{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T01:08:35Z","timestamp":1769216915553,"version":"3.49.0"},"reference-count":32,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2013,12,1]],"date-time":"2013-12-01T00:00:00Z","timestamp":1385856000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,12,1]],"date-time":"2013-12-01T00:00:00Z","timestamp":1385856000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,12,1]],"date-time":"2013-12-01T00:00:00Z","timestamp":1385856000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2013,12,1]],"date-time":"2013-12-01T00:00:00Z","timestamp":1385856000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2013,12,1]],"date-time":"2013-12-01T00:00:00Z","timestamp":1385856000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2013,12,1]],"date-time":"2013-12-01T00:00:00Z","timestamp":1385856000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2013,12,1]],"date-time":"2013-12-01T00:00:00Z","timestamp":1385856000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"name":"Korean government","award":["2011-0028866"],"award-info":[{"award-number":["2011-0028866"]}]},{"name":"Korean government","award":["2011-0030718"],"award-info":[{"award-number":["2011-0030718"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2013,12]]},"DOI":"10.1016\/j.bbrc.2013.10.140","type":"journal-article","created":{"date-parts":[[2013,11,5]],"date-time":"2013-11-05T21:02:12Z","timestamp":1383685332000},"page":"22-27","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["Fenofibrate, a peroxisome proliferator-activated receptor \u03b1 ligand, prevents abnormal liver function induced by a fasting\u2013refeeding process"],"prefix":"10.1016","volume":"442","author":[{"given":"Joon No","family":"Lee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raghbendra Kumar","family":"Dutta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seul-Gi","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae-Young","family":"Lim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Se-Jin","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seong-Kyu","family":"Choe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyeong-Won","family":"Yoo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung Ryel","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Do-Sim","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong-Seob","family":"So","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raekil","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2013.10.140_b0010","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1038\/nature05488","article-title":"Abdominal obesity and metabolic syndrome","volume":"444","author":"Despr\u00e9s","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2013.10.140_b0015","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1146\/annurev.med.56.082103.104751","article-title":"Metabolic syndrome: a clinical and molecular perspective","volume":"56","author":"Moller","year":"2005","journal-title":"Annu. Rev. Med."},{"key":"10.1016\/j.bbrc.2013.10.140_b0020","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1038\/oby.2008.203","article-title":"Eating meals irregularly: a novel environmental risk factor for the metabolic syndrome","volume":"16","author":"Sierra-Johnson","year":"2008","journal-title":"Obesity"},{"key":"10.1016\/j.bbrc.2013.10.140_b0025","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1093\/ajcn.81.2.388","article-title":"Deleterious effects of omitting breakfast on insulin sensitivity and fasting lipid profiles in healthy lean women","volume":"81","author":"Farshchi","year":"2005","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.bbrc.2013.10.140_b0030","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1093\/ajcn\/81.1.16","article-title":"Beneficial metabolic effects of regular meal frequency on dietary thermogenesis, insulin sensitivity, and fasting lipid profiles in healthy obese women","volume":"81","author":"Farshchi","year":"2005","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.bbrc.2013.10.140_b0035","doi-asserted-by":"crossref","first-page":"7707","DOI":"10.1016\/0016-5085(78)90259-7","article-title":"Liver disease and nutrition","volume":"74","author":"Mezey","year":"1978","journal-title":"Gastroenterology"},{"key":"10.1016\/j.bbrc.2013.10.140_b0040","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1172\/JCI200422422","article-title":"Molecular mediators of hepatic steatosis and liver injury","author":"Browning","year":"2004","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbrc.2013.10.140_b0045","doi-asserted-by":"crossref","first-page":"7473","DOI":"10.1073\/pnas.96.13.7473","article-title":"A critical role for the peroxisome proliferator-activated receptor alpha (PPARalpha) in the cellular fasting response: the PPARalpha-null mouse as a model of fatty acid oxidation disorders","volume":"96","author":"Leone","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbrc.2013.10.140_b0050","doi-asserted-by":"crossref","first-page":"5987","DOI":"10.1073\/pnas.95.11.5987","article-title":"Regulation of sterol regulatory element binding proteins in livers of fasted and refed mice","volume":"95","author":"Horton","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbrc.2013.10.140_b0055","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1172\/JCI6223","article-title":"Peroxisome proliferator-activated receptor alpha mediates the adaptive response to fasting","volume":"103","author":"Kersten","year":"1999","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbrc.2013.10.140_b0060","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1210\/en.2005-1132","article-title":"Peroxisome proliferator-activated receptor alpha mediates the effects of high-fat diet on hepatic gene expression","volume":"147","author":"Patsouris","year":"2006","journal-title":"Endocrinology"},{"key":"10.1016\/j.bbrc.2013.10.140_b0065","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1210\/endo.137.1.8536636","article-title":"Differential expression of peroxisome proliferator-activated receptors (PPARs): tissue distribution of PPAR-alpha, -beta, and -gamma in the adult rat","volume":"137","author":"Braissant","year":"1996","journal-title":"Endocrinology"},{"key":"10.1016\/j.bbrc.2013.10.140_b0070","doi-asserted-by":"crossref","first-page":"19228","DOI":"10.1074\/jbc.274.27.19228","article-title":"Peroxisomal and mitochondrial fatty acid beta-oxidation in mice nullizygous for both peroxisome proliferator-activated receptor alpha and peroxisomal fatty acyl-CoA oxidase. Genotype correlation with fatty liver phenotype","volume":"274","author":"Hashimoto","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2013.10.140_b0075","doi-asserted-by":"crossref","first-page":"18767","DOI":"10.1016\/S0021-9258(17)32234-2","article-title":"Peroxisome proliferator-activated receptor mediates induction of the mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase gene by fatty acids","volume":"269","author":"Rodr\u00edguez","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2013.10.140_b0080","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1053\/jhep.2003.50307","article-title":"Central role of PPARalpha-dependent hepatic lipid turnover in dietary steatohepatitis in mice","volume":"38","author":"Ip","year":"2003","journal-title":"Hepatology"},{"key":"10.1016\/j.bbrc.2013.10.140_b0085","doi-asserted-by":"crossref","first-page":"13461","DOI":"10.1021\/bi7018699","article-title":"Ligand specificity of nuclear hormone receptors: sifting through promiscuity","volume":"46","author":"Noy","year":"2007","journal-title":"Biochemistry"},{"key":"10.1016\/j.bbrc.2013.10.140_b0090","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/0002-9343(87)90866-7","article-title":"Fibric acids: effects on lipids and lipoprotein metabolism","volume":"83","author":"Grundy","year":"1987","journal-title":"Am. J. Med."},{"key":"10.1016\/j.bbrc.2013.10.140_b0095","doi-asserted-by":"crossref","first-page":"2753","DOI":"10.1210\/en.2007-0014","article-title":"Peroxisome proliferator-activated receptor alpha protects against obesity-induced hepatic inflammation","volume":"148","author":"Stienstra","year":"2007","journal-title":"Endocrinology"},{"key":"10.1016\/j.bbrc.2013.10.140_b0100","doi-asserted-by":"crossref","first-page":"e52645","DOI":"10.1371\/journal.pone.0052645","article-title":"Liver-specific PGC-1beta deficiency leads to impaired mitochondrial function and lipogenic response to fasting\u2013refeeding","volume":"7","author":"Chambers","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.bbrc.2013.10.140_b0105","doi-asserted-by":"crossref","first-page":"e67631","DOI":"10.1371\/journal.pone.0067631","article-title":"Dynamic regulation of hepatic lipid droplet properties by diet","volume":"8","author":"Crunk","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1016\/j.bbrc.2013.10.140_b0110","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.bcp.2012.05.022","article-title":"Fenofibrate lowers lipid accumulation in myotubes by modulating the PPAR\u03b1\/AMPK\/FoxO1\/ATGL pathway","volume":"84","author":"Chen","year":"2012","journal-title":"Biochem. Pharm."},{"key":"10.1016\/j.bbrc.2013.10.140_b0115","doi-asserted-by":"crossref","first-page":"470","DOI":"10.4254\/wjh.v5.i9.470","article-title":"Current role of fenofibrate in the prevention and management of non-alcohoic fatty liver diseses","volume":"5","author":"Kostapanos","year":"2013","journal-title":"World J. Hepatology"},{"key":"10.1016\/j.bbrc.2013.10.140_b0120","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.dld.2007.10.002","article-title":"J.A. So\u013a\u0131s-Herruzo, A pilot trial of fenofibrate for the treatment of non-alcoholic fatty liver disease","volume":"40","author":"Miranda","year":"2008","journal-title":"Dig. Liver Dis."},{"key":"10.1016\/j.bbrc.2013.10.140_b0125","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cmet.2012.12.002","article-title":"Sestrins activate Nrf2 by promoting p62-dependent autophagic degradation of Keap1 and prevent oxidative liver damage","volume":"17","author":"Bae","year":"2013","journal-title":"Cell Metab."},{"key":"10.1016\/j.bbrc.2013.10.140_b0130","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1002\/hep.20701","article-title":"Design and validation of a histological scoring system for nonalcoholic fatty liver disease","volume":"41","author":"Kleiner","year":"2005","journal-title":"Hepatology"},{"key":"10.1016\/j.bbrc.2013.10.140_b0135","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1172\/JCI25102","article-title":"Inflammation, stress, and diabetes","volume":"115","author":"Wellen","year":"2005","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbrc.2013.10.140_b0140","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1172\/JCI200319451","article-title":"Chronic inflammation in fat plays a critical role in the development of obesity-related insulin resistance","volume":"112","author":"Xu","year":"2003","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbrc.2013.10.140_b0145","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1016\/j.jnutbio.2012.10.006","article-title":"Refeeding with a standard diet after a 48-h fast elicits an inflammatory response in the mouse liver","volume":"24","author":"Oarada","year":"2013","journal-title":"J Nutr. Biochem."},{"key":"10.1016\/j.bbrc.2013.10.140_b0150","doi-asserted-by":"crossref","first-page":"24484","DOI":"10.1074\/jbc.M202449200","article-title":"WY14,643, a peroxisome proliferator-activated receptor alpha (PPARalpha) agonist, improves hepatic and muscle steatosis and reverses insulin resistance in lipoatrophic A-ZIP\/F-1 mice","volume":"277","author":"Chou","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2013.10.140_b0155","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1385\/CBB:32:1-3:73","article-title":"Peroxisomal lipid degradation via beta- and alpha-oxidation in mammals","volume":"32","author":"Mannaerts","year":"2000","journal-title":"Cell Biochem. Biophys."},{"key":"10.1016\/j.bbrc.2013.10.140_b0160","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1089\/ars.2009.2996","article-title":"Peroxisomes are oxidative organelles","volume":"13","author":"Antonenkov","year":"2010","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.bbrc.2013.10.140_b0165","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1042\/bj2180697","article-title":"Peroxisomal beta-oxidation from endogenous substrates: demonstration through H2O2 production in the unanaesthetized mouse","volume":"218","author":"Van den Branden","year":"1984","journal-title":"Biochem. J."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X13018330?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X13018330?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T11:06:30Z","timestamp":1757761590000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X13018330"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12]]},"references-count":32,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["S0006291X13018330"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2013.10.140","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2013,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Fenofibrate, a peroxisome proliferator-activated receptor \u03b1 ligand, prevents abnormal liver function induced by a fasting\u2013refeeding process","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2013.10.140","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}