{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T16:08:25Z","timestamp":1790784505073,"version":"4.1.0"},"reference-count":21,"publisher":"Elsevier BV","issue":"3-4","license":[{"start":{"date-parts":[[2013,12,1]],"date-time":"2013-12-01T00:00:00Z","timestamp":1385856000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81272638"],"award-info":[{"award-number":["81272638"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["31170151"],"award-info":[{"award-number":["31170151"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National Key Basic Research Program of China","award":["2012CB519003"],"award-info":[{"award-number":["2012CB519003"]}]},{"name":"National High Technology Research and Development Program of China","award":["2012AA020803"],"award-info":[{"award-number":["2012AA020803"]}]},{"name":"National High Technology Research and Development Program of China","award":["2012AA02A204"],"award-info":[{"award-number":["2012AA02A204"]}]},{"DOI":"10.13039\/501100004000","name":"Guangzhou Key Program of Science and Technology","doi-asserted-by":"crossref","award":["2012Y2-00026"],"award-info":[{"award-number":["2012Y2-00026"]}],"id":[{"id":"10.13039\/501100004000","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2013,12]]},"DOI":"10.1016\/j.bbrc.2013.11.047","type":"journal-article","created":{"date-parts":[[2013,11,21]],"date-time":"2013-11-21T12:41:02Z","timestamp":1385037662000},"page":"171-176","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["An oncolytic adenovirus enhances antiangiogenic and antitumoral effects of a replication-deficient adenovirus encoding endostatin by rescuing its selective replication in nasopharyngeal carcinoma cells"],"prefix":"10.1016","volume":"442","author":[{"given":"Ran-yi","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-ling","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bi-jun","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao-la","family":"Ke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie-min","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-xia","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiang-xue","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenlin","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2013.11.047_b0005","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1038\/sj.cr.7310108","article-title":"Targeting gene-virotherapy of cancer and its prosperity","volume":"16","author":"Liu","year":"2006","journal-title":"Cell Res."},{"key":"10.1016\/j.bbrc.2013.11.047_b0010","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1038\/nm0697-639","article-title":"ONYX-015, an E1B gene-attenuated adenovirus, causes tumor-specific cytolysis and antitumoral efficacy that can be augmented by standard chemotherapeutic agents","volume":"3","author":"Heise","year":"1997","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbrc.2013.11.047_b0015","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1093\/jnci\/djj111","article-title":"China approves world\u2019s first oncolytic virus therapy for cancer treatment","volume":"98","author":"Garber","year":"2006","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.bbrc.2013.11.047_b0020","doi-asserted-by":"crossref","first-page":"715","DOI":"10.5732\/cjc.010.10010","article-title":"Antiangiogenic therapy: a novel approach to overcome tumor hypoxia","volume":"29","author":"Peng","year":"2010","journal-title":"Chin. J. Cancer"},{"key":"10.1016\/j.bbrc.2013.11.047_b0025","first-page":"1947","article-title":"Endostatin derivative angiogenesis inhibitors","volume":"122","author":"Zheng","year":"2009","journal-title":"Chin. Med. J. (Engl)"},{"key":"10.1016\/j.bbrc.2013.11.047_b0030","doi-asserted-by":"crossref","first-page":"2064","DOI":"10.1002\/ijc.21585","article-title":"Adenovirus-mediated intra-tumoral delivery of the human endostatin gene inhibits tumor growth in nasopharyngeal carcinoma","volume":"118","author":"Li","year":"2006","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.bbrc.2013.11.047_b0035","doi-asserted-by":"crossref","first-page":"648","DOI":"10.4161\/cbt.6.5.4004","article-title":"A phase I clinical trial of an adenovirus-mediated endostatin gene (E10A) in patients with solid tumors","volume":"6","author":"Lin","year":"2007","journal-title":"Cancer Biol. Ther."},{"key":"10.1016\/j.bbrc.2013.11.047_b0040","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1089\/hum.2006.149","article-title":"Long-term toxicity studies in Canine of E10A, an adenoviral vector for human endostatin gene","volume":"18","author":"Huang","year":"2007","journal-title":"Hum. Gene Ther."},{"key":"10.1016\/j.bbrc.2013.11.047_b0045","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1038\/sj.gt.3303038","article-title":"Pharmacokinetic and pharmacodynamic study of intratumoral injection of an adenovirus encoding endostatin in patients with advanced tumors","volume":"15","author":"Li","year":"2008","journal-title":"Gene Ther."},{"key":"10.1016\/j.bbrc.2013.11.047_b0050","first-page":"1503","article-title":"Antiangiogenic gene therapy of cancer utilizing a recombinant adenovirus to elevate systemic endostatin levels in mice","volume":"60","author":"Feldman","year":"2000","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbrc.2013.11.047_b0055","doi-asserted-by":"crossref","first-page":"13","DOI":"10.2174\/1874467210801010013","article-title":"Gene therapy: the first approved gene-based medicines, molecular mechanisms and clinical indications","volume":"1","author":"Raty","year":"2008","journal-title":"Curr. Mol. Pharmacol."},{"key":"10.1016\/j.bbrc.2013.11.047_b0060","first-page":"146","article-title":"About the evaluation of drug combination","volume":"25","author":"Jin","year":"2004","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.bbrc.2013.11.047_b0065","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1002\/ar.22813","article-title":"Tumor-specific cytolysis caused by an E1B55K-attenuated adenovirus in nasopharyngeal carcinoma is augmented by cisplatin","volume":"296","author":"Liu","year":"2013","journal-title":"Anat. Rec. (Hoboken)"},{"key":"10.1016\/j.bbrc.2013.11.047_b0070","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.ccr.2004.11.012","article-title":"Late viral RNA export, rather than p53 inactivation, determines ONYX-015 tumor selectivity","volume":"6","author":"O\u2019Shea","year":"2004","journal-title":"Cancer Cell"},{"key":"10.1016\/j.bbrc.2013.11.047_b0075","series-title":"Principles of Virology: Molecular Biology, Pathogenesis, and Control of Animal Viruses","author":"Flint","year":"2004"},{"key":"10.1016\/j.bbrc.2013.11.047_b0080","doi-asserted-by":"crossref","first-page":"5443","DOI":"10.1128\/JVI.75.12.5443-5447.2001","article-title":"Does the antitumor adenovirus ONYX-015\/dl1520 selectively target cells defective in the p53 pathway?","volume":"75","author":"Dix","year":"2001","journal-title":"J. Virol."},{"key":"10.1016\/j.bbrc.2013.11.047_b0085","doi-asserted-by":"crossref","first-page":"3904","DOI":"10.1128\/JVI.80.8.3904-3911.2006","article-title":"Characterization of the recombinant adenovirus vector AdYB-1: implications for oncolytic vector development","volume":"80","author":"Glockzin","year":"2006","journal-title":"J. Virol."},{"key":"10.1016\/j.bbrc.2013.11.047_b0090","doi-asserted-by":"crossref","first-page":"185","DOI":"10.5732\/cjc.011.10328","article-title":"Nasopharyngeal carcinoma in Indonesia: epidemiology, incidence, signs, and symptoms at presentation","volume":"31","author":"Adham","year":"2012","journal-title":"Chin. J. Cancer"},{"key":"10.1016\/j.bbrc.2013.11.047_b0095","doi-asserted-by":"crossref","first-page":"225","DOI":"10.5732\/cjc.013.10051","article-title":"Molecular targeted agents-where we are and where we are going","volume":"32","author":"Yan","year":"2013","journal-title":"Chin. J. Cancer"},{"key":"10.1016\/j.bbrc.2013.11.047_b0100","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.pep.2007.08.008","article-title":"Bioactivity and stability analysis of endostatin purified from fermentation supernatant of 293 cells transfected with Ad\/rhEndo","volume":"56","author":"Liang","year":"2007","journal-title":"Protein Expr. Purif."},{"key":"10.1016\/j.bbrc.2013.11.047_b0105","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1186\/1479-5876-11-257","article-title":"Antitumor efficacy of a recombinant adenovirus encoding endostatin combined with an E1B55KD-deficient adenovirus in gastric cancer cells","volume":"11","author":"Li","year":"2013","journal-title":"J. Transl. Med."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X13019293?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X13019293?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,8]],"date-time":"2018-10-08T17:53:54Z","timestamp":1539021234000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X13019293"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12]]},"references-count":21,"journal-issue":{"issue":"3-4","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["S0006291X13019293"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2013.11.047","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2013,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"An oncolytic adenovirus enhances antiangiogenic and antitumoral effects of a replication-deficient adenovirus encoding endostatin by rescuing its selective replication in nasopharyngeal carcinoma cells","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2013.11.047","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}