{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T20:04:38Z","timestamp":1767902678239,"version":"3.49.0"},"reference-count":29,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2013,10,1]],"date-time":"2013-10-01T00:00:00Z","timestamp":1380585600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,10,1]],"date-time":"2013-10-01T00:00:00Z","timestamp":1380585600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100002338","name":"Ministry of Education of the People's Republic of China","doi-asserted-by":"publisher","award":["20110131120079"],"award-info":[{"award-number":["20110131120079"]}],"id":[{"id":"10.13039\/501100002338","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2013,10]]},"DOI":"10.1016\/j.bbrc.2013.09.084","type":"journal-article","created":{"date-parts":[[2013,9,24]],"date-time":"2013-09-24T22:05:09Z","timestamp":1380060309000},"page":"330-335","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"title":["Lentiviral-mediated transfer of CDNF promotes nerve regeneration and functional recovery after sciatic nerve injury in adult rats"],"prefix":"10.1016","volume":"440","author":[{"given":"Lei","family":"Cheng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hua","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying-Jun","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Nie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2013.09.084_b0005","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.injury.2005.10.012","article-title":"Regeneration and repair of peripheral nerves","volume":"36","author":"Johnson","year":"2005","journal-title":"Injury"},{"key":"10.1016\/j.bbrc.2013.09.084_b0010","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1097\/00006534-199206000-00029","article-title":"Nerve injuries and their repair: a critical appraisal","volume":"89","author":"Sunderland","year":"1992","journal-title":"Plast. Reconstr. Surg."},{"key":"10.1016\/j.bbrc.2013.09.084_b0015","series-title":"Management of Peripheral Nerve Problems","first-page":"410","article-title":"Nerve grafts: indications, techniques and prognosis","author":"Millesi","year":"1980"},{"key":"10.1016\/j.bbrc.2013.09.084_b0020","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.jconrel.2011.11.036","article-title":"Growth factor delivery systems and repair strategies for damaged peripheral nerves","volume":"161","author":"Madduri","year":"2012","journal-title":"J. Control. Release"},{"key":"10.1016\/j.bbrc.2013.09.084_b0025","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.mcn.2012.04.004","article-title":"Early regenerative effects of NGF-transduced Schwann cells in peripheral nerve repair","volume":"50","author":"Shakhbazau","year":"2012","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.bbrc.2013.09.084_b0030","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1016\/j.ymthe.2005.01.016","article-title":"Lentiviral-mediated transfer of CNTF to Schwann cells within reconstructed peripheral nerve grafts enhances adult retinal ganglion cell survival and axonal regeneration","volume":"11","author":"Hu","year":"2005","journal-title":"Mol. Ther."},{"key":"10.1016\/j.bbrc.2013.09.084_b0035","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1146\/annurev.ne.19.030196.001445","article-title":"Physiology of the neurotrophins","volume":"19","author":"Lewin","year":"1996","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.bbrc.2013.09.084_b0040","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/BF02740621","article-title":"The cellular and molecular basis of peripheral nerve regeneration","volume":"14","author":"Fu","year":"1997","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.bbrc.2013.09.084_b0045","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1002\/mus.880130905","article-title":"Aberrant reinnervation","volume":"13","author":"Sumner","year":"1990","journal-title":"Muscle Nerve"},{"key":"10.1016\/j.bbrc.2013.09.084_b0050","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/nature05957","article-title":"Novel neurotrophic factor CDNF protects and rescues midbrain dopamine neurons in vivo","volume":"448","author":"Lindholm","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2013.09.084_b0055","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1002\/dneu.20760","article-title":"Novel CDNF\/MANF family of neurotrophic factors","volume":"70","author":"Lindholm","year":"2010","journal-title":"Dev. Neurobiol."},{"key":"10.1016\/j.bbrc.2013.09.084_b0060","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.bbrc.2013.04.029","article-title":"Overexpression of conserved dopamine neurotrophic factor (CDNF) in astrocytes alleviates endoplasmic reticulum stress-induced cell damage and inflammatory cytokine secretion","volume":"435","author":"Cheng","year":"2013","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2013.09.084_b0065","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1097\/00006534-198901000-00024","article-title":"Functional evaluation of complete sciatic, peroneal, and posterior tibial nerve lesions in the rat","volume":"83","author":"Bain","year":"1989","journal-title":"Plast. Reconstr. Surg."},{"key":"10.1016\/j.bbrc.2013.09.084_b0070","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1111\/j.1460-9568.2008.06452.x","article-title":"Differential effects of lentiviral vector-mediated overexpression of nerve growth factor and glial cell line-derived neurotrophic factor on regenerating sensory and motor axons in the transected peripheral nerve","volume":"28","author":"Tannemaat","year":"2008","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.bbrc.2013.09.084_b0075","doi-asserted-by":"crossref","first-page":"4332","DOI":"10.1172\/JCI58675","article-title":"Accelerating axonal growth promotes motor recovery after peripheral nerve injury in mice","volume":"121","author":"Ma","year":"2011","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbrc.2013.09.084_b0080","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1111\/j.1471-4159.2012.07792.x","article-title":"Evidence for a systemic regulation of neurotrophin synthesis in response to peripheral nerve injury","volume":"122","author":"Shakhbazau","year":"2012","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbrc.2013.09.084_b0085","series-title":"How to Improve the Results of Peripheral Nerve Surgery","first-page":"51","article-title":"The beneficial effect of genetically engineered Schwann cells with enhanced motility in peripheral nerve regeneration: review","author":"Gravvanis","year":"2007"},{"key":"10.1016\/j.bbrc.2013.09.084_b0090","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1179\/016164104225013798","article-title":"Peripheral nerve regeneration through guidance tubes","volume":"26","author":"Belkas","year":"2004","journal-title":"Neurol. Res."},{"key":"10.1016\/j.bbrc.2013.09.084_b0095","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/S0014-4886(03)00041-4","article-title":"Repair of peripheral nerve transections with fibrin sealant containing neurotrophic factors","volume":"181","author":"Jubran","year":"2003","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.bbrc.2013.09.084_b0100","first-page":"167","article-title":"Nerve growth factor and neurotrophin-3 affect functional recovery following peripheral nerve injury differently","volume":"18","author":"Young","year":"2001","journal-title":"Restor. Neurol. Neurosci."},{"key":"10.1016\/j.bbrc.2013.09.084_b0105","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1385\/JMN:20:2:173","article-title":"MANF","volume":"20","author":"Petrova","year":"2003","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.bbrc.2013.09.084_b0110","doi-asserted-by":"crossref","first-page":"2429","DOI":"10.1073\/pnas.0810996106","article-title":"Evidence that DmMANF is an invertebrate neurotrophic factor supporting dopaminergic neurons","volume":"106","author":"Palgi","year":"2009","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.bbrc.2013.09.084_b0115","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1093\/protein\/gzn080","article-title":"The structure of the conserved neurotrophic factors MANF and CDNF explains why they are bifunctional","volume":"22","author":"Parkash","year":"2009","journal-title":"Protein Eng. Des. Sel."},{"key":"10.1016\/j.bbrc.2013.09.084_b0120","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.expneurol.2010.12.013","article-title":"Chronic infusion of CDNF prevents 6-OHDA-induced deficits in a rat model of Parkinson\u2019s disease","volume":"228","author":"Voutilainen","year":"2011","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.bbrc.2013.09.084_b0125","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.3727\/096368911X600948","article-title":"CDNF protects the nigrostriatal dopamine system and promotes recovery after MPTP treatment in mice","volume":"21","author":"Airavaara","year":"2012","journal-title":"Cell Transplant."},{"key":"10.1016\/j.bbrc.2013.09.084_b0130","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.mcn.2008.07.016","article-title":"MANF is widely expressed in mammalian tissues and differently regulated after ischemic and epileptic insults in rodent brain","volume":"39","author":"Lindholm","year":"2008","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.bbrc.2013.09.084_b0135","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1002\/cne.22039","article-title":"Mesencephalic astrocyte-derived neurotrophic factor reduces ischemic brain injury and promotes behavioral recovery in rats","volume":"515","author":"Airavaara","year":"2009","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.bbrc.2013.09.084_b0140","doi-asserted-by":"crossref","first-page":"2454","DOI":"10.1016\/j.yexcr.2008.05.001","article-title":"Armet, a UPR-upregulated protein, inhibits cell proliferation and ER stress-induced cell death","volume":"314","author":"Apostolou","year":"2008","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.bbrc.2013.09.084_b0145","doi-asserted-by":"crossref","DOI":"10.1007\/s12031-013-0042-4","article-title":"Mesencephalic astrocyte-derived neurotrophic factor inhibits oxygen\u2013glucose deprivation-induced cell damage and inflammation by suppressing endoplasmic reticulum stress in rat primary astrocytes","author":"Zhao","year":"2013","journal-title":"J. Mol. Neurosci."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X13015659?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X13015659?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T11:05:52Z","timestamp":1757761552000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X13015659"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10]]},"references-count":29,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,10]]}},"alternative-id":["S0006291X13015659"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2013.09.084","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2013,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lentiviral-mediated transfer of CDNF promotes nerve regeneration and functional recovery after sciatic nerve injury in adult rats","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2013.09.084","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}