{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:39:29Z","timestamp":1790775569283,"version":"4.1.0"},"reference-count":31,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2013,11,1]],"date-time":"2013-11-01T00:00:00Z","timestamp":1383264000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"NIH","award":["R01 DE020194"],"award-info":[{"award-number":["R01 DE020194"]}]},{"name":"NIH","award":["AR60869"],"award-info":[{"award-number":["AR60869"]}]},{"name":"NIH","award":["T32 AR056950"],"award-info":[{"award-number":["T32 AR056950"]}]},{"name":"NIH","award":["F32 AR60140"],"award-info":[{"award-number":["F32 AR60140"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2013,11]]},"DOI":"10.1016\/j.bbrc.2013.10.155","type":"journal-article","created":{"date-parts":[[2013,11,6]],"date-time":"2013-11-06T16:18:36Z","timestamp":1383754716000},"page":"886-890","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":57,"title":["Sclerostin deficient mice rapidly heal bone defects by activating \u03b2-catenin and increasing intramembranous ossification"],"prefix":"10.1016","volume":"441","author":[{"given":"Meghan E.","family":"McGee-Lawrence","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zachary C.","family":"Ryan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lomeli R.","family":"Carpio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjeev","family":"Kakar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer J.","family":"Westendorf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajiv","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2013.10.155_b0005","doi-asserted-by":"crossref","first-page":"290","DOI":"10.2106\/00004623-200402000-00011","article-title":"The incidence of fractures and dislocations referred for orthopaedic services in a capitated population","volume":"86-A","author":"Brinker","year":"2004","journal-title":"J. Bone Joint Surg. Am."},{"key":"10.1016\/j.bbrc.2013.10.155_b0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.gene.2011.10.044","article-title":"Update on Wnt signaling in bone cell biology and bone disease","volume":"492","author":"Monroe","year":"2012","journal-title":"Gene"},{"key":"10.1016\/j.bbrc.2013.10.155_b0015","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1007\/s11914-009-0012-5","article-title":"Wnt signaling during fracture repair","volume":"7","author":"Secreto","year":"2009","journal-title":"Curr. Osteoporos. Rep."},{"key":"10.1016\/j.bbrc.2013.10.155_b0020","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1172\/JCI33612","article-title":"Building bone to reverse osteoporosis and repair fractures","volume":"118","author":"Khosla","year":"2008","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbrc.2013.10.155_b0025","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/j.bone.2007.12.224","article-title":"Osteocytes, mechanosensing and Wnt signaling","volume":"42","author":"Bonewald","year":"2008","journal-title":"Bone"},{"key":"10.1016\/j.bbrc.2013.10.155_b0030","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1359\/jbmr.081235","article-title":"Where Wnts went: the exploding field of Lrp5 and Lrp6 signaling in bone","volume":"24","author":"Williams","year":"2009","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bbrc.2013.10.155_b0035","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1517\/14728220902841961","article-title":"Wnt signaling as a therapeutic target for bone diseases","volume":"13","author":"Hoeppner","year":"2009","journal-title":"Expert Opin. Ther. Targets"},{"key":"10.1016\/j.bbrc.2013.10.155_b0040","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.gene.2004.06.044","article-title":"Wnt signaling in osteoblasts and bone diseases","volume":"341","author":"Westendorf","year":"2004","journal-title":"Gene"},{"key":"10.1016\/j.bbrc.2013.10.155_b0045","doi-asserted-by":"crossref","first-page":"5522","DOI":"10.1073\/pnas.96.10.5522","article-title":"The cyclin D1 gene is a target of the beta-catenin\/LEF-1 pathway","volume":"96","author":"Shtutman","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbrc.2013.10.155_b0050","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1128\/MCB.22.4.1172-1183.2002","article-title":"Wnt\/beta-catenin\/Tcf signaling induces the transcription of Axin2, a negative regulator of the signaling pathway","volume":"22","author":"Jho","year":"2002","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.bbrc.2013.10.155_b0055","doi-asserted-by":"crossref","first-page":"11937","DOI":"10.1074\/jbc.M211443200","article-title":"Lymphoid enhancer factor-1 and beta-catenin inhibit Runx2-dependent transcriptional activation of the osteocalcin promoter","volume":"278","author":"Kahler","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2013.10.155_b0060","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1093\/hmg\/10.5.537","article-title":"Increased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST)","volume":"10","author":"Balemans","year":"2001","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bbrc.2013.10.155_b0065","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1136\/jmg.39.2.91","article-title":"Identification of a 52kb deletion downstream of the SOST gene in patients with van Buchem disease","volume":"39","author":"Balemans","year":"2002","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.bbrc.2013.10.155_b0070","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/S0092-8674(01)00571-2","article-title":"LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development","volume":"107","author":"Gong","year":"2001","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2013.10.155_b0075","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1056\/NEJMoa013444","article-title":"High bone density due to a mutation in LDL-receptor-related protein 5","volume":"346","author":"Boyden","year":"2002","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbrc.2013.10.155_b0080","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1086\/338450","article-title":"A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait","volume":"70","author":"Little","year":"2002","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.bbrc.2013.10.155_b0085","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1002\/jor.22129","article-title":"Strongly enhanced levels of sclerostin during human fracture healing","volume":"30","author":"Sarahrudi","year":"2012","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.bbrc.2013.10.155_b0090","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1016\/j.bone.2011.08.012","article-title":"Increased callus mass and enhanced strength during fracture healing in mice lacking the sclerostin gene","volume":"49","author":"Li","year":"2011","journal-title":"Bone"},{"key":"10.1016\/j.bbrc.2013.10.155_b0095","first-page":"178","article-title":"Time-dependent effects of sclerostin antibody on a mouse fracture healing model","volume":"13","author":"Cui","year":"2013","journal-title":"J. Musculoskelet. Neuronal Interact."},{"key":"10.1016\/j.bbrc.2013.10.155_b0100","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1002\/jbmr.1803","article-title":"Sclerostin antibody treatment improves bone mass, bone strength, and bone defect regeneration in rats with type 2 diabetes mellitus","volume":"28","author":"Hamann","year":"2013","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bbrc.2013.10.155_b0105","doi-asserted-by":"crossref","first-page":"6199","DOI":"10.1073\/pnas.1221255110","article-title":"Sclerostin alters serum vitamin D metabolite and fibroblast growth factor 23 concentrations and the urinary excretion of calcium","volume":"110","author":"Ryan","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbrc.2013.10.155_b0110","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.ydbio.2006.10.018","article-title":"Craniosynostosis caused by Axin2 deficiency is mediated through distinct functions of beta-catenin in proliferation and differentiation","volume":"301","author":"Liu","year":"2007","journal-title":"Dev. Biol."},{"key":"10.1016\/j.bbrc.2013.10.155_b0115","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1083\/jcb.200107066","article-title":"Impaired mammary gland and lymphoid development caused by inducible expression of Axin in transgenic mice","volume":"155","author":"Hsu","year":"2001","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.bbrc.2013.10.155_b0120","doi-asserted-by":"crossref","first-page":"5291","DOI":"10.1074\/jbc.M112.414995","article-title":"Runx2 protein represses Axin2 expression in osteoblasts and is required for craniosynostosis in Axin2-deficient mice","volume":"288","author":"McGee-Lawrence","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2013.10.155_b0125","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1007\/s00223-009-9314-y","article-title":"Drilled hole defects in mouse femur as models of intramembranous cortical and cancellous bone regeneration","volume":"86","author":"Monfoulet","year":"2010","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.bbrc.2013.10.155_b0130","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1016\/j.bone.2006.05.021","article-title":"TGFbeta inducible early gene-1 knockout mice display defects in bone strength and microarchitecture","volume":"39","author":"Bensamoun","year":"2006","journal-title":"Bone"},{"key":"10.1016\/j.bbrc.2013.10.155_b0135","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1002\/jbmr.141","article-title":"Guidelines for assessment of bone microstructure in rodents using micro-computed tomography","volume":"25","author":"Bouxsein","year":"2010","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bbrc.2013.10.155_b0140","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1359\/JBMR.0301255","article-title":"Mapping quantitative trait loci for vertebral trabecular bone volume fraction and microarchitecture in mice","volume":"19","author":"Bouxsein","year":"2004","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bbrc.2013.10.155_b0145","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.bone.2012.10.015","article-title":"Histone deacetylase 3 is required for maintenance of bone mass during aging","volume":"52","author":"McGee-Lawrence","year":"2013","journal-title":"Bone"},{"key":"10.1016\/j.bbrc.2013.10.155_b0150","doi-asserted-by":"crossref","first-page":"3566","DOI":"10.1242\/jcs.051904","article-title":"Axin2 controls bone remodeling through the beta-catenin-BMP signaling pathway in adult mice","volume":"122","author":"Yan","year":"2009","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.bbrc.2013.10.155_b0155","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3000231","article-title":"Wnt proteins promote bone regeneration","volume":"2","author":"Minear","year":"2010","journal-title":"Sci. Transl. Med."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X13018573?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X13018573?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,11]],"date-time":"2018-10-11T01:22:19Z","timestamp":1539220939000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X13018573"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11]]},"references-count":31,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,11]]}},"alternative-id":["S0006291X13018573"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2013.10.155","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2013,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sclerostin deficient mice rapidly heal bone defects by activating \u03b2-catenin and increasing intramembranous ossification","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2013.10.155","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}