1523\/JNEUROSCI.23-10-04017.2003","article-title":"P38 mitogen-activated protein kinase is activated after a spinal nerve ligation in spinal cord microglia and dorsal root ganglion neurons and contributes to the generation of neuropathic pain","volume":"23","author":"Jin","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbrc.2013.09.071_b0125","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S0006-8993(99)01186-5","article-title":"Microglial reactions after subcutaneous formalin injection into the rat hind paw","volume":"825","author":"Fu","year":"1999","journal-title":"Brain Res."},{"key":"10.1016\/j.bbrc.2013.09.071_b0130","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.pain.2005.02.009","article-title":"Minocycline attenuates mechanical allodynia and proinflammatory cytokine expression in rat models of pain facilitation","volume":"115","author":"Ledeboer","year":"2005","journal-title":"Pain"},{"key":"10.1016\/j.bbrc.2013.09.071_b0135","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/S0166-2236(98)01302-2","article-title":"Does the right side know what the left is doing?","volume":"22","author":"Koltzenburg","year":"1999","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.bbrc.2013.09.071_b0140","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1111\/j.1460-9568.2004.03514.x","article-title":"Complete Freunds adjuvant-induced peripheral inflammation evokes glial activation and proinflammatory cytokine expression in the CNS","volume":"20","author":"Raghavendra","year":"2004","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.bbrc.2013.09.071_b0145","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.ejphar.2009.09.028","article-title":"Spinal astrocyte and microglial activation contributes to rat pain-related behaviors induced by the venom of scorpion Buthus martensi Karch","volume":"623","author":"Jiang","year":"2009","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.bbrc.2013.09.071_b0150","doi-asserted-by":"crossref","first-page":"2431","DOI":"10.1111\/j.1460-9568.2005.04451.x","article-title":"Intrathecal minocycline attenuates peripheral inflammation-induced hyperalgesia by inhibiting p38 MAPK in spinal microglia","volume":"22","author":"Hua","year":"2005","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.bbrc.2013.09.071_b0155","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1038\/nrd1177","article-title":"P38 MAP kinases: key signalling molecules as therapeutic targets for inflammatory diseases","volume":"2","author":"Kumar","year":"2003","journal-title":"Nat. Rev. Drug. Discov."},{"key":"10.1016\/j.bbrc.2013.09.071_b0160","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.brainresbull.2009.04.007","article-title":"Hyper-excitability in low threshold mechanical A fibers is potentially involved in scorpion BmK sting pain","volume":"80","author":"Liu","year":"2009","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.bbrc.2013.09.071_b0165","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/1744-8069-3-33","article-title":"P38 MAPK, microglial signaling, and neuropathic pain","volume":"3","author":"Ji","year":"2007","journal-title":"Mol. Pain"},{"key":"10.1016\/j.bbrc.2013.09.071_b0170","first-page":"359","article-title":"Protein kinases as potential targets for the treatment of pathological pain","author":"Ji","year":"2007","journal-title":"Handb. Exp. Pharmacol."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X13015520?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X13015520?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T14:48:49Z","timestamp":1746024529000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X13015520"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10]]},"references-count":34,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,10]]}},"alternative-id":["S0006291X13015520"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2013.09.071","relation":{},"ISSN":["0006-291X"],"issn-type":[{"type":"print","value":"0006-291X"}],"subject":[],"published":{"date-parts":[[2013,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Microglial activation of p38 contributes to scorpion envenomation-induced hyperalgesia","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2013.09.071","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}