{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T17:31:04Z","timestamp":1776101464237,"version":"3.50.1"},"reference-count":19,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2014,1]]},"DOI":"10.1016\/j.bbrc.2013.12.003","type":"journal-article","created":{"date-parts":[[2013,12,8]],"date-time":"2013-12-08T14:00:43Z","timestamp":1386511243000},"page":"574-579","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":48,"title":["Genetic mutations in adipose triglyceride lipase and myocardial up-regulation of peroxisome proliferated activated receptor-\u03b3 in patients with triglyceride deposit cardiomyovasculopathy"],"prefix":"10.1016","volume":"443","author":[{"given":"Ken-ichi","family":"Hirano","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuya","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiko","family":"Ikeda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Yamaguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuhiro","family":"Zaima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiro","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiko","family":"Sakata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasushi","family":"Sakata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kunihisa","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsushi","family":"Toda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norihide","family":"Fukushima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hatsue","family":"Ishibashi-Ueda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Tavian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hironori","family":"Nagasaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu-Ping","family":"Hui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4640-7730","authenticated-orcid":false,"given":"Hitoshi","family":"Chiba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiki","family":"Sawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masatsugu","family":"Hori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2013.12.003_b0005","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1126\/science.1100747","article-title":"Fat mobilization in adipose tissue is promoted by adipose triglyceride lipase","volume":"306","author":"Zimmermann","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.bbrc.2013.12.003_b0010","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1194\/jlr.R800031-JLR200","article-title":"Adipose triglyceride lipase \u2013 and the lipolytic catabolism of cellular fat stores","volume":"50","author":"Zechner","year":"2009","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.bbrc.2013.12.003_b0015","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1038\/ng1951","article-title":"The gene encoding adipose triglyceride lipase (PNPLA2) is mutated in neutral lipid storage disease with myopathy","volume":"39","author":"Fischer","year":"2007","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bbrc.2013.12.003_b0020","doi-asserted-by":"crossref","first-page":"2877","DOI":"10.1210\/jc.2007-2247","article-title":"The lack of the C-terminal domain of adipose triglyceride lipase causes neutral lipid storage disease through impaired interaction with lipid droplets","volume":"93","author":"Kobayashi","year":"2008","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bbrc.2013.12.003_b0025","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/j.nmd.2008.06.382","article-title":"Distal lipid storage myopathy due to PNPLA2 mutation","volume":"18","author":"Ohkuma","year":"2008","journal-title":"Neuromuscul. Disord."},{"key":"10.1016\/j.bbrc.2013.12.003_b0030","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/j.bbrc.2008.10.081","article-title":"Novel mutations in the adipose triglyceride lipase gene causing neutral lipid storage disease with myopathy","volume":"377","author":"Campagna","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2013.12.003_b0035","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1007\/s00415-011-6055-4","article-title":"The phenotypic spectrum of neutral lipid storage myopathy due to mutations in the PNPLA2 gene","volume":"258","author":"Reilich","year":"2011","journal-title":"J. Neurol."},{"key":"10.1016\/j.bbrc.2013.12.003_b0040","doi-asserted-by":"crossref","first-page":"5318","DOI":"10.1093\/hmg\/dds388","article-title":"Contribution of novel ATGL missense mutations to the clinical phenotype of NLSD-M: a striking low amount of lipase activity may preserve cardiac function","volume":"21","author":"Tavian","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bbrc.2013.12.003_b0045","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1126\/science.1123965","article-title":"Defective lipolysis and altered energy metabolism in mice lacking adipose triglyceride lipase","volume":"312","author":"Haemmerle","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.bbrc.2013.12.003_b0050","doi-asserted-by":"crossref","first-page":"2396","DOI":"10.1056\/NEJMc0805305","article-title":"Triglyceride deposit cardiomyovasculopathy","volume":"359","author":"Hirano","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbrc.2013.12.003_b0055","doi-asserted-by":"crossref","first-page":"702","DOI":"10.5551\/jat.1669","article-title":"A novel clinical entity: triglyceride deposit cardiomyovasculopathy","volume":"16","author":"Hirano","year":"2009","journal-title":"J. Atheroscler. Thromb."},{"key":"10.1016\/j.bbrc.2013.12.003_b0060","article-title":"A novel type of human spontaneous coronary atherosclerosis with triglyceride deposition","author":"Ikeda","year":"2013","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.bbrc.2013.12.003_b0065","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1161\/01.CIR.0000018080.37316.D6","article-title":"Specific cardiomyopathy caused by multisystemic lipid storage in Jordans\u2019 anomaly","volume":"106","author":"Oshima","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.bbrc.2013.12.003_b0070","doi-asserted-by":"crossref","first-page":"3015","DOI":"10.1172\/JCI28898","article-title":"TLR4 links innate immunity and fatty acid-induced insulin resistance","volume":"116","author":"Shi","year":"2006","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbrc.2013.12.003_b0075","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1038\/nm.2439","article-title":"ATGL-mediated fat catabolism regulates cardiac mitochondrial function via PPAR-a and PGC-1","volume":"17","author":"Haemmerle","year":"2011","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbrc.2013.12.003_b0080","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/S1050-1738(03)00026-4","article-title":"Pathophysiology of human genetic CD36 deficiency","volume":"13","author":"Hirano","year":"2003","journal-title":"Trends Cardiovasc. Med."},{"key":"10.1016\/j.bbrc.2013.12.003_b0085","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1093\/cvr\/cvp183","article-title":"A potential link between peroxisome proliferator-activated receptor signaling and the pathogenesis of arrythmogenic right ventricular cardiomyopathy","volume":"84","author":"Djouadi","year":"2009","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.bbrc.2013.12.003_b0090","doi-asserted-by":"crossref","first-page":"2791","DOI":"10.1172\/JCI30335","article-title":"Cardiomyocyte expression of PPARgamma leads to cardiac dysfunction in mice","volume":"117","author":"Son","year":"2007","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbrc.2013.12.003_b0095","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1172\/JCI0214080","article-title":"The cardiac phenotype induced by PPAR\u03b1 overexpression mimics that caused by diabetes mellitus","volume":"109","author":"Finck","year":"2002","journal-title":"J. Clin. Invest."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X13020597?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X13020597?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,8]],"date-time":"2018-10-08T04:58:13Z","timestamp":1538974693000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X13020597"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1]]},"references-count":19,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,1]]}},"alternative-id":["S0006291X13020597"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2013.12.003","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2014,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genetic mutations in adipose triglyceride lipase and myocardial up-regulation of peroxisome proliferated activated receptor-\u03b3 in patients with triglyceride deposit cardiomyovasculopathy","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2013.12.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}