{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T23:19:34Z","timestamp":1782602374466,"version":"3.54.5"},"reference-count":35,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2014,2,1]],"date-time":"2014-02-01T00:00:00Z","timestamp":1391212800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81330042"],"award-info":[{"award-number":["81330042"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81070982"],"award-info":[{"award-number":["81070982"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81371957"],"award-info":[{"award-number":["81371957"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81171714"],"award-info":[{"award-number":["81171714"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81201400"],"award-info":[{"award-number":["81201400"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81301544"],"award-info":[{"award-number":["81301544"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["21037022\/B070203"],"award-info":[{"award-number":["21037022\/B070203"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Doctor startup Foundation of Logistics University of PAPF","award":["WHTD201303-3"],"award-info":[{"award-number":["WHTD201303-3"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2014,2]]},"DOI":"10.1016\/j.bbrc.2014.01.070","type":"journal-article","created":{"date-parts":[[2014,1,27]],"date-time":"2014-01-27T01:45:52Z","timestamp":1390787152000},"page":"395-400","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"title":["ERK2 small interfering RNAs prevent epidural fibrosis via the efficient inhibition of collagen expression and inflammation in laminectomy rats"],"prefix":"10.1016","volume":"444","author":[{"given":"Chao","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohong","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9404-9339","authenticated-orcid":false,"given":"Zhipin","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huabing","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Tong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangzhi","family":"Ning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenyuan","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liwei","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiqing","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2014.01.070_b0005","first-page":"1351","article-title":"Role of antifibrotic cytokine interferon-gamma in the prevention of postlaminectomy peridural fibrosis in rats, Neurosurgery","volume":"62","author":"Emmez","year":"2008"},{"key":"10.1016\/j.bbrc.2014.01.070_b0010","doi-asserted-by":"crossref","first-page":"6965","DOI":"10.1016\/j.biomaterials.2012.06.010","article-title":"Reconstruction of epidural fat with engineered adipose tissue from adipose derived stem cells and PLGA in the rabbit dorsal laminectomy model","volume":"33","author":"Xu","year":"2012","journal-title":"Biomaterials"},{"key":"10.1016\/j.bbrc.2014.01.070_b0015","doi-asserted-by":"crossref","first-page":"147","DOI":"10.5114\/fn.2013.35958","article-title":"Nanofiber nets in prevention of cicatrisation in spinal procedures. Experimental study","volume":"51","author":"Andrychowski","year":"2013","journal-title":"Folia Neuropathol."},{"key":"10.1016\/j.bbrc.2014.01.070_b0020","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1097\/00007632-198509000-00012","article-title":"Pedicle fat grafts for the prevention of scar in low back surgery. A preliminary report on the first 92 cases","volume":"10","author":"Gill","year":"1985","journal-title":"Spine"},{"key":"10.1016\/j.bbrc.2014.01.070_b0025","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1007\/s00586-007-0580-y","article-title":"Preventing peridural fibrosis with nonsteroidal anti-inflammatory drugs","volume":"17","author":"Sandoval","year":"2008","journal-title":"Eur. Spine J."},{"key":"10.1016\/j.bbrc.2014.01.070_b0030","doi-asserted-by":"crossref","first-page":"758","DOI":"10.3171\/2009.6.SPINE08580","article-title":"Use of pimecrolimus to prevent epidural fibrosis in a postlaminectomy rat model","volume":"11","author":"Cemil","year":"2009","journal-title":"J. Neurosurg. Spine"},{"key":"10.1016\/j.bbrc.2014.01.070_b0035","doi-asserted-by":"crossref","first-page":"359","DOI":"10.3349\/ymj.1990.31.4.359","article-title":"An experimental study on prevention of postlaminectomy scar formation","volume":"31","author":"Lee","year":"1990","journal-title":"Yonsei Med. J."},{"key":"10.1016\/j.bbrc.2014.01.070_b0040","doi-asserted-by":"crossref","first-page":"419","DOI":"10.3171\/jns.1978.49.3.0419","article-title":"Prophylaxis of the laminectomy membrane, an experimental study in dogs","volume":"49","author":"Barber\u00e1","year":"1978","journal-title":"J. Neurosurg."},{"key":"10.1016\/j.bbrc.2014.01.070_b0045","doi-asserted-by":"crossref","DOI":"10.1155\/2011\/504967","article-title":"Effect of honey on peridural fibrosis formation after laminectomy in rats: a novel experimental study","author":"Farrokhi","year":"2011","journal-title":"Evid Based Compl. Alternat. Med."},{"key":"10.1016\/j.bbrc.2014.01.070_b0050","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1038\/35078107","article-title":"Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells","volume":"411","author":"Elbashir","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2014.01.070_b0055","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1038\/35888","article-title":"Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans","volume":"391","author":"Fire","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2014.01.070_b0060","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1038\/418244a","article-title":"RNA interference","volume":"418","author":"Hannon","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2014.01.070_b0065","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1111\/j.1600-0625.2007.00574.x","article-title":"RNAi-mediated inhibition of COL1A1 and COL3A1 in human skin fibroblasts","volume":"16","author":"Wang","year":"2007","journal-title":"Exp. Dermatol."},{"key":"10.1016\/j.bbrc.2014.01.070_b0070","first-page":"703","article-title":"Interference targeting transforming growth factor-beta type II receptor suppresses ocular inflammation and fibrosis","volume":"10","author":"Nakamura","year":"2004","journal-title":"Mol. Vis."},{"key":"10.1016\/j.bbrc.2014.01.070_b0075","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1016\/j.bjps.2006.05.007","article-title":"Inhibition of Smad3 expression decreases collagen synthesis in keloid disease fibroblasts","volume":"60","author":"Wang","year":"2007","journal-title":"J. Plast. Reconstr. Aesthet. Surg."},{"key":"10.1016\/j.bbrc.2014.01.070_b0080","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1073\/pnas.232688199","article-title":"Inhibiting HIV-1 infection in human T cells by lentiviral-mediated delivery of small interfering RNA against CCR5","volume":"100","author":"Qin","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbrc.2014.01.070_b0085","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1089\/neu.1995.12.1","article-title":"A sensitive and reliable locomotor rating scale for open field testing in rats","volume":"12","author":"Basso","year":"1995","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.bbrc.2014.01.070_b0090","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.bbrc.2009.11.140","article-title":"Efficient inhibition of the formation of joint adhesions by ERK2 small interfering RNAs","volume":"391","author":"Li","year":"2010","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2014.01.070_b0095","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1111\/j.1471-4159.2010.06579.x","article-title":"Involvement of ERK2 in traumatic spinal cord injury","volume":"113","author":"Yu","year":"2010","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbrc.2014.01.070_b0100","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1111\/j.1471-4159.2009.06396.x","article-title":"Role of M2, M3, and M4 muscarinic receptor subtypes in the spinal cholonergic control of nociception revealed using siRNA in rats","volume":"111","author":"Cai","year":"2009","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbrc.2014.01.070_b0105","article-title":"An experimental novel study: angelica sinensis prevents epidural fibrosis in laminectomy rats via downregulation of hydroxyproline, IL-6, and TGF- \u03b2 1","author":"Zhang","year":"2013","journal-title":"Evid Based Compl. Alternat. Med."},{"key":"10.1016\/j.bbrc.2014.01.070_b0110","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1007\/s11259-009-9221-8","article-title":"ISG15 expression in response to double-stranded RNA or LPS in cultured fetal bovine lung(FBL) cells","volume":"33","author":"Liu","year":"2009","journal-title":"Vet. Res. Commun."},{"key":"10.1016\/j.bbrc.2014.01.070_b0115","doi-asserted-by":"crossref","first-page":"307","DOI":"10.3109\/17453677008991516","article-title":"Decreased granulation tissue reaction after installment ofhyaluronic acid","volume":"41","author":"Rydell","year":"1970","journal-title":"Acta Orthop. Scand."},{"key":"10.1016\/j.bbrc.2014.01.070_b0120","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/s00590-012-0971-6","article-title":"Hydroxycamptothecin liposomes inhibit collagen secretion and induce fibroblast apoptosis in a postlaminectomy rabbit model","volume":"23","author":"Zhu","year":"2013","journal-title":"Eur. J. Orthop. Surg. Traumatol."},{"key":"10.1016\/j.bbrc.2014.01.070_b0125","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1002\/jor.1100180208","article-title":"Adhesion formation can be reduced by the suppression of transforming growth factor-beta1 activity","volume":"18","author":"Fukui","year":"2000","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.bbrc.2014.01.070_b0130","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1227\/00006123-198310000-00003","article-title":"Autogenic fat transplants in the epidural space in routine spine surgery","volume":"13","author":"Bryant","year":"1983","journal-title":"Neurosurgery"},{"key":"10.1016\/j.bbrc.2014.01.070_b0135","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.tvjl.2005.04.011","article-title":"Laminectomy membrane formation in dogs: is the answer still elusive?","volume":"172","author":"Chandler","year":"2006","journal-title":"Vet. J."},{"key":"10.1016\/j.bbrc.2014.01.070_b0140","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1097\/BRS.0b013e3181453fa5","article-title":"Spinal somatosensory evoked potential to evaluate neurophysiologic changes associated with post-laminectomy fibrosis: an experimental study","volume":"32","author":"Jou","year":"2007","journal-title":"Spine"},{"key":"10.1016\/j.bbrc.2014.01.070_b0145","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.spinee.2005.01.010","article-title":"Evaluation of hyaluronic acid sheet for the prevention of postlaminectomy adhesions","volume":"5","author":"Kato","year":"2005","journal-title":"Spine J."},{"key":"10.1016\/j.bbrc.2014.01.070_b0150","doi-asserted-by":"crossref","first-page":"633","DOI":"10.3171\/jns.1985.63.4.0633","article-title":"Symptomatic root compression by a free fat transplant after hemilaminectomy. Case report","volume":"63","author":"Cabezudo","year":"1985","journal-title":"J. Neurosurg."},{"key":"10.1016\/j.bbrc.2014.01.070_b0155","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1097\/00007632-199508150-00008","article-title":"The effect of interposition membrane on the outcome of lumbar laminectomy and discectomy","volume":"20","author":"MacKay","year":"1995","journal-title":"Spine (Phila Pa 1976)"},{"key":"10.1016\/j.bbrc.2014.01.070_b0180","first-page":"262","article-title":"Expression analysis of Akt and MAPK signaling pathways in lung tissue of patients with idiopathic pulmonary fibrosis (IPF)","volume":"30","author":"Antoniou","year":"2010"},{"key":"10.1016\/j.bbrc.2014.01.070_b0165","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1002\/path.1208","article-title":"MAP kinase activation and apoptosis in lung tissues from patients with idiopathic pulmonary fibrosis","volume":"198","author":"Yoshida","year":"2002","journal-title":"J. Pathol."},{"key":"10.1016\/j.bbrc.2014.01.070_b0170","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.neuropharm.2013.11.010","article-title":"All-trans retinoic acid prevents epidural fibrosis through NF-\u03baB signaling pathway in post-laminectomy rats","volume":"79","author":"Zhang","year":"2013","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bbrc.2014.01.070_b0175","article-title":"Calcium channel blockers in reduction of epidural fibrosis and dural adhesions in laminectomy rats","author":"Wang","year":"2013","journal-title":"Eur. J. Orthop. Surg. Traumatol."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X14000941?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X14000941?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,6]],"date-time":"2018-10-06T22:30:23Z","timestamp":1538865023000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X14000941"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2]]},"references-count":35,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,2]]}},"alternative-id":["S0006291X14000941"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2014.01.070","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2014,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"ERK2 small interfering RNAs prevent epidural fibrosis via the efficient inhibition of collagen expression and inflammation in laminectomy rats","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2014.01.070","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}